Induction of IFN-γ cytokine response against hepatitis B surface antigen using melittin

Gastroenterology and Hepatology from Bed to Bench

Volumn 7, Issue 2, 2014, Pages 108-117

  Dezfuli, Hoda Taghizadeh ^a   Shahbazzadeh, Delavar ^b   Eidi, Akram ^a   Bagheri, Kamran Pooshang ^b   Pakravan, Nafiseh ^c   Amini, Safie ^b   Aghasadeghi, Mohammad Reza ^b   Mahdavi, Mehdi ^b  

^a ISLAMIC AZAD UNIVERSITY   (Iran)

^b PASTEUR INSTITUTE OF IRAN   (Iran)

^c ALBORZ UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Adjuvant; Hepatitis B vaccine; IFN ; Melittin; Th1 response

Indexed keywords

GAMMA INTERFERON; HEPATITIS B SURFACE ANTIGEN; HEPATITIS VACCINE; IMMUNOGLOBULIN G1; IMMUNOGLOBULIN G2A; IMMUNOGLOBULIN G2B; IMMUNOGLOBULIN M; INTERLEUKIN 4; MELITTIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY RESPONSE; ARTICLE; CELL PROLIFERATION; CELLULAR IMMUNITY; CONTROLLED STUDY; CYTOKINE RESPONSE; DRUG DOSE COMPARISON; FEMALE; HEPATITIS B; HEPATITIS B VIRUS; INFECTION PREVENTION; LYMPHOCYTE; MOUSE; NONHUMAN; TH1 CELL; TH2 CELL; VACCINATION;

EID: 84897974427     PISSN: 20082258     EISSN: 20084234     Source Type: Journal    
DOI: None     Document Type: Article

References (38)

1. Zhang X, He P, Hu Z, Wang X, Liang Z. Enhanced specific immune responses by CpG DNA in mice immunized with recombinant hepatitis B surface antigen and HB vaccine. Virol J 2011; 8:78-83.
2. Lavanchy D. Hepatitis B virus epidemiology, disease burden, treatment, and current current and emerging prevention and control measures. J Viral Hepat 2004;11:97-107.
3. Thimme R, Wieland S, Steiger C. CD8+ T cells mediate viral clearance and disease pathogenesis during acute hepatitis B virus infection. J Virol 2003; 77:68-76.
4. Chisari FV. Hepatitis B virus immunopathogenesis. Ann Rev Immunol 1995; 13:29-60.
5. Boni C, Fisicaro P, Valdatta C, Amadei B, Di Vincenzo P, Giuberti T, et al. Characterization of hepatitis B virus (HBV)-specific T cell dysfunction in chronic HBV infection. J Virol 2007; 81:4215-25.
6. Sönmez E, Sönmez AS, Bayindir Y, Coskun D, Aritürk S. Antihepatitis B response to hepatitis B vaccine administered simultaneously with tetanus toxoid in nonresponder individuals. Vaccine 2002; 21:243-46.
7. Chen DS. Hepatitis B vaccination: the key towards elimination and eradication of hepatitis B. J Hepatol 2009; 50:805-16.
8. Xu DZ, Zhao K, Guo LM, Li LJ, Xie Q, Ren H, et al. A randomized controlled phase IIb trial of antigenantibody immunogenic complex therapeutic vaccine in chronic hepatitis B patients. PLoS One 2008; 3:e2565.
9. Habermann E. Bee and wasp venoms. Science 1972;177:314-22.
10. Park JH, Kim KH, Lee WR, Han SM, Park KK. Protective effect of melittin on inflammation and apoptosis in acute liver failure. Apoptosis 2012;17:61-69.
11. Dotimas EM, Hider RC. Honey bee venom. Bee World 1987; 68:51-70.
12. van den Bogaart G, Guzmán JV, Mika JT, Poolman B. On the mechanism of pore formation by melittin. J Biol Chem 2008; 283:33854-57.
13. Hussein AA, Nabil ZI, Zalat SM, Rakha MK. Comparative study of the venoms from three species of bees: effects on heart activity and blood. J Nat Toxins 2001; 10:343-57.
14. Shaposhnikova VV, Egorova MV, Kudryavtsev AA, Levitman MKh, Korystov YuN. The effect of melittin on proliferation and death of thymocytes. FEBS Lett 1997; 410:285-88.
15. Attia W, Gabry M, El-Shaikh K, Othman G. Melittin, An active ingredient of honeybee venom (Apis mellifera), as a potent inhibitor of tumor growth in mice. Egyp J Natural Toxins 2009; 6: 33-58.
16. Terwilliger TC, Eisenberg D. The structure of melittin. II. Interpretation of the structure. J Biol Chem 1982; 257:6016-22.
17. Chang JJ, Lewin SR. Immunopathogenesis of hepatitis B virus infection. Immunol Cell Biol 2007;85:16-23.
18. Rehermann B, Nascimbeni M. Immunology of hepatitis B virus and hepatitis C virus infection. Nat Rev Immunol 2005; 5:215-29.
19. Dienstag JL. Hepatitis B virus infection. N Engl J Med 2008; 359:1486-500.
20. Zoulim F, Locarnini S. Hepatitis B virus resistance to nucleos(t)ide analogues. Gastroenterology 2009; 137: 1593-608.
21. Orsolic N, Sver L, Bendelia K, Basic I. Antitumor activity of bee venom. J Period Biol 2001; 103:49-54.
22. King TP, Lu G, Agosto H. Antibody responses to bee melittin (Api m 4) and hornet antigen 5 (Dol m 5) in mice treated with the dominant T-cell epitope peptides. J Allergy Clin Immunol 1998; 101:397-403.
23. Nam S, Ko E, Park SK, Ko S, Jun CY, Shin MK, et al. Bee venom modulates murine Th1/Th2 lineage development. Int Immunopharmacol 2005;5:1406-14.
24. Barnaba V, Franco A, Alberti A, Benvenuto R, Balsano F. Selective killing of hepatitis B envelope antigen-specific B cells by class I- restricted, exogenous antigen- specific Tlymphocytes. Nature 1990; 345:258-60.
25. del Canho R, Grosheide PM, Schalm SW, de Vries RR, Heijtink RA. Failure of neonatal hepatitis B carrier mothers and HLAantigens in neonates. J Hepatol 1994; 20:483-86.
26. George J, John GT, Jacob CK, Shastry JC.Active immunization against hepatitis B infection of a haemodialisis population. Natl Med J India 1994; 7:115-16.
27. Struve J, Aronsson B, Frenning B, Forsgren M, Weiland O. Seroconversion after additional vaccine doses to non-responders to three doses of intradermally or intramuscularly administered recombinant hepatitis B vaccine. Scand J Infect Dis 1994; 26:468-70.
28. Li J, Tan D, Liu H, Li K. CD4(+) CD25(+) FoxP3(+) T regulatory cells in subjects responsive or unresponsive tohepatitis B vaccination. Zhong Nan Da Xue Xue Bao Yi Xue Ban 2011; 36:1046-51.
29. Bramwell VW, Somavarapu S, Outschoorn I, Alpar HO. Adjuvant action of melittin following intranasal immunisation with tetanus and diphtheria toxoi ds. J Drug Target 2003; 11:525-30.
30. Fehlner PF, Berg R, Tam JP, King TP. Murine T cell responses to melittin and its analogs. J Immunol 1991;146:799-806.
31. Zou Z, Li B, Xu D, Zhang Z, Zhao JM, Zhou G, et al. Imbalanced intrahepatic cytokine expression of interferon-gamma, tumor necrosis factor-alpha, and interleukin-10 in patients with acute-on-chronic liver failure associated with hepatitis B virus infection. J Clin Gastroenterol 2009; 43:182-90.
32. Visnjić D, Batinić D, Banfić H. Arachidonic acid mediates interferon-gamma-induced sphingomyelin hydrolysis and monocytic marker expression in HL-60 cell line. Blood 1997; 89:81-91.
33. Paul S, Tabassum S, Islam MN. A study on interferon-gamma (IFN-γamma) response by T cells stimulated by hepatitis B virus core antigen. Bangladesh Med Res Counc Bull 2004; 30:9-15.
34. De Rose R, Tennent J, McWaters P, Chaplin PJ, Wood PR, Kimpton W, et al. Efficacy of DNA vaccination by different rout of immunization in sheep. Vet Immunol Immunopathol 2002; 90:55-63.
35. Orsolić N, Sver L, Verstovsek S, Terzić S, Basić I. Inhibition of mammary carcinoma cell proliferation in vitro and tumor growth in vivo by bee venom. Toxicon 2003; 41:861-70.
36. Martin RM and Lew AM. Is IgG2a a good Th1 marker in mice? Immunol Today 1998; 19:49.
37. Mizel SB, Bates JT. Flagellin as an adjuvant: cellular mechanisms and potential. J Immunol 2010;185:5677-82.
38. Thatte J, Rath S, Bal V. Analysis of immunization route-related variation in the immune response to heatkilled Salmonella typhimurium in mice. Infect Immun 1995; 63:99-103.