Effectiveness of riboflavin in pediatric migraine prevention

Canadian Family Physician

Volumn 60, Issue 3, 2014, Pages

  Sherwood, Michelle ^a   Goldman, Ran D ^a  

^a BC CHILDREN S HOSPITAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

AMITRIPTYLINE; CYPROHEPTADINE; ERGOT ALKALOID; FLUNARIZINE; GABAPENTIN; IBUPROFEN; NORTRIPTYLINE; PARACETAMOL; PLACEBO; PREGABALIN; PROPRANOLOL; RIBOFLAVIN; SUMATRIPTAN; TOPIRAMATE; TRIPTAN DERIVATIVE; VALPROIC ACID; VERAPAMIL; VITAMIN B COMPLEX;

ALTERNATIVE MEDICINE; CHILDHOOD DISEASE; DIARRHEA; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DRUG EFFICACY; DRUG SAFETY; EXERCISE; HEADACHE; HUMAN; LIFESTYLE MODIFICATION; MIGRAINE; RANDOMIZED CONTROLLED TRIAL (TOPIC); REVIEW; STRESS MANAGEMENT; VOMITING; ADOLESCENT; CHILD; MIGRAINE DISORDERS; PRESCHOOL CHILD; TREATMENT OUTCOME;

ADOLESCENT; CHILD; CHILD, PRESCHOOL; HUMANS; MIGRAINE DISORDERS; RIBOFLAVIN; TREATMENT OUTCOME; VITAMIN B COMPLEX;

EID: 84897885098     PISSN: 0008350X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (18)

1. Split W, Neuman W. Epidemiology of migraine among students from randomly selected secondary schools in Lodz. Headache 1999;39(7):494-501.
2. Abu-Arafeh I, Razak S, Sivaraman B, Graham C. Prevalence of headache and migraine in children and adolescents: a systematic review of population-based studies. Dev Med Child Neurol 2010;52(12):1088-97. Epub 2010 Sep 28.
3. International Headache Society. The international classification of headache disorders, 3rd edition (beta version). Cephalalgia 2013;33(9):629-808.
4. Jacobs H, Gladstein J. Pediatric headache: a clinical review. Headache 2012;52(3):333-9.
5. Lewis DW, Yonker M, Winner P, Sowell M. The treatment of pediatric migraine. Pediatr Ann 2005;34(6):448-60.
6. Hämäläinen ML, Hoppu K, Valkeila E, Santavuori P. Ibuprofen or acetaminophen for the acute treatment of migraine in children: a double-blind, randomized, placebo-controlled, crossover study. Neurology 1997;48(1):103-7.
7. Gaul C, Eismann R, Schmidt T, May A, Leinisch E, Wieser T, et al. Use of complementary and alternative medicine in patients suffering from primary headache disorders. Cephalalgia 2009;29(10):1069-78. Epub 2009 Apr 2.
8. Schetzek S, Heinen F, Kruse S, Borggraefe I, Bonfert M, Gaul C, et al. Headache in children: update on complementary treatments. Neuropediatrics 2013;44(1):25-33. Epub 2013 Jan 11.
9. Montagna P, Cortelli P, Monari L, Pierangeli G, Parchi P, Lodi R, et al. 31P-magnetic resonance spectroscopy in migraine without aura. Neurology 1994;44(4):666-9.
10. Sparaco M, Feleppa M, Lipton RB, Rapoport AM, Bigal ME. Mitochondrial dysfunction and migraine: evidence and hypotheses. Cephalalgia 2006;26(4):361-72.
11. Schoenen J, Jacquy J, Lenaerts M. Effectiveness of high-dose riboflavin in migraine prophylaxis. A randomized controlled trial. Neurology 1998;50(2):466-70.
12. Maizels M, Blumenfeld A, Burchette R. A combination of riboflavin, magnesium, and feverfew for migraine prophylaxis: a randomized trial. Headache 2004;44(9):885-90.
13. Condò M, Posar A, Arbizzani A, Parmeggiani A. Riboflavin prophylaxis in pediatric and adolescent migraine. J Headache Pain 2009;10(5):361-5. Epub 2009 Aug 1.
14. MacLennan SC, Wade FM, Forrest KM, Ratanayake PD, Fagan E, Antony J. High-dose riboflavin for migraine prophylaxis in children: a double-blind, randomized, placebo-controlled trial. J Child Neurol 2008;23(11):1300-4.
15. Bruijn J, Duivenvoorden H, Passchier J, Locher H, Dijkstra N, Arts WF. Medium-dose riboflavin as a prophylactic agent in children with migraine: a preliminary placebo-controlled, randomised, double-blind, crossover trial. Cephalalgia 2010;30(12):1426-34. Epub 2010 Mar 26.
16. Zempleni J, Galloway JR, McCormick BD. Pharmacokinetics of orally and intravenously administered riboflavin in healthy humans. Am J Clin Nutr 1996;63(1):54-66.
17. O'Brien HL, Hershey AD. Vitamins and paediatric migraine: riboflavin as a preventative medication. Cephalalgia 2010;30(12):1417-8. Epub 2010 Jul 27.
18. Di Lorenzo C, Pierelli F, Coppola G, Grieco GS, Rengo C, Ciccolella M, et al. Mitochondrial DNA haplogroups influence the therapeutic response to riboflavin in migraineurs. Neurology 2009;72(18):1588-94.