Matrine inhibits proliferation and induces apoptosis of human colon cancer LoVo cells by inactivating Akt pathway

Molecular Biology Reports

Volumn 41, Issue 4, 2014, Pages 2101-2108

  Zhang, Shujun ^a   Cheng, Binglin ^b   Li, Hali ^b   Xu, Wei ^b   Zhai, Bo ^b   Pan, Shangha ^b   Wang, Lei ^a   Liu, Ming ^a   Sun, Xueying ^b  

^a HARBIN MEDICAL UNIVERSITY   (China)

^b THE FIRST AFFILIATED HOSPITAL OF HARBIN MEDICAL UNIVERSITY   (China)

Author keywords

Akt pathway; Apoptosis; Cell cycle; LoVo cells; Matrine

Indexed keywords

CASPASE 9; MATRINE; PROTEIN BAX; PROTEIN BCL 2; PROTEIN KINASE B; PROTEIN P21; PROTEIN P27; ALKALOID; QUINOLIZINE DERIVATIVE;

ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CANCER INHIBITION; CELL CYCLE ARREST; CELL PROLIFERATION; COLON CANCER; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME INACTIVATION; HUMAN; HUMAN CELL; IC 50; UPREGULATION; CELL CYCLE CHECKPOINT; COLON TUMOR; DOSE RESPONSE; DRUG EFFECTS; METABOLISM; SIGNAL TRANSDUCTION; TUMOR CELL LINE;

ALKALOIDS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; CELL CYCLE CHECKPOINTS; CELL LINE, TUMOR; CELL PROLIFERATION; COLONIC NEOPLASMS; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; PROTO-ONCOGENE PROTEINS C-AKT; PROTO-ONCOGENE PROTEINS C-BCL-2; QUINOLIZINES; SIGNAL TRANSDUCTION;

EID: 84897537501     PISSN: 03014851     EISSN: 15734978     Source Type: Journal    
DOI: 10.1007/s11033-014-3059-z     Document Type: Article

References (38)

1. Zhang S, Zhang Y, Zhuang Y, Wang J, Ye J, Zhang S, Wu J, Yu K, Han Y (2012) Matrine induces apoptosis in human acute myeloid leukemia cells via the mitochondrial pathway and Akt inactivation. PLoS One 7:e46853
2. Long Y, Lin XT, Zeng KL, Zhang L (2004) Efficacy of intramuscular matrine in the treatment of chronic hepatitis B. Hepatobiliary Pancreat Dis Int 3:69-72 (Pubitemid 38256128)
3. Zhang JP, Zhang M, Zhou JP, Liu FT, Zhou B, Xie WF, Guo C (2001) Antifibrotic effects of matrine on in vitro and in vivo models of liver fibrosis in rats. Acta Pharmacol Sin 22:183-186 (Pubitemid 32158359)
4. Liu JY, Hu JH, Zhu QG, Li FQ, Wang J, Sun HJ (2007) Effect of matrine on the expression of substance P receptor and inflammatory cytokines production in human skin keratinocytes and fibroblasts. Int Immunopharmacol 7:816-823 (Pubitemid 46635279)
5. Li X, Chu W, Liu J, Xue X, Lu Y, Shan H, Yang B (2009) Antiarrhythmic properties of long-term treatment with matrine in arrhythmic rat induced by coronary ligation. Biol Pharm Bull 32:1521-1526
6. Zhang L, Wang T, Wen X, Wei Y, Peng X, Li H, Wei L (2007) Effect of matrine on HeLa cell adhesion and migration. Eur J Pharmacol 563:69-76 (Pubitemid 46602230)
7. Liu XS, Jiang J, Jiao XY, Wu YE, Lin JH (2006) Matrine-induced apoptosis in leukemia U937 cells: involvement of caspases activation and MAPK-independent pathways. Planta Med 72:501-506 (Pubitemid 43844676)
8. Liu XS, Jiang J (2006) Molecular mechanism of matrine- induced apoptosis in leukemia K562 Cells. Am J Chin Med 34:1095-1103 (Pubitemid 44921253)
9. Jiang H, Hou C, Zhang S, Xie H, Zhou W, Jin Q, Cheng X, Qian R, Zhang X (2007) Matrine upregulates the cell cycle protein E2F-1 and triggers apoptosis via the mitochondrial pathway in K562 cells. Eur J Pharmacol 559:98-108 (Pubitemid 46295409)
10. Luo C, Zhu Y, Jiang T, Lu X, Zhang W, Jing Q, Li J, Pang L, Chen K, Qiu F, Yu X, Yang J, Huang J (2007) Matrine induced gastric cancer MKN45 cells apoptosis via increasing pro-apoptotic molecules of Bcl-2 family. Toxicology 229:245-252 (Pubitemid 44937494)
11. Dai ZJ, Gao J, Ji ZZ, Wang XJ, Ren HT, Liu XX, Wu WY, Kang HF, Guang H (2009) Matrine induces apoptosis in gastric carcinoma cells via alteration of Fas/FasL and activation of caspase-3. J Ethnopharmacol 123:91-96
12. Luo C, Zhong HJ, Zhu LM, Wu XG, Ying JE, Wang XH, Lü WX, Xu Q, Zhu YL, Huang J (2012) Inhibition of matrine against gastric cancer cell line MNK45 growth and its anti-tumor mechanism. Mol Biol Rep 39:5459-5464
13. Zhang Y, Zhang H, Yu P, Liu Q, Liu K, Duan H, Luan G, Yagasaki K, Zhang G (2009) Effects of matrine against the growth of human lung cancer and hepatoma cells as well as lung cancer cell migration. Cytotechnology 59:191-200
14. Yu P, Liu Q, Liu K, Yagasaki K, Wu E, Zhang G (2009) Matrine suppresses breast cancer cell proliferation and invasion via VEGF-Akt-NF-kappaB signaling. Cytotechnology 59:219-229
15. Li LQ, Li XL, Wang L, Du WJ, Guo R, Liang HH, Liu X, Liang DS, Lu YJ, Shan HL, Jiang HC (2012) Matrine Inhibits Breast Cancer Growth Via miR-21/PTEN/Akt Pathway in MCF-7 Cells. Cell Physiol Biochem 30:631-641
16. Yu P, Liu Q, Liu K, Yagasaki K, Wu E (2009) Matrine suppresses breast cancer cell proliferation and invasion via VEGF-Akt-NF-kappaB signaling. Cytotechnology 59:219-229
17. Liu XY, Fang H, Yang ZG, Wang XY, Ruan LM, Fang DR, Ding YG, Wang YN, Zhang Y, Jiang XL, Chen HC (2008) Matrine inhibits invasiveness and metastasis of human malignant melanoma cell line A375 in vitro. Int J Dermatol 47:448-456 (Pubitemid 351560308)
18. Zhang Z, Wang X, Wu W, Wang J, Wang Y, Wu X, Fei X, Li S, Zhang J, Dong P, Gu J, Liu Y (2012) Effects of matrine on proliferation and apoptosis in gallbladder carcinoma cells (GBC-SD). Phytother Res 26:932-937
19. Zhang P, Wang Z, Chong T, Ji Z (2012) Matrine inhibits proliferation and induces apoptosis of the androgen-independent prostate cancer cell line PC-3. Mol Med Rep 5:783-787
20. Liang CZ, Zhang JK, Shi Z, Liu B, Shen CQ, Tao HM (2012) Matrine induces caspase-dependent apoptosis in human osteosarcoma cells in vitro and in vivo through the upregulation of Bax and Fas/FasL and downregulation of Bcl-2. Cancer Chemother Pharmacol 69:317-331
21. Ma L, Wen S, Zhan Y, He Y, Liu X, Jiang J (2008) Anticancer effects of the Chinese medicine matrine on murine hepatocellular carcinoma cells. Planta Med 74:245-251 (Pubitemid 351449946)
22. Zhang S, Qi J, Sun L, Cheng B, Pan S, Zhou M, Sun X (2009) Matrine induces programmed cell death and regulates expression of relevant genes based on PCR array analysis in C6 glioma cells. Mol Biol Rep 35:421-429
23. Li H, Tan G, Jiang X, Qiao H, Pan S, Jiang H, Kanwar JR, Sun X (2010) Matrine inhibits growth of primary and metastatic breast cancer in mice. Am J Chin Med 38:1115-1130
24. Liu T, Song Y, Chen H, Pan S, Sun X (2010) Matrine inhibits proliferation and induces apoptosis of pancreatic cancer cells in vitro and in vivo. Biol Pharm Bull 33:1740-1745
25. Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D (2011) Global cancer statistics. CA Cancer J Clin 61:69-90
26. He C, Sun XP, Qiao H, Jiang X, Wang D, Jin X, Dong X, Wang J, Jiang H, Sun X (2012) Downregulating Hypoxia-inducible factor-2α improves the efficacy of doxorubicin to treat hepatocellular carcinoma. Cancer Sci 103:528-534
27. Manning BD, Cantley LC (2007) AKT/PKB signaling: navigating downstream. Cell 129:1261-1274 (Pubitemid 46962095)
28. Dieterle A, Orth R, Daubrawa M, Grotemeier A, Alers S, Ullrich S, Lammers R, Wesselborg S, Stork B (2009) The Akt inhibitor triciribine sensitizes prostate carcinoma cells to TRAIL-induced apoptosis. Int J Cancer 125:932-941
29. Zheng WH, Quirion R (2006) Insulin-like growth factor-1 (IGF-1) induces the activation/phosphorylation of Akt kinase and cAMP responseelement-binding protein (CREB) by activating different signaling pathways in PC12 cells. BMC Neurosci 7:51 (Pubitemid 44227552)
30. Vivanco I, Sawyers CL (2002) The phosphatidylinositol 3-kinase-AKT pathway in human cancer. Nat Rev Cancer 2:489-501 (Pubitemid 37328931)
31. Zhang Y, Liu X, Zhang J, Li L, Liu C (2012) The expression and clinical significance of PI3 K, pAkt and VEGF in colon cancer. Oncol Lett 4:763-766
32. Ericson K, Gan C, Cheong I, Rago C, Samuels Y, Velculescu VE, Kinzler KW, Huso DL, Vogelstein B, Papadopoulos N (2010) Genetic inactivation of AKT1, AKT2, and PDPK1 in human colorectal cancer cells clarifies their roles in tumor growth regulation. Proc Natl Acad Sci USA 107:2598-2603
33. Lu Z, Hunter T (2010) Ubiquitylation and proteasomal degradation of the p21 Cip1, p27 Kip1 and p57 Kip2 CDK inhibitors. Cell Cycle 9:2342-2352
34. Liang J, Zubovitz J, Petrocelli T, Kotchetkov R, Connor MK, Han K, Lee JH, Ciarallo S, Catzavelos C, Beniston R, Franssen E, Slingerland JM (2002) PKB/Akt phosphorylates p27, impairs nuclear import of p27 and opposes p27-mediated G1 arrest. Nat Med 8:1153-1160 (Pubitemid 35175971)
35. Alao JP (2007) The regulation of cyclin D1 degradation: roles in cancer development and the potential for therapeutic invention. Mol Cancer 6:24 (Pubitemid 46585441)
36. Li T, Wong VK, Yi XQ, Wong YF, Zhou H, Liu L (2010) Matrine induces cell anergy in human Jurkat T cells through modulation of mitogen-activated protein kinases and nuclear factor of activated T-cells signaling with concomitant up-regulation of anergy-associated genes expression. Biol Pharm Bull 33:40-46
37. Chen J, Mei Q, Xu YC, Du J, Wei Y, Xu ZM (2006) Effects of matrine injection on T-lymphocyte subsets of patients with malignant tumor after gamma knife radiosurgery]. [Article in Chinese]. Zhong Xi Yi Jie He Xue Bao 4:78-79
38. Huang S, Fan W, Liu P, Tian J (2011) Meta analysis of compound matrine injection combined with cisplatin chemotherapy for advanced gastric cancer]. [Article in Chinese]. Zhongguo Zhong Yao Za Zhi 36:3198-3202