Combined volatolomics for monitoring of human body chemistry

Scientific Reports

Volumn 4, Issue , 2014, Pages

  Broza, Yoav Y ^a   Zuri, Liat ^a   Haick, Hossam ^a  

^a TECHNION ISRAEL INSTITUTE OF TECHNOLOGY   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

VOLATILE ORGANIC COMPOUND;

ADULT; ART; ARTICLE; BIOCHEMISTRY; BREATH ANALYSIS; CHEMISTRY; FEMALE; HUMAN; MALE; MASS FRAGMENTOGRAPHY; METABOLOMICS; PRINCIPAL COMPONENT ANALYSIS; SKIN;

ADULT; BIOCHEMICAL PROCESSES; BREATH TESTS; FEMALE; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; HUMAN BODY; HUMANS; MALE; METABOLOMICS; PRINCIPAL COMPONENT ANALYSIS; SKIN; VOLATILE ORGANIC COMPOUNDS;

EID: 84898428159     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep04611     Document Type: Article

References (25)

1. Broza, Y. Y. & Haick, H. Nanomaterial-based sensors for detection of disease by volatile organic compounds. Nanomedicine 8, 785-806 (2013).
2. Hakim, M. et al. Volatile organic compounds of lung cancer and possible biochmical pathways. Chem. Rev. 112, 5949-5966 (2012).
3. Boots, A. W. et al. The versatile use of exhaled volatile organic compounds in human health and disease. J Breath Res 6, 027108 (2012).
4. Konvalina, G. & Haick, H. Sensors for breath testing: From nanomaterials to comprehensive disease detection. Acc. Chem. Res. 47, 66-76 (2014).
5. Centerwall, S. A.& Centerwall, W. R. The discovery of phenylketonuria: The story of a young couple, two retarded children, and a scientist. Pediatrics 105, 89-103 (2000). (Pubitemid 30035724)
6. Shirasu, M. & Touhara, K. The scent of disease: volatile organic compounds of the human body related to disease and disorder. J. Biochem. 150, 257-266 (2011).
7. Buszewski, B., Kesy, M., Ligor, T. & Amann, A. Human exhaled air analytics: biomarkers of diseases. Biomed. Chromatog. 21, 553-566 (2007). (Pubitemid 46937852)
8. Curran, A. M., Prada, P. A. & Furton, K. G. The differentiation of the volatile organic signatures of individuals through SPME-GC/MS of characteristic human scent compounds. J. Forensic. Sci. 55, 50-57 (2010).
9. Machado, R. F. et al. Detection of lung cancer by sensor array analyses of exhaled breath. Am. J. Respir. Crit. Care Med. 171, 1286-1291 (2005). (Pubitemid 40740737)
10. Voss, A. et al. Smelling heart failure from human skin odor with an electronic nose. Conf. Proc. IEEE Eng. Med. Biol. Soc. 2012, 4034-4037 (2012).
11. Risby, T. H. in Breath Analysis for Clinical Diagnosis and Therapeutic Monitoring. (eds. Amann, A. & Smith, D.) 251-265 (World Scientific, Singapore; 2005).
12. Syed, Z. & Leal, W. S. Acute olfactory response of Culex mosquitoes to a humanand bird-derived attractant. Proc. Nat. Acad. Sci. USA 106, 18803-18808 (2009).
13. Haick, H., Broza, Y. Y., Mochalski, P., Ruzsanyi, V. & Amann, A. Assessment, origin, and implementation of breath volatile cancer markers. Chem. Soc. Rev. 43, 1423-1449 (2014).
14. Westhoff, M. et al. Ion mobility spectrometry for the detection of volatile organic compounds in exhaled breath of patients with lung cancer: results of a pilot study. Thorax 64, 744-748 (2009).
15. Peng, G. et al. Detection of lung, breast, colorectal, and prostate cancers from exhaled breath using a single array of nanosensors. Br. J. Cancer 103, 542-551 (2010).
16. Xu, Z. Q. et al. A nanomaterial-based breath test for distinguishing gastric cancer from benign gastric conditions. Br. J. Cancer 108, 941-950 (2013).
17. de Lacy Costello, B. et al. A review of the volatiles from the healthy human body. J Breath Res 8, 014001 (2014).
18. Bajtarevic, A. et al. Noninvasive detection of lung cancer by analysis of exhaled breath. BMC Cancer 9, 348 (2009).
19. Broza, Y. Y. et al. A nanomaterial-based breath test for short-term follow-up after lung tumor resection. Nanomedicine (New York, NY, US) 9, 15-21 (2013).
20. Peng, G. et al. Diagnosing lung cancer in exhaled breath using gold nanoparticles. Nature Nanotechol. 4, 669-673 (2009).
21. Zilberman, Y., Ionescu, R., Feng, X., Mullen, K. & Haick, H. Nanoarray of polycyclic aromatic hydrocarbons and carbon nanotubes for accurate and predictive detection in real-world environmental humidity. ACS Nano 5, 6743-6753 (2011).
22. Dovgolevsky, E., Tisch, U. & Haick, H. Chemically sensitive resistors based on monolayer-capped cubic nanoparticles: towards configurable nanoporous sensors. Small 5, 1158-1161 (2009).
23. Peng, G., Trock, E. & Haick, H. Detecting simulated patterns of lung cancer biomarkers by random network of single-walled carbon nanotubes coated with non-polymeric organic materials. Nano Lett. 8, 3631-3635 (2008).
24. Bachar, N. et al. Polycyclic aromatic hydrocarbon for the detection of nonpolar analytes under counteracting humidity conditions. ACS Appl. Mater. Interf. 4, 4960-4965 (2012).
25. Konvalina, G. & Haick, H. Effect of humidity on nanoparticle-based chemiresistors: a comparison between synthetic and real-world samples. ACS Appl. Mater. Interf. 4, 317-325 (2012).