Leishmania braziliensis amastigotes stimulate production of IL-1β, IL-6, IL-10 and TGF-β by peripheral blood mononuclear cells from nonendemic area healthy residents

Parasite Immunology

Volumn 36, Issue 5, 2014, Pages 225-231

  Gomes, C M ^a   Avila L R ^a   Pinto, S A ^b   Duarte, F B ^c   Pereira, L I A ^a   Abrahamsohn, I A ^d   Dorta, M L ^a   Vieira, L Q ^e   Ribeiro Dias, F ^a   Oliveira, M A P ^a  

^a FEDERAL UNIVERSITY OF GOIÁS   (Brazil)

^b Instituto Goiano de Oncologia e Hematologia   (Brazil)

^c Hospital Unique   (Brazil)

^d UNIVERSITY OF SÃO PAULO   (Brazil)

^e FEDERAL UNIVERSITY OF MINAS GERAIS   (Brazil)

Author keywords

Amastigotes; Human; Leishmania (Viannia) braziliensis; Leishmaniasis; Th17

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 17; INTERLEUKIN 1BETA; INTERLEUKIN 23; INTERLEUKIN 6; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR ALPHA;

ADULT; AMASTIGOTE; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMAN; HUMAN CELL; KNOCKOUT MOUSE; LEISHMANIA BRAZILIENSIS; LEISHMANIASIS; MALE; MOUSE; NONHUMAN; NORMAL HUMAN; PARASITE ISOLATION; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; PROMASTIGOTE; TH17 CELL;

AMASTIGOTES; HUMAN; LEISHMANIA (VIANNIA) BRAZILIENSIS; LEISHMANIASIS; TH17;

ANIMALS; CYTOKINES; FEMALE; HUMANS; LEISHMANIA BRAZILIENSIS; LEISHMANIASIS; LEUKOCYTES, MONONUCLEAR; MALE; MICE; MICE, KNOCKOUT; TH17 CELLS;

EID: 84897944811     PISSN: 01419838     EISSN: 13653024     Source Type: Journal    
DOI: 10.1111/pim.12109     Document Type: Article

References (28)

1. Soong L, Henard CA & Melby PC. Immunopathogenesis of non-healing American cutaneous leishmaniasis and progressive visceral leishmaniasis. Semin Immunopathol 2012; 34: 735-751.
2. Carvalho LP, Passos S, Schriefer A & Carvalho EM. Protective and pathologic immune responses in human tegumentary leishmaniasis. Front Immunol 2012; 3: 301.
3. Faria DR, Gollob KJ, Barbosa J Jr, et al. Decreased in situ expression of interleukin-10 receptor is correlated with the exacerbated inflammatory and cytotoxic responses observed in mucosal leishmaniasis. Infect Immun 2005; 73: 7853-7859.
4. Boaventura VS, Santos CS, Cardoso CR, et al. Human mucosal leishmaniasis: neutrophils infiltrate areas of tissue damage that express high levels of Th17-related cytokines. Eur J Immunol 2010; 40: 2830-2836.
5. Bacellar O, Lessa H, Schriefer A, et al. Up-regulation of Th1-type responses in mucosal leishmaniasis patients. Infect Immun 2002; 70: 6734-6740.
6. Bacellar O, Faria D, Nascimento M, et al. Interleukin 17 production among patients with American cutaneous leishmaniasis. J Infect Dis 2009; 200: 75-78.
7. Vieira EL, Keesen TS, Machado PR, et al. Immunoregulatory profile of monocytes from cutaneous leishmaniasis patients and association with lesion size. Parasite Immunol 2013; 35: 65-72.
8. Castellucci L, Menezes E, Oliveira J, et al. IL6 -174 G/C promoter polymorphism influences susceptibility to mucosal but not localized cutaneous leishmaniasis in Brazil. J Infect Dis 2006; 194: 519-527.
9. Amato VS, de Andrade HF & Duarte MI. Mucosal leishmaniasis: in situ characterization of the host inflammatory response, before and after treatment. Acta Trop 2003; 85: 39-49.
10. Boaventura VS, Cafe V, Costa J, et al. Concomitant early mucosal and cutaneous leishmaniasis in Brazil. Am J Trop Med Hyg 2006; 75: 267-269.
11. Nogueira MF, Goto H, Sotto MN & Cuce LC. Cytokine profile in Montenegro skin test of patients with localized cutaneous and mucocutaneous leishmaniasis. Rev Inst Med Trop Sao Paulo 2008; 50: 333-337.
12. Teixeira MC, de Jesus Santos R, Sampaio RB, Pontes-de-Carvalho L & dos-Santos WL. A simple and reproducible method to obtain large numbers of axenic amastigotes of different Leishmania species. Parasitol Res 2002; 88: 963-968.
13. Oliveira MAP, Pires AS, Bastos RP, et al. Leishmania spp. parasite isolation through inoculation of patient biopsy macerates in interferon gamma knockout mice. Rev Inst Med Trop Sao Paulo 2010; 52: 83-88.
14. Schmittgen TD & Livak KJ. Analyzing real-time PCR data by the comparative C(T) method. Nat Protoc 2008; 3: 1101-1108.
15. Mul FP, Zuurbier AE, Janssen H, et al. Sequential migration of neutrophils across monolayers of endothelial and epithelial cells. J Leukoc Biol 2000; 68: 529-537.
16. Fernandez-Figueroa EA, Rangel-Escareno C, Espinosa-Mateos V, et al. Disease severity in patients infected with Leishmania mexicana relates to IL-1beta. PLoS Negl Trop Dis 2012; 6: e1533.
17. Castellucci L, Jamieson SE, Almeida L, et al. Wound healing genes and susceptibility to cutaneous leishmaniasis in Brazil. Infect Genet Evol 2012; 12: 1102-1110.
18. Acosta-Rodriguez EV, Napolitani G, Lanzavecchia A & Sallusto F. Interleukins 1beta and 6 but not transforming growth factor-beta are essential for the differentiation of interleukin 17-producing human T helper cells. Nat Immunol 2007; 8: 942-949.
19. Khader SA & Gopal R. IL-17 in protective immunity to intracellular pathogens. Virulence 2010; 1: 423-427.
20. Sallusto F, Zielinski CE & Lanzavecchia A. Human Th17 subsets. Eur J Immunol 2012; 42: 2215-2220.
21. Belkaid Y & Tarbell K. Regulatory T cells in the control of host-microorganism interactions. Annu Rev Immunol 2009; 27: 551-589.
22. Diehl S & Rincon M. The two faces of IL-6 on Th1/Th2 differentiation. Mol Immunol 2002; 39: 531-536.
23. Ramesh R, Kozhaya L, McKevitt K, et al. Pro-inflammatory human Th17 cells selectively express P-glycoprotein and are refractory to glucocorticoids. J Exp Med 2014; 211: 89-104.
24. Dinarello CA, Simon A & van der Meer JW. Treating inflammation by blocking interleukin-1 in a broad spectrum of diseases. Nat Rev Drug Discov 2012; 11: 633-652.
25. Aung H, Sherman J, Tary-Lehman M & Toossi Z. Analysis of transforming growth factor-beta 1 (TGF-beta1) expression in human monocytes infected with Mycobacterium avium at a single cell level by ELISPOT assay. J Immunol Methods 2002; 259: 25-32.
26. Villiger PM, Cronin MT, Amenomori T, Wachsman W & Lotz M. IL-6 production by human T lymphocytes. Expression in HTLV-1-infected but not in normal T cells. J Immunol 1991; 146: 550-559.
27. Belkaid Y, Mendez S, Lira R, Kadambi N, Milon G & Sacks D. A natural model of Leishmania major infection reveals a prolonged "silent" phase of parasite amplification in the skin before the onset of lesion formation and immunity. J Immunol 2000; 165: 969-977.
28. Micouin A, Rouillard D & Bauvois B. Induction of macrophagic differentiation and cytokine secretion by IgG1 molecules in human normal monocytes and myelogenous leukemia cells. Leukemia 1997; 11: 552-560.