Endothelial dysfunction in adipose triglyceride lipase deficiency

Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids

Volumn 1841, Issue 6, 2014, Pages 906-917

  Schrammel, Astrid ^a   Mussbacher, Marion ^a   Wölkart, Gerald ^a   Stessel, Heike ^a   Pail, Karoline ^a   Winkler, Sarah ^a   Schweiger, Martina ^a   Haemmerle, Guenter ^a   Al Zoughbi, Wael ^b   Höfler, Gerald ^b   Lametschwandtner, Alois ^c   Zechner, Rudolf ^a   Mayer, Bernd ^a  

^a UNIVERSITY OF GRAZ   (Austria)

^b MEDICAL UNIVERSITY OF GRAZ   (Austria)

^c UNIVERSITY OF SALZBURG   (Austria)

Author keywords

Adipose triglyceride lipase; Endothelial dysfunction; Endothelial NO synthase; Perivascular inflammation; Vascular proteasome

Indexed keywords

NITRIC OXIDE SYNTHASE; PIRINIXIC ACID; TRIACYLGLYCEROL LIPASE;

ADIPOSE TISSUE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD VESSEL REACTIVITY; CHEMICAL ANALYSIS; CONTROLLED STUDY; ENDOTHELIAL DYSFUNCTION; ENDOTHELIUM; ENZYME ACTIVITY; HEART MUSCLE CONTRACTILITY; ISOLATED HEART; LIPID METABOLISM; LIPID STORAGE; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; SMOOTH MUSCLE FIBER; VASCULAR SMOOTH MUSCLE; VASODILATATION;

ADIPOSE TRIGLYCERIDE LIPASE; ENDOTHELIAL DYSFUNCTION; ENDOTHELIAL NO SYNTHASE; PERIVASCULAR INFLAMMATION; VASCULAR PROTEASOME;

ADIPOSE TISSUE; ANIMALS; DISEASE MODELS, ANIMAL; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HEART FAILURE; HUMANS; LIPASE; LIPID METABOLISM; MICE; MICE, KNOCKOUT; MYOCYTES, SMOOTH MUSCLE; NITRIC OXIDE SYNTHASE; OBESITY; ORGAN CULTURE TECHNIQUES; OXIDATIVE STRESS; PPAR ALPHA; TRIGLYCERIDES;

EID: 84898020075     PISSN: 13881981     EISSN: 18792618     Source Type: Journal    
DOI: 10.1016/j.bbalip.2014.03.005     Document Type: Article

References (43)

1. G. Haemmerle, A. Lass, R. Zimmermann, G. Gorkiewicz, C. Meyer, J. Rozman, G. Heldmaier, R. Maier, C. Theussl, S. Eder, D. Kratky, E.F. Wagner, M. Klingenspor, G. Hoefler, and R. Zechner Defective lipolysis and altered energy metabolism in mice lacking adipose triglyceride lipase Science 312 2006 734 737
2. G. Wölkart, A. Schrammel, K. Dorffel, G. Haemmerle, R. Zechner, and B. Mayer Cardiac dysfunction in adipose triglyceride lipase deficiency: treatment with a PPARalpha agonist Br. J. Pharmacol. 165 2012 380 389
3. G. Haemmerle, T. Moustafa, G. Woelkart, S. Buttner, A. Schmidt, T. van de Weijer, M. Hesselink, D. Jaeger, P.C. Kienesberger, K. Zierler, R. Schreiber, T. Eichmann, D. Kolb, P. Kotzbeck, M. Schweiger, M. Kumari, S. Eder, G. Schoiswohl, N. Wongsiriroj, N.M. Pollak, F.P. Radner, K. Preiss-Landl, T. Kolbe, T. Rulicke, B. Pieske, M. Trauner, A. Lass, R. Zimmermann, G. Hoefler, S. Cinti, E.E. Kershaw, P. Schrauwen, F. Madeo, B. Mayer, and R. Zechner ATGL-mediated fat catabolism regulates cardiac mitochondrial function via PPAR-alpha and PGC-1 Nat. Med. 17 2011 1076 1085
4. J. Bauersachs, and J.D. Widder Endothelial dysfunction in heart failure Pharmacol. Rep. 60 2008 119 126 (Pubitemid 351586550)
5. D. Fischer, S. Rossa, U. Landmesser, S. Spiekermann, N. Engberding, B. Hornig, and H. Drexler Endothelial dysfunction in patients with chronic heart failure is independently associated with increased incidence of hospitalization, cardiac transplantation, or death Eur. Heart J. 26 2005 65 69 (Pubitemid 40221125)
6. S.D. Katz, K. Hryniewicz, I. Hriljac, K. Balidemaj, C. Dimayuga, A. Hudaihed, and A. Yasskiy Vascular endothelial dysfunction and mortality risk in patients with chronic heart failure Circulation 111 2005 310 314 (Pubitemid 40165337)
7. K. Hirano, Y. Ikeda, N. Zaima, Y. Sakata, and G. Matsumiya Triglyceride deposit cardiomyovasculopathy N. Engl. J. Med. 359 2008 2396 2398
8. J. Fischer, C. Lefevre, E. Morava, J.M. Mussini, P. Laforet, A. Negre-Salvayre, M. Lathrop, and R. Salvayre The gene encoding adipose triglyceride lipase (PNPLA2) is mutated in neutral lipid storage disease with myopathy Nat. Genet. 39 2007 28 30 (Pubitemid 46026498)
9. M.E. Cifuentes, F.E. Rey, O.A. Carretero, and P.J. Pagano Upregulation of p67(phox) and gp91(phox) in aortas from angiotensin II-infused mice Am. J. Physiol. 279 2000 H2234 H2240
10. F. Brunner, P. Andrew, G. Wölkart, R. Zechner, and B. Mayer Myocardial contractile function and heart rate in mice with myocyte-specific overexpression of endothelial nitric oxide synthase Circulation 104 2001 3097 3102 (Pubitemid 34014064)
11. N. Golenhofen, W. Ness, E.F. Wawrousek, and D. Drenckhahn Expression and induction of the stress protein alpha-B-crystallin in vascular endothelial cells Histochem. Cell Biol. 117 2002 203 209 (Pubitemid 34253324)
12. D. Markowitz, S. Goff, and A. Bank A safe packaging line for gene transfer: separating viral genes on two different plasmids J. Virol. 62 1988 1120 1124 (Pubitemid 18082924)
13. M.A. Karasek Microvascular endothelial cell culture J. Invest. Dermatol. 93 1989 33S 38S
14. L.L. Rubin, K. Barbu, F. Bard, C. Cannon, D.E. Hall, H. Horner, M. Janatpour, C. Liaw, K. Manning, and J. Morales et al. Differentiation of brain endothelial cells in cell culture Ann. N. Y. Acad. Sci. 633 1991 420 425
15. H.J. Schnittler, B. Puschel, and D. Drenckhahn Role of cadherins and plakoglobin in interendothelial adhesion under resting conditions and shear stress Am. J. Physiol. 273 1997 H2396 H2405
16. K. Cawley, S. Deegan, A. Samali, and S. Gupta Assays for detecting the unfolded protein response Methods Enzymol. 490 2011 31 51
17. A. Leber, B. Hemmens, B. Klosch, W. Goessler, G. Raber, B. Mayer, and K. Schmidt Characterization of recombinant human endothelial nitric-oxide synthase purified from the yeast Pichia pastoris J. Biol. Chem. 274 1999 37658 37664 (Pubitemid 30026823)
18. B. Mayer, P. Klatt, E.R. Werner, and K. Schmidt Molecular mechanisms of inhibition of porcine brain nitric oxide synthase by the antinociceptive drug 7-nitro-indazole Neuropharmacology 33 1994 1253 1259
19. K. Schmidt, and B. Mayer Assay of tissue activity of nitric oxide synthase M. Maines, L. Costa, D.M. Reed, S. Sassa, J.W.S. Inc Curr Protoc Toxicol 1999 (New York)
20. Y. Li, H. Zhu, P. Kuppusamy, V. Roubaud, J.L. Zweier, and M.A. Trush Validation of lucigenin (bis-N-methylacridinium) as a chemilumigenic probe for detecting superoxide anion radical production by enzymatic and cellular systems J. Biol. Chem. 273 1998 2015 2023 (Pubitemid 28069247)
21. M. Schweiger, R. Schreiber, G. Haemmerle, A. Lass, C. Fledelius, P. Jacobsen, H. Tornqvist, R. Zechner, and R. Zimmermann Adipose triglyceride lipase and hormone-sensitive lipase are the major enzymes in adipose tissue triacylglycerol catabolism J. Biol. Chem. 281 2006 40236 40241 (Pubitemid 46041828)
22. M.M. Bradford A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding Anal. Biochem. 72 1976 248 254
23. R. Zechner, P.C. Kienesberger, G. Haemmerle, R. Zimmermann, and A. Lass Adipose triglyceride lipase and the lipolytic catabolism of cellular fat stores J. Lipid Res. 50 2009 3 21
24. M. Oelze, H. Mollnau, N. Hoffmann, A. Warnholtz, M. Bodenschatz, A. Smolenski, U. Walter, M. Skatchkov, T. Meinertz, and T. Munzel Vasodilator-stimulated phosphoprotein serine 239 phosphorylation as a sensitive monitor of defective nitric oxide/cGMP signaling and endothelial dysfunction Circ. Res. 87 2000 999 1005
25. V. Stangl, M. Lorenz, S. Meiners, A. Ludwig, C. Bartsch, M. Moobed, A. Vietzke, H.T. Kinkel, G. Baumann, and K. Stangl Long-term up-regulation of eNOS and improvement of endothelial function by inhibition of the ubiquitin-proteasome pathway FASEB J. 18 2004 272 279 (Pubitemid 38186246)
26. K.A. Britton, and C.S. Fox Perivascular adipose tissue and vascular disease Clin. Lipidol. 6 2011 79 91
27. M. Gollasch Vasodilator signals from perivascular adipose tissue Br. J. Pharmacol. 165 2012 633 642
28. C.J. Smith, D. Sun, C. Hoegler, B.S. Roth, X. Zhang, G. Zhao, X.B. Xu, Y. Kobari, K. Pritchard, W.C. Sessa, and T.H. Hintze Reduced gene expression of vascular endothelial NO synthase and cyclooxygenase-1 in heart failure Circ. Res. 78 1996 58 64 (Pubitemid 26004121)
29. G. Yan, B. You, S.P. Chen, J.K. Liao, and J. Sun Tumor necrosis factor-alpha downregulates endothelial nitric oxide synthase mRNA stability via translation elongation factor 1-alpha 1 Circ. Res. 103 2008 591 597
30. A. Schrammel, M. Mussbacher, S. Winkler, G. Haemmerle, H. Stessel, G. Wölkart, R. Zechner, and B. Mayer Cardiac oxidative stress in a mouse model of neutral lipid storage disease Biochim. Biophys. Acta 2013 10.1016/j.bbalip.2013.07.004
31. C.T. Aiken, R.M. Kaake, X. Wang, and L. Huang Oxidative stress-mediated regulation of proteasome complexes Mol. Cell. Proteomics 10 2011 (R110 006924)
32. P.M. Benz, C. Blume, S. Seifert, S. Wilhelm, J. Waschke, K. Schuh, F. Gertler, T. Munzel, and T. Renne Differential VASP phosphorylation controls remodeling of the actin cytoskeleton J. Cell Sci. 122 2009 3954 3965
33. N. Schlegel, and J. Waschke Impaired integrin-mediated adhesion contributes to reduced barrier properties in VASP-deficient microvascular endothelium J. Cell. Physiol. 220 2009 357 366
34. A.S. Greenstein, K. Khavandi, S.B. Withers, K. Sonoyama, O. Clancy, M. Jeziorska, I. Laing, A.P. Yates, P.W. Pemberton, R.A. Malik, and A.M. Heagerty Local inflammation and hypoxia abolish the protective anticontractile properties of perivascular fat in obese patients Circulation 119 2009 1661 1670
35. J. Ketonen, T. Pilvi, and E. Mervaala Caloric restriction reverses high-fat diet-induced endothelial dysfunction and vascular superoxide production in C57Bl/6 mice Heart Vessel. 25 2010 254 262
36. C. Marchesi, T. Ebrahimian, O. Angulo, P. Paradis, and E.L. Schiffrin Endothelial nitric oxide synthase uncoupling and perivascular adipose oxidative stress and inflammation contribute to vascular dysfunction in a rodent model of metabolic syndrome Hypertension 54 2009 1384 1392
37. S. Sato, and R.C. Hughes Regulation of secretion and surface expression of Mac-2, a galactoside-binding protein of macrophages J. Biol. Chem. 269 1994 4424 4430
38. S. Cinti, G. Mitchell, G. Barbatelli, I. Murano, E. Ceresi, E. Faloia, S. Wang, M. Fortier, A.S. Greenberg, and M.S. Obin Adipocyte death defines macrophage localization and function in adipose tissue of obese mice and humans J. Lipid Res. 46 2005 2347 2355 (Pubitemid 41532523)
39. H. Sano, D.K. Hsu, J.R. Apgar, L. Yu, B.B. Sharma, I. Kuwabara, S. Izui, and F.T. Liu Critical role of galectin-3 in phagocytosis by macrophages J. Clin. Invest. 112 2003 389 397 (Pubitemid 38063767)
40. H. Sano, D.K. Hsu, L. Yu, J.R. Apgar, I. Kuwabara, T. Yamanaka, M. Hirashima, and F.T. Liu Human galectin-3 is a novel chemoattractant for monocytes and macrophages J. Immunol. 165 2000 2156 2164 (Pubitemid 30643165)
41. G. Fesus, G. Dubrovska, K. Gorzelniak, R. Kluge, Y. Huang, F.C. Luft, and M. Gollasch Adiponectin is a novel humoral vasodilator Cardiovasc. Res. 75 2007 719 727 (Pubitemid 47243720)
42. Y.J. Gao, C. Lu, L.Y. Su, A.M. Sharma, and R.M. Lee Modulation of vascular function by perivascular adipose tissue: the role of endothelium and hydrogen peroxide Br. J. Pharmacol. 151 2007 323 331 (Pubitemid 46842669)
43. N. Maenhaut, C. Boydens, and J. Van de Voorde Hypoxia enhances the relaxing influence of perivascular adipose tissue in isolated mice aorta Eur. J. Pharmacol. 641 2010 207 212