In vivo correlates of molecularly inferred virulence among extraintestinal pathogenic Escherichia coli (ExPEC) in the wax moth Galleria mellonella model system

Virulence

Volumn 5, Issue 3, 2014, Pages 388-393

  Williamson, Deborah A ^a,b   Mills, Grant ^a   Johnson, James R ^c   Porter, Stephen ^c   Wiles, Siouxsie ^a  

^a UNIVERSITY OF AUCKLAND   (New Zealand)

^b INSTITUTE OF ENVIRONMENTAL SCIENCE AND RESEARCH   (New Zealand)

^c VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Escherichia coli; ExPEC; Galleria mellonella; In vivo; Infection model; Virulence

Indexed keywords

CIPROFLOXACIN; VIRULENCE FACTOR;

ANTIMICROBIAL ACTIVITY; ARTICLE; BACTERIAL VIRULENCE; BACTERIUM ISOLATION; CONTROLLED STUDY; EXPERIMENTAL STUDY; EXTRAINTESTINAL PATHOGENIC ESCHERICHIA COLI; GALLERIA MELLONELLA; GENETIC ANALYSIS; GENOTYPE; LARVAL DEVELOPMENT; MOLECULAR BIOLOGY; NONHUMAN; PATHOGENICITY; PHENOTYPIC VARIATION; POLYMERASE CHAIN REACTION; QUANTITATIVE ASSAY; ANIMAL; BIOASSAY; DISEASE MODEL; ESCHERICHIA COLI; GENETICS; GROWTH, DEVELOPMENT AND AGING; LARVA; METABOLISM; MICROBIOLOGY; MOTH; PHYSIOLOGY; SURVIVAL; VIRULENCE;

ANIMALS; BIOLOGICAL ASSAY; DISEASE MODELS, ANIMAL; ESCHERICHIA COLI; LARVA; MOTHS; SURVIVAL ANALYSIS; VIRULENCE; VIRULENCE FACTORS;

EID: 84897933978     PISSN: 21505594     EISSN: 21505608     Source Type: Journal    
DOI: 10.4161/viru.27912     Document Type: Article

References (19)

1. Russo TA, Johnson JR. Medical and economic impact of extraintestinal infections due to Escherichia coli: focus on an increasingly important endemic problem. Microbes Infect 2003; 5:449-56; PMID:12738001; http://dx.doi.org/10.1016/S1286-4579(03)00049-2
2. Kaper JB, Nataro JP, Mobley HL. Pathogenic Escherichia coli. Nat Rev Microbiol 2004; 2:123-40; PMID:15040260; http://dx.doi.org/10.1038/nrmicro818
3. Sannes MR, Kuskowski MA, Owens K, Gajewski A, Johnson JR. Virulence factor profiles and phy-logenetic background of Escherichia coli isolates from veterans with bacteremia and uninfected control subjects. J Infect Dis 2004; 190:2121-8; PMID:15551210; http://dx.doi.org/10.1086/425984
4. Zhang L, Foxman B, Marrs C. Both urinary and rectal Escherichia coli isolates are dominated by strains of phylogenetic group B2. J Clin Microbiol 2002; 40:3951-5; PMID:12409357; http://dx.doi. org/10.1128/JCM.40.11.3951-3955.2002
5. Köhler CD, Dobrindt U. What defines extraintesti-nal pathogenic Escherichia coli? Int J Med Microbiol 2011; 301:642-7; PMID:21982038; http://dx.doi. org/10.1016/j.ijmm.2011.09.006
6. Johnson JR, Russo TA. Molecular epidemiology of extraintestinal pathogenic (uropathogenic) Escherichia coli. Int J Med Microbiol 2005; 295:383-404; PMID: 16238015; http://dx.doi.org/10.1016/j.ijmm.2005.07.005
7. Johnson JR, Johnston B, Clabots C, Kuskowski MA, Pendyala S, Debroy C, Nowicki B, Rice J. Escherichia coli sequence type ST131 as an emerging fluoroquinolone-resistant uropathogen among renal transplant recipients. Antimicrob Agents Chemother 2010; 54:546-50; PMID:19917759; http://dx.doi.org/10.1128/AAC.01089-09
8. Glavis-Bloom J, Muhammed M, Mylonakis E. Of model hosts and man: using Caenorhabditis elegans, Drosophila melanogaster and Galleria mellonella as model hosts for infectious disease research. Adv Exp Med Biol 2012; 710:11-7; PMID:22127881; http://dx.doi.org/10.1007/978-1-4419-5638-5_2
9. Fuchs BB, O'Brien E, Khoury JB, Mylonakis E. Methods for using Galleria mellonella as a model host to study fungal pathogenesis. Virulence 2010; 1:475-82; PMID: 21178 491; http://dx.doi.org/10.4161/viru.1.6.12985
10. Peleg AY, Jara S, Monga D, Eliopoulos GM, Moellering RC Jr., Mylonakis E. Galleria mellonella as a model system to study Acinetobacter baumannii pathogenesis and therapeutics. Antimicrob Agents Chemother 2009; 53:2605-9; PMID:19332683; http://dx.doi.org/10.1128/AAC.01533-08
11. Peleg AY, Monga D, Pillai S, Mylonakis E, Moellering RC Jr., Eliopoulos GM. Reduced susceptibility to van-comycin influences pathogenicity in Staphylococcus aureus infection. J Infect Dis 2009; 199:532-6; PMID:19125671; http://dx.doi.org/10.1086/596511
12. Inglis RF, Gardner A, Cornelis P, Buckling A. Spite and virulence in the bacterium Pseudomonas aeru-ginosa. Proc Natl Acad Sci U S A 2009; 106:5703-7; PMID:19321425; http://dx.doi.org/10.1073/pnas.0810850106
13. Chua KY, Seemann T, Harrison PF, Monagle S, Korman TM, Johnson PD, Coombs GW, Howden BO, Davies JK, Howden BP, et al. The dominant Australian community-acquired methicillin-resis-tant Staphylococcus aureus clone ST93-IV [2B] is highly virulent and genetically distinct. PLoS One 2011; 6:e25887; PMID: 219 913 81; http://dx.doi.org/10.1371/journal.pone.0025887
14. Leuko S, Raivio TL. Mutations that impact the enteropathogenic Escherichia coli Cpx envelope stress response attenuate virulence in Galleria mellonella. Infect Immun 2012; 80:3077-85; PMID:22710873; http://dx.doi.org/10.1128/IAI.00081-12
15. Williamson DA, Freeman JT, Porter S, Roberts S, Wiles S, Paterson DL, Johnson JR. Clinical and molecular correlates of virulence in Escherichia coli causing bloodstream infection following transrec-tal ultrasound-guided (TRUS) prostate biopsy. J Antimicrob Chemother 2013; 68:2898-906; PMID:23833184; http://dx.doi.org/10.1093/jac/dkt276
16. Johnson JR, Porter SB, Zhanel G, Kuskowski MA, Denamur E. Virulence of Escherichia coli clinical isolates in a murine sepsis model in relation to sequence type ST131 status, fluoroquinolone resistance, and virulence genotype. Infect Immun 2012; 80:1554-62; PMID: 22311928; http://dx.doi.org/10.1128/IAI.06388-11
17. Williamson DA, Roberts SA, Paterson DL, Sidjabat H, Silvey A, Masters J, Rice M, Freeman JT. Escherichia coli bloodstream infection after tran-srectal ultrasound-guided prostate biopsy: implications of fluoroquinolone-resistant sequence type 131 as a major causative pathogen. Clin Infect Dis 2012; 54:1406-12; PMID:22419681; http://dx.doi.org/10.1093/cid/cis194
18. Blattner FR, Plunkett G 3rd, Bloch CA, Perna NT, Burland V, Riley M, Collado-Vides J, Glasner JD, Rode CK, Mayhew GF, et al. The complete genome sequence of Escherichia coli K-12. Science 1997; 277:1453-62; PMID:9278503; http://dx.doi.org/10.1126/science.277.5331.1453
19. Johnson JR, Menard M, Johnston B, Kuskowski MA, Nichol K, Zhanel GG. Epidemic clonal groups of Escherichia coli as a cause of antimicrobial-resistant urinary tract infections in Canada, 2002 to 2004. Antimicrob Agents Chemother 2009; 53:2733-9; PMID:19398649; http://dx.doi.org/10.1128/AAC.00297-09