Presence and genetic environment of pleuromutilin-lincosamide-streptogramin a resistance gene lsa(E) in enterococci of human and swine origin

Journal of Antimicrobial Chemotherapy

Volumn 69, Issue 5, 2014, Pages 1424-1426

  Li, Xin Sheng ^a   Dong, Wei Chao ^a   Wang, Xiao Ming ^a   Hu, Gong Zheng ^a   Wang, Ya Bin ^a   Cai, Bai Yi ^b   Wu, Cong Ming ^c   Wang, Yang ^c   Du, Xiang Dang ^a  

^a HENAN AGRICULTURAL UNIVERSITY   (China)

^b EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^c CHINA AGRICULTURAL UNIVERSITY   (China)

Author keywords

Enterococcus faecalis; Enterococcus faecium

Indexed keywords

AMINOGLYCOSIDE; DALFOPRISTIN; LINCOSAMIDE; MIKAMYCIN B; PLEUROMUTILIN; STREPTOGRAMIN DERIVATIVE; VALNEMULIN; ABC TRANSPORTER; ANTIINFECTIVE AGENT; DITERPENE;

ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; BACTERIAL GENE; CONJUGATION; ENTEROCOCCUS CASSELIFLAVUS; ENTEROCOCCUS FAECALIS; ENTEROCOCCUS FAECIUM; ENTEROCOCCUS GALLINARUM; GENE CLUSTER; GENE INSERTION SEQUENCE; HUMAN; LETTER; LSA (E) GENE; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; METHICILLIN SUSCEPTIBLE STAPHYLOCOCCUS AUREUS; MULTILOCUS SEQUENCE TYPING; NONHUMAN; RESTRICTION FRAGMENT; ANIMAL; DNA SEQUENCE; DRUG EFFECTS; ENTEROCOCCUS; GENE ORDER; GENETICS; GRAM POSITIVE INFECTION; ISOLATION AND PURIFICATION; MICROBIOLOGY; MOLECULAR GENETICS; SWINE; SWINE DISEASE; VETERINARY;

ANIMALS; ANTI-BACTERIAL AGENTS; ATP-BINDING CASSETTE TRANSPORTERS; DITERPENES; DRUG RESISTANCE, BACTERIAL; ENTEROCOCCUS; GENE ORDER; GRAM-POSITIVE BACTERIAL INFECTIONS; LINCOSAMIDES; MOLECULAR SEQUENCE DATA; SEQUENCE ANALYSIS, DNA; STREPTOGRAMIN A; SWINE; SWINE DISEASES;

EID: 84898415635     PISSN: 03057453     EISSN: 14602091     Source Type: Journal    
DOI: 10.1093/jac/dkt502     Document Type: Letter

References (13)

1. Gentry DR, McCloskey L, Gwynn MN et al. Genetic characterization of Vga ABC proteins conferring reduced susceptibility to pleuromutilins in Staphylococcus aureus. Antimicrob Agents Chemother 2008; 52: 4507-9.
2. Kadlec K, Schwarz S. Novel ABC transporter gene, vga(C), located on a multiresistance plasmid from a porcine methicillin-resistant Staphylococcus aureus ST398 strain. Antimicrob Agents Chemother 2009; 53: 3589-91.
3. Schwendener S, Perreten V. New transposon Tn6133 in methicillinresistant Staphylococcus aureus ST398 contains vga(E), a novel streptogramin A, pleuromutilin, and lincosamide resistance gene. Antimicrob Agents Chemother 2011; 55: 4900-4.
4. Singh KV, Weinstock GM, Murray BE. An Enterococcus faecalis ABC homologue (Lsa) is required for the resistance of this species to clindamycin and quinupristin-dalfopristin. Antimicrob Agents Chemother 2002; 46: 1845-50.
5. Wendlandt S, Lozano C, Kadlec K et al. The enterococcal ABC transporter gene lsa(E) confers combined resistance to lincosamides, pleuromutilins and streptogramin A antibiotics in methicillin-susceptible and methicillin-resistant Staphylococcus aureus. J Antimicrob Chemother 2013; 68: 473-5.
6. Malbruny B, Werno AM, Murdoch DR et al. Cross-resistance to lincosamides, streptogramins A, and pleuromutilins due to the lsa(C) gene in Streptococcus agalactiae UCN70. Antimicrob Agents Chemother 2011; 55: 1470-4.
7. Li J, Li B,Wendlandt S et al. Identification of a novel vga(E) gene variant that confers resistance to pleuromutilins, lincosamides and streptogramin A antibiotics in staphylococci of porcine origin. J Antimicrob Chemother 2014; 69: 919-23.
8. Lozano C, Aspiroz C, Saenz Y et al. Genetic environment and location of the lnu(A) and lnu(B) genes in methicillin-resistant Staphylococcus aureus and other staphylococci of animal and human origin. J Antimicrob Chemother 2012; 67: 2804-8.
9. Li B,Wendlandt S, Yao J et al. Detection and new genetic environment of the pleuromutilin-lincosamide-streptogramin A resistance gene lsa(E) in methicillin-resistant Staphylococcus aureus of swine origin. J Antimicrob Chemother 2013; 68: 1251-5.
10. Clinical and Laboratory Standards Institute. Performance Standards for Antimicrobial Susceptibility Testing: Twenty-third Informational Supplement M100-S23. CLSI, Wayne, PA, USA, 2013.
11. Liu H,Wang Y,Wu C et al. A novel phenicol exporter gene, fexB, found in enterococci of animal origin. J Antimicrob Chemother 2012; 67: 322-5.
12. Wendlandt S, Li B, Lozano C et al. Identification of the novel spectinomycin resistance gene spw in methicillin-resistant and methicillinsusceptible Staphylococcus aureus of human and animal origin. J Antimicrob Chemother 2013; 68: 1679-80.
13. Wendlandt S, Li B, Ma Z et al. Complete sequence of the multiresistance plasmid pV7037 from a porcine methicillin-resistant Staphylococcus aureus. Vet Microbiol 2013; 166: 650-4.