SN-38-cyclodextrin complexation and its influence on the solubility, stability, and in vitro anticancer activity against ovarian cancer

AAPS PharmSciTech

Volumn 15, Issue 2, 2014, Pages 472-482

  Vangara, Kiran Kumar ^a   Ali, Hamed Ismail ^a   Lu, Dai ^a   Liu, Jingbo Louise ^b   Kolluru, Srikanth ^a   Palakurthi, Srinath ^a  

^a TEXAS A AND M HEALTH SCIENCE CENTER   (United States)

^b TEXAS A AND M UNIVERSITY KINGSVILLE   (United States)

Author keywords

complexation; cyclodextrin; ovarian cancer; SN 38; solubility and stability enhancement

Indexed keywords

BETA CYCLODEXTRIN SULFOBUTYL ETHER; CYCLODEXTRIN; FIRTECAN; PHOSPHATE BUFFERED SALINE; POLYMER; ANTINEOPLASTIC AGENT; CAMPTOTHECIN; IRINOTECAN;

ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; ARTICLE; CANCER CELL; COMPLEX FORMATION; CONTROLLED STUDY; CYTOTOXICITY; DIFFERENTIAL SCANNING CALORIMETRY; DRUG SOLUBILITY; DRUG STABILITY; FEMALE; HUMAN; HUMAN CELL; HYDROGEN BOND; IN VITRO STUDY; INFRARED SPECTROSCOPY; MOLECULAR MODEL; OVARY CANCER; OVARY CARCINOMA; PH; PRIORITY JOURNAL; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; SOLUBILIZATION; X RAY DIFFRACTION; X RAY POWDER DIFFRACTION; ANALOGS AND DERIVATIVES; CHEMISTRY; OVARIAN NEOPLASMS; PATHOLOGY; SOLUBILITY; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; CAMPTOTHECIN; CELL LINE, TUMOR; CYCLODEXTRINS; FEMALE; HUMANS; OVARIAN NEOPLASMS; SOLUBILITY;

EID: 84898038936     PISSN: None     EISSN: 15309932     Source Type: Journal    
DOI: 10.1208/s12249-013-0068-5     Document Type: Article

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