Graph theory enables drug repurposing - How a mathematical model can drive the discovery of hidden mechanisms of action

PLoS ONE

Volumn 9, Issue 1, 2014, Pages

  Gramatica, Ruggero ^a,b   Di Matteo, T ^a   Giorgetti, Stefano ^b   Barbiani, Massimo ^b   Bevec, Dorian ^b   Aste, Tomaso ^c  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b Therametrics AG   (Switzerland)

^c UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERMEDIN; IMATINIB; NATRIURETIC PEPTIDE TYPE C; VASOACTIVE INTESTINAL POLYPEPTIDE;

ACUTE LYMPHOBLASTIC LEUKEMIA; ARTICLE; CHRONIC MYELOID LEUKEMIA; CREUTZFELDT JAKOB DISEASE; DERMATOFIBROSARCOMA PROTUBERANS; DRUG CHOICE; DRUG MECHANISM; DRUG REPOSITIONING; EOSINOPHILIC LEUKEMIA; GASTROINTESTINAL TUMOR; HYPEREOSINOPHILIC SYNDROME; INFORMATION RETRIEVAL; MATHEMATICAL MODEL; PATHOPHYSIOLOGY; RARE DISEASE; SARCOIDOSIS; STOCHASTIC MODEL; SYSTEMIC MASTOCYTOSIS;

BENZAMIDES; COMPUTATIONAL BIOLOGY; COMPUTER GRAPHICS; CREUTZFELDT-JAKOB SYNDROME; DRUG REPOSITIONING; HUMANS; MODELS, THEORETICAL; PIPERAZINES; PYRIMIDINES; SARCOIDOSIS; VASOACTIVE INTESTINAL PEPTIDE;

EID: 84897490774     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0084912     Document Type: Article

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