Low adiponectin levels are an independent predictor of mixed and non-calcified coronary atherosclerotic plaques

PLoS ONE

Volumn 4, Issue 3, 2009, Pages

  Broedl, Uli C ^a   Lebherz, Corinna ^a   Lehrke, Michael ^a   Stark, Renee ^b   Greif, Martin ^a   Becker, Alexander ^a   von Ziegler, Franz ^a   Tittus, Janine ^a   Reiser, Maximilian ^a   Becker, Christoph ^a   Göke, Burkhard ^a   Parhofer, Klaus G ^a   Leber, Alexander W ^a  

^a UNIVERSITY OF MUNICH   (Germany)

^b INSTITUTE OF EPIDEMIOLOGY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ADIPONECTIN;

ACUTE CORONARY SYNDROME; ADULT; AGED; ARTERY CALCIFICATION; ARTICLE; ATHEROSCLEROTIC PLAQUE; COMPUTED TOMOGRAPHIC ANGIOGRAPHY; CONTROLLED STUDY; CORONARY ARTERY ATHEROSCLEROSIS; DISEASE ASSOCIATION; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; MULTIDETECTOR COMPUTED TOMOGRAPHY; PATHOPHYSIOLOGY; PROTEIN BLOOD LEVEL; THORAX PAIN; ANGIOCARDIOGRAPHY; BLOOD; CALCINOSIS; COMPUTER ASSISTED TOMOGRAPHY; CORONARY ARTERY DISEASE; MIDDLE AGED; PATHOLOGY; PREDICTION AND FORECASTING;

ADIPONECTIN; AGED; CALCINOSIS; CHEST PAIN; CORONARY ANGIOGRAPHY; CORONARY ARTERY DISEASE; FEMALE; HUMANS; MALE; MIDDLE AGED; PREDICTIVE VALUE OF TESTS; TOMOGRAPHY, X-RAY COMPUTED;

EID: 62749141298     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0004733     Document Type: Article

References (46)

1. Naghavi M, Libby P, Falk E, Casscells SW, Litovsky S, et al. (2003) From vulnerable plaque to vulnerable patient: a call for new definitions and risk assessment strategies: Part I. Circulation 108: 1664-1672.
2. Virmani R, Kolodgie FD, Burke AP, Farb A, Schwartz SM (2000) Lessons from sudden coronary death: a comprehensive morphological classification scheme for atherosclerotic lesions. Arterioscler Thromb Vasc Biol 20: 1262-1275.
3. Virmani R, Burke AP, Farb A, Kolodgie FD (2006) Pathology of the vulnerable plaque. J Am Coll Cardiol 47: C13-18.
4. Van Gaal LF, Mertens IL, De Block CE (2006) Mechanisms linking obesity with cardiovascular disease. Nature 444: 875-880.
5. Rosito GA, Massaro JM, Hoffmann U, Ruberg FL, Mahabadi AA, et al. (2008) Pericardial fat, visceral abdominal fat, cardiovascular disease risk factors, and vascular calcification in a community-based sample: the Framingham Heart Study. Circulation 117: 605-613.
6. Sacks HS, Fain JN (2007) Human epicardial adipose tissue: A review. Am Heart J 153: 907-917.
7. Berg AH, Scherer PE (2005) Adipose tissue, inflammation, and cardiovascular disease. Circ Res 96: 939-949.
8. Kadowaki T, Yamauchi T (2005) Adiponectin and adiponectin receptors. Endocr Rev 26: 439-451.
9. Yamauchi T, Kamon J, Waki H, Imai Y, Shimozawa N, et al. (2003) Globular adiponectin protected ob/ob mice from diabetes and ApoE-deficient mice from atherosclerosis. J Biol Chem 278: 2461-2468.
10. Kumada M, Kihara S, Sumitsuji S, Kawamoto T, Matsumoto S, et al. (2003) Association of hypoadiponectinemia with coronary artery disease in men. Arterioscler Thromb Vasc Biol 23: 85-89.
11. Koenig W, Khuseyinova N, Baumert J, Meisinger C, Löwel H (2006) Serum concentrations of adiponectin and risk of type 2 diabetes mellitus and coronary heart disease in apparently healthy middle-aged men: results from the 18-year follow-up of a large cohort from southern Germany. J Am Coll Cardiol 48: 1369-1377.
12. Pischon T, Girman CJ, Hotamisligil GS, Rifai N, Hu FB, et al. (2004) Plasma adiponectin levels and risk of myocardial infarction in men. JAMA 291: 1730-1737.
13. Wolk R, Berger P, Lennon RJ, Brilakis ES, Davison DE, et al. (2007) Association between plasma adiponectin levels and unstable coronary syndromes. Eur Heart J 28: 292-298.
14. Maahs DM, Ogden LG, Kinney GL, Wadwa P, Snell-Bergeon JK, et al. (2005) Low plasma adiponectin levels predict progression of coronary artery calcification. Circulation 111: 747-753.
15. von Eynatten M, Schneider JG, Humpert PM, Kreuzer J, Kuecherer H, et al. (2006) Serum adiponectin levels are an independent predictor of the extent of coronary artery disease in men. J Am Coll Cardiol 47: 2124-2126.
16. Otsuka F, Sugiyama S, Kojima S, Maruyoshi H, Funahashi T, et al. (2006) Plasma adiponectin levels are associated with coronary lesion complexity in men with coronary artery disease. J Am Coll Cardiol 48: 1155-1162.
17. Selcuk MT, Selcuk H, Temizhan A, Maden O, Saydam GS, et al. (2008) Impact of plasma adiponectin levels to the presence and severity of coronary artery disease in patients with metabolic syndrome. Coron Artery Dis 19: 79-84.
18. Sattar N, Wannamethee G, Sarwar N, Tchernova J, Cherry L, et al. (2006) Adiponectin and coronary heart disease: a prospective study and meta-analysis. Circulation 114: 623-629.
19. Von Eynatten M, Hamann A, Twardella D, Nawroth PP, Brenner H, et al. (2008) Atherogenic dyslipidaemia but not total- and high-molecular weight adiponectin are associated with the prognostic outcome in patients with coronary heart disease. Eur Heart J 29: 1307-1315.
20. Pasterkamp G, Falk E, Woutman H, Borst C (2000) Techniques characterizing the coronary atherosclerotic plaque: influence on clinical decision making? J Am Coll Cardiol 36: 13-21.
21. Ambrose JA, Tannenbaum MA, Alexopoulos D, Hjemdahl-Monsen CE, Leavy J, et al. (1988) Angiographic progression of coronary artery disease and the development of myocardial infarction. J Am Coll Cardiol 12: 56-62.
22. Little WC, Constantinescu M, Applegate RJ, Kutcher MA, Burrows MT, et al. (1988) Can coronary angiography predict the site of a subsequent myocardial infarction in patients with mild-to-moderate coronary artery disease? Circulation 78: 1157-1166.
23. Pundziute G, Schuijf JD, Jukema JW, Boersma E, de Roos A, et al. (2007) Prognostic value of multislice computed tomography coronary angiography in patients with known or suspected coronary artery disease. J Am Coll Cardiol 49: 62-70.
24. Hoffmann U, Moselewski F, Nieman K, Jang IK, Ferencik M, et al. (2006) Noninvasive assessment of plaque morphology and composition in culprit and stable lesions in acute coronary syndrome and stable lesions in stable angina by multidetector computed tomography. J Am Coll Cardiol 47: 1655-1662.
25. Leber AW, von Ziegler F, Becker A, Becker CR, Reiser M, et al. (2008) Characteristics of coronary plaques before angiographic progression determined by Multi-Slice CT. Int J Cardiovasc Imaging 24: 423-428.
26. Marso SP, Mehta SK, Frutkin A, House JA, McCrary JR, et al. (2008) Low Adiponectin Levels are Associated with Atherogenic Dyslipidemia and Lipid-Rich Plaque in Non-Diabetic Coronary Arteries. Diabetes Care 31: 989-994.
27. Otake H, Shite J, Shinke T, Watanabe S, Tanino Y, et al. (2008) Relation between plasma adiponectin, high-sensitivity C-reactive protein, and coronary plaque components in patients with acute coronary syndrome. Am J Cardiol 101: 1-7.
28. Ng TW, Watts GF, Farvid MS, Chan DC, Barrett PH (2005) Adipocytokines and VLDL metabolism: independent regulatory effects of adiponectin, insulin resistance, and fat compartments on VLDL apolipoprotein B-100 kinetics? Diabetes 54: 795-802.
29. Hattori Y, Suzuki M, Hattori S, Kasai K (2003) Globular adiponectin upregulates nitric oxide production in vascular endothelial cells. Diabetologia 46: 1543-1549.
30. Chen H, Montagnani M, Funahashi T, Shimomura I, Quon MJ (2003) Adiponectin stimulates production of nitric oxide in vascular endothelial cells. J Biol Chem 278: 45021-45026.
31. Motoshima H, Wu X, Mahadev K, Goldstein BJ (2004) Adiponectin suppresses proliferation and superoxide generation and enhances eNOS activity in endothelial cells treated with oxidized LDL. Biochem Biophys Res Commun 315: 264-271.
32. Okamoto Y, Kihara S, Ouchi N, Nishida M, Arita Y, et al. (2002) Adiponectin reduces atherosclerosis in apolipoprotein E-deficient mice. Circulation 106: 2767-2770.
33. Tan KC, Xu A, Chow WS, Lam MC, Ai VH, et al. (2004) Hypoadiponectinemia is associated with impaired endothelium-dependent vasodilation. J Clin Endocrinol Metab 89: 765-769.
34. Kobashi C, Urakaze M, Kishida M, Kibayashi E, Kobayashi H, et al. (2005) Adiponectin inhibits endothelial synthesis of interleukin-8. Circ Res 97: 1245-1252.
35. Ouedraogo R, Gong Y, Berzins B, Wu X, Mahadev K, et al. (2007) Adiponectin deficiency increases leukocyte-endothelium interactions via upregulation of endothelial cell adhesion molecules in vivo. J Clin Invest 117: 1718-1726.
36. Kobayashi H, Ouchi N, Kihara S, Walsh K, Kumada M, et al. (2004) Selective suppression of endothelial cell apoptosis by the high molecular weight form of adiponectin. Circ Res 94: e27-e31.
37. Park PH, McMullen MR, Huang H, Thakur V, Nagy LE (2007) Short-term treatment of RAW264.7 macrophages with adiponectin increases tumor necrosis factor-α (TNF-α) expression via ERK1/2 activation and Egr-1 expression: role of TNF-α in adiponectinstimulated interleukin-10 production. J Biol Chem 282: 21695-21703.
38. Zhao T, Hou M, Xia M, Wang Q, Zhu H, et al. (2005) Globular adiponectin decreases leptin-induced tumor necrosis factor-α expression by murine macrophages: involvement of cAMP-PKA and MAPK pathways. Cell Immunol 238: 19-30.
39. Ouchi N, Kihara S, Arita Y, Nishida M, Matsuyama A, et al. (2001) Adipocyte-derived plasma protein, adiponectin, suppresses lipid accumulation and class A scavenger receptor expression in human monocyte-derived macrophages. Circulation 103: 1057-1063.
40. Takemura Y, Ouchi N, Shibata R, Aprahamian T, Kirber MT, et al. (2007) Adiponectin modulates inflammatory reactions via calreticulin receptor-dependent clearance of early apoptotic bodies. J Clin Invest 117: 375-386.
41. Kubota N, Terauchi Y, Yamauchi T, Kubota T, Moroi M, et al. (2002) Disruption of adiponectin causes insulin resistance and neointimal formation. J Biol Chem 277: 25863-25866.
42. Son BK, Akishita M, Iijima K, Kozaki K, Maemura K, et al. (2008) Adiponectin Antagonizes Stimulatory Effect of TNF{alpha} on Vascular Smooth Muscle Cell Calcification: Regulation of Gas6-Mediated Survival Pathway by AMP-Activated Protein Kinase. Endocrinology 149: 1646-1653.
43. Pischon T, Hotamisligil GS, Rimm EB (2003) Adiponectin: stability in plasma over 36 hours and within-person variation over 1 year. Clin Chem 49: 650-652.
44. Pischon T, Schulze MB, Rimm EB (2007) Letter by Pischon et al regarding article, "Adiponectin and coronary heart disease: a prospective study and metaanalysis". Circulation 115: e322.
45. Leber AW, Becker A, Knez A, von Ziegler F, Sirol M, et al. (2006) Accuracy of 64-slice computed tomography to classify and quantify plaque volumes in the proximal coronary system: a comparative study using intravascular ultrasound. J Am Coll Cardiol 47: 672-677.
46. Gorter PM, van Lindert AS, de Vos AM, Meijs MF, van der Graaf Y, et al. (2008) Quantification of epicardial and peri-coronary fat using cardiac computed tomography; reproducibility and relation with obesity and metabolic syndrome in patients suspected of coronary artery disease. Atherosclerosis 197: 896-903.