Ocimum sanctum L. a potential angiotensin converting enzyme (ACE) inhibitor useful in hypertension

Indian Journal of Natural Products and Resources

Volumn 5, Issue 1, 2014, Pages 83-87

  Chaudhary, Sushil Kumar ^a   Mukherjee, Pulok K ^a   Maity, Niladri ^a   Nema, Neelesh K ^a   Bhadra, Santanu ^a   Saha, Bishnu Pada ^a  

^a JADAVPUR UNIVERSITY   (India)

Author keywords

ACE inhibition; Antioxidant; Eugenol; HPLC; Ocimum sanctum L.

Indexed keywords

EID: 84897559643     PISSN: 09760504     EISSN: 09760512     Source Type: Journal    
DOI: None     Document Type: Article

References (16)

1. Jung W K, Mendis E, Je J Y, Park P J, Son B W, Kim Hyoung Chin, Choi Yang Kyu and Kim Se-Kwon, Angiotensin I-converting enzyme inhibitory peptide from yellowfin sole (Limanda aspera) frame protein and its antihypertensive effect in spontaneously hypertensive rats, Food Chem, 2006, 94, 26-32.
2. Adeneye AA, Ajagbonna OP, Mojiminiyi FBO, Odigie IP, Etarrh RR, Ojobor PD, Adeneye AK, The hypotensive mechanisms for the aqueous stem bark extract of Musanga cecropioides in Sprague-Dawley rats, J Ethnopharmacol, 2006, 106, 203-207.
3. Opie L H. Angiotensin Converting Enzyme Inhibitors: Scientific Basis for Clinical Use, John Wiley and Sons, New York, 1992, 259.
4. Williams LAD, Gossell-Williams M, Sajabi A, Barton E N and Fleischhacker R, Angiotensin Converting Enzyme Inhibiting and Anti-dipsogenic activities of Euphorbia hirta extracts, Phytother Res, 1997, 11, 401-402.
5. Kizhakekuttu T J and Widlansky M E, Natural antioxidants and hypertension: promise and challenges, Cardiovasc Ther, 2010, 28, 20-32.
6. Jung H A, Hyun S K, Kim H R and Choi J S, Angiotensinconverting enzyme I inhibitory activity of phlorotannins from Ecklonia stolonifera, Fisheries Sci, 2006, 72, 1292-1299.
7. Prakash P and Gupta N, Therapeutic uses of Ocimum sanctum Linn. (Tulsi) with a note on eugenol and its pharmacological actions: a short review, Indian J Physiol Pharmacol, 2005, 49, 125-131.
8. Sethi J, Sood S, Seth S and Talwar A, Evaluation of hypoglycemic and antioxidant effect of Ocimum sanctum, Indian J Clin Biochem, 2004, 19, 152-55.
9. Rai V, Iyer U and Mani, UV, Effect of Tulasi (Ocimum sanctum) leaf powder supplementation on blood sugar levels, serum lipids and tissue lipids in diabetic rats, Plant food Hum Nutr, 1997, 50, 9-16.
10. Padalia R C and Verma R S, Comparative volatile oil composition of four Ocimum species from northern India, Nat Prod Res, 2011, 25, 569-575.
11. Cheung H S and Cushman D W, Inhibition of homogeneous angiotensin-converting enzyme of rabbit lung by synthetic venom peptides of Bothrops jararaca, Biochim Biophys Acta, 1973, 293, 451-463.
12. Chaudhary SK, Mukherjee PK, Nema NK Bhadra S and Saha BP, ACE inhibiton activity of standardized extract and fractions of Terminalia bellerica, Orient Pharm Exp Med, 2012, 12, 273-277.
13. Park E J and Jhon DY, The antioxidant, angiotensin converting enzyme inhibition activity and phenolic compounds of bamboo shoot extracts, LWT-Food Sci Technol, 2009, 30, 1-5.
14. Wahile A, Mukherjee K, Kumar V, Saha B P and Mukherjee P K, Antioxidant's potentials of Hypericum hookerianum (Hypericaceae) on CCl4 induced hepatotoxicity in rats, Orient Pharm Exp Med. 2007, 7, 85-93.
15. Bhadra S, Mukherjee P K, Kumar N S and Bandyopadhyay A, Anticholinesterase activity of standardized extract of Illicium verum Hook. f., fruits, Fitoterapia, 2011, 82, 342-346.
16. Kothari S K, Bhattacharya A K and Ramesh S, Essential oil yield and quality of methyl eugenol rich Ocimum tenuiflorum L.f. (syn. O. sanctum L.) grown in South India as influenced by method of harvest, J Chromatogr A, 2004, 1054, 67-72.