Lower adiponectin is associated with subclinical cardiovascular disease among HIV-infected men

AIDS

Volumn 28, Issue 6, 2014, Pages 901-909

  Ketlogetswe, Kerunne S ^a   Post, Wendy S ^a   Li, Xiuhong ^a   Palella, Frank J ^a   Jacobson, Lisa P ^a   Margolick, Joseph B ^a   Kingsley, Lawrence A ^a   Witt, Mallory D ^a   Dobs, Adrian S ^a   Budoff, Matthew J ^a   Brown, Todd T ^a  

^a JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

Adipokines; Adiponectin; Cardiac computed tomography; Coronary computed tomography angiography; Heart; Leptin; Metabolic side effects of HIV infection; Subclinical coronary atherosclerosis

Indexed keywords

ABACAVIR; ADIPOCYTOKINE; ADIPONECTIN; ANTIHYPERTENSIVE AGENT; ANTIRETROVIRUS AGENT; CALCIUM; INTEGRASE INHIBITOR; LEPTIN; NONNUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITOR; PROTEINASE INHIBITOR; TENOFOVIR; VIRUS RNA;

ADULT; AGED; ANTIHYPERTENSIVE THERAPY; ARTICLE; ATHEROSCLEROTIC PLAQUE; BLOOD SAMPLING; CARDIOVASCULAR DISEASE; CD4 LYMPHOCYTE COUNT; CLINICAL ASSESSMENT; COHORT ANALYSIS; COMPUTED TOMOGRAPHIC ANGIOGRAPHY; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED STUDY; CORONARY ARTERY; CORONARY ARTERY ATHEROSCLEROSIS; CORONARY ARTERY OBSTRUCTION; CROSS-SECTIONAL STUDY; DIABETES MELLITUS; DIAGNOSTIC TEST ACCURACY STUDY; DISEASE ASSOCIATION; DISEASE SEVERITY; HEART INFARCTION; HIGHLY ACTIVE ANTIRETROVIRAL THERAPY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS INFECTED PATIENT; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; HYPERTENSION; INTRAABDOMINAL FAT; LABORATORY TEST; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; MULTICENTER STUDY; OBESITY; OBSERVATIONAL STUDY; PREDICTIVE VALUE; PRIORITY JOURNAL; PROSPECTIVE STUDY; PROTEIN BLOOD LEVEL; RACE DIFFERENCE; RISK FACTOR; SENSITIVITY AND SPECIFICITY; SEROLOGY; SUBCUTANEOUS FAT; THIGH;

ADIPONECTIN; ADULT; AGED; ANGIOGRAPHY; ASYMPTOMATIC DISEASES; COHORT STUDIES; CORONARY ARTERY DISEASE; HIV INFECTIONS; HUMANS; LEPTIN; MALE; MIDDLE AGED; PROSPECTIVE STUDIES; TOMOGRAPHY, X-RAY COMPUTED;

EID: 84897983468     PISSN: 02699370     EISSN: 14735571     Source Type: Journal    
DOI: 10.1097/QAD.0000000000000186     Document Type: Article

References (38)

1. Currier JS, Taylor A, Boyd F, Dezii CM, Kawabata H, Burtcel B, et al. Coronary heart disease in HIV-infected individuals. J Acquir Immune Defic Syndr 2003; 33:506-512.
2. Triant VA, Lee H, Hadigan C, Grinspoon SK. Increased acute myocardial infarction rates and cardiovascular risk factors among patients with human immunodeficiency virus disease. J Clin Endocrinol Metab 2007; 92:2506-2512.
3. Grinspoon S, Carr A. Cardiovascular risk and body-fat abnormalities in HIV-infected adults. N Engl J Med 2005; 352:48-62.
4. Ouchi N, Kihara S, Arita Y, Okamoto Y, Maeda K, Kuriyama H, et al. Adiponectin, an adipocyte-derived plasma protein, inhibits endothelial NF-kappaB signaling through a cAMPdependent pathway. Circulation 2000; 102:1296-1301.
5. Boden G, Chen X, Mozzoli M, Ryan I. Effect of fasting on serum leptin in normal human subjects. J Clin Endocrinol Metab 1996; 81:3419-3423.
6. Behre CJ. Adiponectin, obesity and atherosclerosis. Scand J Clin Lab Invest 2007; 67:449-458.
7. Schulze MB, Shai I, Rimm EB, Li T, Rifai N, Hu FB. Adiponectin and future coronary heart disease events among men with type 2 diabetes. Diabetes 2005; 54:534-539.
8. Soderberg S, Ahren B, Jansson JH, Johnson O, Hallmans G, Asplund K, et al. Leptin is associated with increased risk of myocardial infarction. J Intern Med 1999; 246:409-418.
9. Sierra-Johnson J, Romero-Corral A, Lopez-Jimenez F, Gami AS, Sert Kuniyoshi FH, Wolk R, et al. Relation of increased leptin concentrations to history of myocardial infarction and stroke in the United States population. Am J Cardiol 2007; 100:234-239.
10. Bacchetti P, Gripshover B, Grunfeld C, Heymsfield S, McCreath H, Osmond D, et al. Fat distribution in men with HIV infection. J Acquir Immune Defic Syndr 2005; 40:121-131.
11. Addy CL, Gavrila A, Tsiodras S, Brodovicz K, Karchmer AW, Mantzoros CS. Hypoadiponectinemia is associated with insulin resistance, hypertriglyceridemia, and fat redistribution in human immunodeficiency virus-infected patients treated with highly active antiretroviral therapy. J Clin Endocrinol Metab 2003; 88:627-636.
12. Samaras K, Gan SK, Peake PW, Carr A, Campbell LV. Proinflammatory markers, insulin sensitivity, and cardiometabolic risk factors in treated HIV infection. Obesity (Silver Spring) 2009; 17:53-59.
13. Kosmiski L, Kuritzkes D, Lichtenstein K, Eckel R. Adipocytederived hormone levels in HIV lipodystrophy. Antivir Ther 2003; 8:9-15.
14. Mynarcik DC, Combs T, McNurlan MA, Scherer PE, Komaroff E, Gelato MC. Adiponectin and leptin levels in HIV-infected subjects with insulin resistance and body fat redistribution. J Acquir Immune Defic Syndr 2002; 31:514-520.
15. Nagy GS, Tsiodras S, Martin LD, Avihingsanon A, Gavrila A, Hsu WC, et al. Human immunodeficiency virus type 1-related lipoatrophy and lipohypertrophy are associated with serum concentrations of leptin. Clin Infect Dis 2003; 36:795-802.
16. Kaslow RA, Ostrow DG, Detels R, Phair JP, Polk BF, Rinaldo CR Jr. The Multicenter AIDS Cohort Study: rationale, organization, and selected characteristics of the participants. Am J Epidemiol 1987; 126:310-318.
17. Friedewald WT, Levy RI, Fredrickson DS. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem 1972; 18:499-502.
18. Levey AS, Bosch JP, Lewis JB, Greene T, Rogers N, Roth D. A more accurate method to estimate glomerular filtration rate from serum creatinine: a new prediction equation. Modification of Diet in Renal Disease Study Group. Ann Intern Med 1999; 130:461-470.
19. Panel on Antiretroviral Guidelines for Adults and Adolescents. Guidelines for the use of antiretroviral agents in HIV-1-infected adults and adolescents. Department of Health and Human Services. Available at http://aidsinfo.nih.gov/ contentfiles/Adul tandAdolescentGL.pdf [Accessed 1 October 2013].
20. Potretzke AM, Schmitz KH, Jensen MD. Preventing overestimation of pixels in computed tomography assessment of visceral fat. Obes Res 2004; 12:1698-1701.
21. Agatston AS, Janowitz WR, Hildner FJ, Zusmer NR, ViamonteM Jr, Detrano R. Quantification of coronary artery calcium using ultrafast computed tomography. J Am Coll Cardiol 1990; 15:827-832.
22. Hacioglu Y, Gupta M, Choi TY, George RT, Deible CR, Jacobson LP, et al. Use of cardiac coronary CT angiography imaging in an epidemiology study: the Methodology of the Multicenter AIDS Cohort Study cardiovascular disease substudy. Anadolu Kardiyol Derg 2013; 13:207-214.
23. Austen WG, Edwards JE, Frye RL, Gensini GG, Gott VL, Griffith LS, et al. A reporting system on patients evaluated for coronary artery disease. Report of the Ad Hoc Committee for Grading of Coronary Artery Disease, Council on Cardiovascular Surgery, American Heart Association. Circulation 1975; 51:5-40.
24. Pagali SR, Madaj P, Gupta M, Nair S, Hamirani YS, Min JK, et al. Interobserver variations of plaque severity score and segment stenosis score in coronary arteries using 64 slice multidetector computed tomography: a substudy of the ACCURACY trial. J Cardiovasc Comput Tomogr 2010; 4:312-318.
25. Schafer JL. Analysis of incomplete multivariate data. Boca Raton, FL: CRC press; 2010.
26. Maahs DM, Ogden LG, Kinney GL, Wadwa P, Snell-Bergeon JK, Dabelea D, et al. Low plasma adiponectin levels predict progression of coronary artery calcification. Circulation 2005; 111:747-753.
27. Qasim A, Mehta NN, Tadesse MG, Wolfe ML, Rhodes T, Girman C, et al. Adipokines, insulin resistance, and coronary artery calcification. J Am Coll Cardiol 2008; 52:231-236.
28. Rho YH, Chung CP, Solus JF, Raggi P, Oeser A, Gebretsadik T, et al. Adipocytokines, insulin resistance, and coronary atherosclerosis in rheumatoid arthritis. Arthritis Rheum 2010; 62:1259-1264.
29. Broedl UC, Lebherz C, Lehrke M, Stark R, Greif M, Becker A, et al. Low adiponectin levels are an independent predictor of mixed and noncalcified coronary atherosclerotic plaques. PLoS One 2009; 4:e4733.
30. Bamberg F, Truong QA, Koenig W, Schlett CL, Nasir K, Butler J, et al. Differential associations between blood biomarkers of inflammation, oxidation, and lipid metabolism with varying forms of coronary atherosclerotic plaque as quantified by coronary CT angiography. Int J Cardiovasc Imaging 2012; 28:183-192.
31. Norton L, Brodine SK, Medina S, Lemus H, Ricchiuti V, Boswell G, et al. Adiponectin levels and coronary artery disease among HIV-infected men. J AIDS Clin Res ; 4:208. doi: 10.4172/2155-6113.1000208.
32. Pischon T, Girman CJ, Hotamisligil GS, Rifai N, Hu FB, Rimm EB. Plasma adiponectin levels and risk of myocardial infarction in men. JAMA 2004; 291:1730-1737.
33. Lawlor DA, Davey Smith G, Ebrahim S, Thompson C, Sattar N. Plasma adiponectin levels are associated with insulin resistance, but do not predict future risk of coronary heart disease in women. J Clin Endocrinol Metab 2005; 90:5677-5683.
34. Sattar N, Wannamethee G, Sarwar N, Tchernova J, Cherry L, Wallace AM, et al. Adiponectin and coronary heart disease: a prospective study and meta-analysis. Circulation 2006; 114:623-629.
35. McMahon M, Skaggs BJ, Sahakian L, Grossman J, FitzGerald J, Ragavendra N, et al. High plasma leptin levels confer increased risk of atherosclerosis in women with systemic lupus erythematosus, and are associated with inflammatory oxidised lipids. Ann Rheum Dis 2011; 70:1619-1624.
36. Yazici D, Yavuz D, Ogunc AV, Sirikci O, Toprak A, Deyneli O, et al. Serum adipokine levels in type 1 diabetic patients: association with carotid intima media thickness. Metab Syndr Relat Disord 2012; 10:26-31.
37. Kunita E, Yamamoto H, Kitagawa T, Ohashi N, Utsunomiya H, Oka T, et al. Association between plasma high-molecularweight adiponectin and coronary plaque characteristics assessed by computed tomography angiography in conditions of visceral adipose accumulation. Circ J 2012; 76:1687-1696.
38. Wauters M, Van Gaal L. Gender differences in leptin levels and physiology: a role for leptin in human reproduction. J Gend Specif Med 1999; 2:46-51.