Design, synthesis, and pharmacological evaluation of fluorinated tetrahydrouridine derivatives as inhibitors of cytidine deaminase

Journal of Medicinal Chemistry

Volumn 57, Issue 6, 2014, Pages 2582-2588

  Ferraris, Dana ^a,b   Duvall, Bridget ^a,b   Delahanty, Greg ^a,b   Mistry, Bipin ^a   Alt, Jesse ^a,b   Rojas, Camilo ^a,b   Rowbottom, Christopher ^a   Sanders, Kristen ^a   Schuck, Edgar ^a   Huang, Kuan Chun ^a   Redkar, Sanjeev ^c   Slusher, Barbara B ^a,b   Tsukamoto, Takashi ^a,b  

^a EISAI INC   (United States)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c ASTEX PHARMACEUTICALS   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

1(2 DEOXY 2 FLUORO BETA DEXTRO ARABINOFURANOSYL) DIHYDRO 2,4 (1H,3H) PYRIMIDINEDIONE; 1(2 DEOXY 2 FLUORO BETA DEXTRO ARABINOFURANOSYL) TETRAHYDRO 4 HYDROXY 2(1H) PYRIMIDINONE; 1(2 DEOXY 2 FLUORO BETA DEXTRO RIBOFURANOSYL) TETRAHYDRO 2(1H) PYRIMIDINONE; 2' DEOXY 2' FLUORO 3,4,5,6 TETRAHYDROURIDINE; 2' DEOXY 2' FLUORO 5,6 DIHYDROURIDINE; 2' DEOXY 2',2' DIFLUORO 3,4,5,6 TETRAHYDROURIDINE; 2' DEOXY 2',2' DIFLUORO 5,6 DIHYDROURIDINE; 5 AZA 2' DEOXYCYTIDINE; ACID; CYTIDINE DEAMINASE; TETRAHYDROURIDINE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG DESIGN; DRUG POTENTIATION; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; ENZYME SUBSTRATE; EXPERIMENTAL MONKEY; FLUORINATION; GLYCOSYLATION; MAXIMUM PLASMA CONCENTRATION; NONHUMAN;

ANIMALS; AZACITIDINE; BIOLOGICAL AVAILABILITY; CYTIDINE DEAMINASE; DRUG DESIGN; DRUG STABILITY; ENZYME INHIBITORS; EXCITATORY POSTSYNAPTIC POTENTIALS; FLUORINE; GASTRIC JUICE; MACACA MULATTA; MODELS, MOLECULAR; MOLECULAR CONFORMATION; STRUCTURE-ACTIVITY RELATIONSHIP; TETRAHYDROURIDINE;

EID: 84897438697     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm401856k     Document Type: Article

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