Aggregation of human recombinant monoclonal antibodies influences the capacity of dendritic cells to stimulate adaptive T-cell responses in vitro

PLoS ONE

Volumn 9, Issue 1, 2014, Pages

  Rombach Riegraf, Verena ^a   Karle, Anette C ^a   Wolf, Babette ^a   Sordé, Laetitia ^a   Koepke, Stephan ^a   Gottlieb, Sascha ^a,c   Krieg, Jennifer ^a   Djidja, Marie Claude ^a   Baban, Aida ^a   Spindeldreher, Sebastian ^a   Koulov, Atanas V ^a,b   Kiessling, Andrea ^a  

^a NOVARTIS PHARMA AG   (Switzerland)

^b F HOFFMANN LA ROCHE LTD   (Switzerland)

^c MOLECULAR PARTNERS AG   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

HLA DR ANTIGEN; IMMUNOGLOBULIN G ANTIBODY; MONOCLONAL ANTIBODY; RECOMBINANT ANTIBODY;

ADAPTIVE IMMUNITY; ANTIGEN PRESENTATION; ARTICLE; BIOASSAY; CAPILLARY ELECTROPHORESIS; CD4+ T LYMPHOCYTE; CELL ACTIVATION; CELL ACTIVITY; CELL MATURATION; CONTROLLED STUDY; CROSS REACTION; DENDRITIC CELL; GEL PERMEATION CHROMATOGRAPHY; HUMAN; HUMAN CELL; HUMORAL IMMUNITY; IN VITRO STUDY; LIGHT SCATTERING; PEPTIDE MAPPING; PROTEIN AGGREGATION; PROTEIN PROCESSING; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION;

ANTIBODIES, MONOCLONAL; ANTIGEN PRESENTATION; ANTIGEN-PRESENTING CELLS; CD4-POSITIVE T-LYMPHOCYTES; DENDRITIC CELLS; HLA-DR ANTIGENS; HUMANS; RECOMBINANT PROTEINS;

EID: 84898642873     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0086322     Document Type: Article

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