Critical roles of isoleucine-364 and adjacent residues in a hydrophobic gate control of phospholipid transport by the mammalian P4-ATPase ATP8A2

Proceedings of the National Academy of Sciences of the United States of America

Volumn 111, Issue 14, 2014, Pages

  Vestergaard, Anna L ^a   Coleman, Jonathan A ^b   Lemmin, Thomas ^c   Mikkelsen, Stine A ^a   Molday, Laurie L ^b   Vilsen, Bente ^a   Molday, Robert S ^b   Dal Peraro, Matteo ^c   Andersen, Jens Peter ^a  

^a AARHUS UNIVERSITY   (Denmark)

^b UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^c EPFL   (Switzerland)

Author keywords

CAMRQ syndrome; Flippase mechanism; Flippase structure; P type ATPase; Phosphatidylserine transport

Indexed keywords

ADENOSINE TRIPHOSPHATASE; CALCIUM; HYDROCARBON; ISOLEUCINE; MEMBRANE LIPID; PHOSPHATIDYLSERINE; PHOSPHOLIPID; POTASSIUM; SODIUM;

ARTICLE; CEREBELLAR ATAXIA; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CRYSTAL STRUCTURE; DEPHOSPHORYLATION; DYSEQUILIBRIUM SYNDROME; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; HUMAN; HYDROPHILICITY; HYDROPHOBICITY; ION TRANSPORT; MENTAL DEFICIENCY; MOLECULAR DYNAMICS; MUTAGENESIS; NONHUMAN; PHOSPHOLIPID TRANSFER; PHYSICAL DISEASE; PRIORITY JOURNAL; PROTON TRANSPORT; SEQUENCE ALIGNMENT;

CAMRQ SYNDROME; FLIPPASE MECHANISM; FLIPPASE STRUCTURE; P-TYPE ATPASE; PHOSPHATIDYLSERINE TRANSPORT;

ADENOSINE TRIPHOSPHATASES; ANIMALS; BIOLOGICAL TRANSPORT; CATTLE; HUMANS; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; ISOLEUCINE; MODELS, MOLECULAR; MUTAGENESIS; PHOSPHOLIPIDS; SUBSTRATE SPECIFICITY;

EID: 84898045047     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1321165111     Document Type: Article

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