The detection of THC, CBD and CBN in the oral fluid of Sativex® patients using two on-site screening tests and LC-MS/MS

Forensic Science International

Volumn 238, Issue , 2014, Pages 113-119

  Molnar, Anna ^a   Fu, Shanlin ^a   Lewis, John ^a   Allsop, David J ^b   Copeland, Jan ^b  

^a UNIVERSITY OF TECHNOLOGY SYDNEY   (Australia)

^b National Cannabis Prevention and Information Centre   (Australia)

Author keywords

Cannabinoids; Oral fluid

Indexed keywords

CANNABIDIOL; CANNABINOL; DRONABINOL; NABIXIMOLS; PLACEBO; CENTRAL MUSCLE RELAXANT; ORAL SPRAY; PLANT EXTRACT; TETRAHYDROCANNABINOL-CANNABIDIOL COMBINATION;

ADULT; ARTICLE; AUSTRALIA; BODY FLUID; CANNABIS ADDICTION; CLINICAL ARTICLE; CONTROLLED STUDY; DIAGNOSTIC KIT; DOUBLE BLIND PROCEDURE; DRUG MEGADOSE; DRUG SCREENING; FALSE NEGATIVE RESULT; FEMALE; HUMAN; LIMIT OF DETECTION; LIMIT OF QUANTITATION; LIQUID CHROMATOGRAPHY; LOW DRUG DOSE; MALE; MEASUREMENT ACCURACY; MEASUREMENT PRECISION; ORAL FLUID; PILOT STUDY; PRIORITY JOURNAL; SALIVA COLLECTOR; SCREENING TEST; TANDEM MASS SPECTROMETRY; VALIDATION STUDY; CHEMISTRY; CONTROLLED CLINICAL TRIAL; DEVICES; MULTIPLE SCLEROSIS; ORAL SPRAY; SALIVA; SUBSTANCE ABUSE;

ADULT; AUSTRALIA; CANNABIDIOL; CANNABINOL; CHROMATOGRAPHY, LIQUID; DOUBLE-BLIND METHOD; DRONABINOL; FEMALE; HUMANS; MALE; MULTIPLE SCLEROSIS; MUSCLE RELAXANTS, CENTRAL; ORAL SPRAYS; PILOT PROJECTS; PLANT EXTRACTS; SALIVA; SUBSTANCE ABUSE DETECTION; TANDEM MASS SPECTROMETRY;

EID: 84897441685     PISSN: 03790738     EISSN: 18726283     Source Type: Journal    
DOI: 10.1016/j.forsciint.2014.03.004     Document Type: Article

References (18)

1. Transport for New South Wales Roadside Drug Testing 2006, http://roadsafety.transport.nsw.gov.au/downloads/2006_12_drugdriving.pdf (viewed 4 February 2014).
2. Cozart Bioscience Limited, Cozart® DDS: Technical Specifications, viewed 4 February 2014, http://www.igz.ch/puebersicht.asp?action=download&fileid=6431
3. Drummer O.H., Gerostamoulos D., Chu M., Swann P., Boorman M., Cairns I. Drugs in oral fluid in randomly selected drivers. Forensic Sci. Int. 2007, 170:105-110.
4. GW Pharmaceuticals Summary of Product Characteristics 2011, http://www.gwpharm.com/SPC.aspx (viewed 23 July 2013).
5. Australian Government Department of Health and Ageing Therapeutic Goods Administration, Australian Register of Therapeutic Goods (ARTG), viewed 23 July 2013, .
6. Lee D., Karschner E.L., Milman G., Barnes A.J., Goodwin R.S., Huestis M.A. Can oral fluid cannabinoid testing monitor medication compliance and/or cannabis smoking during oral THC and oromucosal Sativex administration?. Drug Alcohol Depend. 2013, 130:68-76.
7. American Psychiatric Association Diagnostic and Statistical Manual of Mental Disorders 2000, American Psychiatric Association, Washington, DC, text rev. fourth ed.
8. Molnar A., Lewis J., Doble P., Hansen G., Prolov T., Fu S. A rapid and sensitive method for the identification of delta-9-tetrahydrocannabinol in oral fluid by liquid chromatography-tandem mass spectrometry. Forensic Sci. Int. 2012, 215:92-96.
9. Peters F.T., Drummer O.H., Musshoff F. Validation of new methods. Forensic Sci. Int. 2007, 165:216-224.
10. Australian Standard® Procedures for Specimen Collection and the Detection and Quantification of Drugs in Oral Fluid 2006, SAI-Global, Sydney, Australia.
11. Walsh J.M., Crouch D.J., Danaceau J.P., Cangianelli L., Liddicoat L., Adkins R. Evaluation of ten oral fluid point-of-collection drug-testing devices. J. Anal. Toxicol. 2007, 31:44-54.
12. Molnar A., Lewis J., Fu S. Recovery of spiked δ9-tetrahydrocannabinol in oral fluid from polypropylene containers. Forensic Sci. Int. 2013, 227:69-73.
13. Swift W., Wong A., Li K., Arnold J., McGregor I. Analysis of cannabis seizures in NSW, Australia: cannabis potency and cannabinoid profile. PLoS One 2013, 8.
14. Fabritius M., Staub C., Mangin P., Giroud C. Analysis of cannabinoids in oral fluid by liquid chromatography-tandem mass spectrometry. Forensic Toxicol. 2013, 31:151-163.
15. Milman G., Barnes A.J., Lowe R.H., Huestis M.A. Simultaneous quantification of cannabinoids and metabolites in oral fluid by two-dimensional gas chromatography mass spectrometry. J. Chromatogr. A 2010, 1217:1513-1521.
16. Moore C., Coulter C., Uges D., Tuyay J., van der Linde S., van Leeuwen A., Garnier M., Orbita J. Cannabinoids in oral fluid following passive exposure to marijuana smoke. Forensic Sci. Int. 2011, 212:227-230.
17. Moore C., Rana S., Coulter C. Simultaneous identification of 2-carboxy-tetrahydrocannabinol, tetrahydrocannabinol, cannabinol and cannabidiol in oral fluid. J. Chromatogr. B 2007, 852:459-464.
18. Lee D., Milman G., Schwope D.M., Barnes A.J., Gorelick D.A., Huestis M.A. Cannabinoid stability in authentic oral fluid after controlled cannabis smoking. Clin. Chem. 2012, 58:1101-1109.