Plasma cytokine expression is associated with cardiac morbidity in chagas disease

PLoS ONE

Volumn 9, Issue 3, 2014, Pages

  Sousa, Giovane Rodrigo ^a   Gomes, Juliana Assis Silva ^a   Fares, Rafaelle Christine Gomes ^b   Damásio, Marcos Paulo De Souza ^a   Chaves, Ana Thereza ^b   Ferreira, Karine Silvestre ^a   Nunes, Maria Carmo Pereira ^a   Medeiros, Nayara Ingrid ^b   Valente, Vanessa Alves Azevedo ^a   Corrêa Oliveira, Rodrigo ^b,c   Rocha, Manoel Otávio Da Costa ^a  

^a FEDERAL UNIVERSITY OF MINAS GERAIS   (Brazil)

^b INSTITUTO OSWALDO CRUZ   (Brazil)

^c Instituto de Pesquisas René Rachou   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 1BETA; INTERLEUKIN 6; TUMOR NECROSIS FACTOR ALPHA; AUTACOID;

ADULT; AGED; ARTICLE; CHAGAS DISEASE; CHRONIC DISEASE; CONGESTIVE CARDIOMYOPATHY; CONTROLLED STUDY; CROSS-SECTIONAL STUDY; CYTOKINE PRODUCTION; DISEASE ASSOCIATION; ENZYME LINKED IMMUNOSORBENT ASSAY; HEART FUNCTION; HEART LEFT VENTRICLE EJECTION FRACTION; HUMAN; IMMUNE RESPONSE; MAJOR CLINICAL STUDY; MORBIDITY; PROTEIN EXPRESSION; TRYPANOSOMA CRUZI; BLOOD; CHAGAS CARDIOMYOPATHY; FLOW CYTOMETRY; IMMUNOLOGY; MIDDLE AGED; YOUNG ADULT;

ADULT; CHAGAS CARDIOMYOPATHY; CHAGAS DISEASE; CROSS-SECTIONAL STUDIES; CYTOKINES; FLOW CYTOMETRY; HUMANS; INFLAMMATION MEDIATORS; INTERFERON-GAMMA; INTERLEUKIN-10; INTERLEUKIN-1BETA; INTERLEUKIN-6; MIDDLE AGED; MORBIDITY; TRYPANOSOMA CRUZI; YOUNG ADULT;

EID: 84897471404     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0087082     Document Type: Article

References (24)

1. Rocha MO, Ribeiro AL, Teixeira MM (2003) Clinical management of chronic Chagas cardiomyopathy. Front Biosci 1: 44-54.
2. Rocha MO, Teixeira MM, Ribeiro AL (2007) An update on the management of Chagas cardiomyopathy. Expert Rev Anti Infect Ther 5: 727-743. (Pubitemid 47250142)
3. Dias JC (1989) The indeterminate form of human chronic Chagas' disease. A clinical epidemiological review. Rev Soc Bras Med Trop 22: 147-156.
4. Dutra WO, Gollob KJ, Pinto-Dias JC, Gazzinelli G, Correa-Oliveira R, et al. (1997) Cytokine mRNA profile of peripheral blood mononuclear cells isolated from individuals with Trypanosoma cruzi chronic infection. Scand J Immunol 45: 74-80. (Pubitemid 27013970)
5. Gomes JA, Bahia-Oliveira LM, Rocha MO, Martins-Filho OA, Gazzinelli G, et al. (2003) Evidence that development of severe cardiomyopathy in human Chagas disease is due to a Th1-specific immune response. Infect Immun 71: 1185-1193. (Pubitemid 36254300)
6. Gomes JA, Bahia-Oliveira LM, Rocha MO, Busek SC, Teixeira MM, et al. (2005) Type 1 chemokine receptor expression in Chagas disease correlates with morbidity in cardiac patients. Infect Immun 73: 7960-7966. (Pubitemid 41740281)
7. Souza PE, Rocha MO, Rocha-Vieira E, Menezes CA, Chaves AC, et al. (2004) Monocytes from patients with indeterminate and cardiac forms of Chagas' disease display distinct phenotypic and functional characteristics associated with morbidity. Infect Immun 72: 5283-5291. (Pubitemid 39223415)
8. Vitelli-Avelar DM, Sathler-Avelar R, Teixeira-Carvalho A, Pinto Dias JC, Gontijo ED, et al. (2008) Strategy to assess the overall cytokine profile of circulating leukocytes and its association with distinct clinical forms of human Chagas disease. Scand J Immunol 68: 516-525.
9. Abel LC, Rizzo LV, Ianni B, Albuquerque F, Bacal F, et al. (2001) Chronic Chagas' disease cardiomyopathy patients display an increased IFN-gamma response to Trypanosoma cruzi infection. J Autoimmun 17: 99-107. (Pubitemid 32751886)
10. de Araújo FF, Corrêa-Oliveira R, Rocha MO, Chaves AT, Fiuza JA, et al. (2012) Foxp3+CD25(high) CD4+ regulatory T cells from indeterminate patients with Chagas disease can suppress the effector cells and cytokines and reveal altered correlations with disease severity. Immunobiology 217: 768-777.
11. Araújo FF, Gomes JA, Rocha MO, Williams-Blangero S, Pinheiro VM, et al. (2007) Potential role of CD4+CD25HIGH regulatory T cells in morbidity in Chagas disease. Front Biosci 1: 2797-2806.
12. de Araújo FF, da Silveira AB, Correa-Oliveira R, Chaves AT, Adad SJ, et al. (2011) Characterization of the presence of Foxp3(+) T cells from patients with different clinical forms of Chagas' disease. Hum Pathol 42: 299-301(a).
13. de Araújo FF, Vitelli-Avelar DM, Teixeira-Carvalho A, Antas PR, Assis Silva Gomes J, et al. (2011) Regulatory T cells phenotype in different clinical forms of Chagas' disease. PLoS Negl Trop Dis 5: e992(b).
14. Chen R, Lowe L, Wilson JD, Crowther E, Tzeggai K, et al. (1999) Simultaneous quantification of six cytokines in a single sample using microparticle-based flow cytometric technology. Clin Chem 45: 1693-1694.
15. Crema E, Monteiro Ide O, Gomes MG, Silva AA, Rodrigues Júnior V (2006). Evaluation of cytokines (MIG, IFN-gamma, TNF-alpha, IL-4, IL-5, and IL-10) during the different evolutive phases of chagasic esophagopathy. Clin Immunol 119: 213-218.
16. Bahia-Oliveira LM, Gomes JA, Rocha MO, Moreira MC, Lemos EM, et al. (1998) IFN-gamma in human Chagas' disease: protection or pathology? Braz J Med Biol Res. 1998; 31: 127-131.
17. Dutra WO, Colley DG, Pinto-Dias JC, Gazzinelli G, Brener Z, et al. (2000) Self and nonself stimulatory molecules induce preferential expansion of CD5C B cells or activated T cells of chagasic patients, respectively. Scand J Immunol 51: 91-97. (Pubitemid 30074309)
18. Talvani A, Rocha MO, Barcelos LS, Gomes YM, Ribeiro AL, et al. (2004) Elevated concentrations of CCL2 and tumor necrosis factor-a in chagasic cardiomyopathy. Clin Infect Dis 38: 943-950. (Pubitemid 38457201)
19. Menezes CA, Rocha MO, Souza PE, Chaves AC, Gollob KJ, et al. (2004) Phenotypic and functional characteristics of CD28+ and CD28- cells from chagasic patients: distinct repertoire and cytokine expression. Clin Exp Immunol 137: 129-138. (Pubitemid 38869787)
20. Souza PE, Rocha MO, Menezes CA, Coelho JS, Chaves AC, et al. (2007) Trypanosoma cruzi infection induces differential modulation of costimulatory molecules and cytokines by monocytes and T cells from patients with indeterminate and cardiac Chagas' disease. Infect Immun 75:1886-1894. (Pubitemid 46559458)
21. Ferreira RC, Ianni BM, Abel LC, Buck P, Mady C, et al. (2003) Increased plasma levels of tumor necrosis factor-a in asymptomatic/ "indeterminate" and Chagas disease cardiomyopathy patients. Mem Inst Oswaldo Cruz 98: 407-411. (Pubitemid 38030560)
22. Altman DG (1991) Practical statistics for medical research. London: Chapman and Hall 419-426.
23. Reis MM, Higuchi Mde L, Benvenuti LA, Aiello VD, Gutierrez PS, et al. (1997) An in situ quantitative immunohistochemical study of cytokines and IL-2R+ in chronic human chagasic myocarditis: correlation with the presence of myocardial Trypanosoma cruzi antigens. Clin Immunol Immunopathol 83: 165-172. (Pubitemid 27195936)
24. Costa GC, da Costa Rocha MO, Moreira PR, Menezes CA, Silva MR, et al. (2009) Functional IL-10 gene polymorphism is associated with Chagas disease cardiomyopathy. J Infect Dis 199: 451-454.