Feasibility of aerosol drug delivery to sleeping infants: A prospective observational study

BMJ Open

Volumn 4, Issue 3, 2014, Pages

  Amirav, Israel ^a,b   Newhouse, Michael T ^c   Luder, Anthony ^a   Halamish, Asaf ^d   Omar, Hamza ^e   Gorenberg, Miguel ^e  

^a BAR ILAN UNIVERSITY   (Israel)

^b UNIVERSITY OF ALBERTA   (Canada)

^c Technosaf ^*  (Israel)

^d Rebecca Sieff Government Hospital   (Israel)

^e ST JOSEPH S HOSPITAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

PENTETATE TECHNETIUM TC 99M; AEROSOL;

AEROSOL; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; DRUG DELIVERY SYSTEM; FEASIBILITY STUDY; FEMALE; HUMAN; INFANT; INFANT MORTALITY; INHALER; MALE; OBSERVATIONAL STUDY; OUTCOME ASSESSMENT; PACIFIER; PILOT STUDY; PROSPECTIVE STUDY; SCINTIGRAPHY; SLEEP; SUDDEN INFANT DEATH SYNDROME; UPPER RESPIRATORY TRACT; WHEEZING; ABNORMAL RESPIRATORY SOUND; ASTHMA; DEVICES; EQUIPMENT DESIGN; EVALUATION STUDY; GERMANY; INHALATIONAL DRUG ADMINISTRATION; LUNG; MASK; NEBULIZER; PROCEDURES; STANDARDS;

ADMINISTRATION, INHALATION; AEROSOLS; ASTHMA; DRUG DELIVERY SYSTEMS; EQUIPMENT DESIGN; FEMALE; GERMANY; HUMANS; INFANT; LUNG; MALE; MASKS; NEBULIZERS AND VAPORIZERS; PILOT PROJECTS; PROSPECTIVE STUDIES; RESPIRATORY SOUNDS; SLEEP;

EID: 84897509693     PISSN: None     EISSN: 20446055     Source Type: Journal    
DOI: 10.1136/bmjopen-2013-004124     Document Type: Article

References (16)

1. Janssens HM, van der Wiel EC, Verbraak AF, et al. Aerosol therapy and the fighting toddler: is administration during sleep an alternative? J Aerosol Med 2003;16:395-400. (Pubitemid 38120945)
2. Esposito-Festen J, Ijsselstijn H, Hop W, et al. Aerosol therapy by pressured metered-dose inhaler-spacer in sleeping young children: to do or not to do? Chest 2006;130:487-92. (Pubitemid 44267017)
3. Smith C, Goldman RD. Nebulizers versus pressurized metered-dose inhalers in preschool children with wheezing. Can Fam Physician 2012;58:528-30.
4. Amirav I, Luder AS, Halamish A, et al. Design of aerosol face masks for children using computerized 3D face analysis. J Aerosol Med Pulm Drug Deliv 2013. [serial online 28 Sep 2013].
5. Newman SP. Scintigraphic assessment of therapeutic aerosols. Crit Rev Ther Drug Carrier Syst 1993;10:65-109. (Pubitemid 23107933)
6. Schultz A, Le Souëf TJ, Venter A, et al. Aerosol inhalation from spacers and valved holding chambers requires few tidal breaths for children. Pediatrics 2010;126:e1493-8.
7. Amirav I, Balanov I, Gorenberg M, et al. Nebulizer hood compared to mask in wheezy infants: aerosol therapy without tears! Arch Dis Child 2003;88:719-23. (Pubitemid 36930312)
8. Amirav I, Balanov I, Gorenberg M, et al. Beta agonist aerosol distribution in RSV bronchiolitis in infants. J Nucl Med 2002;43:487-91. (Pubitemid 34286343)
9. Atkins HL, Weber DA, Susskind H, et al. MIRD dose estimate report no. 16: radiation absorbed dose from technetium-99m-diethylenetriaminepentaacetic acid aerosol. J Nucl Med 1992;33:1717-19.
10. Eggli DF. Pediatric radiopharmaceutical dosages. In: Taylor A, Datz FL, eds. Clinical practice of nuclear medicine. Churchill Livingstone, 1991:450.
11. Tal A, Golan H, Grauer N, et al. Deposition pattern of radiolabeled salbutamol inhaled from a metered-dose inhaler by means of a spacer with mask in young children with airway obstruction. J Pediatr 1996;128:479-84. (Pubitemid 26114084)
12. Murakami G, Igarashi T, Adachi Y, et al. Measurement of bronchial hyperreactivity in infants and preschool children using a new method. Ann Allergy 1990;64:383-7. (Pubitemid 20118973)
13. Noble V, Ruggins NR, Everard ML, et al. Inhaled budesonide for chronic wheezing under 18 months of age. Arch Dis Child 1992;67:285-8.
14. Shah SA, Berlinski AB, Rubin BK. Force-dependent static dead space of face masks used with holding chambers. Respir Care 2006;51:140-4. (Pubitemid 46888412)
15. Amirav I, Luder A, Chleechel A, et al. Lung aerosol deposition in suckling infants. Arch Dis Child 2012;97:497-501.
16. Clarisse B, Demattei C, Nikasinovic L, et al. Bronchial obstructive phenotypes in the first year of life among Paris birth cohort infants. Pediatr Allergy Immunol 2009;20:126-33.