A quantitative LC/MS method targeting urinary 1-methyl-4-imidazoleacetic acid for safety monitoring of the global histamine turnover in clinical studies

Analytical and Bioanalytical Chemistry

Volumn 406, Issue 6, 2014, Pages 1751-1762

  Kolmert, J ^a,b,c,d   Forngren, B ^c,f   Lindberg, J ^c,g   Ohd J ^c,h   Aberg K M ^d   Nilsson, G ^e   Moritz, T ^b   Nordstrom A ^a  

^a UMEÅ UNIVERSITY   (Sweden)

^b SWEDISH UNIVERSITY OF AGRICULTURAL SCIENCES   (Sweden)

^c ASTRAZENECA R AND D   (Sweden)

^d STOCKHOLM UNIVERSITY   (Sweden)

^e KAROLINSKA INSTITUTE   (Sweden)

^f Keele Science Park   (Sweden)

^g Analytical Proof Sweden AB   (Sweden)

^h Shire AG   (Switzerland)

Author keywords

Clinical biomarker; HILIC; Ion suppression; Ion pairing chromatography; LC MS; tele MIAA

Indexed keywords

CLINICAL RESEARCH; CONTROLLED DRUG DELIVERY; DEMOGRAPHY; DRUG PRODUCTS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; ION CHROMATOGRAPHY; IONS; MASS SPECTROMETRY; METABOLITES; SULFONATION;

CLINICAL BIOMARKERS; HILIC; ION SUPPRESSION; ION-PAIRING CHROMATOGRAPHY; LC/MS; TELE-MIAA;

TARGETED DRUG DELIVERY;

HISTAMINE; IMIDAZOLE DERIVATIVE; METHYLIMIDAZOLEACETIC ACID;

AGED; ARTICLE; ELECTROSPRAY MASS SPECTROMETRY; EVALUATION STUDY; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; LIMIT OF DETECTION; MALE; METABOLISM; METHODOLOGY; TANDEM MASS SPECTROMETRY; URINE; YOUNG ADULT;

AGED; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; FEMALE; HISTAMINE; HUMANS; IMIDAZOLES; LIMIT OF DETECTION; MALE; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; TANDEM MASS SPECTROMETRY; YOUNG ADULT;

EID: 84898050858     PISSN: 16182642     EISSN: 16182650     Source Type: Journal    
DOI: 10.1007/s00216-013-7594-6     Document Type: Article

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