Blood expression levels of chemokine receptor CCR3 and chemokine CCL11 in age-related macular degeneration: A case-control study

BMC Ophthalmology

Volumn 14, Issue 1, 2014, Pages

  Falk, Mads Krüger ^a   Singh, Amardeep ^a   Faber, Carsten ^b   Nissen, Mogens Holst ^b   Hviid, Thomas ^a   Sørensen, Torben Lykke ^a  

^a Mental Health Services CPH   (Denmark)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

Age related macular degeneration; CCL11; CCR3; chemokine

Indexed keywords

CHEMOKINE RECEPTOR CCR3; EOTAXIN;

ADULT; AGED; ARTICLE; BLOOD; CASE CONTROL STUDY; FEMALE; FLOW CYTOMETRY; GRANULOCYTE; HUMAN; LEUKOCYTE; MALE; METABOLISM; MIDDLE AGED; RETINA MACULA DEGENERATION; SUBRETINAL NEOVASCULARIZATION; VERY ELDERLY;

ADULT; AGED; AGED, 80 AND OVER; CASE-CONTROL STUDIES; CHEMOKINE CCL11; CHOROIDAL NEOVASCULARIZATION; FEMALE; FLOW CYTOMETRY; GRANULOCYTES; HUMANS; LEUKOCYTES; MACULAR DEGENERATION; MALE; MIDDLE AGED; RECEPTORS, CCR3;

EID: 84897656398     PISSN: None     EISSN: 14712415     Source Type: Journal    
DOI: 10.1186/1471-2415-14-22     Document Type: Article

References (25)

1. Age-related macular degeneration. Lim LS, Mitchell P, Seddon JM, Holz FG, Wong TY, Lancet 2012 379 9827 1728 1738 10.1016/S0140-6736(12)60282-7 22559899
2. Clinical classification of age-related macular degeneration. Ferris FL 3rd, Wilkinson CP, Bird A, Chakravarthy U, Chew E, Csaky K, Sadda SR, Beckman Initiative for Macular Research Classification C, Ophthalmology 2013 120 4 844 851 10.1016/j.ophtha.2012.10.036 23332590
3. Four-Year Treatment Results of Neovascular Age-Related Macular Degeneration With Ranibizumab and Causes for Discontinuation of Treatment. Kruger Falk M, Kemp H, Sorensen TL, Am J Ophthalmol 2012 155 1 89 95 23022167
4. CCR3 is a target for age-related macular degeneration diagnosis and therapy. Takeda A, Baffi JZ, Kleinman ME, Cho WG, Nozaki M, Yamada K, Kaneko H, Albuquerque RJ, Dridi S, Saito K, Raisler BJ, Budd SJ, Geisen P, Munitz A, Ambati BK, Green MG, Ishibashi T, Wright JD, Humbles AA, Gerard CJ, Ogura Y, Pan Y, Smith JR, Grisanti S, Hartnett ME, Rothenberg ME, Ambati J, Nature 2009 460 7252 225 230 10.1038/nature08151 19525930
5. Upregulation of CCR3 by age-related stresses promotes choroidal endothelial cell migration via VEGF-dependent and -independent signaling. Wang H, Wittchen ES, Jiang Y, Ambati B, Grossniklaus HE, Hartnett ME, Invest Ophthalmol Visual Sci 2011 52 11 8271 8277 10.1167/iovs.11-8230
6. Suppression and regression of choroidal neovascularization in mice by a novel CCR2 antagonist, INCB3344. Xie P, Kamei M, Suzuki M, Matsumura N, Nishida K, Sakimoto S, Sakaguchi H, Nishida K, PloS One 2011 6 12 28933 10.1371/journal.pone.0028933 22205983
7. Tachyphylaxis during treatment of exudative age-related macular degeneration with ranibizumab. Eghoj MS, Sorensen TL, Br J Ophthalmol 2012 96 1 21 23 10.1136/bjo.2011.203893 21733918
8. Eotaxin (CCL11) induces in vivo angiogenic responses by human CCR3+ endothelial cells. Salcedo R, Young HA, Ponce ML, Ward JM, Kleinman HK, Murphy WJ, Oppenheim JJ, J Immunol 2001 166 12 7571 7578 11390513
9. The biology of chemokines and their receptors. Rossi D, Zlotnik A, Ann Rev Immunol 2000 18 217 242 10.1146/annurev.immunol.18.1.217
10. Chemokines and their receptors in allergic disease. Pease JE, Williams TJ, J Allergy Clin Immunol 2006 118 2 305 318 quiz 319-320 10.1016/j.jaci.2006. 06.010 16890751
11. CC chemokine receptor-3 as new target for age-related macular degeneration. Sharma NK, Gupta A, Prabhakar S, Singh R, Bhatt AK, Anand A, Gene 2013 523 1 106 111 10.1016/j.gene.2013.03.052 23566847
12. Eotaxin and eosinophil recruitment: implications for human disease. Rankin SM, Conroy DM, Williams TJ, Mol Med Today 2000 6 1 20 27 10.1016/S1357-4310(99)01635-4 10637571
13. Analysis of serum cytokine/chemokine profiles affected by aging and exercise in mice. Jeon H, Mun GI, Boo YC, Cytokine 2012 60 2 487 492 10.1016/j.cyto.2012.07.014 22884519
14. Dynamic alteration of soluble serum biomarkers in healthy aging. Shurin GV, Yurkovetsky ZR, Chatta GS, Tourkova IL, Shurin MR, Lokshin AE, Cytokine 2007 39 2 123 129 10.1016/j.cyto.2007.06.006 17689975
15. New biomarker for neovascular age-related macular degeneration: eotaxin-2. Sharma NK, Prabhakar S, Gupta A, Singh R, Gupta PK, Gupta PK, Anand A, DNA Cell Biol 2012 31 11 1618 1627 10.1089/dna.2012.1786 23025269
16. Increased expression of CD200 on circulating CD11b + monocytes in patients with neovascular age-related macular degeneration. Singh A, Falk MK, Hviid TV, Sorensen TL, Ophthalmology 2013 120 5 1029 1037 10.1016/j.ophtha.2012. 11.002 23410964
17. Severe interference between retinal angiography and automated four-color flow cytometry analysis of blood mononuclear cells. Burgisser P, Vaudaux J, Bart PA, Cytometry Part A: J Int Soc Anal Cytol 2007 71 8 632 636
18. Predictors of 1-year visual outcome in neovascular age-related macular degeneration following intravitreal ranibizumab treatment. Bloch SB, la Cour M, Sander B, Hansen LK, Fuchs J, Lund-Andersen H, Larsen M, Acta Ophthalmol 2013 91 1 42 47 10.1111/j.1755-3768.2011.02268.x 22008284
19. Age-related macular degeneration revisited - piecing the puzzle: the LXIX Edward Jackson memorial lecture. Miller JW, Am J Ophthalmol 2013 155 1 1-35 e13 23245386
20. Tryptase-chymase double-positive human mast cells express the eotaxin receptor CCR3 and are attracted by CCR3-binding chemokines. Romagnani P, De Paulis A, Beltrame C, Annunziato F, Dente V, Maggi E, Romagnani S, Marone G, Am J Pathol 1999 155 4 1195 1204 10.1016/S0002-9440(10)65222-4 10514402
21. Suppression of Laser-Induced Choroidal Neovascularization by a CCR3 Antagonist. Mizutani T, Ashikari M, Tokoro M, Nozaki M, Ogura Y, Invest Ophthalmol Visual Sci 2013 54 2 1564 1572 10.1167/iovs.11-9095
22. Regulation of ocular angiogenesis by Notch signaling: implications in neovascular age-related macular degeneration. Ahmad I, Balasubramanian S, Del Debbio CB, Parameswaran S, Katz AR, Toris C, Fariss RN, Invest Ophthalmol Visual Sci 2011 52 6 2868 2878 10.1167/iovs.10-6608
23. CCR3 and choroidal neovascularization. Li Y, Huang D, Xia X, Wang Z, Luo L, Wen R, PLoS One 2011 6 2 17106 10.1371/journal.pone.0017106 21358803
24. The ageing systemic milieu negatively regulates neurogenesis and cognitive function. Villeda SA, Luo J, Mosher KI, Zou B, Britschgi M, Bieri G, Stan TM, Fainberg N, Ding Z, Eggel A, Lucin KM, Czirr E, Park JS, Couillard-Despres S, Aigner L, Li G, Peskind ER, Kaye JA, Quinn JF, Galasko DR, Xie XS, Rando TA, Wyss-Coray T, Nature 2011 477 7362 90 94 10.1038/nature10357 21886162
25. Interferon gamma-inducible protein-10 (IP-10) and eotaxin as biomarkers in age-related macular degeneration. Mo FM, Proia AD, Johnson WH, Cyr D, Lashkari K, Invest Ophthalmol Visual Sci 2010 51 8 4226 4236 10.1167/iovs.09-3910