Drug Dosing in Patients with Renal Insufficiency in a Hospital Setting using Electronic Prescribing and Automated Reporting of Estimated Glomerular Filtration Rate

Basic and Clinical Pharmacology and Toxicology

Volumn 114, Issue 5, 2014, Pages 407-413

  Nielsen, Anita L ^a   Henriksen, Daniel P ^a   Marinakis, Christianna ^b   Hellebek, Annemarie ^c   Birn, Henrik ^d,e   Nybo, Mads ^a   Søndergaard, Jens ^f   Nymark, Anita ^a   Pedersen, Court ^a  

^a ODENSE UNIVERSITY HOSPITAL   (Denmark)

^b Dansk Lægemiddel Information   (Denmark)

^c UNIVERSITY OF COPENHAGEN   (Denmark)

^d AARHUS UNIVERSITY HOSPITAL   (Denmark)

^e AARHUS UNIVERSITY   (Denmark)

^f UNIVERSITY OF SOUTHERN DENMARK   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

ATENOLOL; BACLOFEN; BENDROFLUMETHIAZIDE; CETIRIZINE; COCODAMOL; CODEINE; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; FONDAPARINUX; GLIMEPIRIDE; HYDROCHLOROTHIAZIDE PLUS LOSARTAN; LORATADINE; MAGNESIUM OXIDE; METFORMIN; METHENAMINE; METOCLOPRAMIDE; MIRTAZAPINE; POTASSIUM CHLORIDE; RAMIPRIL; SIMVASTATIN; SPIRONOLACTONE; THIAZIDE DIURETIC AGENT; TOLTERODINE; TRAMADOL; TROSPIUM CHLORIDE; VALGANCICLOVIR; VANCOMYCIN; ZOLEDRONIC ACID; DRUG;

ADULT; AGED; ARTICLE; AUTOMATED REPORTING OF ESTIMATED GLOMERULAR FILTRATION RATE; AUTOMATION; DECISION SUPPORT SYSTEM; DRUG CONTRAINDICATION; DRUG DOSE REGIMEN; DRUG USE; ELECTRONIC PRESCRIBING; FEMALE; GLOMERULUS FILTRATION RATE; HUMAN; INAPPROPRIATE PRESCRIBING; KIDNEY FAILURE; MAJOR CLINICAL STUDY; MALE; MEDICATION ERROR; PRACTICE GUIDELINE; PRIORITY JOURNAL; TREATMENT REFUSAL; UNIVERSITY HOSPITAL; ADOLESCENT; CLINICAL PRACTICE; DOSE RESPONSE; DRUG-RELATED SIDE EFFECTS AND ADVERSE REACTIONS; HOSPITALIZATION; MIDDLE AGED; PATHOPHYSIOLOGY; PREVENTION AND CONTROL; STANDARDS; STATISTICS AND NUMERICAL DATA; VERY ELDERLY; YOUNG ADULT;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG-RELATED SIDE EFFECTS AND ADVERSE REACTIONS; ELECTRONIC PRESCRIBING; FEMALE; GLOMERULAR FILTRATION RATE; GUIDELINE ADHERENCE; HOSPITALIZATION; HOSPITALS, UNIVERSITY; HUMANS; INAPPROPRIATE PRESCRIBING; MALE; MEDICATION ERRORS; MIDDLE AGED; PHARMACEUTICAL PREPARATIONS; PHYSICIAN'S PRACTICE PATTERNS; PRACTICE GUIDELINES AS TOPIC; RENAL INSUFFICIENCY; YOUNG ADULT;

EID: 84897956808     PISSN: 17427835     EISSN: 17427843     Source Type: Journal    
DOI: 10.1111/bcpt.12185     Document Type: Article

References (29)

1. Binzer K, Hellebek A. 3, 520 medication errors evaluated to assess the potential for IT-based decision support. Stud Health Technol Inform 2011;166:31-7.
2. van Dijk EA, Drabbe NR, Kruijtbosch M, De Smet PA. Drug dose adjustments according to renal function at hospital discharge. Ann Pharmacother 2006;40:1254-60.
3. Markota NP, Markota I, Tomic M, Zelenika A. Inappropriate drug dosage adjustments in patients with renal impairment. J Nephrol 2009;22:497-501.
4. Blix HS, Viktil KK, Moger TA, Reikvam A. Use of renal risk drugs in hospitalized patients with impaired renal function-an underestimated problem? Nephrol Dial Transplant 2006;21:3164-71.
5. Long CL, Raebel MA, Price DW, Magid DJ. Compliance with dosing guidelines in patients with chronic kidney disease. Ann Pharmacother 2004;38:853-8.
6. Hug BL, Witkowski DJ, Sox CM, Keohane CA, Seger DL, Yoon C et al. Occurrence of adverse, often preventable, events in community hospitals involving nephrotoxic drugs or those excreted by the kidney. Kidney Int 2009;76:1192-8.
7. Wessell AM, Litvin C, Jenkins RG, Nietert PJ, Nemeth LS, Ornstein SM. Medication prescribing and monitoring errors in primary care: a report from the Practice Partner research Network. Qual Saf Health Care 2010;19:1-5.
8. Papaioannou A, Clarke JA, Campbell G, Bedard M. Assessment of adherence to renal dosing guidelines in long-term facilities. J Am Ger Soc 2000;48:1470-3.
9. Hudson JQ, Nyman HA. Use of estimated glomerular filtration rate for drug dosing in the chronic kidney disease patient. Curr Opin Nephrol Hypertens 2011;20:482-91.
10. Levey AS, Coresh J, Greene T, Stevens LA, Zhang YL, Hendriksen S et al. Using standardized serum creatinine values in the modification of diet in renal disease study equation for estimating glomerular filtration rate. Ann Intern Med 2006;145:247-54.
11. Metoder til vurdering af nyrefunktion og proteinuri, Dansk Selskab for Klinisk Biokemi og Dansk Nefrologisk Selskab, Juni 2009. http://www.nephrology.dk/Publikationer/5-Metoder_til_vurdering_af_nyrefunktion_og_proteinuri20090618_____DEF.pdf (last accessed on 6 January 2014).
12. Note for guidance on the evaluation of the pharmacokinetics of medicinal products in patients with impaired renal function. Committee for Medicinal Products for Human use (CHMP). EMEA, 23 June 2004.
13. Wuorela M, Kuitunen T, Helen-Salmivaara A. Database to support decision-making concerning pharmacotherapy of patients with renal failure (translation). Finnish Medical Journal 2010;65:3047-9.
14. http://www.promedicin.dk (last accessed on 6 January 2014).
15. Ammenwerth E, Schnell-Inderst P, Machan C, Siebert U. The effect of electronic prescribing on medication errors and adverse events: a systemic review. J Am Med Inform Assoc 2008;15:585-600.
16. Hemmelgarn BR, Zhang J, Manns BJ, James MT, Quinn RR, Ravani P et al. Nephrology visits and health care resource use before and after reporting estimated glomerular filtration rate. JAMA 2010;303:1151-8.
17. Stevens LA, Padala S, Levey AS. Advances in glomerular filtration rate-estimating equations. Cur Opin Nephrol Hypertens 2010;19:298-307.
18. Hassan Y, Al-Ramahi RJ, Aziz NA, Ghazali R. Impact of a renal drug dosing service on dose adjustment in hospitalized patients with chronic kidney disease. Ann Pharmacother 2009;43:1598-605.
19. Graabæk T, Kjeldsen LJ. Medication reviews by pharmacists at hospitals lead to improved patient outcomes: a systemic review. Basic Clin Pharmacol Toxicol 2013;6:359-73.
20. Christensen M, Lundh A. Medication review in hospitalized patients to reduce morbidity and mortality. Cochrane Database Syst Rev 2013;(2):CD008986.
21. Grønkjær LS, Jensen ML, Madsen H, Hallas J. Vellykket implementering af farmaceutisk intervention på Akut Modtage Afdeling. Ugeskr Laeger 2011;173:1353-5.
22. Chertow GM, Lee J, Kuperman GJ, Burdick E, Horsky J, Seger DL et al. Guided medication dosing for inpatients with renal insufficiency. JAMA 2001;286:2839-44.
23. Helmons PJ, Grouls RJ, Roos AN, Bindels AJ, Wessels-Basten SJ, Ackerman EW et al. Using a clinical decision support system to determine the quality of antimicrobial dosing in intensive care patients with renal insufficiency. Qual Saf Health Care 2010;19:22-6.
24. Roberts GW, Farmer CJ, Cheney PC, Govis SM, Belcher TW, Walsh SA et al. Clinical decision support implemented with academic detailing improves prescribing of key renally cleared drugs in the hospital setting. J Am Med Inform Assoc 2010;17:308-12.
25. Seidling HM, Schmitt SP, Bruckner T, Kaltschmidt J, Pruszydio MG, Senger C et al. Patient-specific electronic decision support reduces prescription of excessive doses. Qual Saf Health Care 2010;19:e15.
26. McCoy AB, Waitman LR, Gadd CS, Danciu I, Smith JP, Lewis JB et al. A computerized provider order entry intervention for medication safety during acute kidney injury: a quality improvement report. Am J Kidney Dis 2010;56:832-41.
27. Tawadrous D, Shariff SZ, Haynes RB, Iansavichus AV, Jain AK, Garg AX. Use of decision support systems for kidney-related drug prescribing: a systemic review. Am J Kidney Dis 2011;58:903-14.
28. Sellier E, Colombet I, Sabatier B, Breton G, Nies J, Zapletal E et al. Effect of alerts for drug dosage adjustment in inpatients with renal insufficiency. J Am Med Inform Assoc 2009;16:203-10.
29. Galanter WL, Moja J, Lambert BL. Using computerized provider order entry and clinical decision support to improve prescribing in patients with decreased GFR. Am J Kidney Dis 2010;56:809-12.