Coronary artery calcification and cardiovascular disease in children with chronic kidney disease

Current Opinion in Pediatrics

Volumn 26, Issue 2, 2014, Pages 193-197

  Paoli, Sara ^a   Mitsnefes, Mark M ^b  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

^b CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

Author keywords

Cardiac calcification; Chronic kidney disease; Fibroblast growth factor 23; Klotho

Indexed keywords

FIBROBLAST GROWTH FACTOR 23; GROWTH FACTOR; KLOTHO FACTOR; UNCLASSIFIED DRUG; BETA GLUCURONIDASE; BIOLOGICAL MARKER; FIBROBLAST GROWTH FACTOR; KLOTHO PROTEIN;

CARDIOVASCULAR DISEASE; CHRONIC KIDNEY DISEASE; CORONARY ARTERY CALCIFICATION; END STAGE RENAL DISEASE; HUMAN; PATHOGENESIS; PRIORITY JOURNAL; REVIEW; CALCINOSIS; CHILD; CHRONIC KIDNEY FAILURE; COMPLICATION; CORONARY ARTERY DISEASE; DEFICIENCY; DISEASE COURSE; KIDNEY; METABOLISM; PATHOLOGY; PATHOPHYSIOLOGY; PRESCHOOL CHILD; PROGNOSIS; SIGNAL TRANSDUCTION;

BIOLOGICAL MARKERS; CALCINOSIS; CHILD; CHILD, PRESCHOOL; CORONARY ARTERY DISEASE; DISEASE PROGRESSION; FIBROBLAST GROWTH FACTORS; GLUCURONIDASE; HUMANS; KIDNEY; PROGNOSIS; RENAL INSUFFICIENCY, CHRONIC; SIGNAL TRANSDUCTION;

EID: 84897866750     PISSN: 10408703     EISSN: 1531698X     Source Type: Journal    
DOI: 10.1097/MOP.0000000000000059     Document Type: Review

References (21)

1. Mitsnefes MM, Laskin BL, Dahhou M, et al. Mortality risk among children initially treated with dialysis for end-stage kidney disease. JAMA 2013; 309:1921-1929.
2. Mitsnefes MM. Cardiovascular disease in children with chronic kidney disease. J Am Soc Nephrol 2012; 23:578-585.
3. Hartiala O, Magnussen CG, Kajander S, et al. Adolescence risk factors are predictive of coronary artery calcification at middle age: The cardiovascular risk in young Finns study. J Am Coll Cardiol 2012; 60:1364-1370.
4. Shroff RC, McNair R, Skepper JN, et al. Chronic mineral dysregulation promotes vascular smooth muscle cell adaptation and extracellular matrix calcification. J Am Soc Nephrol 2010; 21:103-112.
5. Shroff R, Long DA, Shanahan C. Mechanistic insights into vascular calcification in CKD. J Am Soc Nephrol 2013; 24:179-189.
6. Siomou E, Stefanidis CJ. FGF-23 in children with CKD: A new player in the development of CKD-mineral and bone disorder. Nephrol Dial Transplant 2012; 27:4259-4262.
7. Hu MC, Kuro-o M, Moe OW. Klotho and chronic kidney disease. Contrib Nephrol 2013; 180:47-63.
8. Lim K, Lu TS, Molostvov G, et al. Vascular Klotho deficiency potentiates the development of human artery calcification and mediates resistance to fibroblast growth factor 23. Circulation 2012; 125:2243-2255.
9. Fang Y, Ginsberg C, Sugatani T, et al. Early chronic kidney disease-mineral bone disorder stimulates vascular calcification. Kidney Int 2014; 85:142-150.
10. Cejka D, Jäger-Lansky A, Kieweg H, et al. Sclerostin serum levels correlate positively with bone mineral density and microarchitecture in haemodialysis patients. Nephrol Dial Transplant 2012; 27:226-230.
11. Hu MC, Shi M, Zhang J, et al. Klotho deficiency causes vascular calcification in chronic kidney disease. J Am Soc Nephrol 2011; 22:124-136.
12. Scialla JJ, Lau WL, Reilly MP, et al., Chronic Renal Insufficiency Cohort Study Investigators. Fibroblast growth factor 23 is not associated with and does not induce arterial calcification. Kidney Int 2013; 83:1159-1168.
13. Lindberg K, Olauson H, Amin R, et al. Arterial klotho expression and FGF23 effects on vascular calcification and function. PLoS ONE 2013; 8:e60658.
14. Jimbo R, Kawakami-Mori F, Mu S, et al. Fibroblast growth factor 23 accelerates phosphate-induced vascular calcification in the absence of Klotho deficiency. Kidney Int 2013. [Epub ahead of print].
15. Wan M, Smith C, Shah V, et al. Fibroblast growth factor 23 and soluble klotho in children with chronic kidney disease. Nephrol Dial Transplant 2013; 28:153-161.
16. Srivaths PR, Silverstein DM, Leung J, et al. Malnutrition-inflammation- coronary calcification in pediatric patients receiving chronic hemodialysis. Hemodial Int 2010; 14:263-269.
17. Srivaths PR, Goldstein SL, Silverstein DM, et al. Elevated FGF 23 and phosphorus are associated with coronary calcification in hemodialysis patients. Pediatr Nephrol 2011; 26:945-951.
18. Srivaths PR, Goldstein SL, Krishnamurthy R, Silverstein DM. High serum phosphorus and FGF 23 levels are associated with progression of coronary calcifications. Pediatr Nephrol 2014; 29:103-109.
19. Lau WL, Leaf EM, Hu MC, et al. Vitamin D receptor agonists increase klotho and osteopontin while decreasing aortic calcification in mice with chronic kidney disease fed a high phosphate diet. Kidney Int 2012; 82:1261-1270.
20. Block GA, Wheeler DC, Persky MS, et al. Effects of phosphate binders in moderate CKD. J Am Soc Nephrol 2012; 23:1407-1415.
21. Zaritsky J, Rastogi A, Fischmann G, et al. Short daily hemodialysis is associated with lower plasma FGF23 levels when compared with conventional hemodialysis. Nephrol Dial Transplant 2013. [Epub ahead of print].