메뉴 건너뛰기




Volumn 204, Issue 7, 2014, Pages 1123-1140

Complexin synchronizes primed vesicle exocytosis and regulates fusion pore dynamics

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM; CELL PROTEIN; PROTEIN COMPLEXIN II; SNARE PROTEIN; SYNAPTOTAGMIN I; UNCLASSIFIED DRUG;

EID: 84897516425     PISSN: 00219525     EISSN: 15408140     Source Type: Journal    
DOI: 10.1083/jcb.201311085     Document Type: Article
Times cited : (51)

References (73)
  • 1
    • 77951667653 scopus 로고    scopus 로고
    • Real-time visualization of complexin during single exocytic events
    • An, S.J., C.P. Grabner, and D. Zenisek. 2010. Real-time visualization of complexin during single exocytic events. Nat. Neurosci. 13:577-583. http:// dx.doi.org/10.1038/nn.2532
    • (2010) Nat. Neurosci. , vol.13 , pp. 577-583
    • An, S.J.1    Grabner, C.P.2    Zenisek, D.3
  • 2
    • 0037166310 scopus 로고    scopus 로고
    • Complexin regulates the closure of the fusion pore during regulated vesicle exocytosis
    • Archer, D.A., M.E. Graham, and R.D. Burgoyne. 2002. Complexin regulates the closure of the fusion pore during regulated vesicle exocytosis. J. Biol. Chem. 277:18249-18252. http://dx.doi.org/10.1074/jbc.C200166200
    • (2002) J. Biol. Chem. , vol.277 , pp. 18249-18252
    • Archer, D.A.1    Graham, M.E.2    Burgoyne, R.D.3
  • 3
    • 0032849774 scopus 로고    scopus 로고
    • An efficient method for infection of adrenal chromaffin cells using the Semliki Forest virus gene expression system
    • Ashery, U., A. Betz, T. Xu, N. Brose, and J. Rettig. 1999. An efficient method for infection of adrenal chromaffin cells using the Semliki Forest virus gene expression system. Eur. J. Cell Biol. 78:525-532. http://dx.doi.org/ 10.1016/S0171-9335(99)80017-X
    • (1999) Eur. J. Cell Biol. , vol.78 , pp. 525-532
    • Ashery, U.1    Betz, A.2    Xu, T.3    Brose, N.4    Rettig, J.5
  • 4
    • 1842475284 scopus 로고    scopus 로고
    • Fusion pore dynamics are regulated by synaptotagmint-SNARE interactions
    • Bai, J., C.T. Wang, D.A. Richards, M.B. Jackson, and E.R. Chapman. 2004. Fusion pore dynamics are regulated by synaptotagmint-SNARE interactions. Neuron. 41:929-942. http://dx.doi.org/10.1016/S0896-6273(04)00117-5
    • (2004) Neuron. , vol.41 , pp. 929-942
    • Bai, J.1    Wang, C.T.2    Richards, D.A.3    Jackson, M.B.4    Chapman, E.R.5
  • 6
    • 0037135615 scopus 로고    scopus 로고
    • X-ray structure of a neuronal complexin-SNARE complex from squid
    • Bracher, A., J. Kadlec, H. Betz, and W. Weissenhorn. 2002. X-ray structure of a neuronal complexin-SNARE complex from squid. J. Biol. Chem. 277:26517-26523. http://dx.doi.org/10.1074/jbc.M203460200
    • (2002) J. Biol. Chem. , vol.277 , pp. 26517-26523
    • Bracher, A.1    Kadlec, J.2    Betz, H.3    Weissenhorn, W.4
  • 7
    • 42949109118 scopus 로고    scopus 로고
    • Altered complexin expression in psychiatric and neurological disorders: cause or consequence? Mol
    • Brose, N. 2008. Altered complexin expression in psychiatric and neurological disorders: cause or consequence? Mol. Cells. 25:7-19.
    • (2008) Cells. , vol.25 , pp. 7-19
    • Brose, N.1
  • 8
    • 2942556888 scopus 로고    scopus 로고
    • Detection of transmitter release with carbon fiber electrodes
    • Bruns, D. 2004. Detection of transmitter release with carbon fiber electrodes. Methods. 33:312-321. http://dx.doi.org/10.1016/j.ymeth.2004.01.004
    • (2004) Methods. , vol.33 , pp. 312-321
    • Bruns, D.1
  • 9
    • 0028978441 scopus 로고
    • Real-time measurement of transmitter release from single synaptic vesicles
    • Bruns, D., and R. Jahn. 1995. Real-time measurement of transmitter release from single synaptic vesicles. Nature. 377:62-65. http://dx.doi.org/10.1038/ 377062a0
    • (1995) Nature. , vol.377 , pp. 62-65
    • Bruns, D.1    Jahn, R.2
  • 10
    • 0033636599 scopus 로고    scopus 로고
    • Quantal release of serotonin
    • Bruns, D., D. Riedel, J. Klingauf, and R. Jahn. 2000. Quantal release of serotonin. Neuron. 28:205-220. http://dx.doi.org/10.1016/S0896-6273(00)00097-0
    • (2000) Neuron. , vol.28 , pp. 205-220
    • Bruns, D.1    Riedel, D.2    Klingauf, J.3    Jahn, R.4
  • 11
  • 12
    • 84872719528 scopus 로고    scopus 로고
    • Complexin activates exocytosis of distinct secretory vesicles controlled by different synaptotagmins
    • Cao, P., X. Yang, and T.C. Südhof. 2013. Complexin activates exocytosis of distinct secretory vesicles controlled by different synaptotagmins. J. Neurosci. 33:1714-1727. http://dx.doi.org/10.1523/JNEUROSCI.4087-12.2013
    • (2013) J. Neurosci. , vol.33 , pp. 1714-1727
    • Cao, P.1    Yang, X.2    Südhof, T.C.3
  • 14
    • 46449093538 scopus 로고    scopus 로고
    • How does synaptotagmin trigger neurotransmitter release? Annu
    • Chapman, E.R. 2008. How does synaptotagmin trigger neurotransmitter release? Annu. Rev. Biochem. 77:615-641. http://dx.doi.org/10.1146/annurev .biochem.77.062005.101135
    • (2008) Rev. Biochem. , vol.77 , pp. 615-641
    • Chapman, E.R.1
  • 15
    • 0037204076 scopus 로고    scopus 로고
    • Three-dimensional structure of the complexin/SNARE complex
    • Chen, X., D.R. Tomchick, E. Kovrigin, D. Araç, M. Machius, T.C. Südhof, and J. Rizo. 2002. Three-dimensional structure of the complexin/SNARE complex. Neuron. 33:397-409. http://dx.doi.org/10.1016/S0896-6273(02)00583-4
    • (2002) Neuron. , vol.33 , pp. 397-409
    • Chen, X.1    Tomchick, D.R.2    Kovrigin, E.3    Araç, D.4    Machius, M.5    Südhof, T.C.6    Rizo, J.7
  • 16
    • 60749096805 scopus 로고    scopus 로고
    • Concurrent binding of complexin and synaptotagmin to liposome-embedded SNARE complexes
    • Chicka, M.C., and E.R. Chapman. 2009. Concurrent binding of complexin and synaptotagmin to liposome-embedded SNARE complexes. Biochemistry. 48:657-659. http://dx.doi.org/10.1021/bi801962d
    • (2009) Biochemistry. , vol.48 , pp. 657-659
    • Chicka, M.C.1    Chapman, E.R.2
  • 17
    • 77957936989 scopus 로고    scopus 로고
    • Comparative analysis of Drosophila and mammalian complexins as fusion clamps and facilitators of neurotransmitter release
    • Cho, R.W., Y. Song, and J.T. Littleton. 2010. Comparative analysis of Drosophila and mammalian complexins as fusion clamps and facilitators of neurotransmitter release. Mol. Cell. Neurosci. 45:389-397. http://dx.doi.org/10.1016/ j.mcn.2010.07.012
    • (2010) Mol. Cell. Neurosci. , vol.45 , pp. 389-397
    • Cho, R.W.1    Song, Y.2    Littleton, J.T.3
  • 18
    • 0026550828 scopus 로고
    • Delay in vesicle fusion revealed by electrochemical monitoring of single secretory events in adrenal chromaffin cells
    • Chow, R.H., L. von Rüden, and E. Neher. 1992. Delay in vesicle fusion revealed by electrochemical monitoring of single secretory events in adrenal chromaffin cells. Nature. 356:60-63. http://dx.doi.org/10.1038/356060a0
    • (1992) Nature. , vol.356 , pp. 60-63
    • Chow, R.H.1    von Rüden, L.2    Neher, E.3
  • 19
    • 0028906872 scopus 로고
    • Cytosolic calcium facilitates release of secretory products after exocytotic vesicle fusion
    • Fernández-Chacón, R., and G. Alvarez de Toledo. 1995. Cytosolic calcium facilitates release of secretory products after exocytotic vesicle fusion. FEBS Lett. 363:221-225. http://dx.doi.org/10.1016/0014-5793(95)00319-5
    • (1995) FEBS Lett. , vol.363 , pp. 221-225
    • Fernández-Chacón, R.1    Alvarez de Toledo, G.2
  • 20
    • 23744436392 scopus 로고    scopus 로고
    • Activity-dependent differential transmitter release in mouse adrenal chromaffin cells
    • Fulop, T., S. Radabaugh, and C. Smith. 2005. Activity-dependent differential transmitter release in mouse adrenal chromaffin cells. J. Neurosci. 25:7324-7332. http://dx.doi.org/10.1523/JNEUROSCI.2042-05.2005
    • (2005) J. Neurosci. , vol.25 , pp. 7324-7332
    • Fulop, T.1    Radabaugh, S.2    Smith, C.3
  • 21
    • 0028061861 scopus 로고
    • Synaptotagmin I: a major Ca2+ sensor for transmitter release at a central synapse
    • Geppert, M., Y. Goda, R.E. Hammer, C. Li, T.W. Rosahl, C.F. Stevens, and T.C. Südhof. 1994. Synaptotagmin I: a major Ca2+ sensor for transmitter release at a central synapse. Cell. 79:717-727. http://dx.doi.org/10 .1016/0092-8674(94)90556-8
    • (1994) Cell. , vol.79 , pp. 717-727
    • Geppert, M.1    Goda, Y.2    Hammer, R.E.3    Li, C.4    Rosahl, T.W.5    Stevens, C.F.6    Südhof, T.C.7
  • 22
    • 33746319639 scopus 로고    scopus 로고
    • A clamping mechanism involved in SNARE-dependent exocytosis
    • Giraudo, C.G., W.S. Eng, T.J. Melia, and J.E. Rothman. 2006. A clamping mechanism involved in SNARE-dependent exocytosis. Science. 313:676-680. http://dx.doi.org/10.1126/science.1129450
    • (2006) Science. , vol.313 , pp. 676-680
    • Giraudo, C.G.1    Eng, W.S.2    Melia, T.J.3    Rothman, J.E.4
  • 23
    • 51049114297 scopus 로고    scopus 로고
    • Distinct domains of complexins bind SNARE complexes and clamp fusion in vitro
    • Giraudo, C.G., A. Garcia-Diaz, W.S. Eng, A. Yamamoto, T.J. Melia, and J.E. Rothman. 2008. Distinct domains of complexins bind SNARE complexes and clamp fusion in vitro. J. Biol. Chem. 283:21211-21219. http://dx.doi .org/10.1074/jbc.M803478200
    • (2008) J. Biol. Chem. , vol.283 , pp. 21211-21219
    • Giraudo, C.G.1    Garcia-Diaz, A.2    Eng, W.S.3    Yamamoto, A.4    Melia, T.J.5    Rothman, J.E.6
  • 26
    • 77955354415 scopus 로고    scopus 로고
    • SNARE force synchronizes synaptic vesicle fusion and controls the kinetics of quantal synaptic transmission
    • Guzman, R.E., Y.N. Schwarz, J. Rettig, and D. Bruns. 2010. SNARE force synchronizes synaptic vesicle fusion and controls the kinetics of quantal synaptic transmission. J. Neurosci. 30:10272-10281. http://dx.doi.org/10 .1523/JNEUROSCI.1551-10.2010
    • (2010) J. Neurosci. , vol.30 , pp. 10272-10281
    • Guzman, R.E.1    Schwarz, Y.N.2    Rettig, J.3    Bruns, D.4
  • 27
    • 79151479103 scopus 로고    scopus 로고
    • Complexin maintains vesicles in the primed state in C
    • Hobson, R.J., Q. Liu, S. Watanabe, and E.M. Jorgensen. 2011. Complexin maintains vesicles in the primed state in C. elegans. Curr. Biol. 21:106-113. http://dx.doi.org/10.1016/j.cub.2010.12.015
    • (2011) elegans. Curr. Biol. , vol.21 , pp. 106-113
    • Hobson, R.J.1    Liu, Q.2    Watanabe, S.3    Jorgensen, E.M.4
  • 28
    • 34748846347 scopus 로고    scopus 로고
    • A complexin fusion clamp regulates spontaneous neurotransmitter release and synaptic growth
    • Huntwork, S., and J.T. Littleton. 2007. A complexin fusion clamp regulates spontaneous neurotransmitter release and synaptic growth. Nat. Neurosci. 10:1235-1237. http://dx.doi.org/10.1038/nn1980
    • (2007) Nat. Neurosci. , vol.10 , pp. 1235-1237
    • Huntwork, S.1    Littleton, J.T.2
  • 29
    • 84870992389 scopus 로고    scopus 로고
    • Complexin controls spontaneous and evoked neurotransmitter release by regulating the timing and properties of synaptotagmin activity
    • Jorquera, R.A., S. Huntwork-Rodriguez, Y. Akbergenova, R.W. Cho, and J.T. Littleton. 2012. Complexin controls spontaneous and evoked neurotransmitter release by regulating the timing and properties of synaptotagmin activity. J. Neurosci. 32:18234-18245. http://dx.doi.org/10.1523/ JNEUROSCI.3212-12.2012
    • (2012) J. Neurosci. , vol.32 , pp. 18234-18245
    • Jorquera, R.A.1    Huntwork-Rodriguez, S.2    Akbergenova, Y.3    Cho, R.W.4    Littleton, J.T.5
  • 30
    • 84863120538 scopus 로고    scopus 로고
    • C-terminal complexin sequence is selectively required for clamping and priming but not for Ca2+ triggering of synaptic exocytosis
    • Kaeser-Woo, Y.J., X. Yang, and T.C. Südhof. 2012. C-terminal complexin sequence is selectively required for clamping and priming but not for Ca2+ triggering of synaptic exocytosis. J. Neurosci. 32:2877-2885. http://dx .doi.org/10.1523/JNEUROSCI.3360-11.2012
    • (2012) J. Neurosci. , vol.32 , pp. 2877-2885
    • Kaeser-Woo, Y.J.1    Yang, X.2    Südhof, T.C.3
  • 31
    • 35348925451 scopus 로고    scopus 로고
    • v-SNARE actions during Ca(2+)-triggered exocytosis
    • Kesavan, J., M. Borisovska, and D. Bruns. 2007. v-SNARE actions during Ca(2+)-triggered exocytosis. Cell. 131:351-363. http://dx.doi.org/10.1016/j.cell .2007.09.025
    • (2007) Cell. , vol.131 , pp. 351-363
    • Kesavan, J.1    Borisovska, M.2    Bruns, D.3
  • 34
    • 0034130493 scopus 로고    scopus 로고
    • Role of actin cortex in the subplasmalemmal transport of secretory granules in PC-12 cells
    • Lang, T., I. Wacker, I. Wunderlich, A. Rohrbach, G. Giese, T. Soldati, and W. Almers. 2000. Role of actin cortex in the subplasmalemmal transport of secretory granules in PC-12 cells. Biophys. J. 78:2863-2877. http:// dx.doi.org/10.1016/S0006-3495(00)76828-7
    • (2000) Biophys. J. , vol.78 , pp. 2863-2877
    • Lang, T.1    Wacker, I.2    Wunderlich, I.3    Rohrbach, A.4    Giese, G.5    Soldati, T.6    Almers, W.7
  • 35
    • 84877821540 scopus 로고    scopus 로고
    • Complexin facilitates exocytosis and synchronizes vesicle release in two secretory model systems
    • Lin, M.Y., J.G. Rohan, H. Cai, K. Reim, C.P. Ko, and R.H. Chow. 2013. Complexin facilitates exocytosis and synchronizes vesicle release in two secretory model systems. J. Physiol. 591:2463-2473.
    • (2013) J. Physiol. , vol.591 , pp. 2463-2473
    • Lin, M.Y.1    Rohan, J.G.2    Cai, H.3    Reim, K.4    Ko, C.P.5    Chow, R.H.6
  • 36
    • 59449087443 scopus 로고    scopus 로고
    • Synaptotagmin-1 utilizes membrane bending and SNARE binding to drive fusion pore expansion
    • Lynch, K.L., R.R. Gerona, D.M. Kielar, S. Martens, H.T. McMahon, and T.F. Martin. 2008. Synaptotagmin-1 utilizes membrane bending and SNARE binding to drive fusion pore expansion. Mol. Biol. Cell. 19:5093-5103. http://dx.doi.org/10.1091/mbc.E08-03-0235
    • (2008) Mol. Biol. Cell. , vol.19 , pp. 5093-5103
    • Lynch, K.L.1    Gerona, R.R.2    Kielar, D.M.3    Martens, S.4    McMahon, H.T.5    Martin, T.F.6
  • 38
    • 79151478184 scopus 로고    scopus 로고
    • Complexin has opposite effects on two modes of synaptic vesicle fusion
    • Martin, J.A., Z. Hu, K.M. Fenz, J. Fernandez, and J.S. Dittman. 2011. Complexin has opposite effects on two modes of synaptic vesicle fusion. Curr. Biol. 21:97-105. http://dx.doi.org/10.1016/j.cub.2010.12.014
    • (2011) Curr. Biol. , vol.21 , pp. 97-105
    • Martin, J.A.1    Hu, Z.2    Fenz, K.M.3    Fernandez, J.4    Dittman, J.S.5
  • 39
    • 58849164361 scopus 로고    scopus 로고
    • Complexin controls the force transfer from SNARE complexes to membranes in fusion
    • Maximov, A., J. Tang, X. Yang, Z.P. Pang, and T.C. Südhof. 2009. Complexin controls the force transfer from SNARE complexes to membranes in fusion. Science. 323:516-521. http://dx.doi.org/10.1126/science.1166505
    • (2009) Science. , vol.323 , pp. 516-521
    • Maximov, A.1    Tang, J.2    Yang, X.3    Pang, Z.P.4    Südhof, T.C.5
  • 40
    • 0028880456 scopus 로고
    • Complexins: cytosolic proteins that regulate SNAP receptor function
    • McMahon, H.T., M. Missler, C. Li, and T.C. Südhof. 1995. Complexins: cytosolic proteins that regulate SNAP receptor function. Cell. 83:111-119. http://dx.doi.org/10.1016/0092-8674(95)90239-2
    • (1995) Cell. , vol.83 , pp. 111-119
    • McMahon, H.T.1    Missler, M.2    Li, C.3    Südhof, T.C.4
  • 41
    • 0031002415 scopus 로고    scopus 로고
    • Estimation of mean exocytic vesicle capacitance in mouse adrenal chromaffin cells
    • Moser, T., and E. Neher. 1997. Estimation of mean exocytic vesicle capacitance in mouse adrenal chromaffin cells. Proc. Natl. Acad. Sci. USA. 94:6735-6740. http://dx.doi.org/10.1073/pnas.94.13.6735
    • (1997) Proc. Natl. Acad. Sci. USA. , vol.94 , pp. 6735-6740
    • Moser, T.1    Neher, E.2
  • 42
    • 32544460031 scopus 로고    scopus 로고
    • Different effects on fast exocytosis induced by synaptotagmin 1 and 2 isoforms and abundance but not by phosphorylation
    • Nagy, G., J.H. Kim, Z.P. Pang, U. Matti, J. Rettig, T.C. Südhof, and J.B. Sørensen. 2006. Different effects on fast exocytosis induced by synaptotagmin 1 and 2 isoforms and abundance but not by phosphorylation. J. Neurosci. 26:632-643. http://dx.doi.org/10.1523/JNEUROSCI.2589-05.2006
    • (2006) J. Neurosci. , vol.26 , pp. 632-643
    • Nagy, G.1    Kim, J.H.2    Pang, Z.P.3    Matti, U.4    Rettig, J.5    Südhof, T.C.6    Sørensen, J.B.7
  • 43
    • 78649954048 scopus 로고    scopus 로고
    • Complexin: does it deserve its name?
    • Neher, E. 2010. Complexin: does it deserve its name?. Neuron. 68:803-806. http://dx.doi.org/10.1016/j.neuron.2010.11.038
    • (2010) Neuron. , vol.68 , pp. 803-806
    • Neher, E.1
  • 44
    • 0033607182 scopus 로고    scopus 로고
    • Content mixing and membrane integrity during membrane fusion driven by pairing of isolated v-SNAREs and t-SNAREs
    • Nickel, W., T. Weber, J.A. McNew, F. Parlati, T.H. Söllner, and J.E. Rothman. 1999. Content mixing and membrane integrity during membrane fusion driven by pairing of isolated v-SNAREs and t-SNAREs. Proc. Natl. Acad. Sci. USA. 96:12571-12576. http://dx.doi.org/10.1073/pnas.96.22.12571
    • (1999) Proc. Natl. Acad. Sci. USA. , vol.96 , pp. 12571-12576
    • Nickel, W.1    Weber, T.2    McNew, J.A.3    Parlati, F.4    Söllner, T.H.5    Rothman, J.E.6
  • 45
    • 84885441178 scopus 로고    scopus 로고
    • Doc2b synchronizes secretion from chromaffin cells by stimulating fast and inhibiting sustained release
    • Pinheiro, P.S., H. de Wit, A.M. Walter, A.J. Groffen, M. Verhage, and J.B. Sørensen. 2013. Doc2b synchronizes secretion from chromaffin cells by stimulating fast and inhibiting sustained release. J. Neurosci. 33:16459-16470. http://dx.doi.org/10.1523/JNEUROSCI.2656-13.2013
    • (2013) J. Neurosci. , vol.33 , pp. 16459-16470
    • Pinheiro, P.S.1    de Wit, H.2    Walter, A.M.3    Groffen, A.J.4    Verhage, M.5    Sørensen, J.B.6
  • 46
    • 0035846908 scopus 로고    scopus 로고
    • Complexins regulate a late step in Ca2+-dependent neurotransmitter release
    • Reim, K., M. Mansour, F. Varoqueaux, H.T. McMahon, T.C. Südhof, N. Brose, and C. Rosenmund. 2001. Complexins regulate a late step in Ca2+-dependent neurotransmitter release. Cell. 104:71-81. http://dx.doi.org/ 10.1016/S0092-8674(01)00192-1
    • (2001) Cell. , vol.104 , pp. 71-81
    • Reim, K.1    Mansour, M.2    Varoqueaux, F.3    McMahon, H.T.4    Südhof, T.C.5    Brose, N.6    Rosenmund, C.7
  • 47
    • 0037174660 scopus 로고    scopus 로고
    • Emerging roles of presynaptic proteins in Ca++-triggered exocytosis
    • Rettig, J., and E. Neher. 2002. Emerging roles of presynaptic proteins in Ca++-triggered exocytosis. Science. 298:781-785. http://dx.doi.org/10.1126/ science.1075375
    • (2002) Science. , vol.298 , pp. 781-785
    • Rettig, J.1    Neher, E.2
  • 48
    • 33746804075 scopus 로고    scopus 로고
    • Hemifusion arrest by complexin is relieved by Ca2+-synaptotagmin I
    • Schaub, J.R., X. Lu, B. Doneske, Y.K. Shin, and J.A. McNew. 2006. Hemifusion arrest by complexin is relieved by Ca2+-synaptotagmin I. Nat. Struct . Mol. Biol. 13:748-750. http://dx.doi.org/10.1038/nsmb1124
    • (2006) Nat. Struct . Mol. Biol. , vol.13 , pp. 748-750
    • Schaub, J.R.1    Lu, X.2    Doneske, B.3    Shin, Y.K.4    McNew, J.A.5
  • 49
    • 41649102893 scopus 로고    scopus 로고
    • Synaptotagmin-1 and-7 are functionally overlapping Ca2+ sensors for exocytosis in adrenal chromaffin cells
    • Schonn, J.S., A. Maximov, Y. Lao, T.C. Südhof, and J.B. Sørensen. 2008. Synaptotagmin-1 and-7 are functionally overlapping Ca2+ sensors for exocytosis in adrenal chromaffin cells. Proc. Natl. Acad. Sci. USA. 105: 3998-4003. http://dx.doi.org/10.1073/pnas.0712373105
    • (2008) Proc. Natl. Acad. Sci. USA. , vol.105 , pp. 3998-4003
    • Schonn, J.S.1    Maximov, A.2    Lao, Y.3    Südhof, T.C.4    Sørensen, J.B.5
  • 51
    • 67650161468 scopus 로고    scopus 로고
    • A role of complexinlipid interactions in membrane fusion
    • Seiler, F., J. Malsam, J.M. Krause, and T.H. Söllner. 2009. A role of complexinlipid interactions in membrane fusion. FEBS Lett. 583:2343-2348. http:// dx.doi.org/10.1016/j.febslet.2009.06.025
    • (2009) FEBS Lett. , vol.583 , pp. 2343-2348
    • Seiler, F.1    Malsam, J.2    Krause, J.M.3    Söllner, T.H.4
  • 52
    • 3442879896 scopus 로고    scopus 로고
    • Formation, stabilisation and fusion of the readily releasable pool of secretory vesicles
    • Sørensen, J.B. 2004. Formation, stabilisation and fusion of the readily releasable pool of secretory vesicles. Pflügers Arch. 448:347-362. http://dx.doi .org/10.1007/s00424-004-1247-8
    • (2004) Pflügers Arch. , vol.448 , pp. 347-362
    • Sørensen, J.B.1
  • 53
    • 0141563427 scopus 로고    scopus 로고
    • Examining synaptotagmin 1 function in dense core vesicle exocytosis under direct control of Ca2+
    • Sørensen, J.B., R. Fernández-Chacón, T.C. Südhof, and E. Neher. 2003. Examining synaptotagmin 1 function in dense core vesicle exocytosis under direct control of Ca2+. J. Gen. Physiol. 122:265-276. http://dx.doi .org/10.1085/jgp.200308855
    • (2003) J. Gen. Physiol. , vol.122 , pp. 265-276
    • Sørensen, J.B.1    Fernández-Chacón, R.2    Südhof, T.C.3    Neher, E.4
  • 56
    • 33748605056 scopus 로고    scopus 로고
    • A complexin/ synaptotagmin 1 switch controls fast synaptic vesicle exocytosis
    • Tang, J., A. Maximov, O.H. Shin, H. Dai, J. Rizo, and T.C. Südhof. 2006. A complexin/ synaptotagmin 1 switch controls fast synaptic vesicle exocytosis. Cell. 126:1175-1187. http://dx.doi.org/10.1016/j.cell.2006.08.030
    • (2006) Cell. , vol.126 , pp. 1175-1187
    • Tang, J.1    Maximov, A.2    Shin, O.H.3    Dai, H.4    Rizo, J.5    Südhof, T.C.6
  • 57
    • 64949163287 scopus 로고    scopus 로고
    • Direct interaction of SNARE complex binding protein synaphin/complexin with calcium sensor synaptotagmin 1
    • Tokumaru, H., C. Shimizu-Okabe, and T. Abe. 2008. Direct interaction of SNARE complex binding protein synaphin/complexin with calcium sensor synaptotagmin 1. Brain Cell Biol. 36:173-189. http://dx.doi.org/ 10.1007/s11068-008-9032-9
    • (2008) Brain Cell Biol. , vol.36 , pp. 173-189
    • Tokumaru, H.1    Shimizu-Okabe, C.2    Abe, T.3
  • 58
    • 0027489573 scopus 로고
    • Cytoskeleton dynamics during neurotransmitter release
    • Trifaró, J.M., and M.L. Vitale. 1993. Cytoskeleton dynamics during neurotransmitter release. Trends Neurosci. 16:466-472. http://dx.doi.org/10 .1016/0166-2236(93)90079-2
    • (1993) Trends Neurosci. , vol.16 , pp. 466-472
    • Trifaró, J.M.1    Vitale, M.L.2
  • 59
    • 0030932857 scopus 로고    scopus 로고
    • DOC2 proteins in rat brain: complementary distribution and proposed function as vesicular adapter proteins in early stages of secretion
    • Verhage, M., K.J. de Vries, H. Røshol, J.P. Burbach, W.H. Gispen, and T.C. Südhof. 1997. DOC2 proteins in rat brain: complementary distribution and proposed function as vesicular adapter proteins in early stages of secretion. Neuron. 18:453-461. http://dx.doi.org/10.1016/S0896-6273(00)81245-3
    • (1997) Neuron. , vol.18 , pp. 453-461
    • Verhage, M.1    de Vries, K.J.2    Røshol, H.3    Burbach, J.P.4    Gispen, W.H.5    Südhof, T.C.6
  • 60
    • 0035949679 scopus 로고    scopus 로고
    • Intracellular calcium dependence of large dense-core vesicle exocytosis in the absence of synaptotagmin I
    • Voets, T., T. Moser, P.E. Lund, R.H. Chow, M. Geppert, T.C. Südhof, and E. Neher. 2001. Intracellular calcium dependence of large dense-core vesicle exocytosis in the absence of synaptotagmin I. Proc. Natl. Acad. Sci. USA. 98:11680-11685. http://dx.doi.org/10.1073/pnas.201398798
    • (2001) Proc. Natl. Acad. Sci. USA. , vol.98 , pp. 11680-11685
    • Voets, T.1    Moser, T.2    Lund, P.E.3    Chow, R.H.4    Geppert, M.5    Südhof, T.C.6    Neher, E.7
  • 61
    • 0035798162 scopus 로고    scopus 로고
    • Synaptotagmin modulation of fusion pore kinetics in regulated exocytosis of dense-core vesicles
    • Wang, C.T., R. Grishanin, C.A. Earles, P.Y. Chang, T.F. Martin, E.R. Chapman, and M.B. Jackson. 2001. Synaptotagmin modulation of fusion pore kinetics in regulated exocytosis of dense-core vesicles. Science. 294:1111-1115. http://dx.doi.org/10.1126/science.1064002
    • (2001) Science. , vol.294 , pp. 1111-1115
    • Wang, C.T.1    Grishanin, R.2    Earles, C.A.3    Chang, P.Y.4    Martin, T.F.5    Chapman, E.R.6    Jackson, M.B.7
  • 62
    • 0041858035 scopus 로고    scopus 로고
    • Different domains of synaptotagmin control the choice between kiss-and-run and full fusion
    • Wang, C.T., J.C. Lu, J. Bai, P.Y. Chang, T.F. Martin, E.R. Chapman, and M.B. Jackson. 2003. Different domains of synaptotagmin control the choice between kiss-and-run and full fusion. Nature. 424:943-947. http://dx.doi .org/10.1038/nature01857
    • (2003) Nature. , vol.424 , pp. 943-947
    • Wang, C.T.1    Lu, J.C.2    Bai, J.3    Chang, P.Y.4    Martin, T.F.5    Chapman, E.R.6    Jackson, M.B.7
  • 63
    • 33644865767 scopus 로고    scopus 로고
    • Synaptotagmin-Ca2+ triggers two sequential steps in regulated exocytosis in rat PC12 cells: fusion pore opening and fusion pore dilation
    • Wang, C.T., J. Bai, P.Y. Chang, E.R. Chapman, and M.B. Jackson. 2006. Synaptotagmin-Ca2+ triggers two sequential steps in regulated exocytosis in rat PC12 cells: fusion pore opening and fusion pore dilation. J. Physiol. 570:295-307.
    • (2006) J. Physiol. , vol.570 , pp. 295-307
    • Wang, C.T.1    Bai, J.2    Chang, P.Y.3    Chapman, E.R.4    Jackson, M.B.5
  • 64
    • 25444473872 scopus 로고    scopus 로고
    • Synaptotagmin VII is targeted to secretory organelles in PC12 cells, where it functions as a high-affinity calcium sensor
    • Wang, P., M.C. Chicka, A. Bhalla, D.A. Richards, and E.R. Chapman. 2005. Synaptotagmin VII is targeted to secretory organelles in PC12 cells, where it functions as a high-affinity calcium sensor. Mol. Cell. Biol. 25:8693-8702. http://dx.doi.org/10.1128/MCB.25.19.8693-8702.2005
    • (2005) Mol. Cell. Biol. , vol.25 , pp. 8693-8702
    • Wang, P.1    Chicka, M.C.2    Bhalla, A.3    Richards, D.A.4    Chapman, E.R.5
  • 66
  • 67
    • 84883308384 scopus 로고    scopus 로고
    • Subtle interplay between synaptotagmin and complexin binding to the SNARE complex
    • Xu, J., K.D. Brewer, R. Perez-Castillejos, and J. Rizo. 2013. Subtle interplay between synaptotagmin and complexin binding to the SNARE complex. J. Mol. Biol. 425:3461-3475. http://dx.doi.org/10.1016/j.jmb.2013.07.001
    • (2013) J. Mol. Biol. , vol.425 , pp. 3461-3475
    • Xu, J.1    Brewer, K.D.2    Perez-Castillejos, R.3    Rizo, J.4
  • 68
    • 34948901461 scopus 로고    scopus 로고
    • Distinct domains of complexin I differentially regulate neurotransmitter release
    • Xue, M., K. Reim, X. Chen, H.T. Chao, H. Deng, J. Rizo, N. Brose, and C. Rosenmund. 2007. Distinct domains of complexin I differentially regulate neurotransmitter release. Nat. Struct. Mol. Biol. 14:949-958. http:// dx.doi.org/10.1038/nsmb1292
    • (2007) Nat. Struct. Mol. Biol. , vol.14 , pp. 949-958
    • Xue, M.1    Reim, K.2    Chen, X.3    Chao, H.T.4    Deng, H.5    Rizo, J.6    Brose, N.7    Rosenmund, C.8
  • 69
    • 45549089944 scopus 로고    scopus 로고
    • Complexins facilitate neurotransmitter release at excitatory and inhibitory synapses in mammalian central nervous system
    • Xue, M., A. Stradomska, H. Chen, N. Brose, W. Zhang, C. Rosenmund, and K. Reim. 2008. Complexins facilitate neurotransmitter release at excitatory and inhibitory synapses in mammalian central nervous system. Proc. Natl. Acad. Sci. USA. 105:7875-7880. http://dx.doi.org/10.1073/ pnas.0803012105
    • (2008) Proc. Natl. Acad. Sci. USA. , vol.105 , pp. 7875-7880
    • Xue, M.1    Stradomska, A.2    Chen, H.3    Brose, N.4    Zhang, W.5    Rosenmund, C.6    Reim, K.7
  • 70
    • 70350772355 scopus 로고    scopus 로고
    • Tilting the balance between facilitatory and inhibitory functions of mammalian and Drosophila Complexins orchestrates synaptic vesicle exocytosis
    • Xue, M., Y.Q. Lin, H. Pan, K. Reim, H. Deng, H.J. Bellen, and C. Rosenmund. 2009. Tilting the balance between facilitatory and inhibitory functions of mammalian and Drosophila Complexins orchestrates synaptic vesicle exocytosis. Neuron. 64:367-380. http://dx.doi.org/10.1016/j.neuron.2009.09.043
    • (2009) Neuron. , vol.64 , pp. 367-380
    • Xue, M.1    Lin, Y.Q.2    Pan, H.3    Reim, K.4    Deng, H.5    Bellen, H.J.6    Rosenmund, C.7
  • 71
    • 77951975523 scopus 로고    scopus 로고
    • Binding of the complexin N terminus to the SNARE complex potentiates synaptic-vesicle fusogenicity
    • Xue, M., T.K. Craig, J. Xu, H.T. Chao, J. Rizo, and C. Rosenmund. 2010. Binding of the complexin N terminus to the SNARE complex potentiates synaptic-vesicle fusogenicity. Nat. Struct. Mol. Biol. 17:568-575. http:// dx.doi.org/10.1038/nsmb.1791
    • (2010) Nat. Struct. Mol. Biol. , vol.17 , pp. 568-575
    • Xue, M.1    Craig, T.K.2    Xu, J.3    Chao, H.T.4    Rizo, J.5    Rosenmund, C.6
  • 72
    • 78649930845 scopus 로고    scopus 로고
    • Complexin clamps asynchronous release by blocking a secondary Ca(2+) sensor via its accessory ? helix
    • Yang, X., Y.J. Kaeser-Woo, Z.P. Pang, W. Xu, and T.C. Südhof. 2010. Complexin clamps asynchronous release by blocking a secondary Ca(2+) sensor via its accessory ? helix. Neuron. 68:907-920. http://dx.doi.org/10 .1016/j.neuron.2010.11.001
    • (2010) Neuron. , vol.68 , pp. 907-920
    • Yang, X.1    Kaeser-Woo, Y.J.2    Pang, Z.P.3    Xu, W.4    Südhof, T.C.5
  • 73
    • 46449139821 scopus 로고    scopus 로고
    • Complexin and Ca2+ stimulate SNARE-mediated membrane fusion
    • Yoon, T.Y., X. Lu, J. Diao, S.M. Lee, T. Ha, and Y.K. Shin. 2008. Complexin and Ca2+ stimulate SNARE-mediated membrane fusion. Nat. Struct. Mol. Biol. 15:707-713. http://dx.doi.org/10.1038/nsmb.1446
    • (2008) Nat. Struct. Mol. Biol. , vol.15 , pp. 707-713
    • Yoon, T.Y.1    Lu, X.2    Diao, J.3    Lee, S.M.4    Ha, T.5    Shin, Y.K.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.