Timing matters: NSAIDs interfere with the late proliferation stage of a repaired rotator cuff tendon healing in rats

Archives of Orthopaedic and Trauma Surgery

Volumn 134, Issue 4, 2014, Pages 515-520

  Chechik, Ofir ^a   Dolkart, Oleg ^a   Mozes, Gavriel ^a   Rak, Ofer ^a   Alhajajra, Fadi ^a   Maman, Eran ^a  

^a TEL AVIV UNIVERSITY   (Israel)

Author keywords

Maximal load; NSAID; Rotator cuff; Tendon healing

Indexed keywords

COLLAGEN; MELOXICAM; SODIUM CHLORIDE;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOMECHANICS; CONTROLLED STUDY; DRUG EFFECT; HEALING; HISTOPATHOLOGY; MALE; NONHUMAN; POSTOPERATIVE PERIOD; PRIORITY JOURNAL; QUALITATIVE ANALYSIS; RAT; RIGIDITY; ROTATOR CUFF; ROTATOR CUFF RUPTURE; TENDON RECONSTRUCTION; VASCULARIZATION;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; BIOMECHANICAL PHENOMENA; DRUG ADMINISTRATION SCHEDULE; MALE; RANDOM ALLOCATION; RATS; RATS, WISTAR; ROTATOR CUFF; TENDONS; THIAZINES; THIAZOLES; WOUND HEALING;

EID: 84897468304     PISSN: 09368051     EISSN: 14343916     Source Type: Journal    
DOI: 10.1007/s00402-014-1928-5     Document Type: Article

References (23)

1. Simon AM, Manigrasso MB, O'Connor JP (2002) Cyclo-oxygenase 2 function is essential for bone fracture healing. J Bone Miner Res 17(6):963-976. doi:10.1359/jbmr.2002.17.6.963 (Pubitemid 34535133)
2. Zhang X, Schwarz EM, Young DA, Puzas JE, Rosier RN, O'Keefe RJ (2002) Cyclooxygenase-2 regulates mesenchymal cell differentiation into the osteoblast lineage and is critically involved in bone repair. J Clin Invest 109(11):1405-1415. doi:10.1172/JCI15681 (Pubitemid 34596166)
3. Cohen DB, Kawamura S, Ehteshami JR, Rodeo SA (2006) Indomethacin and celecoxib impair rotator cuff tendon-to-bone healing. Am J Sports Med 34(3):362-369. doi:10.1177/0363546505280428 (Pubitemid 43260571)
4. Elder CL, Dahners LE, Weinhold PS (2001) A cyclooxygenase-2 inhibitor impairs ligament healing in the rat. Am J Sports Med 29(6):801-805 (Pubitemid 33080866)
5. Ferry ST, Dahners LE, Afshari HM, Weinhold PS (2007) The effects of common anti-inflammatory drugs on the healing rat patellar tendon. Am J Sports Med 35(8):1326-1333. doi:10.1177/0363546507301584 (Pubitemid 47086271)
6. Bogatov VB, Weinhold P, Dahners LE (2003) The influence of a cyclooxygenase-1 inhibitor on injured and uninjured ligaments in the rat. Am J Sports Med 31(4):574-576 (Pubitemid 36875390)
7. Virchenko O, Skoglund B, Aspenberg P (2004) Parecoxib impairs early tendon repair but improves later remodeling. Am J Sports Med 32(7):1743-1747 (Pubitemid 39390526)
8. Fleischmann R, Iqbal I, Slobodin G (2002) Meloxicam. Expert Opin Pharmacother 3(10):1501-1512. doi:10.1517/14656566.3.10.1501 (Pubitemid 35174882)
9. Engelhardt G, Homma D, Schnitzler C (1995) Meloxicam: a potent inhibitor of adjuvant arthritis in the Lewis rat. Inflamm Res 44(12):548-555 (Pubitemid 26008751)
10. Engelhardt G, Bogel R, Schnitzler C, Utzmann R (1996) Meloxicam: influence on arachidonic acid metabolism. Part II. In vivo findings. Biochem Pharmacol 51(1):29-38. doi:0006295295021108
11. Pairet M, van Ryn J, Schierok H, Mauz A, Trummlitz G, Engelhardt G (1998) Differential inhibition of cyclooxygenases-1 and -2 by meloxicam and its 4′-isomer. Inflamm Res 47(6):270-276 (Pubitemid 28325586)
12. Busch U, Schmid J, Heinzel G, Schmaus H, Baierl J, Huber C, Roth W (1998) Pharmacokinetics of meloxicam in animals and the relevance to humans. Drug Metab Dispos 26(6):576-584 (Pubitemid 28498364)
13. Hashmi JA, Yashpal K, Holdsworth DW, Henry JL (2010) Sensory and vascular changes in a rat monoarthritis model: prophylactic and therapeutic effects of meloxicam. Inflamm Res 59(8):667-678. doi:10.1007/s00011-010-0179-3
14. Sui Y, Stanic D, Tomas D, Jarrott B, Horne MK (2009) Meloxicam reduces lipopolysaccharide-induced degeneration of dopaminergic neurons in the rat substantia nigra pars compacta. Neurosci Lett 460(2):121-125. doi:10.1016/j.neulet.2009.05.033
15. Galatz LM, Ball CM, Teefey SA, Middleton WD, Yamaguchi K (2004) The outcome and repair integrity of completely arthroscopically repaired large and massive rotator cuff tears. J Bone Joint Surg Am 86-A(2):219-224 (Pubitemid 38141554)
16. Shadwick RE (1990) Elastic energy storage in tendons: mechanical differences related to function and age. J Appl Physiol 68(3):1033-1040
17. Sharma P, Maffulli N (2006) Biology of tendon injury: healing, modeling and remodeling. J Musculoskelet Neuronal Interact 6(2):181-190 (Pubitemid 44193219)
18. Murphy PG, Loitz BJ, Frank CB, Hart DA (1994) Influence of exogenous growth factors on the synthesis and secretion of collagen types I and III by explants of normal and healing rabbit ligaments. Biochem Cell Biol 72(9-10):403-409
19. Oakes BW (2003) Tissue healing and repair: tendons and ligaments. In: Frontera WR (ed) Rehabilitation of sports injuries: scientific basis. Blackwell, Boston
20. Dahners LE, Gilbert JA, Lester GE, Taft TN, Payne LZ (1988) The effect of a nonsteroidal antiinflammatory drug on the healing of ligaments. Am J Sports Med 16(6):641-646 (Pubitemid 19022505)
21. Marsolais D, Cote CH, Frenette J (2003) Nonsteroidal anti-inflammatory drug reduces neutrophil and macrophage accumulation but does not improve tendon regeneration. Lab Invest 83(7):991-999 (Pubitemid 36899066)
22. Mikolyzk DK, Wei AS, Tonino P, Marra G, Williams DA, Himes RD, Wezeman FH, Callaci JJ (2009) Effect of corticosteroids on the biomechanical strength of rat rotator cuff tendon. J Bone Joint Surg Am 91(5):1172-1180
23. Cheung EV, Silverio L, Sperling JW (2010) Strategies in biologic augmentation of rotator cuff repair: a review. Clin Orthop Relat Res 468(6):1476-1484