A conformational switch in complexin is required for synaptotagmin to trigger synaptic fusion

Nature Structural and Molecular Biology

Volumn 18, Issue 8, 2011, Pages 934-940

  Krishnakumar, Shyam S ^a   Radoff, Daniel T ^a,b   Kümmel, Daniel ^a   Giraudo, Claudio G ^a   Li, Feng ^a   Khandan, Lavan ^a   Baguley, Stephanie Wood ^a   Coleman, Jeff ^a   Reinisch, Karin M ^a   Pincet, Frederic ^a,c   Rothman, James E ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Och Spine at New York Presbyterian Hospitals   (United States)

^c SORBONNE UNIVERSITÉ   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ASPARTIC ACID; CALCIUM; COMPLEXIN; SNARE PROTEIN; SYNAPTOTAGMIN; UNCLASSIFIED DRUG;

ARTICLE; CONFORMATIONAL TRANSITION; EXOCYTOSIS; FLUORESCENCE RESONANCE ENERGY TRANSFER; FUSION GENE; ISOTHERMAL TITRATION CALORIMETRY; MUTATION; PRIORITY JOURNAL; SYNAPTIC MEMBRANE; THERMODYNAMICS;

ADAPTOR PROTEINS, VESICULAR TRANSPORT; AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; HUMANS; MEMBRANE FUSION; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; NERVE TISSUE PROTEINS; PROTEIN STRUCTURE, TERTIARY; RATS; SYNAPTOSOMAL-ASSOCIATED PROTEIN 25; SYNAPTOTAGMINS; SYNTAXIN 1; VESICLE-ASSOCIATED MEMBRANE PROTEIN 2;

EID: 79961028121     PISSN: 15459993     EISSN: 15459985     Source Type: Journal    
DOI: 10.1038/nsmb.2103     Document Type: Article

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