Discovery of 4-anilino α-carbolines as novel Brk inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 24, Issue 8, 2014, Pages 1948-1951

  Mahmoud, Kazem Ahmed ^a   Krug, Martin ^a   Wersig, Tom ^a   Slynko, Inna ^a   Schächtele, Christoph ^b   Totzke, Frank ^b   Sippl, Wolfgang ^a   Hilgeroth, Andreas ^a  

^a MARTIN LUTHER UNIVERSITY HALLE WITTENBERG   (Germany)

^b PROQINASE GMBH   (Germany)

Author keywords

Anticancer activity; Brk inhibitor; Structure activity relationships; Carbolines

Indexed keywords

4 ANILINO ALPHA CARBOLINE DERIVATIVE; ANTINEOPLASTIC AGENT; BREAST TUMOR KINASE; BREAST TUMOR KINASE INHIBITOR; CARBOLINE DERIVATIVE; LAPATINIB; PROTEIN KINASE; PROTEIN KINASE INHIBITOR; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; ARTICLE; BREAST CANCER; CANCER CELL CULTURE; DRUG ACTIVITY; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TARGETING; ENZYME INHIBITION; HUMAN; METASTASIS; MOLECULAR DOCKING; STRUCTURE ACTIVITY RELATION;

ANTICANCER ACTIVITY; BRK INHIBITOR; STRUCTURE-ACTIVITY RELATIONSHIPS; Α-CARBOLINES;

ANILINE COMPOUNDS; ANTINEOPLASTIC AGENTS; CARBOLINES; DRUG DELIVERY SYSTEMS; DRUG DISCOVERY; ENZYME ACTIVATION; HUMANS; NEOPLASM PROTEINS; PROTEIN KINASE INHIBITORS; PROTEIN-TYROSINE KINASES;

EID: 84897498997     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2014.03.002     Document Type: Article

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