One-step surgery with multipotent stem cells for the treatment of large full-thickness chondral defects of the knee

American Journal of Sports Medicine

Volumn 42, Issue 3, 2014, Pages 648-657

  Gobbi, Alberto ^a   Karnatzikos, Georgios ^a   Sankineani, Sukesh Rao ^a  

^a Orthopaedic Arthroscopic Surgery International (OASI) Bioresearch Foundation   (Italy)

Author keywords

BMAC; cartilage; chondral defects; collagen I III matrix; MSCs

Indexed keywords

TISSUE SCAFFOLD;

ADULT; ARTHROSCOPY; ARTICLE; ARTICULAR CARTILAGE; AUTOTRANSPLANTATION; BMAC; CARTILAGE; CHONDRAL DEFECTS; COLLAGEN I/III MATRIX; FEMALE; FOLLOW UP; HUMAN; INJURY; JOINT CHARACTERISTICS AND FUNCTIONS; KNEE; MALE; METHODOLOGY; MIDDLE AGED; MSCS; MULTIPOTENT STEM CELL; NUCLEAR MAGNETIC RESONANCE IMAGING; ORTHOPEDIC SURGERY; OUTCOME ASSESSMENT; PATHOLOGY; PEROPERATIVE CARE; PROSPECTIVE STUDY; SECOND LOOK SURGERY; TRANSPLANTATION; VISUAL ANALOG SCALE;

BMAC; CARTILAGE; CHONDRAL DEFECTS; COLLAGEN I/III MATRIX; MSCS;

ADULT; ARTHROSCOPY; CARTILAGE; CARTILAGE, ARTICULAR; FEMALE; FOLLOW-UP STUDIES; HUMANS; INTRAOPERATIVE CARE; KNEE JOINT; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; MULTIPOTENT STEM CELLS; ORTHOPEDIC PROCEDURES; PATIENT OUTCOME ASSESSMENT; PROSPECTIVE STUDIES; RANGE OF MOTION, ARTICULAR; SECOND-LOOK SURGERY; TISSUE AND ORGAN HARVESTING; TISSUE SCAFFOLDS; TRANSPLANTATION, AUTOLOGOUS; VISUAL ANALOG SCALE;

EID: 84897644982     PISSN: 03635465     EISSN: 15523365     Source Type: Journal    
DOI: 10.1177/0363546513518007     Document Type: Article

References (58)

1. Ando W, Tateishi K, Katakai D, et al. In vitro generation of a scaffold-free tissue-engineered construct (TEC) derived from human synovial mesenchymal stem cells: biological and mechanical properties and further chondrogenic potential. Tissue Eng Part A. 2008 ; 14 (12). 2041-2049
2. Anitua E, Sanchez M, Orive G, Andia I. The potential impact of the preparation rich in growth factors (PRGF) in different medical fields. Biomaterials. 2007 ; 28 (31). 4551-4560 (Pubitemid 47271893)
3. Behrens P, Bitter T, Kurz B, Russlies M. Matrix-associated autologous chondrocyte transplantation/implantation (MACT/MACI): 5-year follow-up. Knee. 2006 ; 13 (3). 194-202 (Pubitemid 44096873)
4. Brittberg M, Lindahl A, Nilsson A, et al. Treatment of deep cartilage defects in the knee with autologous chondrocyte transplantation. N Engl J Med. 1994 ; 331 (14). 889-895 (Pubitemid 24299869)
5. Caplan AI. Mesenchymal stem cells: cell-based reconstructive therapy in orthopedics. Tissue Eng. 2005 ; 11 (7-8). 1198-1211 (Pubitemid 41321423)
6. Caplan AI. Mesenchymal stem cells: the past, the present, the future. Cartilage. 2010 ; 1 (1). 6-9
7. Cavallo C, Desando G, Cattini L, et al. Bone marrow concentrated cell transplantation: rationale for its use in the treatment of human osteochondral lesions. J Biol Regul Homeost Agents. 2013 ; 27 (1). 165-175
8. Chambers SM, Goodell MA. Hematopoietic stem cell aging: wrinkles in stem cell potential. Stem Cell Rev. 2007 ; 3 (3). 201-211 (Pubitemid 350129706)
9. Coelho MB, Cabral JM, Karp JM. Intraoperative stem cell therapy. Annu Rev Biomed Eng. 2012 ; 14: 325-349
10. Dominici M, Le Blanc K, Mueller I, et al. Minimal criteria for defining multipotent mesenchymal stromal cells: the International Society for Cellular Therapy position statement. Cytotherapy. 2006 ; 8 (4). 315-317 (Pubitemid 44269669)
11. Fortier LA, Potter H, Rickey E, et al. Concentrated bone marrow aspirate improves full-thickness cartilage repair compared with microfracture in the equine model. J Bone Joint Surg Am. 2010 ; 92 (10). 1927-1937
12. Gobbi A, Karnatzikos G, Kumar A. Long-term results after microfracture treatment for full-thickness knee chondral lesions in athletes. Knee Surg Sports Traumatol Arthrosc. :
13. Gobbi A, Karnatzikos G, Nakamura N, Mahajan V Sports Injuries: Prevention, Diagnosis, Treatment and Rehabilitation. Doral MN, ed. Berlin: Springer Verlag ; 2012: 739-749.
14. Gobbi A, Karnatzikos G, Scotti C, et al. One-step cartilage repair with bone marrow aspirate concentrated cells and collagen matrix in full-thickness knee cartilage lesions: results at 2 year follow up. Cartilage. 2011 ; 2 (3). 286-299
15. Gobbi A, Kon E, Berruto M, et al. Patellofemoral full-thickness chondral defects treated with second-generation autologous chondrocyte implantation: results at 5 years' follow-up. Am J Sports Med. 2009 ; 37 (6). 1083-1092
16. Grigolo B, Lisignoli G, Desando G, et al. Osteoarthritis treated with mesenchymal stem cells on hyaluronan-based scaffold in rabbit. Tissue Eng Part C Methods. 2009 ; 15 (4). 647-658
17. Harris JD, McNeilan R, Siston RA, Flanigan DC. Survival and clinical outcome of isolated high tibial osteotomy and combined biological knee reconstruction. Knee. 2013 ; 20 (3). 154-161
18. Hermann PC, Huber SL, Herrler T, et al. Concentration of bone marrow total nucleated cells by a point-of-care device provides a high yield and preserves their functional activity. Cell Transplant. 2008 ; 16 (10). 1059-1069 (Pubitemid 351732848)
19. Horas U, Pelinkovic D, Herr G, Aigner T, et al. Autologous chondrocyte implantation and osteochondral cylinder transplantation in cartilage repair of the knee joint: a prospective, comparative trial. J Bone Joint Surg Am. 2003 ; 85 (2). 185-192 (Pubitemid 36538777)
20. Horwitz E, Le BK, Dominici M, et al. Clarification of the nomenclature for MSC: the International Society for Cellular Therapy position statement. Cytotherapy. 2005 ; 7 (5). 393-395 (Pubitemid 41671625)
21. Hui JH, Chen F, Thambyah A, Lee EH. Treatment of chondral lesions in advanced osteochondritis dissecans: a comparative study of the efficacy of chondrocytes, mesenchymal stem cells, periosteal graft, and mosaicplasty (osteochondral autograft) in animal models. J Pediatr Orthop. 2004 ; 24 (4). 427-433 (Pubitemid 38857544)
22. Irrgang JJ, Anderson AF, Boland AL, et al. Development and validation of the International Knee Documentation Committee subjective knee form. Am J Sports Med. 2001 ; 29 (5). 600-613 (Pubitemid 32885251)
23. Jones E, McGonagle D. Human bone marrow mesenchymal stem cells in vivo. Rheumatology (Oxford). 2008 ; 47 (2). 126-131 (Pubitemid 351168218)
24. Knutsen G, Engebretsen L, Ludvigsen TC, et al. Autologous chondrocyte implantation compared with microfracture in the knee: a randomized trial. J Bone Joint Surg Am. 2004 ; 86 (3). 455-464 (Pubitemid 38269014)
25. Kobayashi T, Ochi M, Yanada S, et al. A novel cell delivery system using magnetically labelled mesenchymal stem cells and an external magnetic device for clinical cartilage repair. Arthroscopy. 2008 ; 24 (1). 69-76
26. Kon E, Gobbi A, Filardo G, et al. Arthroscopic second-generation autologous chondrocyte implantation compared with microfracture for chondral lesions of the knee: prospective nonrandomized study at 5 years. Am J Sports Med. 2009 ; 37 (1). 33-41
27. Kotlarz H, Gunnarsson CL, Fang H, Rizzo JA. Insurer and out-of-pocket costs of osteoarthritis in the US: evidence from national survey data. Arthritis Rheum. 2009 ; 60 (12). 3546-3553
28. Kramer DE, Kocher MS. Management of patellar and trochlear chondral injuries. Oper Tech Orthop. 2007 ; 17 (4). 234-243 (Pubitemid 350253666)
29. Lysholm J, Gillquist J. Evaluation of knee ligament surgery results with special emphasis on use of a scoring scale. Am J Sports Med. 1982 ; 10 (3). 150-154 (Pubitemid 12014357)
30. Mandelbaum B, Browne JE, Fu F, et al. Treatment outcomes of autologous chondrocyte implantation for full-thickness articular cartilage defects of the trochlea. Am J Sports Med. 2007 ; 35 (6). 915-921 (Pubitemid 46956309)
31. Mankin HJ. The response of articular cartilage to mechanical injury. J Bone Joint Surg Am. 1982 ; 64 (3). 460-466 (Pubitemid 12153547)
32. Marcacci M, Berruto M, Brocchetta D, et al. Articular cartilage engineering with Hyalograft C: 3-year clinical results. Clin Orthop Relat Res. 2005 ; 435: 96-105 (Pubitemid 40798651)
33. Marx RG, Stump TJ, Jones EC, Wickiewicz TL, Warren RF. Development and evaluation of an activity rating scale for disorders of the knee. Am J Sports Med. 2001 ; 29 (2). 213-218 (Pubitemid 32231037)
34. Minas T, Peterson L. Advanced techniques in autologous chondrocyte transplantation. Clin Sports Med. 1999 ; 18 (1). 13 v - 44 vi
35. Minzlaff P, Feucht MJ, Saier T, et al. Osteochondral autologous transfer combined with valgus high tibial osteotomy: long-term results and survivorship analysis. Am J Sports Med. 2013 ; 41 (10). 2325-2332
36. Nakamura T, Sekiya I, Muneta T, et al. Arthroscopic, histological and MRI analyses of cartilage repair after a minimally invasive method of transplantation of allogeneic synovial mesenchymal stromal cells into cartilage defects in pigs. Cytotherapy. 2012 ; 14 (3). 327-338
37. Nejadnik H, Hui JH, Feng Choong EP, et al. Autologous bone marrow-derived mesenchymal stem cells versus autologous chondrocyte implantation: an observational cohort study. Am J Sports Med. 2010 ; 38 (6). 1110-1116
38. Ochi M, Adachi N, Nobuto H, et al. Articular cartilage repair using tissue engineering technique: novel approach with minimally invasive procedure. Artif Organs. 2004 ; 28 (1). 28-32 (Pubitemid 38234241)
39. Oreffo RO, Bennett A, Carr AJ, Triffitt JT. Patients with primary osteoarthritis show no change with ageing in the number of osteogenic precursors. Scand J Rheumatol. 1998 ; 27 (6). 415-424 (Pubitemid 28535621)
40. Pelttari K, Steck E, Richter W. The use of mesenchymal stem cells for chondrogenesis. Injury. 2008 ; 39: S58 - S65
41. Peterson L, Vasiliadis HS, Brittberg M, Lindahl A. Autologous chondrocyte implantation: a long-term follow-up. Am J Sports Med. 2010 ; 38 (6). 1117-1124
42. Potter HG, Linklater JM, Allen AA, Hannafin JA, Haas SB. Magnetic resonance imaging of articular cartilage in the knee: an evaluation with use of fast-spin-echo imaging. J Bone Joint Surg Am. 1998 ; 80 (9). 1276-1284 (Pubitemid 28443350)
43. Quarto R, Thomas D, Liang CT. Bone progenitor cell deficits and the age-associated decline in bone repair capacity. Calcif Tissue Int. 1995 ; 56 (2). 123-129
44. Robey PG, Bianco P. The use of adult stem cells in rebuilding the human face. J Am Dent Assoc. 2006 ; 137 (7). 961-972 (Pubitemid 44153896)
45. Roobrouck VD, Ulloa-Montoya F, Verfaillie CM. Self-renewal and differentiation capacity of young and aged stem cells. Exp Cell Res. 2008 ; 314 (9). 1937-1944
46. Roos EM, Roos HP, Lohmander LS, Ekdahl C, Beynnon BD. Knee Injury and Osteoarthritis Outcome Score (KOOS): development of a self-administered outcome measure. J Orthop Sports Phys Ther. 1998 ; 28 (2). 88-96 (Pubitemid 28366508)
47. Salzmann GM, Niemeyer P, Steinwachs M, et al. Cartilage repair approach and treatment characteristics across the knee joint: a European survey. Arch Orthop Trauma Surg. 2011 ; 131 (3). 283-291
48. Scotti C, Tonnarelli B, Papadimitropoulos A, et al. Recapitulation of endochondral bone formation using human adult mesenchymal stem cells as a paradigm for developmental engineering. Proc Natl Acad Sci U S A. 2010 ; 107 (16). 7251-7256
49. Scotti C, Wirz D, Wolf F, et al. Engineering human cell-based, functionally integrated osteochondral grafts by biological bonding of engineered cartilage tissues to bony scaffolds. Biomaterials. 2010 ; 31 (8). 2252-2259
50. Sgaglione NA, Miniaci A, Gillogly SD, Carter TR. Update on advanced surgical techniques in the treatment of traumatic focal articular cartilage lesions in the knee. Arthroscopy. 2002 ; 18: 9-32 (Pubitemid 36114595)
51. Takeda H, Nakagawa T, Nakamura K, Engebretsen L. Prevention and management of knee osteoarthritis and knee cartilage injury in sports. Br J Sports Med. 2011 ; 45 (4). 304-309
52. Tateishi K, Ando W, Higuchi C, et al. Comparison of human serum with fetal bovine serum for expansion and differentiation of human synovial MSC: potential feasibility for clinical applications. Cell Transplant. 2008 ; 17 (5). 549-557
53. Tegner Y, Lysholm J. Rating systems in the evaluation of knee ligament injuries. Clin Orthop Relat Res. 1985 ; 198: 43-49 (Pubitemid 16248241)
54. Wakitani S, Imoto K, Yamamoto T, et al. Human autologous culture expanded bone marrow mesenchymal cell transplantation for repair of cartilage defects in osteoarthritic knees. Osteoarthritis Cartilage. 2002 ; 10 (3). 199-206 (Pubitemid 34189569)
55. Widuchowski W, Widuchowski J, Trzaska T. Articular cartilage defects: study of 25,124 knee arthroscopies. Knee. 2007 ; 14 (3). 177-182 (Pubitemid 46695821)
56. Wilke MM, Nydam DV, Nixon AJ. Enhanced early chondrogenesis in articular defects following arthroscopic mesenchymal stem cell implantation in an equine model. J Orthop Res. 2007 ; 25 (7). 913-925 (Pubitemid 47046438)
57. Wright RW. Knee injury outcomes measures. J Am Acad Orthop Surg. 2009 ; 17 (1). 31-39
58. Yanada S, Ochi M, Adachi N, et al. Effects of CD44 antibody - or RGDS peptide - immobilized magnetic beads on cell proliferation and chondrogenesis of mesenchymal stem cells. J Biomed Mater Res A. 2006 ; 77 (4). 773-784 (Pubitemid 47233558)