The selectivity of rostroventral medulla descending control of spinal sensory inputs shifts postnatally from A fibre to C fibre evoked activity

Journal of Physiology

Volumn 592, Issue 7, 2014, Pages 1535-1544

  Koch, Stephanie C ^a   Fitzgerald, Maria ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ACTION POTENTIAL; ADULT; AFFERENT NERVE GROUP 1; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; ELECTROSTIMULATION; FACILITATION; FEMALE; JUVENILE ANIMAL; MALE; MATURATION; MEDULLA OBLONGATA; NERVE CELL EXCITABILITY; NERVE CELL INHIBITION; NERVE CELL NETWORK; NERVE FIBER C; NEWBORN; NONHUMAN; PRIORITY JOURNAL; RAT; ROSTROVENTRAL MEDULLA; SPINAL CORD DORSAL HORN; AGE; ANIMAL; COMPARATIVE STUDY; CYTOLOGY; EVOKED RESPONSE; MYELINATED NERVE; NERVE TRACT; NONMYELINATED NERVE; PHYSIOLOGY; SENSATION; SPINAL NERVE; SPRAGUE DAWLEY RAT; TIME;

AGE FACTORS; ANIMALS; ELECTRIC STIMULATION; EVOKED POTENTIALS; FEMALE; MALE; MEDULLA OBLONGATA; NERVE FIBERS, MYELINATED; NERVE FIBERS, UNMYELINATED; NEURAL INHIBITION; NEURAL PATHWAYS; RATS, SPRAGUE-DAWLEY; SENSATION; SPINAL NERVES; TIME FACTORS;

EID: 84897469024     PISSN: 00223751     EISSN: 14697793     Source Type: Journal    
DOI: 10.1113/jphysiol.2013.267518     Document Type: Article

References (35)

1. Aicher SA, Hermes SM, Whittier KL & Hegarty DM (2012). Descending projections from the rostral ventromedial medulla (RVM) to trigeminal and spinal dorsal horns are morphologically and neurochemically distinct. J Chem Neuroanat 43, 103-111.
2. Basbaum AI & Fields HL (1984). Endogenous pain control systems: brainstem spinal pathways and endorphin circuitry. Annu Rev Neurosci 7, 309-338.
3. Beggs S, Torsney C, Drew LJ & Fitzgerald M (2002). The postnatal reorganization of primary afferent input and dorsal horn cell receptive fields in the rat spinal cord is an activity-dependent process. Eur J Neurosci 16, 1249-1258.
4. Cervero F & Plenderleith MB (1985). C-fibre excitation and tonic descending inhibition of dorsal horn neurones in adult rats treated at birth with capsaicin. J Physiol 365, 223-237.
5. Fields HL, Basbaum AI, Clanton CH & Anderson SD (1977). Nucleus raphe magnus inhibition of spinal cord dorsal horn neurons. Brain Res 126, 441-453.
6. Fields HL, Basbaum AI & Heinricher MM (2006). Central nervous system mechanisms of pain modulation. In Wall and Melzack's Textbook of Pain, 5th edn, ed. McMahon S & Koltzenburg M, pp. 125-142. Elsevier, London.
7. Fitzgerald M & Koltzenburg M (1986). The functional development of descending inhibitory pathways in the dorsolateral funiculus of the newborn rat spinal cord. Brain Res 389, 261-270.
8. Gebhart GF, Sandkuhler J, Thalhammer JG & Zimmermann M (1983). Quantitative comparison of inhibition in spinal cord of nociceptive information by stimulation in periaqueductal grey or nucleus raphe magnus of the cat. J Neurophysiol 50, 1433-1445.
9. Granmo M, Petersson P & Schouenborg J (2008). Action-based body maps in the spinal cord emerge from a transitory floating organization. J Neurosci 28, 5494-5503.
10. Hathway GJ, Koch S, Low L & Fitzgerald M (2009). The changing balance of brainstem-spinal cord modulation of pain processing over the first weeks of rat postnatal life. J Physiol 587, 2927-2935.
11. Hellman KM & Mason P (2012). Opioids disrupt pro-nociceptive modulation mediated by raphe magnus. J Neurosci 32, 13668-13678.
12. Herrero JF & Cervero F (1996). Changes in nociceptive reflex facilitation during carrageenan-induced arthritis. Brain Res 717, 62-68.
13. Herrero JF, Laird JMA & Lopez-Garcia JA (2000). Wind-up of spinal cord neurones and pain sensation: much ado about something? Prog Neurobiol 61, 169-203.
14. Kwok CH, Devonshire IM, Bennett AJ & Hathway GJ (2013). Postnatal maturation of endogenous opioid systems within the periaqueductal grey and spinal dorsal horn of the rat. Pain 155, 168-178.
15. Lu Y, Sweitzer SM, Laurito CE & Yeomans DC (2004). Differential opioid inhibition of C- and Aδ-fiber mediated thermonociception after stimulation of the nucleus raphe magnus. Anesth Analg 98, 414-419.
16. McMullan S & Lumb BM (2006). Spinal dorsal horn neuronal responses to myelinated versus unmyelinated heat nociceptors and their modulation by activation of the periaqueductal grey in the rat. J Physiol 576, 547-556.
17. Mendell LM (1966). Physiological properties of unmyelinated fibre projection to the spinal cord. Exp Neurol 16, 316-332.
18. Nakatsuka T, Ataka T, Kumamoto E, Tamaki T & Yoshimura M (2000). Alteration in synaptic inputs through C-afferent fibers to substantia gelatinosa neurons of the rat spinal dorsal horn during postnatal development. Neuroscience 99, 549-556.
19. Odeh F & Antal M (2001). The projections of the midbrain periaqueductal grey to the pons and medulla oblongata in rats. Eur J Neurosci 14, 1275-1286.
20. Park JS, Nakatsuka T, Nagata K, Higashi H & Yoshimura M (1999). Reorganization of the primary afferent termination in the rat spinal dorsal horn during post-natal development. Brain Res Dev Brain Res 113, 29-36.
21. Porreca F, Ossipov MH & Gebhart GF (2002). Chronic pain and medullary descending facilitation. Trends Neurosci 25, 319-325.
22. Prieto GJ, Cannon JT & Liebeskind JC (1983). N. raphe magnus lesions disrupt stimulation-produced analgesia from ventral but not dorsal midbrain areas in the rat. Brain Res 261, 53-57.
23. Sandkühler J (2009). Models and mechanisms of hyperalgesia and allodynia. Physiol Rev 89, 707-758.
24. Sandkuhler J & Gebhart GF (1984). Characterization of inhibition of a spinal nociceptive reflex by stimulation medially and laterally in the midbrain and medulla in the pentobarbital-anaesthetized rat. Brain Res 305, 67-76.
25. Stanfa LC, Sullivan AF & Dickenson AH (1992). Alterations in neuronal excitability and the potency of spinal mu, delta and kappa opioids after carrageenan-induced inflammation. Pain 50, 345-354.
26. Tavares I & Lima D (1994). Descending projections from the caudal medulla oblongata to the superficial or deep dorsal horn of the rat spinal cord. Exp Brain Res 99, 455-463.
27. Todd AJ (2010). Neuronal circuitry for pain processing in the dorsal horn. Nat Rev Neurosci 11, 823-836.
28. Todd AJ, McGill MM & Shehab SA (2000). Neurokinin 1 receptor expression by neurons in laminae I, III and IV of the rat spinal dorsal horn that project to the brainstem. Eur J Neurosci 12, 689-700.
29. Traub RJ (1997). Spinal modulation of the induction of central sensitization. Brain Res 778, 34-42.
30. Waters AJ & Lumb BM (2008). Descending control of spinal nociception from the periaqueductal grey distinguishes between neurons with and without C-fibre inputs. Pain 134, 32-40.
31. Weinkauf B, Main M, Schmelz M & Rukwied R (2013). Modality-specific nociceptor sensitization following UV-B irradiation of human skin. J Pain 14, 739-746.
32. Weiss T, Straube T, Boettcher J, Hecht H, Spohn D & Miltner WHR (2008). Brain activation upon selective stimulation of cutaneous C- and Aδ-fibers. NeuroImage 41, 1372-1381.
33. Zhuo M & Gebhart GF (1990). Characterization of descending inhibition and facilitation from the nuclei reticularis gigantocellularis and gigantocellularis pars alpha in the rat. Pain 42, 337-350.
34. Zhuo M & Gebhart GF (1994). Effects of neonatal capsaicin treatment on descending modulation of spinal nociception from the rostral, medial medulla in adult rat. Brain Res 645, 164-178.
35. Zhuo M & Gebhart GF (1997). Biphasic modulation of spinal nociceptive transmission from the medullary raphe nuclei in the rat. J Neurophysiol 78, 746-758.