메뉴 건너뛰기




Volumn 29, Issue 1, 2014, Pages 144-150

Impact of IL28B polymorphisms on 24-week telaprevir-based combination therapy for Asian chronic hepatitis C patients with hepatitis C virus genotype 1b

Author keywords

Chronic hepatitis C virus infection; IL28B single nucleotide polymorphism; Pegylated interferon; Ribavirin; Sustained virological response; Telaprevir

Indexed keywords

PEGINTERFERON ALPHA2B; RIBAVIRIN; TELAPREVIR; TELAVIC; UNCLASSIFIED DRUG;

EID: 84897614360     PISSN: 08159319     EISSN: 14401746     Source Type: Journal    
DOI: 10.1111/jgh.12402     Document Type: Article
Times cited : (18)

References (30)
  • 1
    • 33744457959 scopus 로고    scopus 로고
    • Discovery and development of VX-950, a novel, covalent, and reversible inhibitor of hepatitis C virus NS3.4A serine protease
    • Lin C, Kwong AD, Perni RB. Discovery and development of VX-950, a novel, covalent, and reversible inhibitor of hepatitis C virus NS3.4A serine protease. Infect. Disord. Drug Targets 2006; 6: 3-16.
    • (2006) Infect. Disord. Drug Targets , vol.6 , pp. 3-16
    • Lin, C.1    Kwong, A.D.2    Perni, R.B.3
  • 2
    • 65449152185 scopus 로고    scopus 로고
    • Telaprevir with peginterferon and ribavirin for chronic HCV genotype 1 infection
    • McHutchison JG, Everson GT, Gordon SC etal. Telaprevir with peginterferon and ribavirin for chronic HCV genotype 1 infection. N. Engl. J. Med. 2009; 360: 1827-1838.
    • (2009) N. Engl. J. Med. , vol.360 , pp. 1827-1838
    • McHutchison, J.G.1    Everson, G.T.2    Gordon, S.C.3
  • 3
    • 65449171953 scopus 로고    scopus 로고
    • Telaprevir and peginterferon with or without ribavirin for chronic HCV infection
    • Hézode C, Forestier N, Dusheiko G etal. Telaprevir and peginterferon with or without ribavirin for chronic HCV infection. N. Engl. J. Med. 2009; 360: 1839-1850.
    • (2009) N. Engl. J. Med. , vol.360 , pp. 1839-1850
    • Hézode, C.1    Forestier, N.2    Dusheiko, G.3
  • 4
    • 77950817619 scopus 로고    scopus 로고
    • Telaprevir for previously treated chronic HCV infection
    • McHutchison JG, Manns MP, Muir AJ etal. Telaprevir for previously treated chronic HCV infection. N. Engl. J. Med. 2010; 362: 1292-1303.
    • (2010) N. Engl. J. Med. , vol.362 , pp. 1292-1303
    • McHutchison, J.G.1    Manns, M.P.2    Muir, A.J.3
  • 5
    • 79959438789 scopus 로고    scopus 로고
    • Telaprevir for previously untreated chronic hepatitis C virus infection
    • Jacobson IM, McHutchison JG, Dusheiko G etal. Telaprevir for previously untreated chronic hepatitis C virus infection. N. Engl. J. Med. 2011; 364: 2405-2416.
    • (2011) N. Engl. J. Med. , vol.364 , pp. 2405-2416
    • Jacobson, I.M.1    McHutchison, J.G.2    Dusheiko, G.3
  • 6
    • 79959381354 scopus 로고    scopus 로고
    • Telaprevir for retreatment of HCV infection
    • Zeuzem S, Andreone P, Pol S etal. Telaprevir for retreatment of HCV infection. N. Engl. J. Med. 2011; 364: 2417-2428.
    • (2011) N. Engl. J. Med. , vol.364 , pp. 2417-2428
    • Zeuzem, S.1    Andreone, P.2    Pol, S.3
  • 7
    • 80052826527 scopus 로고    scopus 로고
    • Response-guided telaprevir combination treatment for hepatitis C virus infection
    • Sherman KE, Flamm SL, Afdhal NH etal. Response-guided telaprevir combination treatment for hepatitis C virus infection. N. Engl. J. Med. 2011; 365: 1014-1024.
    • (2011) N. Engl. J. Med. , vol.365 , pp. 1014-1024
    • Sherman, K.E.1    Flamm, S.L.2    Afdhal, N.H.3
  • 8
    • 79957963815 scopus 로고    scopus 로고
    • IL28B but not ITPA polymorphism is predictive of response to pegylated interferon, ribavirin, and telaprevir triple therapy in patients with genotype 1 hepatitis C
    • Chayama K, Hayes CN, Abe H etal. IL28B but not ITPA polymorphism is predictive of response to pegylated interferon, ribavirin, and telaprevir triple therapy in patients with genotype 1 hepatitis C. J. Infect. Dis. 2011; 204: 84-93.
    • (2011) J. Infect. Dis. , vol.204 , pp. 84-93
    • Chayama, K.1    Hayes, C.N.2    Abe, H.3
  • 9
    • 83555163652 scopus 로고    scopus 로고
    • Telaprevir with peginterferon and ribavirin for treatment-naive patients chronically infected with HCV of genotype 1 in Japan
    • Kumada H, Toyota J, Okanoue T, Chayama K, Tsubouchi H, Hayashi N. Telaprevir with peginterferon and ribavirin for treatment-naive patients chronically infected with HCV of genotype 1 in Japan. J. Hepatol. 2012; 56: 78-84.
    • (2012) J. Hepatol. , vol.56 , pp. 78-84
    • Kumada, H.1    Toyota, J.2    Okanoue, T.3    Chayama, K.4    Tsubouchi, H.5    Hayashi, N.6
  • 10
    • 84855860896 scopus 로고    scopus 로고
    • Efficacy and safety of telaprevir, a new protease inhibitor, for difficult-to-treat patients with genotype 1 chronic hepatitis C
    • Hayashi N, Okanoue T, Tsubouchi H, Toyota J, Chayama K, Kumada H. Efficacy and safety of telaprevir, a new protease inhibitor, for difficult-to-treat patients with genotype 1 chronic hepatitis C. J. Viral Hepat. 2012; 19: e134-142.
    • (2012) J. Viral Hepat. , vol.19
    • Hayashi, N.1    Okanoue, T.2    Tsubouchi, H.3    Toyota, J.4    Chayama, K.5    Kumada, H.6
  • 11
    • 84897615693 scopus 로고    scopus 로고
    • INCIVEK. FDA Prescribing Information. Vertex Pharmaceuticals Incorporated, Cambridge, MA. May. Cited 17 May 2013. Available from URL:
    • INCIVEK. FDA Prescribing Information. Vertex Pharmaceuticals Incorporated, Cambridge, MA. May 2011. Cited 17 May 2013. Available from URL: http://pi.vrtx.com/files/uspi_telaprevir.pdf
    • (2011)
  • 12
    • 84897643575 scopus 로고    scopus 로고
    • INCIVOVR. European Medicines Agency. Summary of Product Characteristics. Janssen Cilag International NV, Beerse, Belgium. October. Cited 17 May 2013. Available from URL:
    • INCIVOVR. European Medicines Agency. Summary of Product Characteristics. Janssen Cilag International NV, Beerse, Belgium. October 2011. Cited 17 May 2013. Available from URL: http://www.ema.europa.eu/docs/en_GB/document_library/EPAR_-_Product_Information/human/002313/WC500115529.pdf
    • (2011)
  • 13
    • 84897644299 scopus 로고    scopus 로고
    • TELAVIC. Health, Labour and Welfare Ministry. The Proper Usage Guideline for Telaprevir and Product Information. Mitsubishi Tanabe Pharma, Osaka, Japan. September. Cited 17 May 2013. Available from URL:
    • TELAVIC. Health, Labour and Welfare Ministry. The Proper Usage Guideline for Telaprevir and Product Information. Mitsubishi Tanabe Pharma, Osaka, Japan. September 2011. Cited 17 May 2013. Available from URL: http://medical.mt-pharma.co.jp/intro/tlv/use/use00.shtml
    • (2011)
  • 14
    • 0035934568 scopus 로고    scopus 로고
    • Peginterferon alfa-2b plus ribavirin compared with interferon alfa-2b plus ribavirin for initial treatment of chronic hepatitis C: a randomised trial
    • Manns MP, McHutchison JG, Gordon SC etal. Peginterferon alfa-2b plus ribavirin compared with interferon alfa-2b plus ribavirin for initial treatment of chronic hepatitis C: a randomised trial. Lancet 2001; 358: 958-965.
    • (2001) Lancet , vol.358 , pp. 958-965
    • Manns, M.P.1    McHutchison, J.G.2    Gordon, S.C.3
  • 15
    • 0037179698 scopus 로고    scopus 로고
    • Peginterferon alfa-2a plus ribavirin for chronic hepatitis C virus infection
    • Fried MW, Shiffman ML, Reddy KR etal. Peginterferon alfa-2a plus ribavirin for chronic hepatitis C virus infection. N. Engl. J. Med. 2002; 347: 975-982.
    • (2002) N. Engl. J. Med. , vol.347 , pp. 975-982
    • Fried, M.W.1    Shiffman, M.L.2    Reddy, K.R.3
  • 16
    • 68249154875 scopus 로고    scopus 로고
    • Peginterferon alfa-2b or alfa-2a with ribavirin for treatment of hepatitis C infection
    • McHutchison JG, Lawitz EJ, Shiffman ML etal. Peginterferon alfa-2b or alfa-2a with ribavirin for treatment of hepatitis C infection. N. Engl. J. Med. 2009; 361: 580-593.
    • (2009) N. Engl. J. Med. , vol.361 , pp. 580-593
    • McHutchison, J.G.1    Lawitz, E.J.2    Shiffman, M.L.3
  • 17
    • 70349292099 scopus 로고    scopus 로고
    • Genetic variation in IL28B predicts hepatitis C treatment-induced viral clearance
    • Ge D, Fellay J, Thompson A etal. Genetic variation in IL28B predicts hepatitis C treatment-induced viral clearance. Nature 2009; 461: 399-401.
    • (2009) Nature , vol.461 , pp. 399-401
    • Ge, D.1    Fellay, J.2    Thompson, A.3
  • 18
    • 70349652390 scopus 로고    scopus 로고
    • Predictive values of amino acid sequences of the core and NS5A regions in antiviral therapy for hepatitis C: a Japanese multi-center study
    • Okanoue T, Itoh Y, Hashimoto H etal. Predictive values of amino acid sequences of the core and NS5A regions in antiviral therapy for hepatitis C: a Japanese multi-center study. J. Gastroenterol. 2009; 44: 952-963.
    • (2009) J. Gastroenterol. , vol.44 , pp. 952-963
    • Okanoue, T.1    Itoh, Y.2    Hashimoto, H.3
  • 19
    • 84859443973 scopus 로고    scopus 로고
    • Contribution of ribavirin transporter gene polymorphism to treatment response in peginterferon plus ribavirin therapy for HCV genotype 1b patients
    • Tsubota A, Shimada N, Yoshizawa K etal. Contribution of ribavirin transporter gene polymorphism to treatment response in peginterferon plus ribavirin therapy for HCV genotype 1b patients. Liver Int. 2012; 32: 826-836.
    • (2012) Liver Int. , vol.32 , pp. 826-836
    • Tsubota, A.1    Shimada, N.2    Yoshizawa, K.3
  • 20
    • 84876294731 scopus 로고    scopus 로고
    • Limited impact of IL28B genotype on response rates in telaprevir-treated patients with prior treatment failure
    • Pol S, Aerssens J, Zeuzem S etal. Limited impact of IL28B genotype on response rates in telaprevir-treated patients with prior treatment failure. J. Hepatol. 2013; 58: 883-889.
    • (2013) J. Hepatol. , vol.58 , pp. 883-889
    • Pol, S.1    Aerssens, J.2    Zeuzem, S.3
  • 21
    • 70349548852 scopus 로고    scopus 로고
    • IL28B is associated with response to chronic hepatitis C interferon-α and ribavirin therapy
    • Suppiah V, Moldovan M, Ahlenstiel G etal. IL28B is associated with response to chronic hepatitis C interferon-α and ribavirin therapy. Nat. Genet. 2009; 41: 1100-1104.
    • (2009) Nat. Genet. , vol.41 , pp. 1100-1104
    • Suppiah, V.1    Moldovan, M.2    Ahlenstiel, G.3
  • 22
    • 70349533037 scopus 로고    scopus 로고
    • Genome-wide association of IL28B with response to pegylated interferon-a and ribavirin therapy for chronic hepatitis C
    • Tanaka Y, Nishida N, Sugiyama M etal. Genome-wide association of IL28B with response to pegylated interferon-a and ribavirin therapy for chronic hepatitis C. Nat. Genet. 2009; 41: 1105-1109.
    • (2009) Nat. Genet. , vol.41 , pp. 1105-1109
    • Tanaka, Y.1    Nishida, N.2    Sugiyama, M.3
  • 23
    • 22344457187 scopus 로고    scopus 로고
    • Association of amino acid substitution pattern in core protein of hepatitis C virus genotype 1b high viral load and non-virological response to interferon-ribavirin combination therapy
    • Akuta N, Suzuki F, Sezaki H etal. Association of amino acid substitution pattern in core protein of hepatitis C virus genotype 1b high viral load and non-virological response to interferon-ribavirin combination therapy. Intervirology 2005; 48: 372-380.
    • (2005) Intervirology , vol.48 , pp. 372-380
    • Akuta, N.1    Suzuki, F.2    Sezaki, H.3
  • 24
    • 9144257569 scopus 로고    scopus 로고
    • Mutations in the nonstructural protein 5A gene and response to interferon in patients with chronic hepatitis C virus 1b infection
    • Enomoto N, Sakuma I, Asahina Y etal. Mutations in the nonstructural protein 5A gene and response to interferon in patients with chronic hepatitis C virus 1b infection. N. Engl. J. Med. 1996; 334: 77-81.
    • (1996) N. Engl. J. Med. , vol.334 , pp. 77-81
    • Enomoto, N.1    Sakuma, I.2    Asahina, Y.3
  • 25
    • 77949773445 scopus 로고    scopus 로고
    • ITPA gene variants protect against anaemia in patients treated for chronic hepatitis C
    • Fellay J, Thompson AJ, Ge D etal. ITPA gene variants protect against anaemia in patients treated for chronic hepatitis C. Nature 2010; 464: 405-408.
    • (2010) Nature , vol.464 , pp. 405-408
    • Fellay, J.1    Thompson, A.J.2    Ge, D.3
  • 26
    • 77953881002 scopus 로고    scopus 로고
    • Interleukin-28B polymorphism improves viral kinetics and is the strongest pretreatment predictor of sustained virologic response in genotype 1 hepatitis C virus
    • Thompson AJ, Fellay J, Patel K etal. Interleukin-28B polymorphism improves viral kinetics and is the strongest pretreatment predictor of sustained virologic response in genotype 1 hepatitis C virus. Gastroenterology 2010; 139: 120-129.
    • (2010) Gastroenterology , vol.139 , pp. 120-129
    • Thompson, A.J.1    Fellay, J.2    Patel, K.3
  • 27
    • 84880277735 scopus 로고    scopus 로고
    • Telaprevir can be successfully and safely used to treat older patients with genotype 1b chronic hepatitis C
    • Furusyo N, Ogawa E, Nakamuta M etal. Telaprevir can be successfully and safely used to treat older patients with genotype 1b chronic hepatitis C. J. Hepatol. 2013; 59: 205-212.
    • (2013) J. Hepatol. , vol.59 , pp. 205-212
    • Furusyo, N.1    Ogawa, E.2    Nakamuta, M.3
  • 28
    • 84870018199 scopus 로고    scopus 로고
    • Characterization of telaprevir treatment outcomes and resistance in patients with prior treatment failure: results from the REALIZE trial
    • De Meyer S, Dierynck I, Ghys A etal. Characterization of telaprevir treatment outcomes and resistance in patients with prior treatment failure: results from the REALIZE trial. Hepatology 2012; 56: 2106-2115.
    • (2012) Hepatology , vol.56 , pp. 2106-2115
    • De Meyer, S.1    Dierynck, I.2    Ghys, A.3
  • 29
    • 39349089594 scopus 로고    scopus 로고
    • Rapid virologic response: a new milestone in the management of chronic hepatitis C
    • Poordad F, Reddy KR, Martin P. Rapid virologic response: a new milestone in the management of chronic hepatitis C. Clin. Infect. Dis. 2008; 46: 78-84.
    • (2008) Clin. Infect. Dis. , vol.46 , pp. 78-84
    • Poordad, F.1    Reddy, K.R.2    Martin, P.3
  • 30
    • 79958816097 scopus 로고    scopus 로고
    • Rapid virological response is the most important predictor of sustained virological response across genotypes in patients with chronic hepatitis C virus infection
    • Fried MW, Hadziyannis SJ, Shiffman ML, Messinger D, Zeuzem S. Rapid virological response is the most important predictor of sustained virological response across genotypes in patients with chronic hepatitis C virus infection. J. Hepatol. 2011; 55: 69-75.
    • (2011) J. Hepatol. , vol.55 , pp. 69-75
    • Fried, M.W.1    Hadziyannis, S.J.2    Shiffman, M.L.3    Messinger, D.4    Zeuzem, S.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.