Activation of NFAT signaling establishes a tumorigenic microenvironment through cell autonomous and non-cell autonomous mechanisms

Oncogene

Volumn 33, Issue 14, 2014, Pages 1840-1849

  Tripathi, P ^a   Wang, Y ^a   Coussens, M ^a   Manda, K R ^a   Casey, A M ^a   Lin, C ^a   Poyo, E ^a   Pfeifer, J D ^a   Basappa, N ^b   Bates, C M ^c   Ma, L ^a   Zhang, H ^d   Pan, M ^e   Ding, L ^a   Chen, F ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF MARYLAND   (United States)

^c UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^e KAISER PERMANENTE MEDICAL CENTER   (United States)

Author keywords

Microenvironment; NFAT; Tumor; Tumorigenesis

Indexed keywords

CYTOKINE; CYTOKINE RECEPTOR; OSM PROTEIN; OSTEOPONTIN; PROTEIN; STAT3 PROTEIN; TRANSCRIPTION FACTOR NFAT; UNCLASSIFIED DRUG;

ALLELE; ANIMAL CELL; ARTICLE; CARCINOGENESIS; CELL CULTURE; CELL PROLIFERATION; CELL TRANSFORMATION; CONTROLLED STUDY; EMBRYO DEVELOPMENT; FEMALE; HAIR FOLLICLE; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; IN VIVO STUDY; INNATE IMMUNITY; MOUSE; NONHUMAN; ONCOGENE C MYC; OVARY TUMOR; PRIMARY TUMOR; PRIORITY JOURNAL; PROTEIN FUNCTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; SKIN TUMOR; T LYMPHOCYTE; TUMOR GROWTH; TUMOR MICROENVIRONMENT; UPREGULATION;

MUS MUSCULUS;

ANIMALS; CARCINOGENESIS; CARCINOMA, SQUAMOUS CELL; DISEASE MODELS, ANIMAL; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; INFLAMMATION; MICE; MICE, NUDE; MICE, TRANSGENIC; NEOPLASM TRANSPLANTATION; NFATC TRANSCRIPTION FACTORS; OVARIAN NEOPLASMS; SIGNAL TRANSDUCTION; SKIN NEOPLASMS; STEM CELLS; TUMOR MICROENVIRONMENT;

EID: 84898003725     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2013.132     Document Type: Article

References (32)

1. Graef IA, Chen F, Crabtree GR. NFAT signaling in vertebrate development. Curr Opin Genet Dev 2001; 11: 505-512
2. Pan M, Winslow MM, Chen L, Kuo A, Felsher D, Crabtree GR. Enhanced NFATc1 nuclear occupancy causes T cell activation independent of CD28 costimulation. J Immunol 2007; 178: 4315-4321
3. Neal JW, Clipstone NA. A constitutively active NFATc1 mutant induces a transformed phenotype in 3T3-L1 fibroblasts. J Biol Chem 2003; 278: 17246-17254
4. Marafioti T, Pozzobon M, Hansmann ML, Ventura R, Pileri SA, Roberton H, et al. The NFATc1 transcription factor is widely expressed in white cells and translocates from the cytoplasm to the nucleus in a subset of human lymphomas. Br J Haematol 2005; 128: 333-342
5. Medyouf H, Alcalde H, Berthier C, Guillemin MC, dos Santos NR, Janin A, et al. Targeting calcineurin activation as a therapeutic strategy for T-cell acute lymphoblastic leukemia. Nat Med 2007; 13: 736-741
6. Pham LV, Tamayo AT, Yoshimura LC, Lin-Lee YC, Ford RJ. Constitutive NF-kappaB and NFAT activation in aggressive B-cell lymphomas synergistically activates the CD154 gene and maintains lymphoma cell survival. Blood 2005; 106: 3940-3947
7. Buchholz M, Schatz A, Wagner M, Michl P, Linhart T, Adler G, et al. Overexpression of c-myc in pancreatic cancer caused by ectopic activation of NFATc1 and the Ca2/calcineurin signaling pathway. EMBO J. 2006; 25: 3714-3724
8. Jauliac S, Lopez-Rodriguez C, Shaw LM, Brown LF, Rao A, Toker A. The role of NFAT transcription factors in integrin-mediated carcinoma invasion. Nat Cell Biol 2002; 4: 540-544
9. Muller MR, Rao A. NFAT, immunity and cancer: A transcription factor comes of age. Nat Rev Immunol 2010; 10: 645-656
10. Pan MG, Xiong Y, Chen F. NFAT gene family in inflammation and cancer. Curr Mol Med (in press
11. Zhao H, Kegg H, Grady S, Truong HT, Robinson ML, Baum M, et al. Role of fibroblast growth factor receptors 1 and 2 in the ureteric bud. Dev Biol 2004; 276: 403-415
12. Guo Q, Tripathi P, Poyo E, Wang Y, Austin PF, Bates CM, et al. Cell death serves as a single etiological cause of a wide spectrum of congenital urinary tract defects. J Urol 2011; 185: 2320-2328
13. Anderson B, Turner DA, Benda J. Ovarian sarcoma. Gynecol Oncol 1987; 26: 183-192
14. Horsley V, Aliprantis AO, Polak L, Glimcher LH, Fuchs E. NFATc1 balances quiescence and proliferation of skin stem cells. Cell 2008; 132: 299-310
15. Yasaka N, Furue M, Tamaki K. CD44 expression in normal human skin and skin tumors. J Dermatol 1995; 22: 88-94
16. Lin C, Yin Y, Chen H, Fisher AV, Chen F, Rauchman M, et al. Construction and characterization of a doxycycline-inducible transgenic system in Msx2 expressing cells. Genesis 2009; 47: 352-359
17. Lesina M, Kurkowski MU, Ludes K, Rose-John S, Treiber M, Kloppel G, et al. Stat3/ Socs3 activation by IL-6 transsignaling promotes progression of pancreatic intraepithelial neoplasia and development of pancreatic cancer. Cancer Cell 2011; 19: 456-469
18. Torti D, Trusolino L. Oncogene addiction as a foundational rationale for targeted anti-cancer therapy: Promises and perils. EMBO Mol Med 2011; 3: 623-636
19. McCormick F. Cancer therapy based on oncogene addiction. J Surg Oncol 2011; 103: 464-467
20. Graef IA, Chen F, Chen L, Kuo A, Crabtree GR. Signals transduced by Ca(2)/ calcineurin and NFATc3/c4 pattern the developing vasculature. Cell 2001; 105: 863-875
21. Chang CP, McDill BW, Neilson JR, Joist HE, Epstein JA, Crabtree GR, et al. Calcineurin is required in urinary tract mesenchyme for the development of the pyeloureteral peristaltic machinery. J Clin Invest 2004; 113: 1051-1058
22. Li SZ, McDill BW, Kovach PA, Ding L, Go WY, Ho SN, et al. Calcineurin-NFATc signaling pathway regulates AQP2 expression in response to calcium signals and osmotic stress. Am J Physiol Cell Physiol 2007; 292: C1606-C1616
23. Wang Y, Jarad G, Tripathi P, Pan M, Cunningham J, Martin DR, et al. Activation of NFAT signaling in podocytes causes glomerulosclerosis. J Am Soc Nephrol 2010; 21: 1657-1666
24. Sansone P, Bromberg J. Environment, inflammation, and cancer. Curr Opin Genet Dev 2011; 21: 80-85
25. Wu H, Peisley A, Graef IA, Crabtree GR. NFAT signaling and the invention of vertebrates. Trends Cell Biol 2007; 17: 251-260
26. Rao A. Signaling to gene expression: Calcium, calcineurin and NFAT. Nat Immunol. 2009; 10: 3-5
27. Barriere C, Santamaria D, Cerqueira A, Galan J, Martin A, Ortega S, et al. Mice thrive without Cdk4 and Cdk2. Mol Oncol 2007; 1: 72-83
28. Li W, Kotoshiba S, Berthet C, Hilton MB, Kaldis P. Rb/Cdk2/Cdk4 triple mutant mice elicit an alternative mechanism for regulation of the G1/S transition. Proc Natl Acad Sci USA 2009; 106: 486-491
29. Wong SY, Reiter JF. Wounding mobilizes hair follicle stem cells to form tumors. Proc Natl Acad Sci USA 2011; 108: 4093-4098
30. Belteki G, Haigh J, Kabacs N, Haigh K, Sison K, Costantini F, et al. Conditional and inducible transgene expression in mice through the combinatorial use of Cre-mediated recombination and tetracycline induction. Nucleic Acids Res 2005; 33: E51
31. Janik P, Briand P, Hartmann NR. The effect of estrone-progesterone treatment on cell proliferation kinetics of hormone-dependent GR mouse mammary tumors. Cancer Res 1975; 35: 3698-3704
32. McDill BW, Li SZ, Kovach PA, Ding L, Chen F. Congenital progressive hydronephrosis (cph) is caused by an S256L mutation in aquaporin-2 that affects its phosphorylation and apical membrane accumulation. Proc Natl Acad Sci USA 2006; 103: 6952-6957.