Novel specific microRNA biomarkers in idiopathic inflammatory bowel disease unrelated to disease activity

Modern Pathology

Volumn 27, Issue 4, 2014, Pages 602-608

  Lin, Jingmei ^a   Welker, Noah C ^b   Zhao, Zijin ^a   Li, Yong ^a   Zhang, Jianjun ^c   Reuss, Sarah A ^a   Zhang, Xinjun ^a   Lee, Hwajeong ^d   Liu, Yunlong ^a   Bronner, Mary P ^b  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b ARUP LABORATORIES   (United States)

^c Department of Public Health ^*  (United States)

^d ALBANY MEDICAL CENTER   (United States)

Author keywords

colon; Crohn disease; idiopathic inflammatory bowel disease; microRNA; miR 31; next generation sequencing; ulcerative colitis

Indexed keywords

BIOLOGICAL MARKER; MICRORNA; MICRORNA 146A; MICRORNA 206; MICRORNA 31; MICRORNA 424; UNCLASSIFIED DRUG; GENETIC MARKER; MIRN146 MICRORNA, HUMAN; MIRN206 MICRORNA, HUMAN; MIRN31 MICRORNA, HUMAN; MIRN424 MICRORNA, HUMAN;

ADULT; ARTICLE; CLINICAL ARTICLE; COLON RESECTION; CONTROLLED STUDY; CROHN DISEASE; DISEASE ACTIVITY; DIVERTICULOSIS; FEMALE; FROZEN SECTION; HUMAN; HUMAN TISSUE; IDIOPATHIC DISEASE; INFLAMMATORY BOWEL DISEASE; ISCHEMIC COLITIS; MALE; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA SEQUENCE; ULCERATIVE COLITIS; VALIDATION STUDY; ADOLESCENT; AGED; CASE CONTROL STUDY; COLITIS, ULCERATIVE; DIFFERENTIAL DIAGNOSIS; GENE EXPRESSION PROFILING; GENETIC MARKER; GENETIC PREDISPOSITION; GENETICS; MIDDLE AGED; PHENOTYPE; PREDICTIVE VALUE; SEQUENCE ANALYSIS; SEVERITY OF ILLNESS INDEX; VERY ELDERLY; YOUNG ADULT;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; CASE-CONTROL STUDIES; COLITIS, ULCERATIVE; CROHN DISEASE; DIAGNOSIS, DIFFERENTIAL; FEMALE; GENE EXPRESSION PROFILING; GENETIC MARKERS; GENETIC PREDISPOSITION TO DISEASE; HUMANS; MALE; MICRORNAS; MIDDLE AGED; PHENOTYPE; PREDICTIVE VALUE OF TESTS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SEQUENCE ANALYSIS, RNA; SEVERITY OF ILLNESS INDEX; YOUNG ADULT;

EID: 84897546925     PISSN: 08933952     EISSN: 15300285     Source Type: Journal    
DOI: 10.1038/modpathol.2013.152     Document Type: Article

References (23)

1. Xavier RJ, Podolsky DK. Unravelling the pathogenesis of inflammatory bowel disease. Nature 2007;448: 427-434.
2. Kugathasan S, Amre D. Inflammatory bowel disease-environmental modification and genetic determinants. Pediatr Clin North Am 2006;53:727-749.
3. Lawrance IC, Fiocchi C, Chakravarti S. Ulcerative colitis and Crohn's disease: distinctive gene expression profiles and novel susceptibility candidate genes. Hum Mol Genet 2001;10:445-456.
4. Abraham C, Cho JH. Inflammatory bowel disease. N Engl J Med 2009;361:2066-2078.
5. Ambros V. The functions of animal microRNAs. Nature 2004;431:350-355.
6. Bartel DP. MicroRNAs: target recognition and regulatory functions. Cell 2009;136:215-233.
7. Saini HK, Enright AJ, Griffiths-Jones S. Annotation of mammalian primary microRNAs. BMC Genomics 2008;9:564.
8. Lin J, Cao Q, Zhang J, et al. MicroRNA expression patterns in indeterminate inflammatory bowel disease. Mod Pathol 2013;26:148-154.
9. Takagi T, Naito Y, Mizushima K, et al. Increased intestinal expression of heme oxygenase-1 and its localization in patients with ulcerative colitis. J Gastroenterol Hepatol 2008;23(suppl 2):S229-S233.
10. Wu F, Zhang S, Dassopoulos T, et al. Identification of microRNAs associated with ileal and colonic Crohn's disease. Inflamm Bowel Dis 2010;16:1729-1738.
11. Wu F, Zikusoka M, Trindade A, et al. MicroRNAs are differentially expressed in ulcerative colitis and alter expression of macrophage inflammatory peptide-2 alpha. Gastroenterology 2008;135:1624-1635; e24.
12. Duttagupta R, DiRienzo S, Jiang R, et al. Genome-wide maps of circulating miRNA biomarkers for ulcerative colitis. PLoS ONE 2012;7:e31241.
13. Fasseu M, Treton X, Guichard C, et al. Identification of restricted subsets of mature microRNA abnormally expressed in inactive colonic mucosa of patients with inflammatory bowel disease. PLoS ONE 2010;5: pii: e13160.
14. Fujino S, Andoh A, Bamba S, et al. Increased expression of interleukin 17 in inflammatory bowel disease. Gut 2003;52:65-70.
15. Zhang T, Song B, ZhuW, et al. An ileal Crohn's disease gene signature based on whole human genome expression profiles of disease unaffected ileal mucosal biopsies. PLoS ONE 2012;7:e37139.
16. Mesko B, Poliska S, Szegedi A, et al. Peripheral blood gene expression patterns discriminate among chronic inflammatory diseases and healthy controls and identify novel targets. BMC Med Genomics 2010;3:15.
17. Berberian LS, Valles-Ayoub Y, Gordon LK, et al. Expression of a novel autoantibody defined by the VH3-15 gene in inflammatory bowel disease and Campylobacter jejuni enterocolitis. J Immunol 1994; 153:3756-3763.
18. Clark PM, Dawany N, Dampier W, et al. Bioinformatics analysis reveals transcriptome and microRNA signatures and drug repositioning targets for IBD and other autoimmune diseases. Inflamm Bowel Dis 2012;18: 2315-2333.
19. Landgraf P, Rusu M, Sheridan R, et al. A mammalian microRNA expression atlas based on small RNA library sequencing. Cell 2007;129:1401-1414.
20. Grimson A, Farh KK, Johnston WK, et al. MicroRNA targeting specificity in mammals: determinants beyond seed pairing. Mol Cell 2007;27:91-105.
21. Olaru AV, Selaru FM, Mori Y, et al. Dynamic changes in the expression of MicroRNA-31 during inflammatory bowel disease-associated neoplastic transformation. Inflamm Bowel Dis 2011;17:221-231.
22. Valastyan S, Weinberg RA. miR-31: a crucial overseer of tumor metastasis and other emerging roles. Cell Cycle 2010;9:2124-2129.
23. Jiang W, Shadrach B, Carver P, et al. Histomorphologic and molecular features of pouch and peripouch adenocarcinoma: a comparison with ulcerative colitisassociated adenocarcinoma. Am J Surg Pathol 2012; 36:1385-1394.