Rapid prototyping of concave microwells for the formation of 3D multicellular cancer aggregates for drug screening

Advanced Healthcare Materials

Volumn 3, Issue 4, 2014, Pages 609-616

  Tu, Ting Yuan ^a   Wang, Zhe ^a   Bai, Jing ^a   Sun, Wei ^a   Peng, Weng Kung ^a   Huang, Ruby Yun Ju ^b   Thiery, Jean Paul ^c   Kamm, Roger D ^a,d  

^a SINGAPORE MIT ALLIANCE FOR RESEARCH AND TECHNOLOGY   (Singapore)

^b NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^c NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^d Massachusetts Institute of Technology Cambridge   (United States)

Author keywords

Drug screening; Microwells; Multicellular cancer aggregates; Multicellular spheroids

Indexed keywords

AGGREGATES; BIOLOGICAL ORGANS; CARBON DIOXIDE LASERS; CELL CULTURE; CELLS; CONTROLLED DRUG DELIVERY; COSTS; LASER ABLATION; MICROCHANNELS; POLYDIMETHYLSILOXANE; SILICONES;

DRUG SCREENING; FUNCTIONAL ASSAYS; MICROWELLS; MULTICELLULAR AGGREGATES; MULTICELLULAR SPHEROID; POLYDIMETHYLSILOXANE PDMS; SURFACE SMOOTHNESS; TRADITIONAL CULTURES;

DISEASES;

CANERTINIB; DIMETICONE; POLY(METHYL METHACRYLATE); POLYSTYRENE; ANTINEOPLASTIC AGENT;

ARTICLE; BIOTECHNOLOGICAL PRODUCTION; CANCER CELL CULTURE; CARBON DIOXIDE LASER; CELL ADHESION; CELL AGGREGATION; CELL MIGRATION ASSAY; CELL SIZE; CELL STRUCTURE; CELL VIABILITY; CELLULAR DISTRIBUTION; CELLULAR, SUBCELLULAR AND MOLECULAR BIOLOGICAL PHENOMENA AND FUNCTIONS; CONCAVE MICROWELL; CONCENTRATION RESPONSE; CONTROLLED STUDY; CULTURE TECHNIQUE; DISEASE MODEL; DRUG SCREENING; HUMAN; HUMAN CELL; IN VITRO STUDY; LUNG CANCER; PRIORITY JOURNAL; PROCESS OPTIMIZATION; SURFACE PROPERTY; SURFACE ROUNDNESS; SURFACE SMOOTHNESS; THREE DIMENSION MONOLAYER CULTURE; THREE DIMENSIONAL MULTICELLULAR CANCER AGGREGATE; TWO DIMENSION MONOLAYER CULTURE; VALIDATION PROCESS; CELL SURVIVAL; CYTOLOGY; DEVICES; DRUG EFFECTS; MULTICELLULAR SPHEROID; NEOPLASMS; PATHOLOGY; PROCEDURES; TUMOR CELL CULTURE; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS; CELL CULTURE TECHNIQUES; CELL LINE, TUMOR; CELL SURVIVAL; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; NEOPLASMS; SPHEROIDS, CELLULAR; TUMOR CELLS, CULTURED;

EID: 84898639652     PISSN: 21922640     EISSN: 21922659     Source Type: Journal    
DOI: 10.1002/adhm.201300151     Document Type: Article

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