The interaction of calcium entry and calcium sensitization in the control of vascular tone and blood pressure of normotensive and hypertensive rats

Physiological Research

Volumn 63, Issue SUPPL., 2014, Pages

  Zicha, J ^a   Behuliak, M ^a   Pinterova M ^a   Bencze, M ^a   Kunes J ^a   Vaneckova I ^a  

^a INSTITUTE OF PHYSIOLOGY   (Czech Republic)

Author keywords

Bay k8644; Ca2+ entry; Calcium sensitization; Fasudil; Nifedipine; Rhoa Rho kinase

Indexed keywords

CALCIUM; CALCIUM CHANNEL; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN;

ANIMAL; BIOLOGICAL MODEL; BLOOD PRESSURE; CALCIUM SIGNALING; CHANNEL GATING; HYPERTENSION; METABOLISM; PATHOPHYSIOLOGY; RAT; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; REVIEW; SPONTANEOUSLY HYPERTENSIVE RAT; VASOCONSTRICTION;

ANIMALS; BLOOD PRESSURE; CALCIUM; CALCIUM CHANNELS; CALCIUM SIGNALING; HYPERTENSION; ION CHANNEL GATING; MODELS, CARDIOVASCULAR; RATS; RATS, INBRED SHR; RENIN-ANGIOTENSIN SYSTEM; RHOA GTP-BINDING PROTEIN; VASOCONSTRICTION;

EID: 84897632452     PISSN: 08628408     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (17)

1. ALVAREZ SM, MINER AS, BROWNE BM, RATZ PH. Failure of Bay K 8644 to induce RhoA kinase-dependent calcium sensitization in rabbit blood vessels. Br J Pharmacol 160: 1326-1337, 2010.
2. 2+ entry in the control of blood pressure and adrenergic vasoconstriction in conscious Wistar-Kyoto and spontaneously hypertensive rats. J Hypertens 31: 2025-2035, 2013.
3. HEAD RJ. Hypernoradrenergic innervation: its relationship to functional and hyperplastic changes in the vasculature of the spontaneously hypertensive rat. Blood Vessels 26: 1-20, 1989.
4. KAZDA S, GARTHOFF B, LUCKHAUS G. Calcium and malignant hypertension in animal experiment: effects of experimental manipulation of calcium influx. Am J Nephrol 6 (Suppl 1): 145-150, 1986.
5. KUNEŠ J, HOJNÁ S, KADLECOVÁ M, DOBEŠOVÁ Z, RAUCHOVÁ H, VOKURKOVÁ M, LOUKOTOVÁ J, PECHÁNOVÁ O, ZICHA J. Altered balance of vasoactive systems in experimental hypertension: the role of relative NO deficiency. Physiol Res 53 (Suppl 1): S23-S34, 2004.
6. LÍŠKOVÁ S, KUNEŠ J, ZICHA J. Nifedipine-sensitive vascular reactivity of femoral arteries in WKY: the effects of pertussis toxin pretreatment and endothelium removal. Physiol Res 56: 663-666, 2007.
7. NELSON MT, STANDEN MB, BRAYDEN JE, WORLEY JF. Noradrenaline contracts arteries by activating voltagedependent calcium channels. Nature 336: 382-385, 1988.
8. PAULIS L, LÍŠKOVÁ S, PINTÉROVÁ M, DOBEŠOVÁ Z, KUNEŠ J, ZICHA J. Nifedipine-sensitive noradrenergic vasoconstriction is enhanced in spontaneously hypertensive rats: the influence of chronic captopril treatment. Acta Physiol (Oxford) 191: 255-266, 2007.
9. PINTÉROVÁ M, LÍŠKOVÁ S, DOBEŠOVÁ Z, BEHULIAK M, KUNEŠ J, ZICHA J. Impaired control of L-type voltage-dependent calcium channels in experimental hypertension. Physiol Res 58 (Suppl 2): S43-S54, 2009.
10. PINTÉROVÁ M, KAREN P, KUNEŠ J, ZICHA J. Role of nifedipine-sensitive sympathetic vasoconstriction in maintenance of high blood pressure in spontaneously hypertensive rats: effect of Gi-protein inactivation by pertussis toxin. J Hypertens 28: 969-978, 2010.
11. PINTÉROVÁ M, KUNEŠ J, ZICHA J. Altered neural and vascular mechanisms in hypertension. Physiol Res 60: 381-402, 2011.
12. 2+ channels in mesenteric and skeletal arteries of SHR. Hypertension 40: 214-219, 2002.
13. 2+ sensitization of contraction in vascular smooth muscle. J Biol Chem 275: 21722-21729, 2000.
14. SOMLYO AP, SOMLYO AV. Signal transduction by G-proteins, Rho-kinase and protein phosphatase to smooth muscle and non-muscle myosin II. J Physiol Lond 522: 177-185, 2000.
15. TSAI MH, JIANG MJ. Rho-kinase-mediated regulation of receptor-agonist-stimulated smooth muscle contraction. Pflügers Arch 453: 223-232, 2006.
16. UEHATA M, ISHIZAKI T, SATOH H, ONO T, KAWAHARA T, MORISHITA T, TAMAKAWA H, YAMAGAMI K, INUI J, MAEKAWA M, NARUMIYA S. Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension. Nature 389: 990-994, 1997.
17. WIRTH A. Rho kinase and hypertension. Biochim Biophys Acta 1802: 1276-1284, 2010.