High-throughput epitope binning assays on label-free array-based biosensors can yield exquisite epitope discrimination that facilitates the selection of monoclonal antibodies with functional activity

PLoS ONE

Volumn 9, Issue 3, 2014, Pages

  Abdiche, Yasmina Noubia ^a   Miles, Adam ^b   Eckman, Josh ^b   Foletti, Davide ^a   Van Blarcom, Thomas J ^a   Yeung, Yik Andy ^a   Pons, Jaume ^a   Rajpal, Arvind ^a  

^a PFIZER INC   (United States)

^b Wasatch Microfluidics   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EPITOPE; GRN PROTEIN, HUMAN; MONOCLONAL ANTIBODY; SIGNAL PEPTIDE;

ANTIBODY DETECTION; ANTIBODY SCREENING; ANTIGEN ANTIBODY REACTION; ANTIGEN BINDING; ANTIGEN DETECTION; ARTICLE; BIOSENSOR; COMPARATIVE EFFECTIVENESS; CONTINUOUS FLOW REACTOR; CONTROLLED STUDY; HIGH THROUGHPUT SCREENING; INTERFEROMETRY; LIGAND BINDING; PREDICTIVE VALUE; PROBABILITY; SURFACE PLASMON RESONANCE; GENETIC PROCEDURES; HUMAN; IMMUNOLOGY; PROCEDURES; STAINING;

ANTIBODIES, MONOCLONAL; BIOSENSING TECHNIQUES; EPITOPES; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; INTERFEROMETRY; STAINING AND LABELING; SURFACE PLASMON RESONANCE;

EID: 84898614037     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0092451     Document Type: Article

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