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Volumn 28, Issue 12, 2013, Pages 1815-1822

Aberrant cytokeratin expression as a possible prognostic predictor in poorly differentiated colorectal carcinoma

Author keywords

Colorectal carcinoma; Cytokeratin 20; Cytokeratin 7; Mismatch repair; Prognosis

Indexed keywords

ANTINEOPLASTIC AGENT; CYTOKERATIN 20; CYTOKERATIN 7; PROTEIN MLH1; PROTEIN MSH2;

EID: 84897587046     PISSN: 08159319     EISSN: 14401746     Source Type: Journal    
DOI: 10.1111/jgh.12319     Document Type: Article
Times cited : (24)

References (33)
  • 1
    • 0020467073 scopus 로고
    • The catalog of human cytokeratins: patterns of expression in normal epithelia, tumors and cultured cells
    • Moll R, Franke WW, Schiller DL, Geiger B, Krepler R. The catalog of human cytokeratins: patterns of expression in normal epithelia, tumors and cultured cells. Cell 1982; 31: 11-24.
    • (1982) Cell , vol.31 , pp. 11-24
    • Moll, R.1    Franke, W.W.2    Schiller, D.L.3    Geiger, B.4    Krepler, R.5
  • 2
    • 0027275596 scopus 로고
    • The human gene encoding cytokeratin 20 and its expression during fetal development and in gastrointestinal carcinomas
    • Moll R, Zimbelmann R, Goldschmidt MD etal. The human gene encoding cytokeratin 20 and its expression during fetal development and in gastrointestinal carcinomas. Differentiation 1993; 53: 75-93.
    • (1993) Differentiation , vol.53 , pp. 75-93
    • Moll, R.1    Zimbelmann, R.2    Goldschmidt, M.D.3
  • 3
    • 1942530860 scopus 로고    scopus 로고
    • Diagnostic strategies for unknown primary cancer
    • Varadhachary GR, Abbruzzese JL, Lenzi R. Diagnostic strategies for unknown primary cancer. Cancer 2004; 100: 1776-1785.
    • (2004) Cancer , vol.100 , pp. 1776-1785
    • Varadhachary, G.R.1    Abbruzzese, J.L.2    Lenzi, R.3
  • 4
    • 0026561237 scopus 로고
    • Cytokeratin 20 in human carcinomas. A new histodiagnostic marker detected by monoclonal antibodies
    • Moll R, Löwe A, Laufer J, Franke WW. Cytokeratin 20 in human carcinomas. A new histodiagnostic marker detected by monoclonal antibodies. Am. J. Pathol. 1992; 140: 427-447.
    • (1992) Am. J. Pathol. , vol.140 , pp. 427-447
    • Moll, R.1    Löwe, A.2    Laufer, J.3    Franke, W.W.4
  • 5
    • 0028587723 scopus 로고
    • Utility of cytokeratin immunostaining in separating pulmonary adenocarcinomas from colonic adenocarcinomas
    • Loy TS, Calaluce RD. Utility of cytokeratin immunostaining in separating pulmonary adenocarcinomas from colonic adenocarcinomas. Am. J. Clin. Pathol. 1994; 102: 764-767.
    • (1994) Am. J. Clin. Pathol. , vol.102 , pp. 764-767
    • Loy, T.S.1    Calaluce, R.D.2
  • 7
    • 0033795923 scopus 로고    scopus 로고
    • Cytokeratin 7 and cytokeratin 20 expression in epithelial neoplasms: a survey of 435 cases
    • Chu P, Wu E, Weiss LM. Cytokeratin 7 and cytokeratin 20 expression in epithelial neoplasms: a survey of 435 cases. Mod. Pathol. 2000; 13: 962-972.
    • (2000) Mod. Pathol. , vol.13 , pp. 962-972
    • Chu, P.1    Wu, E.2    Weiss, L.M.3
  • 8
    • 0029007555 scopus 로고
    • Keratin 20: immunohistochemical marker for gastrointestinal, urothelial, and Merkel cell carcinomas
    • Miettinen M. Keratin 20: immunohistochemical marker for gastrointestinal, urothelial, and Merkel cell carcinomas. Mod. Pathol. 1995; 8: 384-388.
    • (1995) Mod. Pathol. , vol.8 , pp. 384-388
    • Miettinen, M.1
  • 9
    • 0036857269 scopus 로고    scopus 로고
    • Expression of cytokeratins 7 and 20 in primary carcinomas of the stomach and colorectum and their value in the differential diagnosis of metastatic carcinomas to the ovary
    • Park SY, Kim HS, Hong EK, Kim WH. Expression of cytokeratins 7 and 20 in primary carcinomas of the stomach and colorectum and their value in the differential diagnosis of metastatic carcinomas to the ovary. Hum. Pathol. 2002; 33: 1078-1085.
    • (2002) Hum. Pathol. , vol.33 , pp. 1078-1085
    • Park, S.Y.1    Kim, H.S.2    Hong, E.K.3    Kim, W.H.4
  • 11
    • 33748636460 scopus 로고    scopus 로고
    • Colorectal cancer in U.S. adults younger than 50 years of age, 1998-2001
    • Fairley TL, Cardinez CJ, Martin J etal. Colorectal cancer in U.S. adults younger than 50 years of age, 1998-2001. Cancer 2006; 107 (Suppl. 5): 1153-1161.
    • (2006) Cancer , vol.107 , Issue.5 SUPPL. , pp. 1153-1161
    • Fairley, T.L.1    Cardinez, C.J.2    Martin, J.3
  • 12
    • 79961088717 scopus 로고    scopus 로고
    • Carcinoma of the colon and rectum
    • In: Bozman FT, Carneiro F, Hruban RH, Theise ND, eds., 4th edn. Lyon: IARC Press
    • Hamilton SR, Bosmann FT, Boffetta P etal. Carcinoma of the colon and rectum. In: Bozman FT, Carneiro F, Hruban RH, Theise ND, eds. WHO Classification of Tumours of the Digestive System, 4th edn. Lyon: IARC Press, 2010; 134-146.
    • (2010) WHO Classification of Tumours of the Digestive System , pp. 134-146
    • Hamilton, S.R.1    Bosmann, F.T.2    Boffetta, P.3
  • 13
    • 84897671518 scopus 로고    scopus 로고
    • American Joint Committee on Cancer. Colon and Rectum Cancer Staging, 7th edn. Cited 18 Oct 2012. Available from URL:
    • American Joint Committee on Cancer. Colon and Rectum Cancer Staging, 7th edn. 2009. Cited 18 Oct 2012. Available from URL: http://www.cancerstaging.org/staging/index.html
    • (2009)
  • 14
    • 0033847116 scopus 로고    scopus 로고
    • Colon signet ring cell adenocarcinoma: immunohistochemical characterization and comparison with gastric and typical colon adenocarcinomas
    • Goldstein NS, Long A, Kuan SF, Hart J. Colon signet ring cell adenocarcinoma: immunohistochemical characterization and comparison with gastric and typical colon adenocarcinomas. Appl. Immunohistochem. Mol. Morphol. 2000; 8: 183-188.
    • (2000) Appl. Immunohistochem. Mol. Morphol. , vol.8 , pp. 183-188
    • Goldstein, N.S.1    Long, A.2    Kuan, S.F.3    Hart, J.4
  • 15
    • 84857753342 scopus 로고    scopus 로고
    • Keratin 20-a diagnostic and prognostic marker in colorectal cancer?
    • Harbaum L, Pollheimer MJ, Kornprat P etal. Keratin 20-a diagnostic and prognostic marker in colorectal cancer? Histol. Histopathol. 2012; 27: 347-356.
    • (2012) Histol. Histopathol. , vol.27 , pp. 347-356
    • Harbaum, L.1    Pollheimer, M.J.2    Kornprat, P.3
  • 16
    • 34848842992 scopus 로고    scopus 로고
    • Selecting immunohistochemical cut-off scores for novel biomarkers of progression and survival in colorectal cancer
    • Zlobec I, Steele R, Terracciano L, Jass JR, Lugli A. Selecting immunohistochemical cut-off scores for novel biomarkers of progression and survival in colorectal cancer. J. Clin. Pathol. 2007; 60: 1112-1116.
    • (2007) J. Clin. Pathol. , vol.60 , pp. 1112-1116
    • Zlobec, I.1    Steele, R.2    Terracciano, L.3    Jass, J.R.4    Lugli, A.5
  • 17
    • 0032852979 scopus 로고    scopus 로고
    • Immunohistochemistry for hMLH1 and hMSH2: a practical test for DNA mismatch repair-deficient tumors
    • Marcus VA, Madlensky L, Gryfe R etal. Immunohistochemistry for hMLH1 and hMSH2: a practical test for DNA mismatch repair-deficient tumors. Am. J. Surg. Pathol. 1999; 23: 1248-1255.
    • (1999) Am. J. Surg. Pathol. , vol.23 , pp. 1248-1255
    • Marcus, V.A.1    Madlensky, L.2    Gryfe, R.3
  • 18
    • 12244282084 scopus 로고    scopus 로고
    • Expression of cytokeratins 7 and 20 in carcinomas of the gastrointestinal tract
    • Kende AI, Carr NJ, Sobin LH. Expression of cytokeratins 7 and 20 in carcinomas of the gastrointestinal tract. Histopathology 2003; 42: 137-140.
    • (2003) Histopathology , vol.42 , pp. 137-140
    • Kende, A.I.1    Carr, N.J.2    Sobin, L.H.3
  • 19
    • 33748082975 scopus 로고    scopus 로고
    • Cytokeratins 7 and 20 in primary and secondary mucinous tumors of the ovary: analysis of coordinate immunohistochemical expression profiles and staining distribution in 179 cases
    • Vang R, Gown AM, Barry TS etal. Cytokeratins 7 and 20 in primary and secondary mucinous tumors of the ovary: analysis of coordinate immunohistochemical expression profiles and staining distribution in 179 cases. Am. J. Surg. Pathol. 2006; 30: 1130-1139.
    • (2006) Am. J. Surg. Pathol. , vol.30 , pp. 1130-1139
    • Vang, R.1    Gown, A.M.2    Barry, T.S.3
  • 20
    • 79952452428 scopus 로고    scopus 로고
    • Cytokeratin 7 and cytokeratin 20 expression in colorectal adenocarcinomas
    • Bayrak R, Yenidünya S, Haltas H. Cytokeratin 7 and cytokeratin 20 expression in colorectal adenocarcinomas. Pathol. Res. Pract. 2011; 207: 156-160.
    • (2011) Pathol. Res. Pract. , vol.207 , pp. 156-160
    • Bayrak, R.1    Yenidünya, S.2    Haltas, H.3
  • 21
    • 57749112183 scopus 로고    scopus 로고
    • Differential diagnostic and functional role of the multi-marker phenotype CDX2/CK20/CK7 in colorectal cancer stratified by mismatch repair status
    • Lugli A, Tzankov A, Zlobec I, Terracciano LM. Differential diagnostic and functional role of the multi-marker phenotype CDX2/CK20/CK7 in colorectal cancer stratified by mismatch repair status. Mod. Pathol. 2008; 21: 1403-1412.
    • (2008) Mod. Pathol. , vol.21 , pp. 1403-1412
    • Lugli, A.1    Tzankov, A.2    Zlobec, I.3    Terracciano, L.M.4
  • 22
    • 10744233937 scopus 로고    scopus 로고
    • Revised Bethesda Guidelines for hereditary nonpolyposis colorectal cancer (Lynch syndrome) and microsatellite instability
    • Umar A, Boland CR, Terdiman JP etal. Revised Bethesda Guidelines for hereditary nonpolyposis colorectal cancer (Lynch syndrome) and microsatellite instability. J. Natl. Cancer Inst. 2004; 96: 261-268.
    • (2004) J. Natl. Cancer Inst. , vol.96 , pp. 261-268
    • Umar, A.1    Boland, C.R.2    Terdiman, J.P.3
  • 23
    • 2542476370 scopus 로고    scopus 로고
    • Reduced expression of cytokeratin 20 in colorectal carcinomas with high levels of microsatellite instability
    • McGregor DK, Wu TT, Rashid A, Luthra R, Hamilton SR. Reduced expression of cytokeratin 20 in colorectal carcinomas with high levels of microsatellite instability. Am. J. Surg. Pathol. 2004; 28: 712-718.
    • (2004) Am. J. Surg. Pathol. , vol.28 , pp. 712-718
    • McGregor, D.K.1    Wu, T.T.2    Rashid, A.3    Luthra, R.4    Hamilton, S.R.5
  • 24
    • 84859996800 scopus 로고    scopus 로고
    • CK20 expression enhances the invasiveness of tamoxifen-resistant MCF-7 cells
    • Min YS, Yi EH, Lee JK etal. CK20 expression enhances the invasiveness of tamoxifen-resistant MCF-7 cells. Anticancer Res. 2012; 32: 1221-1228.
    • (2012) Anticancer Res. , vol.32 , pp. 1221-1228
    • Min, Y.S.1    Yi, E.H.2    Lee, J.K.3
  • 25
    • 84880065915 scopus 로고    scopus 로고
    • Differential mucin phenotypes and their significance in a variation of colorectal carcinoma
    • Imai Y, Yamagishi H, Fukuda K, Ono Y, Inoue T, Ueda Y. Differential mucin phenotypes and their significance in a variation of colorectal carcinoma. World J. Gastroenterol. 2013; 19: 3957-3968.
    • (2013) World J. Gastroenterol. , vol.19 , pp. 3957-3968
    • Imai, Y.1    Yamagishi, H.2    Fukuda, K.3    Ono, Y.4    Inoue, T.5    Ueda, Y.6
  • 26
    • 17344392128 scopus 로고    scopus 로고
    • Molecular cloning, sequencing and expression of the mRNA encoding human Cdx1 and Cdx2 homeobox. Down-regulation of Cdx1 and Cdx2 mRNA expression during colorectal carcinogenesis
    • Mallo GV, Rechreche H, Frigerio JM etal. Molecular cloning, sequencing and expression of the mRNA encoding human Cdx1 and Cdx2 homeobox. Down-regulation of Cdx1 and Cdx2 mRNA expression during colorectal carcinogenesis. Int. J. Cancer 1997; 74: 35-44.
    • (1997) Int. J. Cancer , vol.74 , pp. 35-44
    • Mallo, G.V.1    Rechreche, H.2    Frigerio, J.M.3
  • 27
    • 0032737566 scopus 로고    scopus 로고
    • Cdx1 promotes differentiation in a rat intestinal epithelial cell line
    • Soubeyran P, André F, Lissitzky JC etal. Cdx1 promotes differentiation in a rat intestinal epithelial cell line. Gastroenterology 1999; 117: 1326-1338.
    • (1999) Gastroenterology , vol.117 , pp. 1326-1338
    • Soubeyran, P.1    André, F.2    Lissitzky, J.C.3
  • 28
    • 7244232714 scopus 로고    scopus 로고
    • CDX1 expression is reduced in colorectal carcinoma and is associated with promoter hypermethylation
    • Pilozzi E, Onelli MR, Ziparo V, Mercantini P, Ruco L. CDX1 expression is reduced in colorectal carcinoma and is associated with promoter hypermethylation. J. Pathol. 2004; 204: 289-295.
    • (2004) J. Pathol. , vol.204 , pp. 289-295
    • Pilozzi, E.1    Onelli, M.R.2    Ziparo, V.3    Mercantini, P.4    Ruco, L.5
  • 29
    • 0037184038 scopus 로고    scopus 로고
    • DNA methylation down-regulates CDX1 gene expression in colorectal cancer cell lines
    • Suh ER, Ha CS, Rankin EB, Toyota M, Traber PG. DNA methylation down-regulates CDX1 gene expression in colorectal cancer cell lines. J. Biol. Chem. 2002; 277: 35795-35800.
    • (2002) J. Biol. Chem. , vol.277 , pp. 35795-35800
    • Suh, E.R.1    Ha, C.S.2    Rankin, E.B.3    Toyota, M.4    Traber, P.G.5
  • 30
    • 0347635513 scopus 로고    scopus 로고
    • Loss of CDX1 expression in colorectal carcinoma: promoter methylation, mutation, and loss of heterozygosity analyses of 37 cell lines
    • Wong NA, Britton MP, Choi GS etal. Loss of CDX1 expression in colorectal carcinoma: promoter methylation, mutation, and loss of heterozygosity analyses of 37 cell lines. Proc. Natl. Acad. Sci. U.S.A. 2004; 101: 574-579.
    • (2004) Proc. Natl. Acad. Sci. U.S.A. , vol.101 , pp. 574-579
    • Wong, N.A.1    Britton, M.P.2    Choi, G.S.3
  • 31
    • 60549115231 scopus 로고    scopus 로고
    • Gastrointestinal differentiation marker Cytokeratin 20 is regulated by homeobox gene CDX1
    • Chan CW, Wong NA, Liu Y etal. Gastrointestinal differentiation marker Cytokeratin 20 is regulated by homeobox gene CDX1. Proc. Natl. Acad. Sci. U.S.A. 2009; 106: 1936-1941.
    • (2009) Proc. Natl. Acad. Sci. U.S.A. , vol.106 , pp. 1936-1941
    • Chan, C.W.1    Wong, N.A.2    Liu, Y.3
  • 33
    • 33745541234 scopus 로고    scopus 로고
    • CpG island methylator phenotype underlies sporadic microsatellite instability and is tightly associated with BRAF mutation in colorectal cancer
    • Weisenberger DJ, Siegmund KD, Campan M etal. CpG island methylator phenotype underlies sporadic microsatellite instability and is tightly associated with BRAF mutation in colorectal cancer. Nat. Genet. 2006; 38: 787-793.
    • (2006) Nat. Genet. , vol.38 , pp. 787-793
    • Weisenberger, D.J.1    Siegmund, K.D.2    Campan, M.3


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