Histone deacetylase inhibitor sodium butyrate promotes the osteogenic differentiation of rat adipose-derived stem cells

Development Growth and Differentiation

Volumn 56, Issue 3, 2014, Pages 206-213

  Hu, Xiaoqing ^a   Fu, Yutuo ^b   Zhang, Xin ^a   Dai, Linghui ^a   Zhu, Jingxian ^a   Bi, Zhenggang ^b   Ao, Yingfang ^a   Zhou, Chunyan ^c  

^a PEKING UNIVERSITY THIRD HOSPITAL   (China)

^b THE FIRST AFFILIATED HOSPITAL OF HARBIN MEDICAL UNIVERSITY   (China)

^c PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

Author keywords

Adipose derived stem cells; Epigenetic regulation; Histone deacetylase inhibitor; Osteogenic differentiation; Sodium butyrate

Indexed keywords

BUTYRIC ACID; TRANSCRIPTION FACTOR RUNX2; HISTONE DEACETYLASE INHIBITOR; PRIMER DNA; RUNX2 PROTEIN, RAT;

ADIPOSE DERIVED STEM CELL; ADIPOSE TISSUE; ADULT STEM CELL; ANIMAL CELL; ARTICLE; BONE DEVELOPMENT; BONE TISSUE; CELL DIFFERENTIATION; CONTROLLED STUDY; DIETARY FIBER; FERMENTATION; GASTROINTESTINAL TRACT; HEMATOPOIETIC STEM CELL; HOMEOSTASIS; IN VITRO STUDY; MALE; MOUSE; NONHUMAN; PROMOTER REGION; PROTEIN EXPRESSION; TISSUE ENGINEERING; TISSUE REGENERATION; TISSUE REPAIR; ANALYSIS OF VARIANCE; ANIMAL; APOPTOSIS; CHROMATIN IMMUNOPRECIPITATION; CYTOLOGY; DRUG EFFECTS; FLOW CYTOMETRY; GENETIC EPIGENESIS; GENETICS; PHYSIOLOGY; RAT; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STEM CELL; WESTERN BLOTTING;

RATTUS;

ADIPOSE TISSUE; ANALYSIS OF VARIANCE; ANIMALS; APOPTOSIS; BLOTTING, WESTERN; BUTYRIC ACID; CELL DIFFERENTIATION; CHROMATIN IMMUNOPRECIPITATION; CORE BINDING FACTOR ALPHA 1 SUBUNIT; DNA PRIMERS; EPIGENESIS, GENETIC; FLOW CYTOMETRY; HISTONE DEACETYLASE INHIBITORS; OSTEOGENESIS; PROMOTER REGIONS, GENETIC; RATS; REAL-TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; STEM CELLS;

EID: 84898057082     PISSN: 00121592     EISSN: 1440169X     Source Type: Journal    
DOI: 10.1111/dgd.12119     Document Type: Article

References (20)

1. Al, B. F., De, K. J., Vanhaecke, T. & Rogiers, V. 2011. Current status of human adipose-derived stem cells: differentiation into hepatocyte-like cells. Sci. World J. 11, 1568-1581.
2. Berdasco, M. & Esteller, M. 2011. DNA methylation in stem cell renewal and multipotency. Stem. Cell Res. Ther. 2, 42.
3. Collas, P., Noer, A. & Sorensen, A. L. 2008. Epigenetic Basis for the Differentiation Potential of Mesenchymal and Embryonic Stem Cells. Transfus. Med. Hemother. 35, 205-215.
4. Gabory, A., Attig, L. & Junien, C. 2011. Developmental programming and epigenetics. Am. J. Clin. Nutr. 94, 1943S-1952S.
5. Gersbach, C. A., Byers, B. A., Pavlath, G. K. & Garcia, A. J. 2004. Runx2/Cbfa1 stimulates transdifferentiation of primary skeletal myoblasts into a mineralizing osteoblastic phenotype. Exp. Cell Res. 300, 406-417.
6. Ghosh, S. K., Perrine, S. P., Williams, R. M. & Faller, D. V. 2012. Histone deacetylase inhibitors are potent inducers of gene expression in latent EBV and sensitize lymphoma cells to nucleoside antiviral agents. Blood 119, 1008-1017.
7. Guan, M., Yao, W., Liu, R., Lam, K. S., Nolta, J., Jia, J., Panganiban, B., Meng, L., Zhou, P., Shahnazari, M., Ritchie, R. O. & Lane, N. E. 2012. Directing mesenchymal stem cells to bone to augment bone formation and increase bone mass. Nat. Med. 18, 456-462.
8. Han, J. W. & Yoon, Y. S. 2012. Epigenetic landscape of pluripotent stem cells. Antioxid. Redox Signal. 17, 205-223.
9. Hu, X., Zhang, X., Dai, L., Zhu, J., Jia, Z., Wang, W., Zhou, C. & Ao, Y. 2013. Histone deacetylase inhibitor trichostatin A promotes the osteogenic differentiation of rat adipose-derived stem cells by altering the epigenetic modifications on Runx2 promoter in a BMP signaling-dependent manner. Stem Cells Dev. 22, 248-255.
10. Lee, B., Thirunavukkarasu, K., Zhou, L., Pastore, L., Baldini, A., Hecht, J., Geoffroy, V., Ducy, P. & Karsenty, G. 1997. Missense mutations abolishing DNA binding of the osteoblast-specific transcription factor OSF2/CBFA1 in cleidocranial dysplasia. Nat. Genet. 16, 307-310.
11. Lee, S., Park, J. R., Seo, M. S., Roh, K. H., Park, S. B., Hwang, J. W., Sun, B., Seo, K., Lee, Y. S., Kang, S. K., Jung, J. W. & Kang, K. S. 2009. Histone deacetylase inhibitors decrease proliferation potential and multilineage differentiation capability of human mesenchymal stem cells. Cell Prolif. 42, 711-720.
12. Li, Z., Liu, C., Xie, Z., Song, P., Zhao, R. C., Guo, L., Liu, Z. & Wu, Y. 2011. Epigenetic dysregulation in mesenchymal stem cell aging and spontaneous differentiation. PLoS ONE 6, e20526.
13. Liu, Z., Li, T., Liu, Y., Jia, Z., Li, Y., Zhang, C., Chen, P., Ma, K., Affara, N. & Zhou, C. 2009. WNT signaling promotes Nkx2.5 expression and early cardiomyogenesis via downregulation of Hdac1. Biochim. Biophys. Acta 1793, 300-311.
14. Mundra, V., Gerling, I. C. & Mahato, R. I. 2013. Mesenchymal stem cell-based therapy. Mol. Pharm. 10, 77-89.
15. Musumeci, G., Lo, F. D., Loreto, C., Giuffrida, R., Caggia, S., Leonardi, R. & Cardile, V. 2011. Mesenchymal stem cells from adipose tissue which have been differentiated into chondrocytes in three-dimensional culture express lubricin. Exp. Biol. Med. 236, 1333-1341.
16. Phillips, J. E., Guldberg, R. E. & Garcia, A. J. 2007. Dermal fibroblasts genetically modified to express Runx2/Cbfa1 as a mineralizing cell source for bone tissue engineering. Tissue Eng. 13, 2029-2040.
17. Schroeder, T. M. & Westendorf, J. J. 2005. Histone deacetylase inhibitors promote osteoblast maturation. J. Bone Miner. Res. 20, 2254-2263.
18. Vishnubalaji, R., Manikandan, M., Al-Nbaheen, M., Kadalmani, B., Aldahmash, A. & Alajez, N. M. 2012. In vitro differentiation of human skin-derived multipotent stromal cells into putative endothelial-like cells. BMC Dev. Biol. 12, 7.
19. Wan, S. W., Makpol, S., Sathapan, S. & Chua, K. H. 2012. 5-azacytidine is insufficient for cardiogenesis in human adipose-derived stem cells. J. Negat. Results Biomed. 11, 3.
20. Zhang, X., Yang, M., Lin, L., Chen, P., Ma, K. T., Zhou, C. Y. & Ao, Y. F. 2006. Runx2 overexpression enhances osteoblastic differentiation and mineralization in adipose-derived stem cells in vitro and in vivo. Calcif. Tissue Int. 79, 169-178.