Circulating T follicular helper cell and regulatory T cell frequencies are influenced by B cell depletion in patients with granulomatosis with polyangiitis

Rheumatology (United Kingdom)

Volumn 53, Issue 4, 2014, Pages 621-630

  Zhao, Yuan ^a   Lutalo, Pamela M K ^a,b   Thomas, Jessica E ^a   Sangle, Shirish ^b   Choong, Lee Meng ^b   Tyler, Jennifer R ^a   Tree, Timothy ^a,b   Spencer, Jo ^a   D'cruz, David P ^b  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b GUY'S AND ST THOMAS' NHS FOUNDATION TRUST   (United Kingdom)

Author keywords

B cell depletion; Follicular helper T (TFH); Granulomatosis with polyangiitis (GPA); Regulatory T (Treg) cells

Indexed keywords

RITUXIMAB;

ADULT; AGED; ARTICLE; AUTOIMMUNE DISEASE; CIRCULATING T FOLLICULAR HELPER CELL; CLINICAL ARTICLE; COCULTURE; CONTROLLED STUDY; EFFECTOR CELL; FEMALE; FLOW CYTOMETRY; FUNCTIONAL STATUS; GRANULOMATOSIS; GRANULOMATOSIS WITH POLYANGIITIS; HELPER CELL; HUMAN; HUMAN CELL; HUMORAL IMMUNE DEFICIENCY; IMMUNOSUPPRESSIVE TREATMENT; IN VITRO STUDY; LYMPHOCYTE FUNCTION; MALE; MIDDLE AGED; PERIPHERAL BLOOD MONONUCLEAR CELL; PERIPHERAL LYMPHOCYTE; PRIORITY JOURNAL; REGULATORY T LYMPHOCYTE; T CELL CULTURE; T LYMPHOCYTE SUBPOPULATION; VASCULITIS; VERY ELDERLY;

B CELL DEPLETION; FOLLICULAR HELPER T (TFH); GRANULOMATOSIS WITH POLYANGIITIS (GPA); REGULATORY T (TREG) CELLS;

ADULT; AGED; ANTIBODIES, MONOCLONAL, MURINE-DERIVED; B-LYMPHOCYTES; CASE-CONTROL STUDIES; COCULTURE TECHNIQUES; FEMALE; HUMANS; IMMUNOLOGIC FACTORS; LYMPHOCYTE DEPLETION; MALE; MIDDLE AGED; T-LYMPHOCYTE SUBSETS; T-LYMPHOCYTES, HELPER-INDUCER; T-LYMPHOCYTES, REGULATORY; WEGENER GRANULOMATOSIS; YOUNG ADULT;

EID: 84897832163     PISSN: 14620324     EISSN: 14620332     Source Type: Journal    
DOI: 10.1093/rheumatology/ket406     Document Type: Article

References (41)

1. Seo P, Stone JH. The antineutrophil cytoplasmic antibody-associated vasculitides. Am J Med 2004;117:39-50.
2. Berden A, Goceroglu A, Jayne D et al. Diagnosis and management of ANCA associated vasculitis. BMJ 2012;344:e26.
3. Falk RJ, Gross WL, Guillevin L et al. Granulomatosis with polyangiitis (Wegener's): an alternative name for Wegener's granulomatosis. J Am Soc Nephrol 2011;22:587-8.
4. Hu N, Westra J, Kallenberg CG. Membrane-bound proteinase 3 and its receptors: relevance for the pathogenesis of Wegener's granulomatosis. Autoimmun Rev 2009;8:510-4.
5. van der Woude FJ, Rasmussen N, Lobatto S et al. Autoantibodies against neutrophils and monocytes: tool for diagnosis and marker of disease activity in Wegener's granulomatosis. Lancet 1985;1:425-9.
6. Brockmann H, Schwarting A, Kriegsmann J et al. Proteinase-3 as the major autoantigen of c-ANCA is strongly expressed in lung tissue of patients with Wegener's granulomatosis. Arthritis Res 2002;4:220-5.
7. Rarok AA, Stegeman CA, Limburg PC et al. Neutrophil membrane expression of proteinase 3 (PR3) is related to relapse in PR3-ANCA-associated vasculitis. J Am Soc Nephrol 2002;13:2232-8.
8. Voswinkel J, Mueller A, Kraemer JA et al. B lymphocyte maturation in Wegener's granulomatosis: a comparative analysis of VH genes from endonasal lesions. Ann Rheum Dis 2006;65:859-64.
9. Voswinkel J, Assmann G, Held G et al. Single cell analysis of B lymphocytes from Wegener's granulomatosis: B cell receptors display affinity maturation within the granulomatous lesions. Clin Exp Immunol 2008;154:339-45.
10. Mueller A, Holl-Ulrich K, Lamprecht P et al. Germinal centre-like structures in Wegener's granuloma: the morphological basis for autoimmunity? Rheumatology 2008;47:1111-3.
11. Stone JH, Merkel PA, Spiera R et al. Rituximab versus cyclophosphamide for ANCA-associated vasculitis. N Engl J Med 2010;363:221-32.
12. Jones RB, Tervaert JW, Hauser T et al. Rituximab versus cyclophosphamide in ANCA-associated renal vasculitis. N Engl J Med 2010;363:211-20.
13. Yu S, Maiti PK, Dyson M et al. B cell-deficient NOD.H-2h4 mice have CD4+CD25+ T regulatory cells that inhibit the development of spontaneous autoimmune thyroiditis. J Exp Med 2006;203:349-58.
14. Stasi R, Cooper N, Del Poeta G et al. Analysis of regulatory T-cell changes in patients with idiopathic thrombocytopenic purpura receiving B cell-depleting therapy with rituximab. Blood 2008;112:1147-50.
15. Sfikakis PP, Souliotis VL, Fragiadaki KG et al. Increased expression of the FoxP3 functional marker of regulatory T cells following B cell depletion with rituximab in patients with lupus nephritis. Clin Immunol 2007;123:66-73.
16. Hu C, Deng S, Wong FS et al. Anti-CD20 treatment prolongs syngeneic islet graft survival and delays the onset of recurrent autoimmune diabetes. Ann N Y Acad Sci 2008;1150:217-9.
17. Liu YJ, Johnson GD, Gordon J et al. Germinal centres in T-cell-dependent antibody responses. Immunol Today 1992;13:17-21.
18. Golby SJ, Dunn-Walters DK, Spencer J. Human tonsillar germinal center T cells are a diverse and widely disseminated population. Eur J Immunol 1999;29:3729-36.
19. Vinuesa CG, Cook MC. Blood relatives of follicular helper T cells. Immunity 2011;34:10-2.
20. Simpson N, Gatenby PA, Wilson A et al. Expansion of circulating T cells resembling follicular helper T cells is a fixed phenotype that identifies a subset of severe systemic lupus erythematosus. Arthritis Rheum 2010;62:234-44.
21. Morita R, Schmitt N, Bentebibel SE et al. Human blood CXCR5(+)CD4(+) T cells are counterparts of T follicular cells and contain specific subsets that differentially support antibody secretion. Immunity 2011;34:108-21.
22. Chevalier N, Jarrossay D, Ho E et al. CXCR5 expressing human central memory CD4 T cells and their relevance for humoral immune responses. J Immunol 2011;186:5556-68.
23. Linterman MA, Rigby RJ, Wong RK et al. Follicular helper T cells are required for systemic autoimmunity. J Exp Med 2009;206:561-76.
24. Sakaguchi S. Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in immunological tolerance to self and non-self. Nat Immunol 2005;6:345-52.
25. von Boehmer H. Mechanisms of suppression by suppressor T cells. Nat Immunol 2005;6:338-44.
26. Abdulahad WH, Stegeman CA, van der Geld YM et al. Functional defect of circulating regulatory CD4+ T cells in patients with Wegener's granulomatosis in remission. Arthritis Rheum 2007;56:2080-91.
27. Morgan MD, Day CJ, Piper KP et al. Patients with Wegener's granulomatosis demonstrate a relative deficiency and functional impairment of T-regulatory cells. Immunology 2010;130:64-73.
28. Rimbert M, Hamidou M, Braudeau C et al. Decreased numbers of blood dendritic cells and defective function of regulatory T cells in antineutrophil cytoplasmic antibodyassociated vasculitis. PLoS One 2011;6:e18734.
29. Leavitt RY, Fauci AS, Bloch DA et al. The American College of Rheumatology 1990 criteria for the classification of Wegener's granulomatosis. Arthritis Rheum 1990;33:1101-7.
30. Stone JH, Hoffman GS, Merkel PA et al. A disease-specific activity index for Wegener's granulomatosis: modification of the Birmingham Vasculitis Activity Score. International Network for the Study of the Systemic Vasculitides (INSSYS). Arthritis Rheum 2001;44:912-20.
31. Exley AR, Bacon PA, Luqmani RA et al. Development and initial validation of the vasculitis damage index for the standardized clinical assessment of damage in the systemic vasculitides. Arthritis Rheum 1997;40:371-80.
32. Sneller MC. Rituximab and Wegener's granulomatosis: are B cells a target in vasculitis treatment? Arthritis Rheum 2005;52:1-5.
33. Liu W, Putnam AL, Xu-Yu Z et al. CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ T reg cells. J Exp Med 2006;203:1701-11.
34. Seddiki N, Santner-Nanan B, Martinson J et al. Expression of interleukin (IL)-2 and IL-7 receptors discriminates between human regulatory and activated T cells. J Exp Med 2006;203:1693-700.
35. Miyara M, Yoshioka Y, Kitoh A et al. Functional delineation and differentiation dynamics of human CD4+ T cells expressing the FoxP3 transcription factor. Immunity 2009;30:899-911.
36. Lindley S, Dayan CM, Bishop A et al. Defective suppressor function in CD4(+)CD25(+) T-cells from patients with type 1 diabetes. Diabetes 2005;54:92-9.
37. Valencia X, Yarboro C, Illei G et al. Deficient CD4+CD25high T regulatory cell function in patients with active systemic lupus erythematosus. J Immunol 2007;178:2579-88.
38. Miyara M, Amoura Z, Parizot C et al. Global natural regulatory T cell depletion in active systemic lupus erythematosus. J Immunol 2005;175:8392-400.
39. Akbar AN, Taams LS, Salmon M et al. The peripheral generation of CD4+ CD25+ regulatory T cells. Immunology 2003;109:319-25.
40. Martini H, Enright V, Perro M et al. Importance of B cell costimulation in CD4(+) T cell differentiation: X-linked agammaglobulinaemia, a human model. Clin Exp Immunol 2011;164:381-7.
41. Hamel KM, Cao Y, Ashaye S et al. B cell depletion enhances T regulatory cell activity essential in the suppression of arthritis. J Immunol 2011;187:4900-6.