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Volumn 10, Issue 1, 2014, Pages 217-227

Personalized therapeutics for levofloxacin: A focus on pharmacokinetic concerns

Author keywords

Drug interactions; Fluoroquinolone resistance; Individual dosing; Patient complexity; Personalized medicine; Pharmacodynamics; Pharmacokinetics; Therapeutics

Indexed keywords

CYCLOSPORIN; LEVOFLOXACIN; MULTIDRUG AND TOXIN EXTRUSION PROTEIN 1; MULTIDRUG RESISTANCE PROTEIN; ORGANIC CATION TRANSPORTER 1; QUINOLINE DERIVED ANTIINFECTIVE AGENT; SOLUTE CARRIER ORGANIC ANION TRANSPORTER 1A2; TACROLIMUS; TAMSULOSIN; WARFARIN;

EID: 84897996366     PISSN: 11766336     EISSN: 1178203X     Source Type: Journal    
DOI: 10.2147/TCRM.S59079     Document Type: Review
Times cited : (12)

References (62)
  • 1
    • 84898001864 scopus 로고    scopus 로고
    • International Pharmaceutical Federation. Available from: Accessed December 4, 2013
    • International Pharmaceutical Federation. Towards a future vision for complex patients. Available from: http://www.fip.org/dublin2013/Dublin/2041/ProGramme/. Accessed December 4, 2013.
    • Towards a future vision for complex patients.
  • 2
    • 84890515013 scopus 로고    scopus 로고
    • Navigating complex patients using an innovative tool: The MTM Spider Web
    • Morello CM, Hirsch JD, Lee KC. Navigating complex patients using an innovative tool: the MTM Spider Web. J Am Pharm Assoc (2003). 2013;53:530-538.
    • (2013) J Am Pharm Assoc (2003). , vol.53 , pp. 530-538
    • Morello, C.M.1    Hirsch, J.D.2    Lee, K.C.3
  • 3
    • 84897989337 scopus 로고    scopus 로고
    • Joint Commission International. Oak Brook, IL, USA: Joint Commission International; Available from: Accessed March 20, 2013
    • Joint Commission International. JCI accreditation standards for hospitals. Oak Brook, IL, USA: Joint Commission International; 2010. Available from: http://www.jointcommissioninternational.org/common/pdfs/jcia/IAS400_Standards_Lists_Only.pdf. Accessed March 20, 2013.
    • (2010) JCI accreditation standards for hospitals.
  • 4
    • 84880953187 scopus 로고    scopus 로고
    • Patient diagnosis on electronic prescription orders: A key element for appropriateness review by pharmacists
    • Li W, Zhou Q. Patient diagnosis on electronic prescription orders: a key element for appropriateness review by pharmacists. Res Social Adm Pharm. 2013;9:493-494.
    • (2013) Res Social Adm Pharm. , vol.9 , pp. 493-494
    • Li, W.1    Zhou, Q.2
  • 5
    • 84880953755 scopus 로고    scopus 로고
    • Intervention for improving the appropriateness of physician orders for oral medications in geriatric VIP patients during the journey to JCI accreditation
    • Zhu LL, Zhou Q. Intervention for improving the appropriateness of physician orders for oral medications in geriatric VIP patients during the journey to JCI accreditation. Ther Clin Risk Manag. 2013;9: 273-275.
    • (2013) Ther Clin Risk Manag. , vol.9 , pp. 273-275
    • Zhu, L.L.1    Zhou, Q.2
  • 6
    • 56749125023 scopus 로고    scopus 로고
    • Levofloxacin in the treatment of complicated urinary tract infections and acute pyelonephritis
    • McGregor JC, Allen GP, Bearden DT. Levofloxacin in the treatment of complicated urinary tract infections and acute pyelonephritis. Ther Clin Risk Manag. 2008;4:843-853.
    • (2008) Ther Clin Risk Manag. , vol.4 , pp. 843-853
    • McGregor, J.C.1    Allen, G.P.2    Bearden, D.T.3
  • 7
    • 34250011998 scopus 로고    scopus 로고
    • Skin and skin structure infections: Treatment with newer generation fluoroquinolones
    • Giordano P, Weber K, Gesin G, Kubert J. Skin and skin structure infections: treatment with newer generation fluoroquinolones. Ther Clin Risk Manag. 2007;3:309-317.
    • (2007) Ther Clin Risk Manag. , vol.3 , pp. 309-317
    • Giordano, P.1    Weber, K.2    Gesin, G.3    Kubert, J.4
  • 9
    • 0035661937 scopus 로고    scopus 로고
    • Predicting antibacterial response from pharmacodynamic and pharmacokinetic profiles
    • Nicolau DP. Predicting antibacterial response from pharmacodynamic and pharmacokinetic profiles. Infection. 2001;29 Suppl 2:11-15.
    • (2001) Infection. , vol.29 , Issue.SUPPL. 2 , pp. 11-15
    • Nicolau, D.P.1
  • 10
    • 84868603184 scopus 로고    scopus 로고
    • Declining susceptibilities of Gram-negative bacteria to the fluoroquinolones: Effects on pharmacokinetics, pharmacodynamics, and clinical outcomes
    • Labreche MJ, Frei CR. Declining susceptibilities of Gram-negative bacteria to the fluoroquinolones: effects on pharmacokinetics, pharmacodynamics, and clinical outcomes. Am J Health Syst Pharm. 2012;69:1863-1870.
    • (2012) Am J Health Syst Pharm. , vol.69 , pp. 1863-1870
    • Labreche, M.J.1    Frei, C.R.2
  • 11
    • 2442549489 scopus 로고    scopus 로고
    • Relationship between fluoroquinolone area under the curve: Minimum inhibitory concentration ratio and the probability of eradication of the infecting pathogen, in patients with nosocomial pneumonia
    • Drusano GL, Preston SL, Fowler C, Corrado M, Weisinger B, Kahn J. Relationship between fluoroquinolone area under the curve: minimum inhibitory concentration ratio and the probability of eradication of the infecting pathogen, in patients with nosocomial pneumonia. J Infect Dis. 2004;189:1590-1597.
    • (2004) J Infect Dis. , vol.189 , pp. 1590-1597
    • Drusano, G.L.1    Preston, S.L.2    Fowler, C.3    Corrado, M.4    Weisinger, B.5    Kahn, J.6
  • 12
    • 62949178700 scopus 로고    scopus 로고
    • Effect of differences in MIC values on clinical outcomes in patients with bloodstream infections caused by Gram-negative organisms treated with levofloxacin
    • Defife R, Scheetz MH, Feinglass JM, Postelnick MJ, Scarsi KK. Effect of differences in MIC values on clinical outcomes in patients with bloodstream infections caused by Gram-negative organisms treated with levofloxacin. Antimicrob Agents Chemother. 2009;53:1074-1079.
    • (2009) Antimicrob Agents Chemother. , vol.53 , pp. 1074-1079
    • Defife, R.1    Scheetz, M.H.2    Feinglass, J.M.3    Postelnick, M.J.4    Scarsi, K.K.5
  • 13
    • 40349113718 scopus 로고    scopus 로고
    • Levofloxacin: A review of its use as a high-dose, short-course treatment for bacterial infection
    • Anderson VR, Perry CM. Levofloxacin: a review of its use as a high-dose, short-course treatment for bacterial infection. Drugs. 2008;68: 535-565.
    • (2008) Drugs. , vol.68 , pp. 535-565
    • Anderson, V.R.1    Perry, C.M.2
  • 14
    • 84855263441 scopus 로고    scopus 로고
    • Cumulative clinical experience from over a decade of use of levofloxacin in community-acquired pneumonia: Critical appraisal and role in therapy
    • Noreddin AM, Elkhatib WF, Cunnion KM, Zhanel GG. Cumulative clinical experience from over a decade of use of levofloxacin in community-acquired pneumonia: critical appraisal and role in therapy. Drug Healthc Patient Saf. 2011;3:59-68.
    • (2011) Drug Healthc Patient Saf. , vol.3 , pp. 59-68
    • Noreddin, A.M.1    Elkhatib, W.F.2    Cunnion, K.M.3    Zhanel, G.G.4
  • 15
    • 79959220301 scopus 로고    scopus 로고
    • Pharmacokinetics of intravenous levofloxacin administered at 750 milligrams in obese adults
    • Cook AM, Martin C, Adams VR, Morehead RS. Pharmacokinetics of intravenous levofloxacin administered at 750 milligrams in obese adults. Antimicrob Agents Chemother. 2011;55:3240-3243.
    • (2011) Antimicrob Agents Chemother. , vol.55 , pp. 3240-3243
    • Cook, A.M.1    Martin, C.2    Adams, V.R.3    Morehead, R.S.4
  • 16
    • 33745983271 scopus 로고    scopus 로고
    • Altered steady state pharmacokinetics of levofloxacin in adult cystic fibrosis patients receiving calcium carbonate
    • Pai MP, Allen SE, Amsden GW. Altered steady state pharmacokinetics of levofloxacin in adult cystic fibrosis patients receiving calcium carbonate. J Cyst Fibros. 2006;5:153-157.
    • (2006) J Cyst Fibros. , vol.5 , pp. 153-157
    • Pai, M.P.1    Allen, S.E.2    Amsden, G.W.3
  • 18
    • 16844364507 scopus 로고    scopus 로고
    • Levofloxacin pharmacokinetics in children
    • Chien S, Wells TG, Blumer JL, et al. Levofloxacin pharmacokinetics in children. J Clin Pharmacol. 2005;45:153-160.
    • (2005) J Clin Pharmacol. , vol.45 , pp. 153-160
    • Chien, S.1    Wells, T.G.2    Blumer, J.L.3
  • 19
    • 22544460247 scopus 로고    scopus 로고
    • Comparison of gatifloxacin and levofloxacin administered at various dosing regimens to hospitalised patients with community-acquired pneumonia: Pharmacodynamic target attainment study using North American surveillance data for Streptococcus pneumoniae
    • Noreddin AM, Hoban DJ, Zhanel GG. Comparison of gatifloxacin and levofloxacin administered at various dosing regimens to hospitalised patients with community-acquired pneumonia: pharmacodynamic target attainment study using North American surveillance data for Streptococcus pneumoniae. Int J Antimicrob Agents. 2005;26: 120-125.
    • (2005) Int J Antimicrob Agents. , vol.26 , pp. 120-125
    • Noreddin, A.M.1    Hoban, D.J.2    Zhanel, G.G.3
  • 20
    • 0037707561 scopus 로고    scopus 로고
    • Pharmacokinetics and pharmacodynamics of intravenous levofloxacin in patients with early-onset ventilator-associated pneumonia
    • Pea F, Di Qual E, Cusenza A, Brollo L, Baldassarre M, Furlanut M. Pharmacokinetics and pharmacodynamics of intravenous levofloxacin in patients with early-onset ventilator-associated pneumonia. Clin Pharmacokinet. 2003;42:589-598.
    • (2003) Clin Pharmacokinet. , vol.42 , pp. 589-598
    • Pea, F.1    Di Qual, E.2    Cusenza, A.3    Brollo, L.4    Baldassarre, M.5    Furlanut, M.6
  • 21
    • 0031959626 scopus 로고    scopus 로고
    • Levofloxacin population pharmacokinetics and creation of a demographic model for prediction of individual drug clearance in patients with serious community-acquired infection
    • Preston SL, Drusano GL, Berman AL, et al. Levofloxacin population pharmacokinetics and creation of a demographic model for prediction of individual drug clearance in patients with serious community-acquired infection. Antimicrob Agents Chemother. 1998;42:1098-1104.
    • (1998) Antimicrob Agents Chemother. , vol.42 , pp. 1098-1104
    • Preston, S.L.1    Drusano, G.L.2    Berman, A.L.3
  • 22
  • 23
    • 79958856036 scopus 로고    scopus 로고
    • Levofloxacin weight-adjusted dosing and pharmacokinetic disposition in a morbidly obese patient
    • Luque S, Grau S, Valle M, Colino CI, Ferrer A. Levofloxacin weight-adjusted dosing and pharmacokinetic disposition in a morbidly obese patient. J Antimicrob Chemother. 2011;66:1653-1654.
    • (2011) J Antimicrob Chemother. , vol.66 , pp. 1653-1654
    • Luque, S.1    Grau, S.2    Valle, M.3    Colino, C.I.4    Ferrer, A.5
  • 24
    • 80052878641 scopus 로고    scopus 로고
    • Pharmacokinetics of moxifloxacin in plasma and tissue of morbidly obese patients
    • Kees MG, Weber S, Kees F, Horbach T. Pharmacokinetics of moxifloxacin in plasma and tissue of morbidly obese patients. J Antimicrob Chemother. 2011;66:2330-2335.
    • (2011) J Antimicrob Chemother. , vol.66 , pp. 2330-2335
    • Kees, M.G.1    Weber, S.2    Kees, F.3    Horbach, T.4
  • 26
    • 84870165826 scopus 로고    scopus 로고
    • Fluoroquinolones in the treatment of bronchopulmonary disease in cystic fibrosis
    • Hurley M, Smyth A. Fluoroquinolones in the treatment of bronchopulmonary disease in cystic fibrosis. Ther Adv Respir Dis. 2012;6:363-373.
    • (2012) Ther Adv Respir Dis. , vol.6 , pp. 363-373
    • Hurley, M.1    Smyth, A.2
  • 28
    • 79957942626 scopus 로고    scopus 로고
    • Levofloxacin inhalation solution (MP-376) in patients with cystic fibrosis with Pseudomonas aeruginosa
    • Mpex 204 Study Group
    • Geller DE, Flume PA, Staab D, Fischer R, Loutit JS, Conrad DJ; Mpex 204 Study Group. Levofloxacin inhalation solution (MP-376) in patients with cystic fibrosis with Pseudomonas aeruginosa. Am J Respir Crit Care Med. 2011;183:1510-1516.
    • (2011) Am J Respir Crit Care Med. , vol.183 , pp. 1510-1516
    • Geller, D.E.1    Flume, P.A.2    Staab, D.3    Fischer, R.4    Loutit, J.S.5    Conrad, D.J.6
  • 29
    • 22544467452 scopus 로고    scopus 로고
    • Comparative bioavailability of two formulations of levofloxacin and effect of sex on bioequivalence analysis. Data from a randomised, 2 × 2 crossover trial in healthy volunteers
    • Almeida S, Filipe A, Almeida A, Wong H, Caparrós N, Tanguay M. Comparative bioavailability of two formulations of levofloxacin and effect of sex on bioequivalence analysis. Data from a randomised, 2 × 2 crossover trial in healthy volunteers. Arzneimittelforschung. 2005;55:414-419.
    • (2005) Arzneimittelforschung. , vol.55 , pp. 414-419
    • Almeida, S.1    Filipe, A.2    Almeida, A.3    Wong, H.4    Caparrós, N.5    Tanguay, M.6
  • 30
    • 0030790098 scopus 로고    scopus 로고
    • Absence of age and gender effects on the pharmacokinetics of a single 500-milligram oral dose of levofloxacin in healthy subjects
    • Chien SC, Chow AT, Natarajan J, et al. Absence of age and gender effects on the pharmacokinetics of a single 500-milligram oral dose of levofloxacin in healthy subjects. Antimicrob Agents Chemother. 1997;41:1562-1565.
    • (1997) Antimicrob Agents Chemother. , vol.41 , pp. 1562-1565
    • Chien, S.C.1    Chow, A.T.2    Natarajan, J.3
  • 31
    • 84897986519 scopus 로고    scopus 로고
    • Food and Drug Administration. Available from: Accessed December 4, 2013
    • Food and Drug Administration. Levaquin medication guide. Available from: http://www.fda.gov/downloads/Drugs/./UCM133684.pdf. Accessed December 4, 2013.
    • Levaquin medication guide.
  • 32
    • 84879724442 scopus 로고    scopus 로고
    • Prevalence and risk factor analysis of resistant Escherichia coli urinary tract infections in the emergency department
    • Bailey AM, Weant KA, Baker SN. Prevalence and risk factor analysis of resistant Escherichia coli urinary tract infections in the emergency department. Pharm Pract (Granada). 2013;11:96-101.
    • (2013) Pharm Pract (Granada). , vol.11 , pp. 96-101
    • Bailey, A.M.1    Weant, K.A.2    Baker, S.N.3
  • 33
    • 0028968482 scopus 로고
    • Premarketing population pharmacokinetic study of levofloxacin in normal subjects and patients with infectious diseases
    • Tanigawara Y, Nomura H, Kagimoto N, Okumura K, Hori R. Premarketing population pharmacokinetic study of levofloxacin in normal subjects and patients with infectious diseases. Biol Pharm Bull. 1995;18:315-320.
    • (1995) Biol Pharm Bull. , vol.18 , pp. 315-320
    • Tanigawara, Y.1    Nomura, H.2    Kagimoto, N.3    Okumura, K.4    Hori, R.5
  • 35
    • 0036795265 scopus 로고    scopus 로고
    • Pharmacokinetics of intravenous and oral levofloxacin in critically ill adults in a medical intensive care unit
    • Rebuck JA, Fish DN, Abraham E. Pharmacokinetics of intravenous and oral levofloxacin in critically ill adults in a medical intensive care unit. Pharmacotherapy. 2002;22:1216-1225.
    • (2002) Pharmacotherapy. , vol.22 , pp. 1216-1225
    • Rebuck, J.A.1    Fish, D.N.2    Abraham, E.3
  • 37
    • 0030864108 scopus 로고    scopus 로고
    • Pharmacokinetic profile of levofloxacin following once-daily 500-milligram oral or intravenous doses
    • Chien SC, Rogge MC, Gisclon LG, et al. Pharmacokinetic profile of levofloxacin following once-daily 500-milligram oral or intravenous doses. Antimicrob Agents Chemother. 1997;41:2256-2260.
    • (1997) Antimicrob Agents Chemother. , vol.41 , pp. 2256-2260
    • Chien, S.C.1    Rogge, M.C.2    Gisclon, L.G.3
  • 38
    • 84862912918 scopus 로고    scopus 로고
    • Clinical and economic impact of a pharmacist-managed iv-to-po conversion service for levofloxacin in Taiwan
    • Yen YH, Chen HY, Wuan-Jin L, Lin YM, Shen WC, Cheng KJ. Clinical and economic impact of a pharmacist-managed iv-to-po conversion service for levofloxacin in Taiwan. Int J Clin Pharmacol Ther. 2012;50:136-141.
    • (2012) Int J Clin Pharmacol Ther. , vol.50 , pp. 136-141
    • Yen, Y.H.1    Chen, H.Y.2    Wuan-Jin, L.3    Lin, Y.M.4    Shen, W.C.5    Cheng, K.J.6
  • 39
    • 84855432761 scopus 로고    scopus 로고
    • Evaluation by Monte Carlo simulation of levofloxacin dosing for complicated urinary tract infections caused by Escherichia coli or Pseudomonas aeruginosa
    • Deguchi T, Seike K, Yasuda M, Matsumoto T. Evaluation by Monte Carlo simulation of levofloxacin dosing for complicated urinary tract infections caused by Escherichia coli or Pseudomonas aeruginosa. J Infect Chemother. 2011;17:726-730.
    • (2011) J Infect Chemother. , vol.17 , pp. 726-730
    • Deguchi, T.1    Seike, K.2    Yasuda, M.3    Matsumoto, T.4
  • 40
    • 0030843525 scopus 로고    scopus 로고
    • Effects of food and sucralfate on a single oral dose of 500 milligrams of levofloxacin in healthy subjects
    • Lee LJ, Hafkin B, Lee ID, Hoh J, Dix R. Effects of food and sucralfate on a single oral dose of 500 milligrams of levofloxacin in healthy subjects. Antimicrob Agents Chemother. 1997;41:2196-2200.
    • (1997) Antimicrob Agents Chemother. , vol.41 , pp. 2196-2200
    • Lee, L.J.1    Hafkin, B.2    Lee, I.D.3    Hoh, J.4    Dix, R.5
  • 41
    • 0043014533 scopus 로고    scopus 로고
    • Lack of bioequivalence of levofloxacin when coadministered with a mineral-fortified breakfast of juice and cereal
    • Amsden GW, Whitaker AM, Johnson PW. Lack of bioequivalence of levofloxacin when coadministered with a mineral-fortified breakfast of juice and cereal. J Clin Pharmacol. 2003;43:990-995.
    • (2003) J Clin Pharmacol. , vol.43 , pp. 990-995
    • Amsden, G.W.1    Whitaker, A.M.2    Johnson, P.W.3
  • 42
    • 0348112532 scopus 로고    scopus 로고
    • Lack of bioequivalence when levofloxacin and calcium-fortified orange juice are coadministered to healthy volunteers
    • Wallace AW, Victory JM, Amsden GW. Lack of bioequivalence when levofloxacin and calcium-fortified orange juice are coadministered to healthy volunteers. J Clin Pharmacol. 2003;43:539-544.
    • (2003) J Clin Pharmacol. , vol.43 , pp. 539-544
    • Wallace, A.W.1    Victory, J.M.2    Amsden, G.W.3
  • 43
    • 84886946045 scopus 로고    scopus 로고
    • Comparison of results after flouroquinolones and combination therapies in type IIIA chronic prostatitis
    • Altintas R, Oguz F, Beytur A, Ediz C, Gunes A, Ozer A. Comparison of results after flouroquinolones and combination therapies in type IIIA chronic prostatitis. Actas Urol Esp. 2013;37:619-624.
    • (2013) Actas Urol Esp. , vol.37 , pp. 619-624
    • Altintas, R.1    Oguz, F.2    Beytur, A.3    Ediz, C.4    Gunes, A.5    Ozer, A.6
  • 44
    • 84874631218 scopus 로고    scopus 로고
    • Tamsulosin alters levofloxacin pharmacokinetics in prostates derived from rats with acute bacterial prostatitis
    • Qin GD, Xiao MZ, Zhou YD, et al. Tamsulosin alters levofloxacin pharmacokinetics in prostates derived from rats with acute bacterial prostatitis. Asian J Androl. 2013;15:254-260.
    • (2013) Asian J Androl. , vol.15 , pp. 254-260
    • Qin, G.D.1    Xiao, M.Z.2    Zhou, Y.D.3
  • 46
    • 34447317219 scopus 로고    scopus 로고
    • Interaction between warfarin and levofloxacin: Case series
    • Vadlamudi RS, Smalligan RD, Ismail HM. Interaction between warfarin and levofloxacin: case series. South Med J. 2007;100:720-724.
    • (2007) South Med J. , vol.100 , pp. 720-724
    • Vadlamudi, R.S.1    Smalligan, R.D.2    Ismail, H.M.3
  • 47
    • 84880380846 scopus 로고    scopus 로고
    • Readmissions for warfarin-related bleeding in pediatric patients after hospital discharge
    • Moffett BS, Kim S, Bomgaars LR. Readmissions for warfarin-related bleeding in pediatric patients after hospital discharge. Pediatr Blood Cancer. 2013;60:1503-1506.
    • (2013) Pediatr Blood Cancer. , vol.60 , pp. 1503-1506
    • Moffett, B.S.1    Kim, S.2    Bomgaars, L.R.3
  • 49
    • 84870574003 scopus 로고    scopus 로고
    • Warfarin-antibiotic interactions in older adults of an outpatient anticoagulation clinic
    • Ghaswalla PK, Harpe SE, Tassone D, Slattum PW. Warfarin-antibiotic interactions in older adults of an outpatient anticoagulation clinic. Am J Geriatr Pharmacother. 2012;10:352-360.
    • (2012) Am J Geriatr Pharmacother. , vol.10 , pp. 352-360
    • Ghaswalla, P.K.1    Harpe, S.E.2    Tassone, D.3    Slattum, P.W.4
  • 50
    • 84897713557 scopus 로고    scopus 로고
    • Warfarin interactions with antibiotics in the ambulatory care setting
    • Clark NP, Delate T, Riggs CS, et al. Warfarin interactions with antibiotics in the ambulatory care setting. JAMA Intern Med. 2014;174:409-416.
    • (2014) JAMA Intern Med. , vol.174 , pp. 409-416
    • Clark, N.P.1    Delate, T.2    Riggs, C.S.3
  • 52
    • 33344471694 scopus 로고    scopus 로고
    • Pharmacokinetic interaction between levofloxacin and ciclosporin or tacrolimus in kidney transplant recipients: Ciclosporin, tacrolimus and levofloxacin in renal transplantation
    • Federico S, Carrano R, Capone D, Gentile A, Palmiero G, Basile V. Pharmacokinetic interaction between levofloxacin and ciclosporin or tacrolimus in kidney transplant recipients: ciclosporin, tacrolimus and levofloxacin in renal transplantation. Clin Pharmacokinet. 2006;45:169-175.
    • (2006) Clin Pharmacokinet. , vol.45 , pp. 169-175
    • Federico, S.1    Carrano, R.2    Capone, D.3    Gentile, A.4    Palmiero, G.5    Basile, V.6
  • 53
    • 84859981569 scopus 로고    scopus 로고
    • Fluoroquinolone disposition: Identification of the contribution of renal secretory and reabsorptive drug transporters
    • Mulgaonkar A, Venitz J, Sweet DH. Fluoroquinolone disposition: identification of the contribution of renal secretory and reabsorptive drug transporters. Expert Opin Drug Metab Toxicol. 2012;8: 553-569.
    • (2012) Expert Opin Drug Metab Toxicol. , vol.8 , pp. 553-569
    • Mulgaonkar, A.1    Venitz, J.2    Sweet, D.H.3
  • 54
    • 33847235324 scopus 로고    scopus 로고
    • Identification of influx transporter for the quinolone antibacterial agent levofloxacin
    • Maeda T, Takahashi K, Ohtsu N, et al. Identification of influx transporter for the quinolone antibacterial agent levofloxacin. Mol Pharm. 2007;4: 85-94.
    • (2007) Mol Pharm. , vol.4 , pp. 85-94
    • Maeda, T.1    Takahashi, K.2    Ohtsu, N.3
  • 55
    • 0035023064 scopus 로고    scopus 로고
    • Active intestinal secretion of new quinolone antimicrobials and the partial contribution of P-glycoprotein
    • Naruhashi K, Tamai I, Inoue N, et al. Active intestinal secretion of new quinolone antimicrobials and the partial contribution of P-glycoprotein. J Pharm Pharmacol. 2001;53:699-709.
    • (2001) J Pharm Pharmacol. , vol.53 , pp. 699-709
    • Naruhashi, K.1    Tamai, I.2    Inoue, N.3
  • 56
    • 8544227674 scopus 로고    scopus 로고
    • Transport of quinolone antibacterial drugs by human P-glycoprotein expressed in a kidney epithelial cell line, LLC-PK1
    • Ito T, Yano I, Tanaka K, Inui KI. Transport of quinolone antibacterial drugs by human P-glycoprotein expressed in a kidney epithelial cell line, LLC-PK1. J Pharmacol Exp Ther. 1997;282:955-960.
    • (1997) J Pharmacol Exp Ther. , vol.282 , pp. 955-960
    • Ito, T.1    Yano, I.2    Tanaka, K.3    Inui, K.I.4
  • 57
    • 84877843706 scopus 로고    scopus 로고
    • Human organic cation transporters 1 (SLC22A1), 2 (SLC22A2), and 3 (SLC22A3) as disposition pathways for fluoroquinolone antimicrobials
    • Mulgaonkar A, Venitz J, Gründemann D, Sweet DH. Human organic cation transporters 1 (SLC22A1), 2 (SLC22A2), and 3 (SLC22A3) as disposition pathways for fluoroquinolone antimicrobials. Antimicrob Agents Chemother. 2013;57:2705-2711.
    • (2013) Antimicrob Agents Chemother. , vol.57 , pp. 2705-2711
    • Mulgaonkar, A.1    Venitz, J.2    Gründemann, D.3    Sweet, D.H.4
  • 58
    • 59649105503 scopus 로고    scopus 로고
    • Functional characterization of multidrug and toxin extrusion protein 1 as a facilitative transporter for fluoroquinolones
    • Ohta KY, Imamura Y, Okudaira N, Atsumi R, Inoue K, Yuasa H. Functional characterization of multidrug and toxin extrusion protein 1 as a facilitative transporter for fluoroquinolones. J Pharmacol Exp Ther. 2009;328:628-634.
    • (2009) J Pharmacol Exp Ther. , vol.328 , pp. 628-634
    • Ohta, K.Y.1    Imamura, Y.2    Okudaira, N.3    Atsumi, R.4    Inoue, K.5    Yuasa, H.6
  • 59
    • 65649132986 scopus 로고    scopus 로고
    • Pharmacogenetics of the organic anion transporting polypeptide 1A2
    • Franke RM, Scherkenbach LA, Sparreboom A. Pharmacogenetics of the organic anion transporting polypeptide 1A2. Pharmacogenomics. 2009;10:339-344.
    • (2009) Pharmacogenomics. , vol.10 , pp. 339-344
    • Franke, R.M.1    Scherkenbach, L.A.2    Sparreboom, A.3
  • 60
    • 84874606257 scopus 로고    scopus 로고
    • Impact of genetic variation in OATP transporters to drug disposition and response
    • Gong IY, Kim RB. Impact of genetic variation in OATP transporters to drug disposition and response. Drug Metab Pharmacokinet. 2013;28:4-18.
    • (2013) Drug Metab Pharmacokinet. , vol.28 , pp. 4-18
    • Gong, I.Y.1    Kim, R.B.2
  • 61
    • 84875830097 scopus 로고    scopus 로고
    • ABCB1 gene polymorphisms, ABCB1 haplotypes and ABCG2 c.421c. A are determinants of inter-subject variability in rosuvastatin pharmacokinetics
    • Zhou Q, Ruan ZR, Yuan H, Xu DH, Zeng S. ABCB1 gene polymorphisms, ABCB1 haplotypes and ABCG2 c.421c. A are determinants of inter-subject variability in rosuvastatin pharmacokinetics. Pharmazie. 2013;68:129-134.
    • (2013) Pharmazie. , vol.68 , pp. 129-134
    • Zhou, Q.1    Ruan, Z.R.2    Yuan, H.3    Xu, D.H.4    Zeng, S.5
  • 62
    • 84885063981 scopus 로고    scopus 로고
    • A gene-gene interaction between polymorphisms in the OCT2 and MATE1 genes influences the renal clearance of metformin
    • Christensen MM, Pedersen RS, Stage TB, et al. A gene-gene interaction between polymorphisms in the OCT2 and MATE1 genes influences the renal clearance of metformin. Pharmacogenet Genomics. 2013;23:526-534.
    • (2013) Pharmacogenet Genomics. , vol.23 , pp. 526-534
    • Christensen, M.M.1    Pedersen, R.S.2    Stage, T.B.3


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