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Novel therapies for hepatitis C: insights from the structure of the virus
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Fusco, D.N.1
Chung, R.T.2
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78049375232
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Mechanism of activation of PSI-7851 and its diastereoisomer PSI-7977
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Murakami E, Tolstykh T, Bao H, Niu C, Steuer HM, Bao D, et al. Mechanism of activation of PSI-7851 and its diastereoisomer PSI-7977. J Biol Chem 2010;285:34337-34347.
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Bao, D.6
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84877730954
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Sofosbuvir for previously untreated chronic hepatitis C infection
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Lawitz E, Mangia A, Wyles D, Rodriguez-Torres M, Hassanein T, Gordon SC, et al. Sofosbuvir for previously untreated chronic hepatitis C infection. N Engl J Med 2013;368:1878-1887.
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Lawitz, E.1
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Hassanein, T.5
Gordon, S.C.6
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4
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84877739274
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Sofosbuvir for hepatitis C genotype 2 or 3 in patients without treatment options
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Jacobson IM, Gordon SC, Kowdley KV, Yoshida EM, Rodriguez-Torres M, Sulkowski MS, et al. Sofosbuvir for hepatitis C genotype 2 or 3 in patients without treatment options. N Engl J Med 2013;368:1867-1877.
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Washington, DC, November 1-5, Abstract 1085.
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Zeuzem S DG, Salupere R, et al. Sofosbuvir+ribavirin for 12 or 24 weeks for patients with HCV genotype 2 or 3: the VALENCE trial. 64th Annual Meeting of the American Association for the Study of Liver Diseases, Washington, DC, November 1-5, 2013. Abstract 1085.
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Sofosbuvir+ribavirin for 12 or 24 weeks for patients with HCV genotype 2 or 3: the VALENCE trial. 64th Annual Meeting of the American Association for the Study of Liver Diseases
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Zeuzem, S.D.1
Salupere, R.2
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Washington, DC, November 1-5, Abstract 212.
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Sulkowski MS R-TM, Lalezari JP, et al. All-oral therapy with sofosbuvir plus ribavirin for the treatment of HCV genotype 1, 2, and 3 infection in patients co-infected with HIV (PHOTON-1). 64th Annual Meeting of the American Association for the Study of Liver Diseases, Washington, DC, November 1-5, 2013. Abstract 212.
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All-oral therapy with sofosbuvir plus ribavirin for the treatment of HCV genotype 1, 2, and 3 infection in patients co-infected with HIV (PHOTON-1). 64th Annual Meeting of the American Association for the Study of Liver Diseases
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Sulkowski, M.R.-T.1
Lalezari, J.P.2
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7
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65749112245
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In vitro activity and preclinical profile of TMC435350, a potent hepatitis C virus protease inhibitor
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Lin TI, Lenz O, Fanning G, Verbinnen T, Delouvroy F, Scholliers A, et al. In vitro activity and preclinical profile of TMC435350, a potent hepatitis C virus protease inhibitor. Antimicrob Agents Chemother 2009;53:1377-1385.
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Jacobson IM. Simeprevir (TMC435) with peginterferon/ribavirin for chronic HCV genotype 1 infection in treatment-naive patients; results from QUEST-1, a phase III trial. Digestive Disease Week, Orlando, FL, May 18-21, 2013. Abstract 1674582.
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Simeprevir (TMC435) with peginterferon/ribavirin for chronic HCV genotype 1 infection in treatment-naive patients; results from QUEST-1, a phase III trial. Digestive Disease Week
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Poordad F. Simeprevir with peginterferon-a2a or -a2b and ribavirin in treatment-naive HCV genotype 1 patients: QUEST-2, a randomized phase III trial. Digestive Disease Week, Orlando, FL, May 18-21, 2013. Abstract 070313.
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Simeprevir with peginterferon-a2a or -a2b and ribavirin in treatment-naive HCV genotype 1 patients: QUEST-2, a randomized phase III trial. Digestive Disease Week
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Poordad, F.1
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Orlando, FL, May 18-21, Abstract 869b.
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Lawitz E. Simeprevir with peginterferon/ribavirin for treatment of chronic HCV genotype 1 infection in patients who relapsed after previous interferon-based therapy: results from PROMISE, a phase III trial. Digestive Disease Week, Orlando, FL, May 18-21, 2013. Abstract 869b.
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(2013)
Simeprevir with peginterferon/ribavirin for treatment of chronic HCV genotype 1 infection in patients who relapsed after previous interferon-based therapy: results from PROMISE, a phase III trial. Digestive Disease Week
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Lawitz, E.1
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11
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84892806505
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Simeprevir increases rate of sustained virologic response among treatment-experienced patients with HCV genotype-1 infection: a phase IIb trial
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Zeuzem S, Berg T, Gane E, Ferenci P, Foster GR, Fried MW, et al. Simeprevir increases rate of sustained virologic response among treatment-experienced patients with HCV genotype-1 infection: a phase IIb trial. Gastroenterology 2014;146:430-441.
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84894621765
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Sofosbuvir and ledipasvir fixed-dose combination with and without ribavirin in treatment-naive and previously treated patients with genotype 1 hepatitis C virus infection (LONESTAR): an open-label, randomised, phase 2 trial
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Lawitz E, Poordad F, Pang PS, Hyland RH, Ding X, Mo H, et al. Sofosbuvir and ledipasvir fixed-dose combination with and without ribavirin in treatment-naive and previously treated patients with genotype 1 hepatitis C virus infection (LONESTAR): an open-label, randomised, phase 2 trial. Lancet 2014;383:515-523.
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13
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84895736477
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SVR results of a once-daily regimen of simeprevir (TMC435) plus sofosbuvir (GS-7977) with or without ribavirin in cirrhotic and non-cirrhotic HCV genotype 1 treatment-naïve and prior null responder patients: the COSMOS study
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Jacobson IM, Ghalib RH, Rodriguez-Torres M, Younossi ZM, Corregidor A, Sulkowski MS, et al. SVR results of a once-daily regimen of simeprevir (TMC435) plus sofosbuvir (GS-7977) with or without ribavirin in cirrhotic and non-cirrhotic HCV genotype 1 treatment-naïve and prior null responder patients: the COSMOS study. Hepatology 2013;58:1379A.
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Corregidor, A.5
Sulkowski, M.S.6
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