Online integrity monitoring in the Protein A step of mAb Production Processes-increasing reliability and process robustness

Biotechnology Progress

Volumn 30, Issue 2, 2014, Pages 383-390

  Bork, Christopher ^a   Holdridge, Sarah ^a   Walter, Mark ^a   Fallon, Eric ^a   Pohlscheidt, Michael ^a  

^a GENENTECH INC   (United States)

Author keywords

Chromatography; HETP; Integrity monitoring; Protein A; Transition analysis

Indexed keywords

CHROMATOGRAPHY; COLUMN CHROMATOGRAPHY; EFFICIENCY; FIBER OPTIC SENSORS; PACKED BEDS; PURIFICATION; QUALITY CONTROL; REMOVAL;

ANTIBODY PURIFICATION; HETP; INTEGRITY MONITORING; MANUFACTURING OPERATIONS; PROTEIN A; REMOVAL OF IMPURITIES; STATE-OF-THE-ART TECHNOLOGY; TRANSITION ANALYSIS;

ANTIBODIES;

MONOCLONAL ANTIBODY; RECOMBINANT PROTEIN; STAPHYLOCOCCUS PROTEIN A;

ANIMAL; CHEMISTRY; CHO CELL LINE; CRICETULUS; HAMSTER; ISOLATION AND PURIFICATION; LIQUID CHROMATOGRAPHY; METABOLISM; PROCEDURES; REPRODUCIBILITY; STANDARDS; THEORETICAL MODEL;

ANIMALS; ANTIBODIES, MONOCLONAL; CHO CELLS; CHROMATOGRAPHY, LIQUID; CRICETINAE; CRICETULUS; MODELS, THEORETICAL; RECOMBINANT PROTEINS; REPRODUCIBILITY OF RESULTS; STAPHYLOCOCCAL PROTEIN A;

EID: 84898541514     PISSN: 87567938     EISSN: 15206033     Source Type: Journal    
DOI: 10.1002/btpr.1849     Document Type: Article

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