-
1
-
-
0035822038
-
The hemophilias - from royal genes to gene therapy
-
Mannucci PM, Tuddenham EG. The hemophilias - from royal genes to gene therapy. N Engl J Med. 2001;344(23):1773-1779.
-
(2001)
N Engl J Med
, vol.344
, Issue.23
, pp. 1773-1779
-
-
Mannucci, P.M.1
Tuddenham, E.G.2
-
2
-
-
34547757915
-
Prophylaxis versus episodic treatment to prevent joint disease in boys with severe hemophilia
-
Manco-Johnson MJ, Abshire TC, Shapiro AD, et al. Prophylaxis versus episodic treatment to prevent joint disease in boys with severe hemophilia. N Engl J Med. 2007;357(6):535-544.
-
(2007)
N Engl J Med
, vol.357
, Issue.6
, pp. 535-544
-
-
Manco-Johnson, M.J.1
Abshire, T.C.2
Shapiro, A.D.3
-
3
-
-
79953306825
-
A randomized clinical trial of prophylaxis in children with hemophilia A (the ESPRIT Study)
-
ESPRIT Study Group
-
Gringeri A, Lundin B, von Mackensen S, Mantovani L, Mannucci PM; ESPRIT Study Group. A randomized clinical trial of prophylaxis in children with hemophilia A (the ESPRIT Study). J Thromb Haemost. 2011;9(4):700-710.
-
(2011)
J Thromb Haemost
, vol.9
, Issue.4
, pp. 700-710
-
-
Gringeri, A.1
Lundin, B.2
von Mackensen, S.3
Mantovani, L.4
Mannucci, P.M.5
-
4
-
-
59849093369
-
rAHF-PFM Study Group. Break-through bleeding in relation to predicted factor VIII levels in patients receiving prophylactic treatment for severe hemophilia A
-
Collins PW, Blanchette VS, Fischer K, et al; rAHF-PFM Study Group. Break-through bleeding in relation to predicted factor VIII levels in patients receiving prophylactic treatment for severe hemophilia A. J Thromb Haemost. 2009;7(3):413-420.
-
(2009)
J Thromb Haemost
, vol.7
, Issue.3
, pp. 413-420
-
-
Collins, P.W.1
Blanchette, V.S.2
Fischer, K.3
-
5
-
-
74749088081
-
Factor VIII requirement to maintain a target plasma level in the prophylactic treatment of severe hemophilia A: Influences of variance in pharmacokinetics and treatment regimens
-
Collins PW, Björkman S, Fischer K, et al. Factor VIII requirement to maintain a target plasma level in the prophylactic treatment of severe hemophilia A: influences of variance in pharmacokinetics and treatment regimens. J Thromb Haemost. 2010;8(2):269-275.
-
(2010)
J Thromb Haemost
, vol.8
, Issue.2
, pp. 269-275
-
-
Collins, P.W.1
Björkman, S.2
Fischer, K.3
-
6
-
-
78649903536
-
Venous access in the management of hemophilia
-
Valentino LA, Kawji M, Grygotis M. Venous access in the management of hemophilia. Blood Rev. 2011;25(1):11-15.
-
(2011)
Blood Rev
, vol.25
, Issue.1
, pp. 11-15
-
-
Valentino, L.A.1
Kawji, M.2
Grygotis, M.3
-
7
-
-
84859197329
-
Safety and prolonged activity of recombinant factor VIII Fc fusion protein in hemophilia A patients
-
Powell JS, Josephson NC, Quon D, et al. Safety and prolonged activity of recombinant factor VIII Fc fusion protein in hemophilia A patients. Blood. 2012;119(13):3031-3037.
-
(2012)
Blood
, vol.119
, Issue.13
, pp. 3031-3037
-
-
Powell, J.S.1
Josephson, N.C.2
Quon, D.3
-
8
-
-
84862908041
-
Recombinant factor IX-Fc fusion protein (rFIXFc) demonstrates safety and prolonged activity in a phase 1/2a study in hemophilia B patients
-
Shapiro AD, Ragni MV, Valentino LA, et al. Recombinant factor IX-Fc fusion protein (rFIXFc) demonstrates safety and prolonged activity in a phase 1/2a study in hemophilia B patients. Blood. 2012;119(3):666-672.
-
(2012)
Blood
, vol.119
, Issue.3
, pp. 666-672
-
-
Shapiro, A.D.1
Ragni, M.V.2
Valentino, L.A.3
-
9
-
-
84893123337
-
Phase 3 study of recombinant factor VIII Fc fusion protein in severe hemophilia A
-
Mahlangu J, Powell JS, Ragni MV, et al. Phase 3 study of recombinant factor VIII Fc fusion protein in severe hemophilia A. Blood. 2014;123:317-325.
-
(2014)
Blood
, vol.123
, pp. 317-325
-
-
Mahlangu, J.1
Powell, J.S.2
Ragni, M.V.3
-
10
-
-
84889769562
-
Phase 3 study of recombinant factor IX Fc fusion protein in hemophilia B
-
Powell JS, Pasi KJ, Ragni MV, et al. Phase 3 study of recombinant factor IX Fc fusion protein in hemophilia B. N Engl J Med. 2013;369:2313-2323.
-
(2013)
N Engl J Med
, vol.369
, pp. 2313-2323
-
-
Powell, J.S.1
Pasi, K.J.2
Ragni, M.V.3
-
11
-
-
0029900294
-
Treatment of septic shock with the tumor necrosis factor receptor:Fc fusion protein. The Soluble TNF Receptor Sepsis Study Group
-
Fisher CJ, Agosti JM, Opal SM, et al. Treatment of septic shock with the tumor necrosis factor receptor:Fc fusion protein. The Soluble TNF Receptor Sepsis Study Group. N Engl J Med. 1996;334(26):1697-1702.
-
(1996)
N Engl J Med
, vol.334
, Issue.26
, pp. 1697-1702
-
-
Fisher, C.J.1
Agosti, J.M.2
Opal, S.M.3
-
12
-
-
0035954670
-
Treatment of chronic plaque psoriasis by selective targeting of memory effector T lymphocytes
-
Alefacept Clinical Study Group
-
Ellis CN, Krueger GG; Alefacept Clinical Study Group. Treatment of chronic plaque psoriasis by selective targeting of memory effector T lymphocytes. N Engl J Med. 2001;345(4):248-255.
-
(2001)
N Engl J Med
, vol.345
, Issue.4
, pp. 248-255
-
-
Ellis, C.N.1
Krueger, G.G.2
-
13
-
-
24944498854
-
Abatacept for rheumatoid arthritis refractory to tumor necrosis factor alpha inhibition
-
Genovese MC, Becker JC, Schiff M, et al. Abatacept for rheumatoid arthritis refractory to tumor necrosis factor alpha inhibition. N Engl J Med. 2005;353(11):1114-1123.
-
(2005)
N Engl J Med
, vol.353
, Issue.11
, pp. 1114-1123
-
-
Genovese, M.C.1
Becker, J.C.2
Schiff, M.3
-
14
-
-
0030880901
-
Expression of the neonatal Fc receptor, FcRn, on human intestinal epithelial cells
-
Israel EJ, Taylor S, Wu Z, et al. Expression of the neonatal Fc receptor, FcRn, on human intestinal epithelial cells. Immunology. 1997;92(1): 69-74.
-
(1997)
Immunology
, vol.92
, Issue.1
, pp. 69-74
-
-
Israel, E.J.1
Taylor, S.2
Wu, Z.3
-
15
-
-
0037025895
-
Receptor-mediated immunoglobulin G transport across mucosal barriers in adult life: Functional expression of FcRn in the mammalian lung
-
Spiekermann GM, Finn PW, Ward ES, et al. Receptor-mediated immunoglobulin G transport across mucosal barriers in adult life: functional expression of FcRn in the mammalian lung. J Exp Med. 2002;196(3): 303-310.
-
(2002)
J Exp Med
, vol.196
, Issue.3
, pp. 303-310
-
-
Spiekermann, G.M.1
Finn, P.W.2
Ward, E.S.3
-
16
-
-
0034023794
-
Characterization and localization of the neonatal Fc receptor in adult human kidney
-
Haymann JP, Levraud JP, Bouet S, et al. Characterization and localization of the neonatal Fc receptor in adult human kidney. J Am Soc Nephrol. 2000;11(4):632-639.
-
(2000)
J Am Soc Nephrol
, vol.11
, Issue.4
, pp. 632-639
-
-
Haymann, J.P.1
Levraud, J.P.2
Bouet, S.3
-
17
-
-
0035113258
-
Expression of functionally active FcRn and the differentiated bidirectional transport of IgG in human placental endothelial cells
-
Antohe F, Rǎdulescu L, Gafencu A, Gheţie V, Simionescu M. Expression of functionally active FcRn and the differentiated bidirectional transport of IgG in human placental endothelial cells. Hum Immunol. 2001;62(2):93-105.
-
(2001)
Hum Immunol
, vol.62
, Issue.2
, pp. 93-105
-
-
Antohe, F.1
Rǎdulescu, L.2
Gafencu, A.3
Gheţie, V.4
Simionescu, M.5
-
18
-
-
0037325779
-
Evidence to support the cellular mechanism involved in serum IgG homeostasis in humans
-
Ward ES, Zhou J, Ghetie V, Ober RJ. Evidence to support the cellular mechanism involved in serum IgG homeostasis in humans. Int Immunol. 2003;15(2):187-195.
-
(2003)
Int Immunol
, vol.15
, Issue.2
, pp. 187-195
-
-
Ward, E.S.1
Zhou, J.2
Ghetie, V.3
Ober, R.J.4
-
19
-
-
0842343448
-
Visualizing the site and dynamics of IgG salvage by the MHC class I-related receptor, FcRn
-
Ober RJ, Martinez C, Vaccaro C, Zhou J, Ward ES. Visualizing the site and dynamics of IgG salvage by the MHC class I-related receptor, FcRn. J Immunol. 2004;172(4):2021-2029.
-
(2004)
J Immunol
, vol.172
, Issue.4
, pp. 2021-2029
-
-
Ober, R.J.1
Martinez, C.2
Vaccaro, C.3
Zhou, J.4
Ward, E.S.5
-
20
-
-
11844250025
-
A passionate kiss, then run: Exocytosis and recycling of IgG by FcRn
-
Lencer WI, Blumberg RS. A passionate kiss, then run: exocytosis and recycling of IgG by FcRn. Trends Cell Biol. 2005;15(1):5-9.
-
(2005)
Trends Cell Biol
, vol.15
, Issue.1
, pp. 5-9
-
-
Lencer, W.I.1
Blumberg, R.S.2
-
21
-
-
0020541752
-
Intracellular distribution and degradation of immunoglobulin G and immunoglobulin G fragments injected into HeLa cells
-
McGarry T, Hough R, Rogers S, Rechsteiner M. Intracellular distribution and degradation of immunoglobulin G and immunoglobulin G fragments injected into HeLa cells. J Cell Biol. 1983;96(2):338-346.
-
(1983)
J Cell Biol
, vol.96
, Issue.2
, pp. 338-346
-
-
McGarry, T.1
Hough, R.2
Rogers, S.3
Rechsteiner, M.4
-
22
-
-
0026601671
-
A study of macromolecular diffusion through native porcine mucus
-
Desai MA, Mutlu M, Vadgama P. A study of macromolecular diffusion through native porcine mucus. Experientia. 1992;48(1):22-26.
-
(1992)
Experientia
, vol.48
, Issue.1
, pp. 22-26
-
-
Desai, M.A.1
Mutlu, M.2
Vadgama, P.3
-
23
-
-
3042795848
-
Pulmonary delivery of an erythropoietin Fc fusion protein in non-human primates through an immunoglobulin transport pathway
-
Bitonti AJ, Dumont JA, Low SC, et al. Pulmonary delivery of an erythropoietin Fc fusion protein in non-human primates through an immunoglobulin transport pathway. Proc Natl Acad Sci U S A. 2004;101(26): 9763-9768.
-
(2004)
Proc Natl Acad Sci U S A
, vol.101
, Issue.26
, pp. 9763-9768
-
-
Bitonti, A.J.1
Dumont, J.A.2
Low, S.C.3
-
24
-
-
77950391547
-
Prolonged activity of factor IX as a monomeric Fc fusion protein
-
Peters RT, Low SC, Kamphaus GD, et al. Prolonged activity of factor IX as a monomeric Fc fusion protein. Blood. 2010;115(10):2057-2064.
-
(2010)
Blood
, vol.115
, Issue.10
, pp. 2057-2064
-
-
Peters, R.T.1
Low, S.C.2
Kamphaus, G.D.3
-
25
-
-
0033012077
-
Etanercept, a novel drug for the treatment of patients with severe, active rheumatoid arthritis
-
discussion 1-2
-
Goldenberg MM. Etanercept, a novel drug for the treatment of patients with severe, active rheumatoid arthritis. Clin Ther. 1999;21(1):75-87.discussion 1-2.
-
(1999)
Clin Ther
, vol.21
, Issue.1
, pp. 75-87
-
-
Goldenberg, M.M.1
-
26
-
-
84859192874
-
Prolonged activity of a recombinant factor VIII-Fc fusion protein in hemophilia A mice and dogs
-
Dumont JA, Liu T, Low SC, et al. Prolonged activity of a recombinant factor VIII-Fc fusion protein in hemophilia A mice and dogs. Blood. 2012;119(13):3024-3030.
-
(2012)
Blood
, vol.119
, Issue.13
, pp. 3024-3030
-
-
Dumont, J.A.1
Liu, T.2
Low, S.C.3
-
27
-
-
84873043409
-
Biochemical and functional characterization of a recombinant monomeric factor VIII-Fc fusion protein
-
Peters RT, Toby G, Lu Q, et al. Biochemical and functional characterization of a recombinant monomeric factor VIII-Fc fusion protein. J Thromb Haemost. 2013;11(1):132-141.
-
(2013)
J Thromb Haemost
, vol.11
, Issue.1
, pp. 132-141
-
-
Peters, R.T.1
Toby, G.2
Lu, Q.3
-
28
-
-
84861642572
-
Human cells: New platform for recombinant therapeutic protein production
-
Swiech K, Picanço-Castro V, Covas DT. Human cells: new platform for recombinant therapeutic protein production. Protein Expr Purif. 2012;84(1):147-153.
-
(2012)
Protein Expr Purif
, vol.84
, Issue.1
, pp. 147-153
-
-
Swiech, K.1
Picanço-Castro, V.2
Covas, D.T.3
-
29
-
-
84860912187
-
Production platforms for biotherapeutic glycoproteins. Occurrence, impact, and challenges of non-human sialylation
-
Ghaderi D, Zhang M, Hurtado-Ziola N, Varki A. Production platforms for biotherapeutic glycoproteins. Occurrence, impact, and challenges of non-human sialylation. Biotechnol Genet Eng Rev. 2012;28: 147-175.
-
(2012)
Biotechnol Genet Eng Rev
, vol.28
, pp. 147-175
-
-
Ghaderi, D.1
Zhang, M.2
Hurtado-Ziola, N.3
Varki, A.4
-
31
-
-
0035895058
-
Recombinant Factor IX Study Group. Human recombinant factor IX: Safety and efficacy studies in hemophilia B patients previously treated with plasma-derived factor IX concentrates
-
Roth DA, Kessler CM, Pasi KJ, Rup B, Courter SG, Tubridy KL; Recombinant Factor IX Study Group. Human recombinant factor IX: safety and efficacy studies in hemophilia B patients previously treated with plasma-derived factor IX concentrates. Blood. 2001;98(13): 3600-3606.
-
(2001)
Blood
, vol.98
, Issue.13
, pp. 3600-3606
-
-
Roth, D.A.1
Kessler, C.M.2
Pasi, K.J.3
Rup, B.4
Courter, S.G.5
Tubridy, K.L.6
-
32
-
-
84897488040
-
-
Biogen Idec. Study of Recombinant Coagulation Factor VIII Fc Fusion Protein, BIIB 031, in Pediatric PTP Subjects With Hemophilia A. Updated December 12, 2013. Available from, NLM identifier: NCT01458106. Accessed February 17, 2014
-
Biogen Idec. Study of Recombinant Coagulation Factor VIII Fc Fusion Protein, BIIB 031, in Pediatric PTP Subjects With Hemophilia A. Updated December 12, 2013. Available from: http://clinicaltrials.gov/show/NCT01458106. NLM identifier: NCT01458106. Accessed February 17, 2014.
-
-
-
-
33
-
-
84897551652
-
-
ClinicalTrials.gov. Long-Term Safety and Efficacy of Recombinant Human Coagulation Factor VIII Fusion Protein (rFVIIIFc) in the Prevention and Treatment of Bleeding Episodes in Previously Treated Subjects With Hemophilia A. Last updated September 12, 2013. Available from
-
ClinicalTrials.gov. Long-Term Safety and Efficacy of Recombinant Human Coagulation Factor VIII Fusion Protein (rFVIIIFc) in the Prevention and Treatment of Bleeding Episodes in Previously Treated Subjects With Hemophilia A. Last updated September 12, 2013. Available from: http://clinicaltrials.gov/show/NCT01454739.
-
-
-
-
34
-
-
84897488823
-
-
ClinicalTrials.gov. Study of Recombinant Coagulation Factor IX Fc Fusion Protein, BIIB 029, in Pediatric PTP Subjects With Hemophilia B. Updated September 12, 2013. Available from
-
ClinicalTrials.gov. Study of Recombinant Coagulation Factor IX Fc Fusion Protein, BIIB 029, in Pediatric PTP Subjects With Hemophilia B. Updated September 12, 2013. Available from: http://clinicaltrials.gov/show/NCT01440946.
-
-
-
-
35
-
-
84897530973
-
-
ClinicalTrials.gov. Long-Term Safety and Efficacy of Recombinant Human Coagulation Factor IX Fusion Protein (rFIXFc) in the Prevention and Treatment of Bleeding Episodes in Previously Treated Subjects With Hemophilia B (B-YOND). Last updated September 12, 2013. Available from
-
ClinicalTrials.gov. Long-Term Safety and Efficacy of Recombinant Human Coagulation Factor IX Fusion Protein (rFIXFc) in the Prevention and Treatment of Bleeding Episodes in Previously Treated Subjects With Hemophilia B (B-YOND). Last updated September 12, 2013. Available from: http://clinicaltrials.gov/show/NCT01425723.
-
-
-
-
36
-
-
84866594053
-
Safety and pharmacokinetics of a novel recombinant fusion protein linking coagulation factor IX with albumin (rIX-FP) in hemophilia B patients
-
Santagostino E, Negrier C, Klamroth R, et al. Safety and pharmacokinetics of a novel recombinant fusion protein linking coagulation factor IX with albumin (rIX-FP) in hemophilia B patients. Blood. 2012;120(12):2405-2411.
-
(2012)
Blood
, vol.120
, Issue.12
, pp. 2405-2411
-
-
Santagostino, E.1
Negrier, C.2
Klamroth, R.3
|