Safety evaluation of orally administered afoxolaner in 8-week-old dogs

Veterinary Parasitology

Volumn 201, Issue 3-4, 2014, Pages 198-203

  Drag, Marlene ^a   Saik, Judith ^a   Harriman, Jay ^a   Larsen, Diane ^a  

^a BOEHRINGER INGELHEIM PHARMA GMBH AND CO KG   (Germany)

Author keywords

Afoxolaner; Dogs; Oral treatment; Safety

Indexed keywords

AFOXOLANER; NEXGARD; UNCLASSIFIED DRUG;

ANIMAL EUTHANASIA; ARTICLE; AUTOPSY; BEAGLE; BLOOD SAMPLING; CONTROLLED STUDY; DIARRHEA; DRUG BLOOD LEVEL; DRUG DOSE REGIMEN; DRUG EXPOSURE; DRUG FORMULATION; DRUG SAFETY; FEMALE; GROWTH; HISTOPATHOLOGY; MALE; NONHUMAN; PHYSICAL EXAMINATION; PUPPY; RANDOMIZED CONTROLLED TRIAL; REPEATED DRUG DOSE; VOMITING;

CANIS FAMILIARIS;

AFOXOLANER; DOGS; ORAL TREATMENT; SAFETY;

ADMINISTRATION, ORAL; ANIMALS; ANTIPARASITIC AGENTS; BODY WEIGHT; DOGS; FEMALE; ISOXAZOLES; MALE; NAPHTHALENES; RANDOM ALLOCATION; SAFETY;

EID: 84898058468     PISSN: 03044017     EISSN: 18732550     Source Type: Journal    
DOI: 10.1016/j.vetpar.2014.02.022     Document Type: Article

References (8)

1. Beugnet F., Franc M. Insecticide and acaricide molecules and/or combinations to prevent pet infestation by ectoparasites. Trends Parasitol. 2012, 28:267-279.
2. Blagburn B.L., Young D.R., Moran C., Meyer J.A., Leigh-Heffron A., Paarlberg T., Zimmermann A.G., Mowrey D., Wiseman S., Snyder D.E. Effects of orally administered spinosad (Comfortis) in dogs on adult and immature stages of the cat flea (Ctenocephalides felis). Vet. Parasitol. 2010, 168:312-317.
3. EMA Veterinary Medicines and Product Data Management, Guidance Notes on the Use of VeDDRA Terminology for Reporting Suspected Adverse Reactions in Animals and Humans. EMA/CVMP/PhVWP/288284/2007-Rev.6, 13 June 2013 2013, 11 pp. http://www.ema.europa.eu/.
4. Letendre L., Huang R., Kvaternick V., Harriman J., Drag M., Soll M. The intravenous and oral pharmacokinetics of afoxolaner used as a monthly chewable antiparasitic for dogs. Vet. Parasitol. 2014, 201:190-197.
5. Shoop W., Hartline E., Gould B., Waddell M., McDowell R., Kinney J., Lahm G., Long J., Xu M., Wagerle T., Jones G., Dietrich R., Cordova D., Schroeder M., Rhoades D., Benner E., Confalone P. Discovery and Mode of Action of Afoxolaner, a New Isoxazoline Parasiticide for Dogs. Vet. Parasitol. 2014, 201:179-189.
6. Stockham S.L., Scott M.A. Fundamentals of Veterinary Clinical Pathology 2002, Iowa State Press, 299 pp.
7. USDA Animal Welfare Regulations, 9CFR http://awic.nal.usda.gov/government-and-professional-resources/federal-laws/animal-welfare-act.
8. VICH Guideline GL 43. Target animal safety for veterinary pharmaceutical products http://www.vichsec.org/en/guidelines2.htm.