Tideglusib reduces progression of brain atrophy in progressive supranuclear palsy in a randomized trial

Movement Disorders

Volumn 29, Issue 4, 2014, Pages 479-487

  Höglinger, Günter U ^a,b,c   Huppertz, Hans Jürgen ^d   Wagenpfeil, Stefan ^e   Andrés, María V ^f   Belloch, Vincente ^g   León, Teresa ^f   del Ser, Teodoro ^h  

^a PHILIPPS UNIVERSITY MARBURG   (Germany)

^b TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^c GERMAN CENTER FOR NEURODEGENERATIVE DISEASES DZNE   (Germany)

^d SWISS EPILEPSY CENTER   (Switzerland)

^e SAARLAND UNIVERSITY   (Germany)

^f Noscira   (Spain)

^g Scientific Department Exploraciones Radiológicas Especiales ERESA   (Spain)

^h AUTONOMOUS UNIVERSITY OF MADRID   (Spain)

Author keywords

Glycogen synthase kinase 3; Progressive supranuclear palsy; Randomized controlled clinical trial; Tideglusib; Volumetric MRI

Indexed keywords

4 BENZYL 2 METHYL 1,2,4 THIAZOLIDINE 3,5 DIONE; PLACEBO; TIDEGLUSIB; ENZYME INHIBITOR; GLYCOGEN SYNTHASE KINASE 3; THIADIAZOLE DERIVATIVE;

ADULT; AGED; ARTICLE; BRAIN ATROPHY; BRAIN STEM; CAUDATE NUCLEUS; CONTROLLED STUDY; DISEASE COURSE; DOUBLE BLIND PROCEDURE; FEMALE; FRONTAL LOBE; HIPPOCAMPUS; HUMAN; MAJOR CLINICAL STUDY; MALE; MESENCEPHALON; MIDDLE AGED; MULTICENTER STUDY; NUCLEAR MAGNETIC RESONANCE IMAGING; OCCIPITAL LOBE; PARIETAL LOBE; PHASE 2 CLINICAL TRIAL; PRIORITY JOURNAL; PROGRESSIVE SUPRANUCLEAR PALSY; RANDOMIZED CONTROLLED TRIAL; ANTAGONISTS AND INHIBITORS; ATROPHY; BRAIN; DRUG EFFECTS; ORGAN SIZE; PATHOLOGY; SUPRANUCLEAR PALSY, PROGRESSIVE; VERY ELDERLY;

AGED; AGED, 80 AND OVER; ATROPHY; BRAIN; DISEASE PROGRESSION; DOUBLE-BLIND METHOD; ENZYME INHIBITORS; FEMALE; GLYCOGEN SYNTHASE KINASE 3; HUMANS; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; ORGAN SIZE; SUPRANUCLEAR PALSY, PROGRESSIVE; THIADIAZOLES;

EID: 84898056494     PISSN: 08853185     EISSN: 15318257     Source Type: Journal    
DOI: 10.1002/mds.25815     Document Type: Article

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