Molecular basis for preventing α-synuclein aggregation by a molecular tweezer

Journal of Biological Chemistry

Volumn 289, Issue 15, 2014, Pages 10727-10737

  Acharya, Srabasti ^a   Safaie, Brian M ^b   Wongkongkathep, Piriya ^c   Ivanova, Magdalena I ^b,e   Attar, Aida ^b,c   Klärner, Frank Gerrit ^d   Schrader, Thomas ^d   Loo, Joseph A ^b,c   Bitan, Gal ^b,c   Lapidus, Lisa J ^a  

^a MICHIGAN STATE UNIVERSITY   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d UNIVERSITY OF DUISBURG ESSEN   (Germany)

^e UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FLUORESCENCE; PROTEINS; SELF ASSEMBLY;

AMYLOIDOGENIC PROTEINS; FLUORESCENCE ANALYSIS; MOLECULAR BASIS; MOLECULAR TWEEZERS; N-TERMINALS; PHOTO-INDUCED; SIDE-CHAINS; STRONG BINDING;

CHAINS;

ALPHA SYNUCLEIN; CLR01 PROTEIN; MEMBRANE PROTEIN; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; BINDING SITE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; ENZYME INHIBITION; FLUORESCENCE ANALYSIS; MASS SPECTROMETRY; MATHEMATICAL ANALYSIS; MOLECULAR MECHANICS; NONHUMAN; OLIGOMERIZATION; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN CROSS LINKING; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE;

INHIBITOR; INTRAMOLECULAR DIFFUSION; MASS SPECTROMETRY (MS); PARKINSON'S DISEASE; PROTEIN AGGREGATION; SPECTROSCOPY; Α-SYNUCLEIN;

ALPHA-SYNUCLEIN; AMINO ACID SEQUENCE; BINDING SITES; BRIDGED COMPOUNDS; DIFFUSION; HUMANS; KINETICS; LYSINE; MASS SPECTROMETRY; MOLECULAR SEQUENCE DATA; ORGANOPHOSPHATES; PARKINSON DISEASE; PROBABILITY; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; SPECTROMETRY, FLUORESCENCE; TREATMENT OUTCOME;

EID: 84898619520     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.524520     Document Type: Article

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