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Volumn 10, Issue , 2014, Pages 169-176

Neurogenic orthostatic hypotension in Parkinson's disease: Evaluation, management, and emerging role of droxidopa

Author keywords

(Pre)syncope; Autonomic; Falls; Lightheadedness; Norepinephrine; Treatment

Indexed keywords

PLACEBO; THREO 3,4 DIHYDROXYPHENYLSERINE;

EID: 84898001030     PISSN: 11766344     EISSN: 11782048     Source Type: Journal    
DOI: 10.2147/VHRM.S53983     Document Type: Review
Times cited : (31)

References (85)
  • 1
  • 2
    • 4644262954 scopus 로고    scopus 로고
    • Frequency of orthostatic hypotension in a community based cohort of patients with Parkinson's disease
    • Allcock LM, Ullyart K, Kenny RA, Burn DJ. Frequency of orthostatic hypotension in a community based cohort of patients with Parkinson's disease. J Neurol Neurosurg Psychiatry. 2004;75(10):1470-1471.
    • (2004) J Neurol Neurosurg Psychiatry. , vol.75 , Issue.10 , pp. 1470-1471
    • Allcock, L.M.1    Ullyart, K.2    Kenny, R.A.3    Burn, D.J.4
  • 3
    • 82955174295 scopus 로고    scopus 로고
    • Orthostatic hypotension: A non-motor complication assessment in 82 patients with idiopathic Parkinson's disease in Phramongkutklao Hospital
    • Sithinamsuwan P, Orrawanhanothai P, Thithum K, etal. Orthostatic hypotension: a non-motor complication assessment in 82 patients with idiopathic Parkinson's disease in Phramongkutklao Hospital. J Med Assoc Thai. 2010;93 Suppl 6:S93-S99.
    • (2010) J Med Assoc Thai. , vol.93 , Issue.SUPPL. 6
    • Sithinamsuwan, P.1    Orrawanhanothai, P.2    Thithum, K.3
  • 4
    • 84860823589 scopus 로고    scopus 로고
    • Cardiovascular dysautonomia in Parkinson disease: From pathophysiology to pathogenesis
    • Jain S, Goldstein DS. Cardiovascular dysautonomia in Parkinson disease: from pathophysiology to pathogenesis. Neurobiol Dis. 2012;46(3):572-580.
    • (2012) Neurobiol Dis. , vol.46 , Issue.3 , pp. 572-580
    • Jain, S.1    Goldstein, D.S.2
  • 5
    • 80052374159 scopus 로고    scopus 로고
    • The prevalence of symptomatic orthostatic hypotension in patients with Parkinson's disease and atypical parkinsonism
    • Ha AD, Brown CH, York MK, Jankovic J. The prevalence of symptomatic orthostatic hypotension in patients with Parkinson's disease and atypical parkinsonism. Parkinsonism Relat Disord. 2011;17(8): 625-628.
    • (2011) Parkinsonism Relat Disord. , vol.17 , Issue.8 , pp. 625-628
    • Ha, A.D.1    Brown, C.H.2    York, M.K.3    Jankovic, J.4
  • 6
    • 0035987860 scopus 로고    scopus 로고
    • To stand on one's own legs
    • Mathias CJ. To stand on one's own legs. Clin Med. 2002;2(3): 237-245.
    • (2002) Clin Med. , vol.2 , Issue.3 , pp. 237-245
    • Mathias, C.J.1
  • 7
    • 55349121610 scopus 로고    scopus 로고
    • Generalized and neurotransmitter-selective noradrenergic denervation in Parkinson's disease with orthostatic hypotension
    • Sharabi Y, Imrich R, Holmes C, Pechnik S, Goldstein DS. Generalized and neurotransmitter-selective noradrenergic denervation in Parkinson's disease with orthostatic hypotension. Mov Disord. 2008;23(12):1725-1732.
    • (2008) Mov Disord. , vol.23 , Issue.12 , pp. 1725-1732
    • Sharabi, Y.1    Imrich, R.2    Holmes, C.3    Pechnik, S.4    Goldstein, D.S.5
  • 8
    • 0021342386 scopus 로고
    • Orthostatic hypotension. I. Functional and neurogenic causes
    • Schatz IJ. Orthostatic hypotension. I. Functional and neurogenic causes. Arch Intern Med. 1984;144(4):773-777.
    • (1984) Arch Intern Med. , vol.144 , Issue.4 , pp. 773-777
    • Schatz, I.J.1
  • 9
    • 79958702577 scopus 로고    scopus 로고
    • Consensus statement on the definition of orthostatic hypotension, neurally mediated syncope and the postural tachycardia syndrome
    • Freeman R, Wieling W, Axelrod FB, etal. Consensus statement on the definition of orthostatic hypotension, neurally mediated syncope and the postural tachycardia syndrome. Clin Auton Res. 2011;21(2):69-72.
    • (2011) Clin Auton Res. , vol.21 , Issue.2 , pp. 69-72
    • Freeman, R.1    Wieling, W.2    Axelrod, F.B.3
  • 10
    • 38949188680 scopus 로고    scopus 로고
    • Clinical practice. Neurogenic orthostatic hypotension
    • Freeman R. Clinical practice. Neurogenic orthostatic hypotension. N Engl J Med. 2008;358(6):615-624.
    • (2008) N Engl J Med. , vol.358 , Issue.6 , pp. 615-624
    • Freeman, R.1
  • 11
    • 77957235662 scopus 로고    scopus 로고
    • Neurogenic orthostatic hypotension of Parkinson's disease: What exploration for what treatment?
    • Senard JM, Pathak A. Neurogenic orthostatic hypotension of Parkinson's disease: what exploration for what treatment? Rev Neurol (Paris). 2010;166(10):779-784.
    • (2010) Rev Neurol (Paris). , vol.166 , Issue.10 , pp. 779-784
    • Senard, J.M.1    Pathak, A.2
  • 12
    • 59049097509 scopus 로고    scopus 로고
    • Neurogenic orthostatic hypotension: A pathophysiological approach
    • Goldstein DS, Sharabi Y. Neurogenic orthostatic hypotension: a pathophysiological approach. Circulation. 2009;119(1):139-146.
    • (2009) Circulation. , vol.119 , Issue.1 , pp. 139-146
    • Goldstein, D.S.1    Sharabi, Y.2
  • 13
    • 0014333151 scopus 로고
    • Decreased noradrenaline (norepinephrine) synthesis in neurogenic orthostatic hypotension
    • Goodall MC, Harlan WR Jr, Alton H. Decreased noradrenaline (norepinephrine) synthesis in neurogenic orthostatic hypotension. Circulation. 1968;38(3):592-603.
    • (1968) Circulation. , vol.38 , Issue.3 , pp. 592-603
    • Goodall, M.C.1    Harlan Jr., W.R.2    Alton, H.3
  • 14
    • 0024467362 scopus 로고
    • Patterns of plasma levels of catechols in neurogenic orthostatic hypotension
    • Goldstein DS, Polinsky RJ, Garty M, etal. Patterns of plasma levels of catechols in neurogenic orthostatic hypotension. Ann Neurol. 1989;26(4):558-563.
    • (1989) Ann Neurol. , vol.26 , Issue.4 , pp. 558-563
    • Goldstein, D.S.1    Polinsky, R.J.2    Garty, M.3
  • 15
    • 58349097105 scopus 로고    scopus 로고
    • Functional effects of cardiac sympathetic denervation in neurogenic orthostatic hypotension
    • Imrich R, Eldadah BA, Bentho O, etal. Functional effects of cardiac sympathetic denervation in neurogenic orthostatic hypotension. Parkinsonism Relat Disord. 2009;15(2):122-127.
    • (2009) Parkinsonism Relat Disord. , vol.15 , Issue.2 , pp. 122-127
    • Imrich, R.1    Eldadah, B.A.2    Bentho, O.3
  • 16
    • 80054100195 scopus 로고    scopus 로고
    • Mechanisms of orthostatic hypotension and supine hypertension in Parkinson disease
    • Sharabi Y, Goldstein DS. Mechanisms of orthostatic hypotension and supine hypertension in Parkinson disease. J Neurol Sci. 2011;310(1-2): 123-128.
    • (2011) J Neurol Sci. , vol.310 , Issue.1-2 , pp. 123-128
    • Sharabi, Y.1    Goldstein, D.S.2
  • 17
    • 0141889849 scopus 로고    scopus 로고
    • Orthostatic hypotension in de novo Parkinson disease
    • Bonuccelli U, Lucetti C, Del Dotto P, etal. Orthostatic hypotension in de novo Parkinson disease. Arch Neurol. 2003;60(10):1400-1404.
    • (2003) Arch Neurol. , vol.60 , Issue.10 , pp. 1400-1404
    • Bonuccelli, U.1    Lucetti, C.2    Del Dotto, P.3
  • 18
  • 19
    • 4644323707 scopus 로고    scopus 로고
    • Autonomic failure as the initial presentation of Parkinson disease and dementia with Lewy bodies
    • Kaufmann H, Nahm K, Purohit D, Wolfe D. Autonomic failure as the initial presentation of Parkinson disease and dementia with Lewy bodies. Neurology. 2004;63(6):1093-1095.
    • (2004) Neurology. , vol.63 , Issue.6 , pp. 1093-1095
    • Kaufmann, H.1    Nahm, K.2    Purohit, D.3    Wolfe, D.4
  • 20
    • 78751491530 scopus 로고    scopus 로고
    • Cardiovascular dysautonomia in de novo Parkinson's disease without orthostatic hypotension
    • Oka H, Toyoda C, Yogo M, Mochio S. Cardiovascular dysautonomia in de novo Parkinson's disease without orthostatic hypotension. Eur J Neurol. 2011;18(2):286-292.
    • (2011) Eur J Neurol. , vol.18 , Issue.2 , pp. 286-292
    • Oka, H.1    Toyoda, C.2    Yogo, M.3    Mochio, S.4
  • 21
    • 0037461288 scopus 로고    scopus 로고
    • Plasma levels of catechols and metanephrines in neurogenic orthostatic hypotension
    • Goldstein DS, Holmes C, Sharabi Y, Brentzel S, Eisenhofer G. Plasma levels of catechols and metanephrines in neurogenic orthostatic hypotension. Neurology. 2003;60(8):1327-1332.
    • (2003) Neurology. , vol.60 , Issue.8 , pp. 1327-1332
    • Goldstein, D.S.1    Holmes, C.2    Sharabi, Y.3    Brentzel, S.4    Eisenhofer, G.5
  • 22
    • 0037777802 scopus 로고    scopus 로고
    • Cerebrospinal fluid levels of catechols in patients with neurogenic orthostatic hypotension
    • Goldstein DS, Holmes C, Patronas N, Kopin IJ. Cerebrospinal fluid levels of catechols in patients with neurogenic orthostatic hypotension. Clin Sci (Lond). 2003;104(6):649-654.
    • (2003) Clin Sci (Lond). , vol.104 , Issue.6 , pp. 649-654
    • Goldstein, D.S.1    Holmes, C.2    Patronas, N.3    Kopin, I.J.4
  • 23
    • 0021346160 scopus 로고
    • Orthostatic hypotension. II. Clinical diagnosis, testing, and treatment
    • Schatz IJ. Orthostatic hypotension. II. Clinical diagnosis, testing, and treatment. Arch Intern Med. 1984;144(5):1037-1041.
    • (1984) Arch Intern Med. , vol.144 , Issue.5 , pp. 1037-1041
    • Schatz, I.J.1
  • 24
    • 41949090127 scopus 로고    scopus 로고
    • Management of neurogenic orthostatic hypotension: An update
    • Low PA, Singer W. Management of neurogenic orthostatic hypotension: an update. Lancet Neurol. 2008;7(5):451-458.
    • (2008) Lancet Neurol. , vol.7 , Issue.5 , pp. 451-458
    • Low, P.A.1    Singer, W.2
  • 25
    • 74149083448 scopus 로고    scopus 로고
    • Cardiovascular autonomic dysfunction in Parkinson's disease
    • Ziemssen T, Reichmann H. Cardiovascular autonomic dysfunction in Parkinson's disease. J Neurol Sci. 2010;289(1-2):74-80.
    • (2010) J Neurol Sci. , vol.289 , Issue.1-2 , pp. 74-80
    • Ziemssen, T.1    Reichmann, H.2
  • 26
    • 0035212613 scopus 로고    scopus 로고
    • Mechanisms underlying the impairment in orthostatic tolerance after nocturnal recumbency in patients with autonomic failure
    • Omboni S, Smit AA, van Lieshout JJ, Settels JJ, Langewouters GJ, Wieling W. Mechanisms underlying the impairment in orthostatic tolerance after nocturnal recumbency in patients with autonomic failure. Clin Sci (Lond). 2001;101(6):609-618.
    • (2001) Clin Sci (Lond). , vol.101 , Issue.6 , pp. 609-618
    • Omboni, S.1    Smit, A.A.2    van Lieshout, J.J.3    Settels, J.J.4    Langewouters, G.J.5    Wieling, W.6
  • 27
    • 0027389076 scopus 로고
    • Hemodynamic and autonomic nervous system responses to mixed meal ingestion in healthy young and old subjects and dysautonomic patients with postprandial hypotension
    • Lipsitz LA, Ryan SM, Parker JA, Freeman R, Wei JY, Goldberger AL. Hemodynamic and autonomic nervous system responses to mixed meal ingestion in healthy young and old subjects and dysautonomic patients with postprandial hypotension. Circulation. 1993;87(2):391-400.
    • (1993) Circulation. , vol.87 , Issue.2 , pp. 391-400
    • Lipsitz, L.A.1    Ryan, S.M.2    Parker, J.A.3    Freeman, R.4    Wei, J.Y.5    Goldberger, A.L.6
  • 28
    • 0022921837 scopus 로고
    • Cardiovascular and norepinephrine responses after meal consumption in elderly (older than 75 years) persons with postprandial hypotension and syncope
    • Lipsitz LA, Pluchino FC, Wei JY, Minaker KL, Rowe JW. Cardiovascular and norepinephrine responses after meal consumption in elderly (older than 75 years) persons with postprandial hypotension and syncope. Am J Cardiol. 1986;58(9):810-815.
    • (1986) Am J Cardiol. , vol.58 , Issue.9 , pp. 810-815
    • Lipsitz, L.A.1    Pluchino, F.C.2    Wei, J.Y.3    Minaker, K.L.4    Rowe, J.W.5
  • 29
    • 27744536829 scopus 로고    scopus 로고
    • Heat-related morbidity in patients with orthostatic hypotension and primary autonomic failure
    • Pathak A, Lapeyre-Mestre M, Montastruc JL, Senard JM. Heat-related morbidity in patients with orthostatic hypotension and primary autonomic failure. Mov Disord. 2005;20(9):1213-1219.
    • (2005) Mov Disord. , vol.20 , Issue.9 , pp. 1213-1219
    • Pathak, A.1    Lapeyre-Mestre, M.2    Montastruc, J.L.3    Senard, J.M.4
  • 30
    • 0034913776 scopus 로고    scopus 로고
    • Orthostatic hypotension in patients with Parkinson's disease: Pathophysiology and management
    • Senard JM, Brefel-Courbon C, Rascol O, Montastruc JL. Orthostatic hypotension in patients with Parkinson's disease: pathophysiology and management. Drugs Aging. 2001;18(7):495-505.
    • (2001) Drugs Aging. , vol.18 , Issue.7 , pp. 495-505
    • Senard, J.M.1    Brefel-Courbon, C.2    Rascol, O.3    Montastruc, J.L.4
  • 31
    • 0025882914 scopus 로고
    • Cardiovascular reflexes and autonomic dysfunction in Parkinson's disease
    • Meco G, Pratesi L, Bonifati V. Cardiovascular reflexes and autonomic dysfunction in Parkinson's disease. J Neurol. 1991;238(4):195-199.
    • (1991) J Neurol. , vol.238 , Issue.4 , pp. 195-199
    • Meco, G.1    Pratesi, L.2    Bonifati, V.3
  • 32
    • 0035015384 scopus 로고    scopus 로고
    • Acute orthostatic hypotension when starting dopamine agonist therapy in parkinson disease: The role of domperidone therapy
    • Lang AE. Acute orthostatic hypotension when starting dopamine agonist therapy in parkinson disease: the role of domperidone therapy. Arch Neurol. 2001;58(5):835.
    • (2001) Arch Neurol. , vol.58 , Issue.5 , pp. 835
    • Lang, A.E.1
  • 33
    • 77950669992 scopus 로고    scopus 로고
    • Clinical review and treatment of select adverse effects of dopamine receptor agonists in Parkinson's disease
    • Wood LD. Clinical review and treatment of select adverse effects of dopamine receptor agonists in Parkinson's disease. Drugs Aging. 2010;27(4):295-310.
    • (2010) Drugs Aging. , vol.27 , Issue.4 , pp. 295-310
    • Wood, L.D.1
  • 35
    • 84878784233 scopus 로고    scopus 로고
    • Twenty-four hour non-invasive ambulatory blood pressure and heart rate monitoring in Parkinson's disease
    • Stuebner E, Vichayanrat E, Low DA, Mathias CJ, Isenmann S, Haensch CA. Twenty-four hour non-invasive ambulatory blood pressure and heart rate monitoring in Parkinson's disease. Front Neurol. 2013;4:49.
    • (2013) Front Neurol. , vol.4 , pp. 49
    • Stuebner, E.1    Vichayanrat, E.2    Low, D.A.3    Mathias, C.J.4    Isenmann, S.5    Haensch, C.A.6
  • 36
    • 84863980921 scopus 로고    scopus 로고
    • Standing worsens cognitive functions in patients with neurogenic orthostatic hypotension
    • Poda R, Guaraldi P, Solieri L, etal. Standing worsens cognitive functions in patients with neurogenic orthostatic hypotension. Neurol Sci. 2012;33(2):469-473.
    • (2012) Neurol Sci. , vol.33 , Issue.2 , pp. 469-473
    • Poda, R.1    Guaraldi, P.2    Solieri, L.3
  • 37
    • 84859161160 scopus 로고    scopus 로고
    • The Orthostatic Hypotension Questionnaire (OHQ): Validation of a novel symptom assessment scale
    • Kaufmann H, Malamut R, Norcliffe-Kaufmann L, Rosa K, Freeman R. The Orthostatic Hypotension Questionnaire (OHQ): validation of a novel symptom assessment scale. Clin Auton Res. 2012;22(2):79-90.
    • (2012) Clin Auton Res. , vol.22 , Issue.2 , pp. 79-90
    • Kaufmann, H.1    Malamut, R.2    Norcliffe-Kaufmann, L.3    Rosa, K.4    Freeman, R.5
  • 38
    • 0030001065 scopus 로고    scopus 로고
    • "Subclinical" orthostatic hypotension is associated with dizziness in elderly patients with Parkinson disease
    • Hillen ME, Wagner ML, Sage JI. "Subclinical" orthostatic hypotension is associated with dizziness in elderly patients with Parkinson disease. Arch Phys Med Rehabil. 1996;77(7):710-712.
    • (1996) Arch Phys Med Rehabil. , vol.77 , Issue.7 , pp. 710-712
    • Hillen, M.E.1    Wagner, M.L.2    Sage, J.I.3
  • 40
    • 84855614914 scopus 로고    scopus 로고
    • Autonomic involvement in Parkinson's disease: Pathology, pathophysiology, clinical features and possible peripheral biomarkers
    • Cersosimo MG, Benarroch EE. Autonomic involvement in Parkinson's disease: pathology, pathophysiology, clinical features and possible peripheral biomarkers. J Neurol Sci. 2012;313(1-2):57-63.
    • (2012) J Neurol Sci. , vol.313 , Issue.1-2 , pp. 57-63
    • Cersosimo, M.G.1    Benarroch, E.E.2
  • 41
    • 0020635456 scopus 로고
    • Urinary catecholamine metabolites distinguish different types of sympathetic neuronal dysfunction in patients with orthostatic hypotension
    • Kopin IJ, Polinsky RJ, Oliver JA, Oddershede IR, Ebert MH. Urinary catecholamine metabolites distinguish different types of sympathetic neuronal dysfunction in patients with orthostatic hypotension. J Clin Endocrinol Metab. 1983;57(3):632-637.
    • (1983) J Clin Endocrinol Metab. , vol.57 , Issue.3 , pp. 632-637
    • Kopin, I.J.1    Polinsky, R.J.2    Oliver, J.A.3    Oddershede, I.R.4    Ebert, M.H.5
  • 42
    • 84882950668 scopus 로고    scopus 로고
    • Autonomic function tests: Some clinical applications
    • Low PA, Tomalia VA, Park KJ. Autonomic function tests: some clinical applications. J Clin Neurol. 2013;9(1):1-8.
    • (2013) J Clin Neurol. , vol.9 , Issue.1 , pp. 1-8
    • Low, P.A.1    Tomalia, V.A.2    Park, K.J.3
  • 44
    • 58549112580 scopus 로고    scopus 로고
    • Cardiac denervation occurs inde-pendent of orthostatic hypotension and impaired heart rate variability in Parkinson's disease
    • Haensch CA, Lerch H, Jorg J, Isenmann S. Cardiac denervation occurs inde-pendent of orthostatic hypotension and impaired heart rate variability in Parkinson's disease. Parkinsonism Relat Disord. 2009;15(2):134-137.
    • (2009) Parkinsonism Relat Disord. , vol.15 , Issue.2 , pp. 134-137
    • Haensch, C.A.1    Lerch, H.2    Jorg, J.3    Isenmann, S.4
  • 46
    • 17144436220 scopus 로고    scopus 로고
    • The pressor response to water drinking in humans: A sympathetic reflex?
    • Jordan J, Shannon JR, Black BK, etal. The pressor response to water drinking in humans: a sympathetic reflex? Circulation. 2000;101(5): 504-509.
    • (2000) Circulation. , vol.101 , Issue.5 , pp. 504-509
    • Jordan, J.1    Shannon, J.R.2    Black, B.K.3
  • 47
    • 78650436451 scopus 로고    scopus 로고
    • Acute fluid ingestion in the treatment of orthostatic intolerance-important implications for daily practice
    • Z'Graggen WJ, Hess CW, Humm AM. Acute fluid ingestion in the treatment of orthostatic intolerance-important implications for daily practice. Eur J Neurol. 2010;17(11):1370-1376.
    • (2010) Eur J Neurol. , vol.17 , Issue.11 , pp. 1370-1376
    • Z'Graggen, W.J.1    Hess, C.W.2    Humm, A.M.3
  • 48
    • 0030320004 scopus 로고    scopus 로고
    • Role of physical countermaneuvers in the management of orthostatic hypotension: Efficacy and biofeedback augmentation
    • Bouvette CM, McPhee BR, Opfer-Gehrking TL, Low PA. Role of physical countermaneuvers in the management of orthostatic hypotension: efficacy and biofeedback augmentation. Mayo Clin Proc. 1996;71(9):847-853.
    • (1996) Mayo Clin Proc. , vol.71 , Issue.9 , pp. 847-853
    • Bouvette, C.M.1    McPhee, B.R.2    Opfer-Gehrking, T.L.3    Low, P.A.4
  • 49
    • 3242676724 scopus 로고    scopus 로고
    • Use of lower abdominal compression to combat orthostatic hypotension in patients with autonomic dysfunction
    • Smit AA, Wieling W, Fujimura J, etal. Use of lower abdominal compression to combat orthostatic hypotension in patients with autonomic dysfunction. Clin Auton Res. 2004;14(3):167-175.
    • (2004) Clin Auton Res. , vol.14 , Issue.3 , pp. 167-175
    • Smit, A.A.1    Wieling, W.2    Fujimura, J.3
  • 50
    • 33746498812 scopus 로고    scopus 로고
    • Lower limb and abdominal compression bandages prevent progressive orthostatic hypotension in elderly persons: A randomized single-blind controlled study
    • Podoleanu C, Maggi R, Brignole M, etal. Lower limb and abdominal compression bandages prevent progressive orthostatic hypotension in elderly persons: a randomized single-blind controlled study. J Am Coll Cardiol. 2006;48(7):1425-1432.
    • (2006) J Am Coll Cardiol. , vol.48 , Issue.7 , pp. 1425-1432
    • Podoleanu, C.1    Maggi, R.2    Brignole, M.3
  • 51
    • 0034464802 scopus 로고    scopus 로고
    • Fludrocortisone and sleeping in the head-up position limit the postural decrease in cardiac output in autonomic failure
    • van Lieshout JJ, ten Harkel AD, Wieling W. Fludrocortisone and sleeping in the head-up position limit the postural decrease in cardiac output in autonomic failure. Clin Auton Res. 2000;10(1):35-42.
    • (2000) Clin Auton Res. , vol.10 , Issue.1 , pp. 35-42
    • van Lieshout, J.J.1    ten Harkel, A.D.2    Wieling, W.3
  • 52
    • 0000547654 scopus 로고
    • Successful treatment of orthostatic hypotension with 9-alpha-fluorohydrocortisone
    • Hickler RB, Thompson GR, Fox LM, Hamlin JT 3rd. Successful treatment of orthostatic hypotension with 9-alpha-fluorohydrocortisone. N Engl J Med. 1959;261:788-791.
    • (1959) N Engl J Med. , vol.261 , pp. 788-791
    • Hickler, R.B.1    Thompson, G.R.2    Fox, L.M.3    Hamlin III, J.T.4
  • 53
    • 0031842178 scopus 로고    scopus 로고
    • A double-blind, dose-response study of midodrine in neurogenic orthostatic hypotension
    • Wright RA, Kaufmann HC, Perera R, etal. A double-blind, dose-response study of midodrine in neurogenic orthostatic hypotension. Neurology. 1998;51(1):120-124.
    • (1998) Neurology. , vol.51 , Issue.1 , pp. 120-124
    • Wright, R.A.1    Kaufmann, H.C.2    Perera, R.3
  • 54
    • 0027291916 scopus 로고
    • Neurogenic orthostatic hypotension: A double-blind, placebo-controlled study with midodrine
    • Jankovic J, Gilden JL, Hiner BC, etal. Neurogenic orthostatic hypotension: a double-blind, placebo-controlled study with midodrine. Am J Med. 1993;95(1):38-48.
    • (1993) Am J Med. , vol.95 , Issue.1 , pp. 38-48
    • Jankovic, J.1    Gilden, J.L.2    Hiner, B.C.3
  • 55
    • 0031004940 scopus 로고    scopus 로고
    • Efficacy of midodrine vs placebo in neurogenic orthostatic hypotension. A randomized, double-blind multicenter study. Midodrine Study Group
    • Low PA, Gilden JL, Freeman R, Sheng KN, McElligott MA. Efficacy of midodrine vs placebo in neurogenic orthostatic hypotension. A randomized, double-blind multicenter study. Midodrine Study Group. JAMA. 1997;277(13):1046-1051.
    • (1997) JAMA. , vol.277 , Issue.13 , pp. 1046-1051
    • Low, P.A.1    Gilden, J.L.2    Freeman, R.3    Sheng, K.N.4    McElligott, M.A.5
  • 56
    • 33645739276 scopus 로고    scopus 로고
    • Pyridostigmine treatment trial in neurogenic orthostatic hypotension
    • Singer W, Sandroni P, Opfer-Gehrking TL, etal. Pyridostigmine treatment trial in neurogenic orthostatic hypotension. Arch Neurol. 2006;63(4):513-518.
    • (2006) Arch Neurol. , vol.63 , Issue.4 , pp. 513-518
    • Singer, W.1    Sandroni, P.2    Opfer-Gehrking, T.L.3
  • 57
    • 0029100203 scopus 로고
    • Effect of recombinant erythropoietin on anemia and orthostatic hypotension in primary autonomic failure
    • Perera R, Isola L, Kaufmann H. Effect of recombinant erythropoietin on anemia and orthostatic hypotension in primary autonomic failure. Clin Auton Res. 1995;5(4):211-213.
    • (1995) Clin Auton Res. , vol.5 , Issue.4 , pp. 211-213
    • Perera, R.1    Isola, L.2    Kaufmann, H.3
  • 58
    • 0027293272 scopus 로고
    • Treatment of orthostatic hypotension with erythropoietin
    • Hoeldtke RD, Streeten DH. Treatment of orthostatic hypotension with erythropoietin. N Engl J Med. 1993;329(9):611-615.
    • (1993) N Engl J Med. , vol.329 , Issue.9 , pp. 611-615
    • Hoeldtke, R.D.1    Streeten, D.H.2
  • 59
    • 0022534565 scopus 로고
    • The effect of desmopressin on nocturnal polyuria, overnight weight loss, and morning postural hypotension in patients with autonomic failure
    • Mathias CJ, Fosbraey P, da Costa DF, Thornley A, Bannister R. The effect of desmopressin on nocturnal polyuria, overnight weight loss, and morning postural hypotension in patients with autonomic failure. Br Med J (Clin Res Ed). 1986;293(6543):353-354.
    • (1986) Br Med J (Clin Res Ed). , vol.293 , Issue.6543 , pp. 353-354
    • Mathias, C.J.1    Fosbraey, P.2    da Costa, D.F.3    Thornley, A.4    Bannister, R.5
  • 60
    • 0018639607 scopus 로고
    • Effects of indomethacin on postural hypotension in Parkinsonism
    • Abate G, Polimeni RM, Cuccurullo F, Puddu P, Lenzi S. Effects of indomethacin on postural hypotension in Parkinsonism. Br Med J. 1979;2(6203):1466-1468.
    • (1979) Br Med J. , vol.2 , Issue.6203 , pp. 1466-1468
    • Abate, G.1    Polimeni, R.M.2    Cuccurullo, F.3    Puddu, P.4    Lenzi, S.5
  • 61
    • 0021826968 scopus 로고
    • Hemodynamic and humoral effects of caffeine in autonomic failure. Therapeutic implications for postprandial hypotension
    • Onrot J, Goldberg MR, Biaggioni I, Hollister AS, Kingaid D, Robertson D. Hemodynamic and humoral effects of caffeine in autonomic failure. Therapeutic implications for postprandial hypotension. N Engl J Med. 1985;313(9):549-554.
    • (1985) N Engl J Med. , vol.313 , Issue.9 , pp. 549-554
    • Onrot, J.1    Goldberg, M.R.2    Biaggioni, I.3    Hollister, A.S.4    Kingaid, D.5    Robertson, D.6
  • 64
    • 0029561818 scopus 로고
    • Alpha sympathomimetic treatment of autonomic insufficiency with orthostatic hypotension
    • Fouad-Tarazi FM, Okabe M, Goren H. Alpha sympathomimetic treatment of autonomic insufficiency with orthostatic hypotension. Am J Med. 1995;99(6):604-610.
    • (1995) Am J Med. , vol.99 , Issue.6 , pp. 604-610
    • Fouad-Tarazi, F.M.1    Okabe, M.2    Goren, H.3
  • 65
    • 84857634531 scopus 로고    scopus 로고
    • Synergistic effect of norepinephrine transporter blockade and alpha-2 antagonism on blood pressure in autonomic failure
    • Okamoto LE, Shibao C, Gamboa A, etal. Synergistic effect of norepinephrine transporter blockade and alpha-2 antagonism on blood pressure in autonomic failure. Hypertension. 2012;59(3):650-656.
    • (2012) Hypertension. , vol.59 , Issue.3 , pp. 650-656
    • Okamoto, L.E.1    Shibao, C.2    Gamboa, A.3
  • 66
    • 0025879223 scopus 로고
    • The treatment of orthostatic hypotension with dihydroxyphenylserine
    • Freeman R, Landsberg L. The treatment of orthostatic hypotension with dihydroxyphenylserine. Clin Neuropharmacol. 1991;14(4):296-304.
    • (1991) Clin Neuropharmacol. , vol.14 , Issue.4 , pp. 296-304
    • Freeman, R.1    Landsberg, L.2
  • 67
    • 0042663999 scopus 로고    scopus 로고
    • Norepinephrine precursor therapy in neurogenic orthostatic hypotension
    • Kaufmann H, Saadia D, Voustianiouk A, etal. Norepinephrine precursor therapy in neurogenic orthostatic hypotension. Circulation. 2003;108(6):724-728.
    • (2003) Circulation. , vol.108 , Issue.6 , pp. 724-728
    • Kaufmann, H.1    Saadia, D.2    Voustianiouk, A.3
  • 68
    • 33847770509 scopus 로고    scopus 로고
    • L-Dihydroxyphenylserine (L-DOPS): A norepinephrine prodrug
    • Goldstein DS. L-Dihydroxyphenylserine (L-DOPS): a norepinephrine prodrug. Cardiovasc Drug Rev. 2006;24(3-4):189-203.
    • (2006) Cardiovasc Drug Rev. , vol.24 , Issue.3-4 , pp. 189-203
    • Goldstein, D.S.1
  • 69
    • 0029774224 scopus 로고    scopus 로고
    • Could treatment with DOPS do for autonomic failure what DOPA did for Parkinson's disease?
    • Kaufmann H. Could treatment with DOPS do for autonomic failure what DOPA did for Parkinson's disease? Neurology. 1996;47(6): 1370-1371.
    • (1996) Neurology. , vol.47 , Issue.6 , pp. 1370-1371
    • Kaufmann, H.1
  • 70
    • 0002779506 scopus 로고
    • Therapeutic effects of L-DOPS in Parkinson's disease, double-blind comparative study against placebo as control in patients with long-term levodopa therapy
    • Narabayashi H, Nakanishi T. Therapeutic effects of L-DOPS in Parkinson's disease, double-blind comparative study against placebo as control in patients with long-term levodopa therapy. Clin Eval. 1987;15: 423-457.
    • (1987) Clin Eval. , vol.15 , pp. 423-457
    • Narabayashi, H.1    Nakanishi, T.2
  • 71
    • 0031905450 scopus 로고    scopus 로고
    • Effects of L-threo-Dops on orthostatic hypotension in Parkinson's disease
    • Japanese
    • Yanagisawa N, Ikeda S, Hashimoto T, etal. [Effects of L-threo-Dops on orthostatic hypotension in Parkinson's disease]. No To Shinkei. 1998;50(2):157-163. Japanese.
    • (1998) No To Shinkei. , vol.50 , Issue.2 , pp. 157-163
    • Yanagisawa, N.1    Ikeda, S.2    Hashimoto, T.3
  • 72
    • 43449127457 scopus 로고    scopus 로고
    • A double-blind, randomized, placebo-controlled study to determine the efficacy and safety of droxidopa in the treatment of orthostatic hypotension associated with multiple system atrophy and Parkinson's disease
    • Mathias CJ, Senard JM, Cortelli P. A double-blind, randomized, placebo-controlled study to determine the efficacy and safety of droxidopa in the treatment of orthostatic hypotension associated with multiple system atrophy and Parkinson's disease. Clin Auton Res. 2007;17:272.
    • (2007) Clin Auton Res. , vol.17 , pp. 272
    • Mathias, C.J.1    Senard, J.M.2    Cortelli, P.3
  • 73
    • 13244281685 scopus 로고    scopus 로고
    • Clinical pharmacokinetics of the norepinephrine precursor L-threo-DOPS in primary chronic autonomic failure
    • Goldstein DS, Holmes C, Kaufmann H, Freeman R. Clinical pharmacokinetics of the norepinephrine precursor L-threo-DOPS in primary chronic autonomic failure. Clin Auton Res. 2004;14(6):363-368.
    • (2004) Clin Auton Res. , vol.14 , Issue.6 , pp. 363-368
    • Goldstein, D.S.1    Holmes, C.2    Kaufmann, H.3    Freeman, R.4
  • 74
    • 84880117209 scopus 로고    scopus 로고
    • Treatment with droxidopa-a phase III multinational, placebo-controlled, parallel group, withdrawal-design study in subjects with neurogenic orthostatic hypotension and non-diabetic autonomic neuropathy
    • the Droxidopa Study Group
    • Kaufmann H, Mathias C, Freeman R, Low P, Biaggioni I, the Droxidopa Study Group. Treatment with droxidopa-a phase III multinational, placebo-controlled, parallel group, withdrawal-design study in subjects with neurogenic orthostatic hypotension and non-diabetic autonomic neuropathy. Clin Auton Res. 2009;19:281.
    • (2009) Clin Auton Res. , vol.19 , pp. 281
    • Kaufmann, H.1    Mathias, C.2    Freeman, R.3    Low, P.4    Biaggioni, I.5
  • 75
    • 84898009505 scopus 로고    scopus 로고
    • Treatment of neurogenic orthostatic hypotension: Results from a multi-center, double-blind, randomized, placebo-controlled, parallel group, induction design study
    • PL02.001
    • Kaufmann H, Freeman R, Biaggioni I, Low P, Pedder S, Hewitt A, Mathias C. Treatment of neurogenic orthostatic hypotension: results from a multi-center, double-blind, randomized, placebo-controlled, parallel group, induction design study. Neurology. 2012;78:PL02.001.
    • (2012) Neurology. , vol.78
    • Kaufmann, H.1    Freeman, R.2    Biaggioni, I.3    Low, P.4    Pedder, S.5    Hewitt, A.6    Mathias, C.7
  • 76
    • 84898017176 scopus 로고    scopus 로고
    • Durability of effect with long-term, open-label droxidopa treatment in patients with symptomatic neurogenic orthostatic hypotension (NOH 303)
    • Isaacson S, Shill H, Vernino S, Cioffi C, Hutchman R. Durability of effect with long-term, open-label droxidopa treatment in patients with symptomatic neurogenic orthostatic hypotension (NOH 303). Mov Disord. 2012;27:S424-S425.
    • (2012) Mov Disord. , vol.27
    • Isaacson, S.1    Shill, H.2    Vernino, S.3    Cioffi, C.4    Hutchman, R.5
  • 77
    • 84897979908 scopus 로고    scopus 로고
    • Effects of droxidopa (Northera™) on 24hour blood pressure (BP) in patients with symptomatic neurogenic orthostatic hypotension (NOH)
    • Kaufmann H, Klos K, Hutchman R, Isaacson S. Effects of droxidopa (Northera™) on 24hour blood pressure (BP) in patients with symptomatic neurogenic orthostatic hypotension (NOH). Mov Disord. 2010;25: S405-S406.
    • (2010) Mov Disord. , vol.25
    • Kaufmann, H.1    Klos, K.2    Hutchman, R.3    Isaacson, S.4
  • 78
    • 84897997490 scopus 로고    scopus 로고
    • A multicenter, open-label study to assess the long-term safety of droxidopa in patients with symptomatic neurogenic orthostatic hypotension (NOH 304)
    • Shill H, Vernino S, Hutchman R, Adkins L, Isaacson S. A multicenter, open-label study to assess the long-term safety of droxidopa in patients with symptomatic neurogenic orthostatic hypotension (NOH 304). Mov Disord. 2012;27:S428.
    • (2012) Mov Disord. , vol.27
    • Shill, H.1    Vernino, S.2    Hutchman, R.3    Adkins, L.4    Isaacson, S.5
  • 79
    • 84925491831 scopus 로고    scopus 로고
    • Droxidopa treatment impact on orthostatic symptoms and standing systolic blood pressure in patients with Parkinson's disease and symptomatic neurogenic orthostatic hypotension: Study 306
    • Emerging Science Abstract 010
    • Isaacson SH, Hauser RA, Szakacs CBN, Cioffi CC. Droxidopa treatment impact on orthostatic symptoms and standing systolic blood pressure in patients with Parkinson's disease and symptomatic neurogenic orthostatic hypotension: Study 306. Neurology. 2013;80:Emerging Science Abstract 010.
    • (2013) Neurology , vol.80
    • Isaacson, S.H.1    Hauser, R.A.2    Szakacs, C.B.N.3    Cioffi, C.C.4
  • 80
    • 84897984339 scopus 로고    scopus 로고
    • Impact of droxidopa treatment in patients with Parkinson's disease and symptomatic neurogenic orthostatic hypotension (study 306)
    • Isaacson S, Hauser RA, Szakacs CBN, Cioffi CC. Impact of droxidopa treatment in patients with Parkinson's disease and symptomatic neurogenic orthostatic hypotension (study 306). Mov Disord. 2013;28 Suppl 1:468.
    • (2013) Mov Disord. , vol.28 , Issue.SUPPL. 1 , pp. 468
    • Isaacson, S.1    Hauser, R.A.2    Szakacs, C.B.N.3    Cioffi, C.C.4
  • 81
    • 84874621116 scopus 로고    scopus 로고
    • Impact of treatment with droxidopa in repeat fallers with Parkinson's disease and symptomatic neurogenic orthostatic hypotension (NOH 306A)
    • Hauser RA, Schwieterman W, Isaacson S. Impact of treatment with droxidopa in repeat fallers with Parkinson's disease and symptomatic neurogenic orthostatic hypotension (NOH 306A). Mov Disord. 2012;27:S423.
    • (2012) Mov Disord. , vol.27
    • Hauser, R.A.1    Schwieterman, W.2    Isaacson, S.3
  • 82
    • 84897986777 scopus 로고    scopus 로고
    • Analysis of efficacy in patients with symptomatic neurogenic orthostatic hypotension treated with droxidopa and dopa-decarboxylase inhibitors
    • Biaggioni I, Low P, Rowse G, Kaufmann H. Analysis of efficacy in patients with symptomatic neurogenic orthostatic hypotension treated with droxidopa and dopa-decarboxylase inhibitors. Mov Disord. 2012;27: S422-S423.
    • (2012) Mov Disord. , vol.27
    • Biaggioni, I.1    Low, P.2    Rowse, G.3    Kaufmann, H.4
  • 83
    • 84897983829 scopus 로고    scopus 로고
    • Analysis of efficacy and safety outcomes in patients treated with droxidopa in combination with other drug classes
    • LeWitt P, Gorny S. Analysis of efficacy and safety outcomes in patients treated with droxidopa in combination with other drug classes. Mov Disord. 2012;27:S425-S426.
    • (2012) Mov Disord. , vol.27
    • LeWitt, P.1    Gorny, S.2
  • 84
    • 84897976028 scopus 로고    scopus 로고
    • Safety and efficacy of droxidopa in patients previously treated with midodrine
    • Low P, Nelson J, Stacy M. Safety and efficacy of droxidopa in patients previously treated with midodrine. Mov Disord. 2012;27:S426.
    • (2012) Mov Disord. , vol.27
    • Low, P.1    Nelson, J.2    Stacy, M.3
  • 85
    • 84897987775 scopus 로고    scopus 로고
    • Integrated efficacy analysis of droxidopa in 2 double-blind, placebo-controlled Phase 3studies in patients with neurogenic orthostatic hypotension
    • Mathias C, Low P, Freeman R, Hewitt L, Kaufmann H. Integrated efficacy analysis of droxidopa in 2 double-blind, placebo-controlled Phase 3studies in patients with neurogenic orthostatic hypotension. Mov Disord. 2012;27:S426.
    • (2012) Mov Disord. , vol.27
    • Mathias, C.1    Low, P.2    Freeman, R.3    Hewitt, L.4    Kaufmann, H.5


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