Antibacterial activity of pepducins, allosterical modulators of formyl peptide receptor signaling

Antimicrobial Agents and Chemotherapy

Volumn 58, Issue 5, 2014, Pages 2985-2988

  Winther, Malene ^a   Gabl, Michael ^a   Oprea, Tudor I ^a,b   Jönsson, Bodil ^a   Boulay, Francois ^c   Bylund, Johan ^a   Dahlgren, Claes ^a   Forsman, Huamei ^a  

^a UNIVERSITY OF GOTHENBURG   (Sweden)

^b UNIVERSITY OF NEW MEXICO SCHOOL OF MEDICINE   (United States)

^c INSERM   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIINFECTIVE AGENT; FORMYLPEPTIDE RECEPTOR; G PROTEIN COUPLED RECEPTOR; PEPDUCIN; UNCLASSIFIED DRUG;

ALLOSTERISM; AMINO ACID SEQUENCE; ANTIBACTERIAL ACTIVITY; ARTICLE; BACTERIAL GROWTH; BACTERICIDAL ACTIVITY; IMMUNOMODULATION; INNATE IMMUNITY; LEUKOCYTE ACTIVATION; NEUTROPHIL; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; DRUG EFFECTS; HUMAN; METABOLISM;

ANTI-BACTERIAL AGENTS; HUMANS; NEUTROPHILS; RECEPTORS, FORMYL PEPTIDE; RECEPTORS, G-PROTEIN-COUPLED; SIGNAL TRANSDUCTION;

EID: 84898622292     PISSN: 00664804     EISSN: 10986596     Source Type: Journal    
DOI: 10.1128/AAC.02716-13     Document Type: Article

References (18)

1. Rodriguez de Castro F, Naranjo OR, Marco JA, Violan JS. 2009. New antimicrobial molecules and new antibiotic strategies. Semin. Respir. Crit. Care Med. 30:161-171. http://dx.doi.org/10.1055/s-0029-1202935.
2. Mandal SM, Barbosa AE, Franco OL. 2013. Lipopeptides in microbial infection control: scope and reality for industry. Biotechnol. Adv. 31:338-345. http://dx.doi.org/10.1016/j.biotechadv.2013.01.004.
3. O'Callaghan K, Kuliopulos A, Covic L. 2012. Turning receptors on and off with intracellular pepducins: new insights into G-protein-coupled receptor drug development. J. Biol. Chem. 287:12787-12796. http://dx.doi.org/10.1074/jbc.R112. 355461.
4. Jerala R. 2007. Synthetic lipopeptides: a novel class of anti-infectives. Expert Opin. Invest. Drugs 16:1159-1169. http://dx.doi.org/10.1517/13543784.16. 8.1159.
5. Covic L, Gresser AL, Talavera J, Swift S, Kuliopulos A. 2002. Activation and inhibition of G protein-coupled receptors by cell-penetrating membrane-tethered peptides. Proc. Natl. Acad. Sci. U. S. A. 99:643-648. http://dx.doi.org/10.1073/pnas.022460899.
6. Fu H, Karlsson J, Bylund J, Movitz C, Karlsson A, Dahlgren C. 2006. Ligand recognition and activation of formyl peptide receptors in neutrophils. J. Leukoc. Biol. 79:247-256. http://dx.doi.org/10.1189/jlb.0905498.
7. Murphy PM. 1994. The molecular biology of leukocyte chemoattractant receptors. Annu. Rev. Immunol. 12:593-633. http://dx.doi.org/10.1146/annurev.iy. 12.040194.003113.
8. Ye RD, Boulay F, Wang JM, Dahlgren C, Gerard C, Parmentier M, Serhan CN, Murphy PM. 2009. International union of basic and clinical pharmacology. LXXIII. Nomenclature for the formyl peptide receptor (FPR) family. Pharmacol. Rev. 61:119-161. http://dx.doi.org/10.1124/pr.109.001578.
9. Forsman H, Bylund J, Oprea TI, Karlsson A, Boulay F, Rabiet MJ, Dahlgren C. 2013. The leukocyte chemotactic receptor FPR2, but not the closely related FPR1, is sensitive to cell-penetrating pepducins with amino acid sequences descending from the third intracellular receptor loop. Biochim. Biophys. Acta 1833:1914-1923. http://dx.doi.org/10.1016/j.bbamcr.2013.03.026.
10. Forsman H, Andreasson E, Karlsson J, Boulay F, Rabiet MJ, Dahlgren C. 2012. Structural characterization and inhibitory profile of formyl peptide receptor 2 selective peptides descending from a PIP2-binding domain of gelsolin. J. Immunol. 189:629-637. http://dx.doi.org/10.4049/jimmunol.1101616.
11. Hultmark D, Engstrom A, Andersson K, Steiner H, Bennich H, Boman HG. 1983. Insect immunity. Attacins, a family of antibacterial proteins from Hyalophora cecropia. EMBO J. 2:571-576.
12. Gales AC, Reis AO, Jones RN. 2001. Contemporary assessment of antimicrobial susceptibility testing methods for polymyxin B and colistin: review of available interpretative criteria and quality control guidelines. J. Clin. Microbiol. 39:183-190. http://dx.doi.org/10.1128/JCM.39.1.183-190.2001.
13. Bylund J, Bjornsdottir H, Sundqvist M, Karlsson A, Dahlgren C. 2014. Measurement of respiratory burst products, released or retained, during activation of professional phagocytes. Methods Mol. Biol. 1124:321-338. http://dx.doi.org/10.1007/978-1-62703-845-4-21.
14. Kyte J, Doolittle RF. 1982. A simple method for displaying the hydropathic character of a protein. J. Mol. Biol. 157:105-132. http://dx.doi.org/10.1016/0022-2836(82)90515-0.
15. Bylund J, Christophe T, Boulay F, Nystrom T, Karlsson A, Dahlgren C. 2001. Proinflammatory activity of a cecropin-like antibacterial peptide from Helicobacter pylori. Antimicrob. Agents Chemother. 45:1700-1704. http://dx.doi.org/10.1128/AAC.45.6.1700-1704.2001.
16. De Y, Chen Q, Schmidt AP, Anderson GM, Wang JM, Wooters J, Oppenheim JJ, Chertov O. 2000. LL-37, the neutrophil granule-And epithelial cell-derived cathelicidin, utilizes formyl peptide receptor-like 1 (FPRL1) as a receptor to chemoattract human peripheral blood neutrophils, monocytes, and T cells. J. Exp. Med. 192:1069-1074. http://dx.doi.org/10.1084/jem.192.7.1069.
17. Rezansoff AJ, Hunter HN, Jing W, Park IY, Kim SC, Vogel HJ. 2005. Interactions of the antimicrobial peptide Ac-FRWWHR-NH(2) with model membrane systems and bacterial cells. J. Pept. Res. 65:491-501. http://dx.doi.org/10. 1111/j.1399-3011.2005.00263.x.
18. Shai Y, Makovitzky A, Avrahami D. 2006. Host defense peptides and lipopeptides: modes of action and potential candidates for the treatment of bacterial and fungal infections. Curr. Protein Pept. Sci. 7:479-486. http://dx.doi.org/10.2174/138920306779025620.