메뉴 건너뛰기




Volumn 15, Issue 5, 2014, Pages 301-310

A meta-analysis of the efficacy and safety of unboosted atazanavir compared with ritonavir-boosted protease inhibitor maintenance therapy in HIV-infected adults with established virological suppression after induction

Author keywords

Atazanavir; HIV; Meta analysis; Ritonavir; Unboosted

Indexed keywords

ATAZANAVIR; INDINAVIR PLUS RITONAVIR; LOPINAVIR PLUS RITONAVIR; LOW DENSITY LIPOPROTEIN CHOLESTEROL; RITONAVIR; RITONAVIR PLUS SAQUINAVIR; TRIACYLGLYCEROL; VIRUS RNA;

EID: 84897450953     PISSN: 14642662     EISSN: 14681293     Source Type: Journal    
DOI: 10.1111/hiv.12118     Document Type: Article
Times cited : (20)

References (30)
  • 1
    • 84864131448 scopus 로고    scopus 로고
    • Antiretroviral treatment of adult HIV infection. 2012 recommendations on the international antiviral society - USA Panel
    • Thompson MA, Aberg JA, Hoy JF etal. Antiretroviral treatment of adult HIV infection. 2012 recommendations on the international antiviral society - USA Panel. JAMA 2012; 308: 387-402.
    • (2012) JAMA , vol.308 , pp. 387-402
    • Thompson, M.A.1    Aberg, J.A.2    Hoy, J.F.3
  • 2
    • 84897374977 scopus 로고    scopus 로고
    • Panel on Antiretroviral Guidelines for Adults and Adolescents. Guidelines for the use of antiretroviral agents in HIV-1-infected adults and adolescents. Department of Health and Human Services. Available at:(accessed 15 May 2013).
    • Panel on Antiretroviral Guidelines for Adults and Adolescents. Guidelines for the use of antiretroviral agents in HIV-1-infected adults and adolescents. Department of Health and Human Services. Available at: http://aidsinfo.nih.gov/ContentFiles/AdultandAdolescentGL.pdf (accessed 15 May 2013).
  • 3
    • 78651113527 scopus 로고    scopus 로고
    • Unboosted Atazanavir-based therapy maintains control of HIV type-1 replication as effectively as a ritonavir-boosted regimen
    • Ghosn J, Carosi G, Moreno S etal. Unboosted Atazanavir-based therapy maintains control of HIV type-1 replication as effectively as a ritonavir-boosted regimen. Antivir Ther 2010; 15: 993-1002.
    • (2010) Antivir Ther , vol.15 , pp. 993-1002
    • Ghosn, J.1    Carosi, G.2    Moreno, S.3
  • 5
    • 13944282290 scopus 로고    scopus 로고
    • Protease inhibitor exposure and increased risk of cardiovascular disease in HIV-1 infected patients
    • Iloeje UH, Yuan Y, L'italien G etal. Protease inhibitor exposure and increased risk of cardiovascular disease in HIV-1 infected patients. HIV Med 2005; 6: 37-44.
    • (2005) HIV Med , vol.6 , pp. 37-44
    • Iloeje, U.H.1    Yuan, Y.2    L'italien, G.3
  • 6
    • 0345064200 scopus 로고    scopus 로고
    • Combination antiretroviral therapy and the risk of myocardial infarction
    • Friis-Moller N, Sabin CA, Weber R etal. Combination antiretroviral therapy and the risk of myocardial infarction. N Engl J Med 2003; 349: 1993-2003.
    • (2003) N Engl J Med , vol.349 , pp. 1993-2003
    • Friis-Moller, N.1    Sabin, C.A.2    Weber, R.3
  • 7
    • 34247537169 scopus 로고    scopus 로고
    • Class of antiretroviral drugs and the risk of myocardial infarction
    • DAD Study Group
    • DAD Study Group, Friis-Moller N, Reiss P etal. Class of antiretroviral drugs and the risk of myocardial infarction. N Engl J Med 2007; 356: 1723-1735.
    • (2007) N Engl J Med , vol.356 , pp. 1723-1735
    • Friis-Moller, N.1    Reiss, P.2
  • 8
    • 0038046900 scopus 로고    scopus 로고
    • Incidence of hyperlipidemia in a cohort of 212 HIV-infected patients receiving a protease inhibitor-based antiretroviral therapy
    • Calza L, Manfredi R, Farneti B, Chiodo F. Incidence of hyperlipidemia in a cohort of 212 HIV-infected patients receiving a protease inhibitor-based antiretroviral therapy. Int J Antimicrob Agents 2003; 22: 54-59.
    • (2003) Int J Antimicrob Agents , vol.22 , pp. 54-59
    • Calza, L.1    Manfredi, R.2    Farneti, B.3    Chiodo, F.4
  • 9
    • 28444452174 scopus 로고    scopus 로고
    • The effect of low-dose ritonavir monotherapy on fasting serum lipid concentrations
    • Shafran SD, Mashinter LD, Roberts SE. The effect of low-dose ritonavir monotherapy on fasting serum lipid concentrations. HIV Med 2005; 6: 421-425.
    • (2005) HIV Med , vol.6 , pp. 421-425
    • Shafran, S.D.1    Mashinter, L.D.2    Roberts, S.E.3
  • 10
    • 77955622847 scopus 로고    scopus 로고
    • Lipid profiles in HIV-infected adults receiving Atazanavir and Atazanavir/ritonavir: systematic review and meta-analysis of randomized controlled trials
    • Carey D, Amin J, Boyd M, Petoumenos K, Emery S. Lipid profiles in HIV-infected adults receiving Atazanavir and Atazanavir/ritonavir: systematic review and meta-analysis of randomized controlled trials. J Antimicrob Chemother 2010; 65: 1878-1888.
    • (2010) J Antimicrob Chemother , vol.65 , pp. 1878-1888
    • Carey, D.1    Amin, J.2    Boyd, M.3    Petoumenos, K.4    Emery, S.5
  • 11
    • 84872289310 scopus 로고    scopus 로고
    • Atazanavir is not associated with an increased risk of cardio- or cerebrovascular disease events
    • Monforte AD, Reiss P, Ryom L etal. Atazanavir is not associated with an increased risk of cardio- or cerebrovascular disease events. AIDS 2013; 27: 407-415.
    • (2013) AIDS , vol.27 , pp. 407-415
    • Monforte, A.D.1    Reiss, P.2    Ryom, L.3
  • 12
    • 84897386794 scopus 로고    scopus 로고
    • TM (Atazanavir sulfate) Azapeptide Inhibitor of HIV-1 Protease. Quebec, Canada. Prepared December 3, Revised May 11, 2012). Control Number: 154449.
    • TM (Atazanavir sulfate) Azapeptide Inhibitor of HIV-1 Protease. Quebec, Canada. Prepared December 3, 2003 (Revised May 11, 2012). Control Number: 154449.
    • (2003)
  • 13
    • 84897433525 scopus 로고    scopus 로고
    • TM (Atazanavir sulfate). New Jersey, USA. Approved. Revised March 2012. 1246226B2. 687US11PBS05504.
    • TM (Atazanavir sulfate). New Jersey, USA. Approved 2003. Revised March 2012. 1246226B2. 687US11PBS05504.
    • (2003)
  • 14
    • 77955415316 scopus 로고    scopus 로고
    • Similar efficacy and tolerability of Atazanavir compared with Atazanavir/ritonavir, each with abacavir/lamivudine after initial suppression with abacavir/lamivudine plus ritonavir-boosted Atazanavir in HIV-infected patients
    • Squires KE, Young B, Dejesus E etal. Similar efficacy and tolerability of Atazanavir compared with Atazanavir/ritonavir, each with abacavir/lamivudine after initial suppression with abacavir/lamivudine plus ritonavir-boosted Atazanavir in HIV-infected patients. AIDS 2010; 24: 2019-2027.
    • (2010) AIDS , vol.24 , pp. 2019-2027
    • Squires, K.E.1    Young, B.2    Dejesus, E.3
  • 15
    • 84862134392 scopus 로고    scopus 로고
    • Unboosted Atazanavir for treatment of HIV infection: rationale and recommendations for use
    • Focà E, Ripamonti D, Motta D, Torti C. Unboosted Atazanavir for treatment of HIV infection: rationale and recommendations for use. Drugs 2012; 72: 1161-1173.
    • (2012) Drugs , vol.72 , pp. 1161-1173
    • Focà, E.1    Ripamonti, D.2    Motta, D.3    Torti, C.4
  • 16
    • 77953672515 scopus 로고    scopus 로고
    • 96-week efficacy and safety of atazanavir, with and without ritonavir, in a HAART regimen in treatment-naive patients
    • Malan DR, Krantz E, David N etal. 96-week efficacy and safety of atazanavir, with and without ritonavir, in a HAART regimen in treatment-naive patients. J Int Assoc Physicians AIDS Care (Chic) 2010; 9: 34-42.
    • (2010) J Int Assoc Physicians AIDS Care (Chic) , vol.9 , pp. 34-42
    • Malan, D.R.1    Krantz, E.2    David, N.3
  • 17
    • 85100415918 scopus 로고    scopus 로고
    • Higgins JPT, Green S, eds. Cochrane handbook for systematic reviews of interventions version 5.1.0. The Cochrane Collaboration. Available at:(accessed 20 August 2012).
    • Higgins JPT, Green S, eds. Cochrane handbook for systematic reviews of interventions version 5.1.0. The Cochrane Collaboration. 2011. Available at: http://www.cochrane-handbook.org (accessed 20 August 2012).
    • (2011)
  • 18
    • 84897376807 scopus 로고    scopus 로고
    • Simplification to Abacavir/Lamivudine + Atazanavir From Tenofovir/Emtricitabine + Atazanavir/Ritonavir Maintains Viral Suppression and Improves Bone Biomarkers. Oral Abstract H-556c. 52nd ICAAC. San Francisco, CA. September 9-12
    • Wohl D, Bhatti L, Small CB etal. Simplification to Abacavir/Lamivudine + Atazanavir From Tenofovir/Emtricitabine + Atazanavir/Ritonavir Maintains Viral Suppression and Improves Bone Biomarkers. Oral Abstract H-556c. 52nd ICAAC. San Francisco, CA. September 9-12, 2012.
    • (2012)
    • Wohl, D.1    Bhatti, L.2    Small, C.B.3
  • 19
    • 37549038211 scopus 로고    scopus 로고
    • Efficacy and safety of replacing lopinavir with Atazanavir in HIV-infected patients with undetectable plasma viraemia: final results of the SLOAT trial
    • Soriano V, García-Gasco P, Vispo E etal. Efficacy and safety of replacing lopinavir with Atazanavir in HIV-infected patients with undetectable plasma viraemia: final results of the SLOAT trial. J Antimicrob Chemother 2008; 61: 200-205.
    • (2008) J Antimicrob Chemother , vol.61 , pp. 200-205
    • Soriano, V.1    García-Gasco, P.2    Vispo, E.3
  • 20
    • 34249078589 scopus 로고    scopus 로고
    • Efficacy and safety of Atazanavir-based highly activeantiretroviral therapy in patients with virologic suppression switched from a stable, boosted or unboosted protease inhibitor treatment regimen: the SWAN study (AI424-097) 48-week results
    • Gatell J, Salmon-Ceron D, Lazzarin A etal. Efficacy and safety of Atazanavir-based highly activeantiretroviral therapy in patients with virologic suppression switched from a stable, boosted or unboosted protease inhibitor treatment regimen: the SWAN study (AI424-097) 48-week results. Clin Infect Dis 2007; 44: 1484-1492.
    • (2007) Clin Infect Dis , vol.44 , pp. 1484-1492
    • Gatell, J.1    Salmon-Ceron, D.2    Lazzarin, A.3
  • 21
    • 84897416946 scopus 로고    scopus 로고
    • Atazanavir (ATV)-Containing Antiretroviral Treatment is not Associated with an Increased Risk of Cardio- or Cerebro-Vascular Events (CVE) in the D:A:D Study. [Poster No. 823]. CROI.
    • D'arminio Monforte A, Reiss P, Ryom L etal. Atazanavir (ATV)-Containing Antiretroviral Treatment is not Associated with an Increased Risk of Cardio- or Cerebro-Vascular Events (CVE) in the D:A:D Study. [Poster No. 823]. CROI 2012.
    • (2012)
    • D'arminio Monforte, A.1    Reiss, P.2    Ryom, L.3
  • 22
    • 72449169534 scopus 로고    scopus 로고
    • Efficacy and safety of boosted and unboosted atazanavir-containing antiretroviral regimens in real life: results from a multicentre cohort study
    • Giuntini R, Martinelli C, Ricci E etal. Efficacy and safety of boosted and unboosted atazanavir-containing antiretroviral regimens in real life: results from a multicentre cohort study. HIV Med 2010; 11: 40-45.
    • (2010) HIV Med , vol.11 , pp. 40-45
    • Giuntini, R.1    Martinelli, C.2    Ricci, E.3
  • 23
    • 69249131697 scopus 로고    scopus 로고
    • Unboosted atazanavir plus co-formulated lamivudine/abacavir as a ritonavir-sparing simplification strategy in routine clinical practice
    • Santos JR, Moltó J, Llibre JM etal. Unboosted atazanavir plus co-formulated lamivudine/abacavir as a ritonavir-sparing simplification strategy in routine clinical practice. HIV Clin Trials 2009; 10: 129-134.
    • (2009) HIV Clin Trials , vol.10 , pp. 129-134
    • Santos, J.R.1    Moltó, J.2    Llibre, J.M.3
  • 24
    • 84897402582 scopus 로고    scopus 로고
    • Maintenance therapy with unboosted atazanavir is comparable to boosted strategy in experienced patients, even with tenofovir: a multicentre propensity-adjusted cohort. 6th IAS conference on HIV pathogenesis, treatment and prevention. Rome, July [Abstract no. CDB359].
    • Hocqueloux L, Le Moal G, De la Tribonnier X etal. Maintenance therapy with unboosted atazanavir is comparable to boosted strategy in experienced patients, even with tenofovir: a multicentre propensity-adjusted cohort. 6th IAS conference on HIV pathogenesis, treatment and prevention. Rome, July 2011 [Abstract no. CDB359].
    • (2011)
    • Hocqueloux, L.1    Le Moal, G.2    De la Tribonnier, X.3
  • 25
    • 80052871466 scopus 로고    scopus 로고
    • Efficacy and safety of a switch to unboosted atazanavir in combination with nucleoside analogues in HIV-1-infected patients with virological suppression under antiretroviral therapy
    • Pavie J, Porcher R, Torti C etal. Efficacy and safety of a switch to unboosted atazanavir in combination with nucleoside analogues in HIV-1-infected patients with virological suppression under antiretroviral therapy. J Antimicrob Chemother 2011; 66: 2372-2378.
    • (2011) J Antimicrob Chemother , vol.66 , pp. 2372-2378
    • Pavie, J.1    Porcher, R.2    Torti, C.3
  • 26
    • 84891727841 scopus 로고    scopus 로고
    • Efficacy of boosted and unboosted atazanavir-based therapy in patients without prior antiretroviral treatment failure [abstract P079]
    • Wentzell J, Kravcik S, Giguere P. Efficacy of boosted and unboosted atazanavir-based therapy in patients without prior antiretroviral treatment failure [abstract P079]. Can J Infect Dis Med Microbiol 2012; 23 (Suppl A): 66A.
    • (2012) Can J Infect Dis Med Microbiol , vol.23 , Issue.SUPPL. A
    • Wentzell, J.1    Kravcik, S.2    Giguere, P.3
  • 27
    • 27144482749 scopus 로고    scopus 로고
    • Comparison of atazanavir with lopinavir/ritonavir in patients with prior protease inhibitor failure: a randomized multinational trial
    • Cohen C, Nieto-Cisneros L, Zala C etal. Comparison of atazanavir with lopinavir/ritonavir in patients with prior protease inhibitor failure: a randomized multinational trial. Curr Med Res Opin 2005; 21: 1683-1692.
    • (2005) Curr Med Res Opin , vol.21 , pp. 1683-1692
    • Cohen, C.1    Nieto-Cisneros, L.2    Zala, C.3
  • 28
    • 84921703883 scopus 로고    scopus 로고
    • Atazanavir: new recommendations if combined with tenofovir (Viread) - and warning on Viagra, Cialis, and Levitra
    • Atazanavir: new recommendations if combined with tenofovir (Viread) - and warning on Viagra, Cialis, and Levitra. AIDS Treat News 2004; 399: 5.
    • (2004) AIDS Treat News , vol.399 , pp. 5
  • 29
    • 84875158790 scopus 로고    scopus 로고
    • Negligible effect of tenofovir on atazanavir trough concentrations and genotypic inhibitory quotients in the presence and absence of ritonavir
    • Fournier C, Higgins N, Thomas R etal. Negligible effect of tenofovir on atazanavir trough concentrations and genotypic inhibitory quotients in the presence and absence of ritonavir. Ther Drug Monit 2013; 35: 264-269.
    • (2013) Ther Drug Monit , vol.35 , pp. 264-269
    • Fournier, C.1    Higgins, N.2    Thomas, R.3
  • 30
    • 84897436372 scopus 로고    scopus 로고
    • Similar efficacy and tolerability of atazanavir (ATV) compared to ATV/ritonavir (RTV), each in combination with abacavir/lamivudine (ABC/3TC) after initial suppression with ABC/3TC + ATV/RTV in HIV-1 infected patients: Final (144 weeks) results of the op. 6th IAS Conference on HIV Pathogenesis, Treatment and Prevention. Rome, July [Abstract no. MOPE215].
    • Squires K, Young B, Dejesus E etal. Similar efficacy and tolerability of atazanavir (ATV) compared to ATV/ritonavir (RTV), each in combination with abacavir/lamivudine (ABC/3TC) after initial suppression with ABC/3TC + ATV/RTV in HIV-1 infected patients: Final (144 weeks) results of the op. 6th IAS Conference on HIV Pathogenesis, Treatment and Prevention. Rome, July 2011 [Abstract no. MOPE215].
    • (2011)
    • Squires, K.1    Young, B.2    Dejesus, E.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.