Late-onset depression in the absence of stroke: Associated with silent brain infarctions, microbleeds and lesion locations

International Journal of Medical Sciences

Volumn 11, Issue 6, 2014, Pages 587-592

  Wu, Ri Han ^a   Feng, Chao ^a,b   Xu, Yu ^a   Hua, Ting ^a   Liu, Xue Yuan ^a   Fang, Min ^a  

^a TENTH PEOPLE S HOSPITAL OF TONGJI UNIVERSITY   (China)

^b ZHEJIANG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

Late onset depression; Microbleeds; Silent brain infarctions; Stroke

Indexed keywords

AGED; ARTICLE; BASAL GANGLION; BRAIN DAMAGE; BRAIN HEMORRHAGE; BRAIN INFARCTION; BRAIN REGION; CASE CONTROL STUDY; CLINICAL EVALUATION; CONTROLLED STUDY; DEPRESSION; DISEASE ASSOCIATION; DSM-IV; FEMALE; HUMAN; LATE ONSET DEPRESSION; LEFT HEMISPHERE; MAJOR CLINICAL STUDY; MALE; NEUROIMAGING; NUCLEAR MAGNETIC RESONANCE IMAGING; PREVALENCE; RISK ASSESSMENT; RISK FACTOR; SUSCEPTIBILITY WEIGHTED IMAGING; CEREBROVASCULAR ACCIDENT; COMPLICATION; ONSET AGE; PATHOLOGY; RADIOGRAPHY;

AGE OF ONSET; AGED; BASAL GANGLIA; BRAIN INFARCTION; CEREBRAL HEMORRHAGE; DEPRESSION; FEMALE; HUMANS; MAGNETIC RESONANCE IMAGING; MALE; RISK FACTORS; STROKE;

EID: 84898441097     PISSN: 14491907     EISSN: None     Source Type: Journal    
DOI: 10.7150/ijms.8025     Document Type: Article

References (30)

1. Bukh JD, Bock C, Vinberg M, Gether U, Kessing LV. Differences between early and late onset adult depression. Clin Pract Epidemiol Ment Health 2011;7: 140-147.
2. Korten NC, Comijs HC, Lamers F, Penninx BW. Early and late onset depression in young and middle aged adults: differential symptomatology, characteristics and risk factors? J Affect Disord 2012;138: 259-267.
3. Sperner-Unterweger B, Kohl C, Fuchs D. Immune Changes and Neurotransmitters: Possible Interactions in Depression? Prog Neuropsychopharmacol Biol Psychiatry. 2012.
4. Loubinoux I, Kronenberg G, Endres M, Schumann-Bard P, Freret T, et al. Post-stroke depression: mechanisms, translation and therapy. J Cell Mol Med 2012;16: 1961-1969.
5. Eisch AJ, Petrik D. Depression and hippocampal neurogenesis: a road to remission? Science 2012;338: 72-75.
6. Lieverse R, de Vries R, Hoogendoorn AW, Smit JH, Hoogendijk WJ. Social Support and Social Rhythm Regularity in Elderly Patients With Major Depressive Disorder. Am J Geriatr Psychiatry. 2012.
7. Papazacharias A, Logroscino G, Barulli MR, Nardini M. Late life depression and late onset depression: are the same clinical and pathopsysiological picture? Psychiatr Danub 22 SUPPL 2010;1: S108-110.
8. Xekardaki A, Santos M, Hof P, Kovari E, Bouras C, et al. Neuropathological substrates and structural changes in late-life depression: the impact of vascular burden. Acta Neuropathol 2012;124: 453-464.
9. Tang WK, Lu JY, Chen YK, Chu WC, Mok V, et al. Association of frontal subcortical circuits infarcts in poststroke depression: a magnetic resonance imaging study of 591 Chinese patients with ischemic stroke. J Geriatr Psychiatry Neurol 2011;24: 44-49.
10. Salloway S, Malloy P, Kohn R, Gillard E, Duffy J, et al. MRI and neuropsychological differences in earlyand late-life-onset geriatric depression. Neurology 1996;46: 1567-1574.
11. Fujikawa T, Yamawaki S, Touhouda Y. Incidence of silent cerebral infarction in patients with major depression. Stroke 1993;24: 1631-1634.
12. Alexopoulos GS, Meyers BS, Young RC, Campbell S, Silbersweig D, et al. 'Vascular depression' hypothesis. Arch Gen Psychiatry 1997;54: 915-922.
13. Alexopoulos GS, Bruce ML, Silbersweig D, Kalayam B, Stern E. Vascular depression: a new view of late-onset depression. Dialogues Clin Neurosci 1999;1: 68-80.
14. Sneed JR, Culang-Reinlieb ME. The vascular depression hypothesis: an update. Am J Geriatr Psychiatry 2011;19: 99-103.
15. Dalby RB, Chakravarty MM, Ahdidan J, Sorensen L, Frandsen J, et al. Localization of white-matter lesions and effect of vascular risk factors in late-onset major depression. Psychol Med 2010;40: 1389-1399.
16. Saavedra Perez HC, Direk N, Hofman A, Vernooij MW, Tiemeier H, et al. Silent brain infarcts: a cause of depression in the elderly? Psychiatry Res 2013;211: 180-182.
17. de Moraes SA, Soares WJ, Rodrigues RA, Fett WC, Ferriolli E, et al. Dizziness in community-dwelling older adults: a population-based study. Braz J Otorhinolaryngol 2011; 77: 691-699.
18. Hur YM, Burri A, Spector TD. The Genetic and Environmental Structure of the Covariation Among the Symptoms of Insomnia, Fatigue, and Depression in Adult Females. Twin Res Hum Genet. 2012; 15(6): 1-7.
19. Nakao M, Yano E. Prediction of major depression in Japanese adults: somatic manifestation of depression in annual health examinations. J Affect Disord 2006; 90: 29-35.
20. Tsui YK, Tsai FY, Hasso AN, Greensite F, Nguyen BV. Susceptibility-weighted imaging for differential diagnosis of cerebral vascular pathology: a pictorial review. J Neurol Sci 2009; 287: 7-16.
21. Lubben JE. Assessing social networks among elderly populations. Fam Community Health 1988; 11: 42-52.
22. Xiong YY, Mok V. Age-Related White Matter Changes. Journal of Aging Research 2011; 2011: 1-13.
23. Fazekas F, Chawluk JB, Alavi A, Hurtig HI, Zimmerman RA. MR signal abnormalities at 1.5 T in Alzheimer's dementia and normal aging. AJR 1987; 149: 351-356.
24. Vermeer SE, Longstreth WT, Koudstaal PJ. Silent brain infarcts: a systematic review. The Lancet Neurology 2007; 6: 611-619.
25. Poels MMF, Ikram MA, van der Lugt A, Hofman A, Krestin GP, et al. Incidence of Cerebral Microbleeds in the General Population: The Rotterdam Scan Study. Stroke 2011; 42: 656-661.
26. Moran C, Phan TG, Srikanth VK. Cerebral small vessel disease: a review of clinical, radiological, and histopathological phenotypes. International Journal of Stroke 2012; 7: 36-46.
27. Pantoni L. Cerebral small vessel disease: from pathogenesis and clinical characteristics to therapeutic challenges. Lancet Neurol 2010; 9: 689-701.
28. Terroni L, Amaro E, Iosifescu DV, Tinone G, Sato JR, et al. Stroke lesion in cortical neural circuits and post-stroke incidence of major depressive episode: A 4-month prospective study. World Journal of Biological Psychiatry 2011; 12: 539-548.
29. Charidimou A, Gang Q, Werring DJ. Sporadic cerebral amyloid angiopathy revisited: recent insights into pathophysiology and clinical spectrum. Journal of Neurology, Neurosurgery & Psychiatry 2011; 83: 124-137.
30. Poels MM, Ikram MA, van der Lugt A, Hofman A, Niessen WJ, et al. Cerebral microbleeds are associated with worse cognitive function: the Rotterdam Scan Study. Neurology 2012; 78: 326-333.