A prospective assessment of the natural course of the exocrine pancreatic function in patients with a pancreatic head tumor

Journal of Clinical Gastroenterology

Volumn 48, Issue 5, 2014, Pages

  Sikkens, Edmée C M ^a   Cahen, Djuna L ^a   De Wit, Jill ^a   Looman, Caspar W N ^a   Van Eijck, Casper ^a   Bruno, Marco J ^a  

^a ERASMUS MEDICAL CENTER   (Netherlands)

Author keywords

ampullary carcinoma; biliary carcinoma; enzyme replacement therapy; exocrine pancreatic insufficiency; pancreatic cancer; steatorrhea; weight loss

Indexed keywords

AGED; BILE DUCT TUMOR; COHORT ANALYSIS; EXOCRINE PANCREATIC INSUFFICIENCY; FEMALE; FOLLOW UP; HUMAN; MALE; MIDDLE AGED; PANCREAS; PANCREAS FUNCTION TEST; PANCREAS TUMOR; PATHOLOGY; PATHOPHYSIOLOGY; PREVALENCE; PROSPECTIVE STUDY; STEATORRHEA;

AGED; BILE DUCT NEOPLASMS; COHORT STUDIES; EXOCRINE PANCREATIC INSUFFICIENCY; FEMALE; FOLLOW-UP STUDIES; HUMANS; MALE; MIDDLE AGED; PANCREAS, EXOCRINE; PANCREATIC FUNCTION TESTS; PANCREATIC NEOPLASMS; PREVALENCE; PROSPECTIVE STUDIES; STEATORRHEA;

EID: 84898457310     PISSN: 01920790     EISSN: 15392031     Source Type: Journal    
DOI: 10.1097/MCG.0b013e31829f56e7     Document Type: Article

References (26)

1. Rocha-Lima CM. New directions in the management of advanced pancreatic cancer: a review. Anticancer Drugs. 2008; 19:435-446.
2. Gullick HD. Carcinoma of the pancreas; a review and critical study of 100 cases. Medicine (Baltimore). 1959;38:47-84.
3. Heber D, Tchekmedyian NS. Pathophysiology of cancer: hormonal and metabolic abnormalities. Oncology. 1992; 49(suppl 2):28-31.
4. Pasquali C, Fogar P, Sperti C, et al. Efficacy of a pancreatic enzyme formulation in the treatment of steatorrhea in patients with chronic pancreatitis. Curr Ther Res Clin Exp. 1996;57: 358-365.
5. Richter E, Denecke A, Klapdor S, et al. Parenteral nutrition support for patients with pancreatic cancer-improvement of the nutritional status and the therapeutic outcome. Anticancer Res. 2012;32:2111-2118.
6. Klapdor R, Bahlo M, Babinsky A, et al. Reflections on treatment strategies for palliative chemotherapy of pancreatic cancer. Anticancer Res. 2007;27:1789-1794.
7. Bossola M, Pacelli F, Tortorelli A, et al. Cancer cachexia: it's time for more clinical trials. Ann Surg Oncol. 2007;14:276-285.
8. Ockenga J, Valentini L. Review article: anorexia and cachexia in gastrointestinal cancer. Aliment Pharmacol Ther. 2005;22: 583-594.
9. Bruno MJ, Haverkort EB, Tijssen GP, et al. Placebo controlled trial of enteric coated pancreatin microsphere treatment in patients with unresectable cancer of the pancreatic head region. Gut. 1998;42:92-96.
10. Loser C, Mollgaard A, Folsch UR. Faecal elastase 1: a novel, highly sensitive, and specific tubeless pancreatic function test. Gut. 1996;39:580-586.
11. Carroccio A, Verghi F, Santini B, et al. Diagnostic accuracy of fecal elastase 1 assay in patients with pancreatic maldigestion or intestinal malabsorption: a collaborative study of the Italian Society of Pediatric Gastroenterology and Hepatology. Dig Dis Sci. 2001;46:1335-1342.
12. Stein J, Jung M, Sziegoleit A, et al. Immunoreactive elastase I: clinical evaluation of a new noninvasive test of pancreatic function. Clin Chem. 1996;42:222-226.
13. Ihse I, Arnesjo B, Kugelberg C, et al. Intestinal activities of trypsin, lipase, and phospholipase after a test meal. An evaluation of 474 examinations. Scand J Gastroenterol. 1977;12:663-668.
14. Kato H, Nakao A, Kishimoto W, et al. 13C-labeled trioctanoin breath test for exocrine pancreatic function test in patients after pancreatoduodenectomy. Am J Gastroenterol. 1993;88:64-69.
15. Matsumoto J, Traverso LW. Exocrine function following the whipple operation as assessed by stool elastase. J Gastrointest Surg. 2006;10:1225-1229.
16. Tran TC, van't Hof G, Kazemier G, et al. Pancreatic fibrosis correlates with exocrine pancreatic insufficiency after pancrea-toduodenectomy. Dig Surg. 2008;25:311-318.
17. Guidelines for the management of patients with pancreatic cancer periampullary and ampullary carcinomas. Gut. 2005; 54(suppl 5):v1-v16.
18. Sikkens EC, Cahen DL, van Eijck C, et al. The daily practice of pancreatic enzyme replacement therapy after pancreatic surgery: a Northern European Survey: enzyme replacement after surgery. J Gastrointest Surg. 2012;16:1487-1492.
19. Sikkens EC, Cahen DL, van Eijck C, et al. Patients with exocrine insufficiency due to chronic pancreatitis are undertreated: a Dutch national survey. Pancreatology. 2012;12:71-73.
20. Bruno MJ. Maldigestion and exocrine pancreatic insufficiency after pancreatic resection for malignant disease: pathofysiology and treatment. Pancreatology. 2001;1:55-61.
21. Bo-Linn GW, Fordtran JS. Fecal fat concentration in patients with steatorrhea. Gastroenterology. 1984;87:319-322.
22. Halloran CM, Cox TF, Chauhan S, et al. Partial pancreatic resection for pancreatic malignancy is associated with sustained pancreatic exocrine failure and reduced quality of life: a prospective study. Pancreatology. 2011;11:535-545.
23. Cavalot F, Bonomo K, Perna P, et al. Pancreatic elastase-1 in stools, a marker of exocrine pancreas function, correlates with both residual beta-cell secretion and metabolic control in type 1 diabetic subjects. Diabetes Care. 2004;27:2052-2054.
24. Dominguez-Munoz JE, Hieronymus C, Sauerbruch T, et al. Fecal elastase test: evaluation of a new noninvasive pancreatic function test. Am J Gastroenterol. 1995;90:1834-1837.
25. Dominici R, Franzini C. Fecal elastase-1 as a test for pancreatic function: a review. Clin Chem Lab Med. 2002;40: 325-332.
26. Stein J, Schoonbroodt D, Jung M, et al. Mesure de I'elastase 1 fecale par immunoreactivite: une nouvelle approche indirecte de la fonction pancreatique [Measurement of fecal elastase 1 by immunoreactivity: a new indirect test of the pancreatic function]. Gastroenterol Clin Biol. 1996;20:424-429.